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1. 发明申请

US20050131205A1 Chain extended dendritic polyether 有权
标题翻译：链延长树枝状聚醚
公开(公告)号：US20050131205A1
公开(公告)日：2005-06-16
申请号：US10501024
申请日：2003-01-22
申请人： Bo Häggman , David James , Hakan Bjornberg , Birger Midelf
发明人： Bo Häggman , David James , Hakan Bjornberg , Birger Midelf
IPC分类号： C08G65/28 , C08G65/18 , C08G65/26 , C08G83/00 , C09D11/10 , C09D171/00 , C09J171/00 , C08G59/00
CPC分类号： C08G83/003 , C08G65/2609
摘要： A chain extended dendritic polyether comprising a dendritic core polymer and a chain extension bonded to said core polymer, which chain extended dendritic polyether optionally is at least partially chain terminated and/or partially functionalised. The core polymer is a polyhydric dendritic polyether and the chain extension is obtained by addition of at least one alkylene oxide to at least one hydroxyl group in said core polymer.
摘要翻译：一种链延长的树枝状聚醚，其包含树枝状核聚合物和与所述芯聚合物结合的链延伸，所述链延长树枝状聚醚任选地至少部分链终止和/或部分官能化。核心聚合物是多羟基树枝状聚醚，并且通过在所述芯聚合物中的至少一个羟基上加入至少一种烯化氧来获得链延伸。

2. 发明授权

US07186771B2 Air drying waterborne resin composition 有权
标题翻译：空气干燥水性树脂组合物
公开(公告)号：US07186771B2
公开(公告)日：2007-03-06
申请号：US10532058
申请日：2003-10-16
申请人： Bo Haggman , Hakan Bjornberg , Birger Midelf , David James
发明人： Bo Haggman , Hakan Bjornberg , Birger Midelf , David James
IPC分类号： C08J3/00 , C08K5/00 , C08L67/00 , C08L75/00 , C08G18/42
CPC分类号： C08L101/005 , C09D201/005 , C08L2666/14
摘要： An air drying waterborne resin composition is disclosed. Said resin composition comprises at least one amphiphlic air drying dendritic polymer, at least one non-amphiphilic air drying alkyd resin, at least one drier initiating and/or promoting autoxidation, and water, and optionally at least one anionic and/or nonionic surfactant, and/or at least one coalescent agent. Said at least one amphiphilic air drying dendritic polymer is built up from a polyhydric dendritic core polymer having terminal hydroxyl groups and at least one unsaturated carboxylic acid and at least one adduct, obtainable by addition of a monoalkylated polyethylene glycol to a dicarboxylic acid or anhydride and/or a diisocyanate, each bonded to at least one terminal hydroxyl group in said polyhydric dendritic core polymer.
摘要翻译：公开了一种空气干燥水性树脂组合物。所述树脂组合物包含至少一种两亲空气干燥树枝状聚合物，至少一种非两亲空气干燥醇酸树脂，至少一种引发和/或促进自动氧化的干燥剂，以及任选至少一种阴离子和/或非离子表面活性剂，和/或至少一种聚结剂。所述至少一种两亲空气干燥树枝状聚合物由具有末端羟基和至少一种不饱和羧酸的多元树枝状核聚合物和至少一种加合物构成，所述加成物可通过将二烷基化聚乙二醇加入到二羧酸或酸酐中而得到， /或二异氰酸酯，各自与所述多羟基树枝状核聚合物中的至少一个末端羟基键合。

3. 发明授权

US07176264B2 Process for manufacture of a dendritic polyether 有权
标题翻译：制备树枝状聚醚的方法
公开(公告)号：US07176264B2
公开(公告)日：2007-02-13
申请号：US10416712
申请日：2001-11-12
申请人： Bo Pettersson , David James , Birger Midelf , Hakan Bjornberg , Nicola Rehnberg
发明人： Bo Pettersson , David James , Birger Midelf , Hakan Bjornberg , Nicola Rehnberg
IPC分类号： C08G65/18
CPC分类号： C08G83/003 , C08G65/18 , C08G65/22
摘要： A process for manufacture of a dendritic polyether comprising a core, derived from a compound having two or more hydroxyl groups, and at least one branching generation being built up from at least one hydroxyoxetane having one oxetane group and at least one hydroxyl group is disclosed. The process comprises ring opening addition to said core and ring opening polymerization of said hydroxyoxetane. A mixture of the core compound and at least one cationic initiator is prepared and said hydroxyoxetane is fed to said mixture at a rate resulting in and/or maintaining a reaction temperature below onset at thermal degradation and in an amount resulting in at least one branching generation. The initiator is present in an amount of 0.1–0.5% by weight calculated on said core and said oxetane, preferably in an amount giving a ratio hydroxyl groups to initiator of between 1:0.01 and 1:0.05. Yielded dendritic polyether is sebsequently neutralised by addition of at least one alkaline compound and optionally purified.
摘要翻译：公开了一种制备树枝状聚醚的方法，该树枝状聚醚包含衍生自具有两个或多个羟基的化合物的核心，以及由至少一种具有一个氧杂环丁烷基团和至少一个羟基的羟基氧杂环丁烷构成的至少一种支链产物。该方法包括加入所述核心的开环和所述羟基氧杂环丁烷的开环聚合。制备核心化合物和至少一种阳离子引发剂的混合物，并且所述羟基氧杂环丁烷以导致和/或保持反应温度低于起始时的热降解速率并以导致至少一个分支生成的量加入所述混合物。引发剂的存在量为所述核和所述氧杂环丁烷计算的0.1-0.5重量％，优选以使得羟基与引发剂的比例在1:0.01至1:0.05之间。随后通过加入至少一种碱性化合物中和得到的树枝状聚醚并任选地进行纯化。

4. 发明申请

US20060052510A1 Air drying waterborne resin composition 有权
标题翻译：空气干燥水性树脂组合物
公开(公告)号：US20060052510A1
公开(公告)日：2006-03-09
申请号：US10532058
申请日：2003-10-16
申请人： Bo Haggman , Hakan Bjornberg , Birger Midelf , David James
发明人： Bo Haggman , Hakan Bjornberg , Birger Midelf , David James
IPC分类号： C08G18/42
CPC分类号： C08L101/005 , C09D201/005 , C08L2666/14
摘要： An air drying waterborne resin composition is disclosed. Said resin composition comprises at least one amphiphlic air drying dendritic polymer, at least one non-amphiphilic air drying alkyd resin, at least one drier initiating and/or promoting autoxidation, and water, and optionally at least one anionic and/or nonionic surfactant, and/or at least one coalescent agent. Said at least one amphiphilic air drying dendritic polymer is built up from a polyhydric dendritic core polymer having terminal hydroxyl groups and at least one unsaturated carboxylic acid and at least one adduct, obtainable by addition of a monoalkylated polyethylene glycol to a dicarboxylic acid or anhydride and/or a diisocyanate, each bonded to at least one terminal hydroxyl group in said polyhydric dendritic core polymer.
摘要翻译：公开了一种空气干燥水性树脂组合物。所述树脂组合物包含至少一种两亲空气干燥树枝状聚合物，至少一种非两亲空气干燥醇酸树脂，至少一种引发和/或促进自动氧化的干燥剂，以及任选至少一种阴离子和/或非离子表面活性剂，和/或至少一种聚结剂。所述至少一种两亲空气干燥树枝状聚合物由具有末端羟基和至少一种不饱和羧酸的多元树枝状核聚合物和至少一种加合物构成，所述加成物可通过将二烷基化聚乙二醇加入到二羧酸或酸酐中而得到， /或二异氰酸酯，各自与所述多羟基树枝状核聚合物中的至少一个末端羟基键合。

5. 发明授权

US07091308B2 Chain extended dendritic polyether 有权
标题翻译：链延长树枝状聚醚
公开(公告)号：US07091308B2
公开(公告)日：2006-08-15
申请号：US10501024
申请日：2003-01-22
申请人： Bo Haggman , David James , Hakan Bjornberg , Birger Midelf
发明人： Bo Haggman , David James , Hakan Bjornberg , Birger Midelf
IPC分类号： C08G59/06 , C08G65/14
CPC分类号： C08G83/003 , C08G65/2609
摘要： A chain extended dendritic polyether comprising a dendritic core polymer and a chain extension bonded to said core polymer, which chain extended dendritic polyether optionally is at least partially chain terminated and/or partially functionalised. The core polymer is a polyhydric dendritic polyether and the chain extension is obtained by addition of at least one alkylene oxide to at least one hydroxyl group in said core polymer.
摘要翻译：一种链延长的树枝状聚醚，其包含树枝状核聚合物和与所述芯聚合物结合的链延伸，所述链延长树枝状聚醚任选地至少部分链终止和/或部分官能化。核心聚合物是多羟基树枝状聚醚，并且通过在所述芯聚合物中的至少一个羟基上加入至少一种烯化氧来获得链延伸。

6. 发明授权

US09090569B2 Triazone compounds that modulate HSP90 activity 有权
标题翻译：调节HSP90活性的三嗪类化合物
公开(公告)号：US09090569B2
公开(公告)日：2015-07-28
申请号：US12604970
申请日：2009-10-23
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/4196 , C07D249/08 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

7. 发明申请

US20130296378A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
公开(公告)号：US20130296378A1
公开(公告)日：2013-11-07
申请号：US13857665
申请日：2013-04-05
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Prezewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Prezewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D401/04 , A61K45/06 , A61K31/4439 , C07D401/14
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

8. 发明申请

US20130169234A1 METHOD AND SYSTEM FOR CONTROLLING ENERGY STORAGE DEVICE 有权
标题翻译：控制能量储存装置的方法和系统
公开(公告)号：US20130169234A1
公开(公告)日：2013-07-04
申请号：US13338380
申请日：2011-12-28
申请人： Christopher James Chuah , Roger Bull , James Sudworth , Vincent Boccanfuso , David James
发明人： Christopher James Chuah , Roger Bull , James Sudworth , Vincent Boccanfuso , David James
IPC分类号： H02J7/00
CPC分类号： H01M10/44 , G01R31/3624 , G01R31/3679 , H01M10/443 , H01M10/448 , H01M10/48 , H01M10/486
摘要： A system and method of use including a controller responsive to a deviation in absolute value or relative slope and operable to terminate a discharge operation in an energy storage device is provided. The absolute value or relative slope is determined at sampling frequency based upon a combination of measured operating parameters, for example, potential and current. Any deviation in the absolute value or relative slope indicates that a threshold limit in the available energy of the system has been reached, for example when active materials in the device are at a point of depletion, indicating a need to cease the discharge operation. The system and method operate on a real-time basis, providing instantaneous SOH information with regard to the device.
摘要翻译：提供了一种系统和使用方法，其包括响应于绝对值或相对斜率的偏差并可操作以终止能量存储装置中的放电操作的控制器。基于测量的操作参数（例如电位和电流）的组合，以采样频率确定绝对值或相对斜率。绝对值或相对斜率的任何偏差表示已经达到系统可用能量的阈限，例如当器件中的活性材料处于耗尽点时，表示需要停止放电操作。该系统和方法在实时的基础上运行，提供关于设备的即时SOH信息。

9. 发明授权

US08299107B2 Triazole compounds that modulate HSP90 activity 有权
标题翻译：调节HSP90活性的三唑化合物
公开(公告)号：US08299107B2
公开(公告)日：2012-10-30
申请号：US12526491
申请日：2008-02-08
申请人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa K. Przewloka
发明人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa K. Przewloka
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： C07D417/14 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to the use of a substituted triazole compound of the invention, or a composition comprising such a compound in the preparation of a medicament for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及本发明的取代的三唑化合物或包含这种化合物的组合物在制备用于预防或治疗有需要的受试者中的过度增殖性疾病如癌症的药物中的用途。

10. 发明授权

US07919487B2 Heteroaryl compounds 有权
标题翻译：杂芳基化合物
公开(公告)号：US07919487B2
公开(公告)日：2011-04-05
申请号：US11271704
申请日：2005-11-10
申请人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
发明人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/50 , A61K31/53 , A61K31/505 , C07D413/14 , C07D251/02 , C07D401/14
CPC分类号： C07D213/75 , C07D213/77 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/56 , C07D251/42 , C07D251/52 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D491/10
摘要： This invention relates to compounds of formula (I): their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.
摘要翻译：本发明涉及式（I）化合物：它们的组成及其使用方法。化合物（和组合物）可用于调节由IL-12介导的IL-12产生和过程。

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