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1. 发明授权

US08222262B2 Indazolyl derivatives useful as potassium channel modulating agents 有权
标题翻译：可用作钾通道调节剂的吲唑基衍生物
公开(公告)号：US08222262B2
公开(公告)日：2012-07-17
申请号：US12444344
申请日：2007-10-03
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Palle Christophersen , Tina Holm Johansen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Palle Christophersen , Tina Holm Johansen
IPC分类号： A61K31/517
CPC分类号： C07D403/04 , C07D401/04
摘要： Potassium channel modulating agents of Formula Ia or Ib and enantiomers and mixtures enantiomers and N-oxides thereof, and pharmaceutically acceptable salts thereof, and their use in the preparation of pharmaceutical compositions. Also, pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, e.g., respiratory diseases, epilepsy, convulsions, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, irritable bowel syndrome, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, traumatic brain injury, psychosis, schizophrenia, anxiety, depression, dementia, memory and attention deficits, Alzheimer's disease, dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, migraine, arrhythmia, hypertension, absence seizures, myotonic muscle dystrophia, xerostomi, diabetes type II, hyperinsulinemia, premature labor, baldness, cancer, immune suppression, or pain.
摘要翻译：式Ia或Ib的钾通道调节剂及其对映异构体及其混合物对映异构体和N-氧化物及其药学上可接受的盐及其在制备药物组合物中的用途。此外，可用于治疗或缓解与钾通道活动相关的疾病或病症的药物组合物，例如呼吸系统疾病，癫痫，惊厥，血管痉挛，冠状动脉痉挛，肾脏疾病，多囊肾病，膀胱痉挛，尿失禁，膀胱流出阻塞，肠易激综合征，胃肠功能障碍，分泌性腹泻，局部缺血，脑缺血，缺血性心脏病，心绞痛，冠心病，创伤性脑损伤，精神病，精神分裂症，焦虑症，抑郁症，痴呆，记忆和注意力缺陷，老年痴呆症，痛经，发作性睡眠，雷诺病，间歇性跛行，Sjorgren综合征，偏头痛，心律失常，高血压，不存在癫痫发作，强直肌营养不良，口干燥症，II型糖尿病，高胰岛素血症，早产，秃发，癌症，免疫抑制或疼痛。

2. 发明申请

US20100035934A1 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译：吡啶并吡唑衍生物及其作为钾通道调节剂的用途
公开(公告)号：US20100035934A1
公开(公告)日：2010-02-11
申请号：US12525512
申请日：2008-02-01
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Tina Holm Johansen , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/4439 , C07D401/04 , A61P3/10 , A61P25/18 , A61P35/00
CPC分类号： C07D401/04 , C07D405/14
摘要： This invention relates to novel pyridinyl-pyrazole derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译：本发明涉及新的吡啶基 - 吡唑衍生物及其作为钾通道调节剂的用途。此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。

3. 发明申请

US20090306102A1 2-PYRIDIN-2-YL-QUINAZOLINE DERIVATIVES AS POTASSIUM CHANNEL MODULATING AGENTS FOR THE TREATMENT OF RESPIRATORY DISEASES 审中-公开
标题翻译：作为用于治疗呼吸道疾病的钾通道调节剂的2-吡啶-2-基 - 喹喔啉衍生物
公开(公告)号：US20090306102A1
公开(公告)日：2009-12-10
申请号：US12095281
申请日：2006-12-18
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Lene Teuber , Dan Peters , Charlotte Hougaard , Tina Holm Johansen , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Lene Teuber , Dan Peters , Charlotte Hougaard , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/517 , C07D401/04 , A61P25/00 , A61P11/00
CPC分类号： C07D401/04
摘要： This invention relates to novel pyridinyl-quinazoline derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译：本发明涉及新的吡啶基 - 喹唑啉衍生物及其作为钾通道调节剂的用途。此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。

4. 发明授权

US08048877B2 Guanidine derivatives and their medical use 有权
标题翻译：胍衍生物及其医疗用途
公开(公告)号：US08048877B2
公开(公告)日：2011-11-01
申请号：US12279928
申请日：2007-03-22
申请人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strøbæk , Tina Holm Johansen , Palle Christophersen
发明人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strøbæk , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/55 , C07D243/04
CPC分类号： C07D233/46 , C07D235/30 , C07D239/14 , C07D239/84 , C07D243/04
摘要： This invention relates to novel guanidine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型胍衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

5. 发明授权

US08362024B2 Purinyl derivatives and their use as potassium channel modulators 有权
标题翻译：嘌呤衍生物及其作为钾通道调节剂的用途
公开(公告)号：US08362024B2
公开(公告)日：2013-01-29
申请号：US12593194
申请日：2008-03-27
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Tina Holm Johansen , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Tina Holm Johansen , Palle Christophersen
IPC分类号： C07D473/16 , A61K31/52 , C07D473/40
CPC分类号： C07D473/16 , C07D473/24
摘要： This invention relates to novel purinyl derivatives of formula Ia or Ib Wherein the symbols are as defined in the Specification and of pharmaceutically acceptable salts thereof useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.
摘要翻译：本发明涉及式Ia或Ib的新型嘌呤基衍生物，其中符号如本说明书中所定义，及其药学上可接受的盐可用于治疗或缓解与钾通道活性相关的疾病或病症，用于制备用于这种治疗的药物和含有这些化合物的药物组合物。

6. 发明授权

US08039632B2 2-aminio-pyridine derivatives and their use as potassium channel modulators 有权
标题翻译： 2-氨基吡啶衍生物及其作为钾通道调节剂的用途
公开(公告)号：US08039632B2
公开(公告)日：2011-10-18
申请号：US12514532
申请日：2007-11-12
申请人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strøbæk , Tina Holm Johansen , Palle Christophersen
发明人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strøbæk , Tina Holm Johansen , Palle Christophersen
IPC分类号： C07D213/72 , A61K31/44
CPC分类号： C07D213/74
摘要： This invention relates to novel 2-amino-pyridine derivative useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型2-氨基 - 吡啶衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

7. 发明申请

US20100035951A1 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS 审中-公开
标题翻译： 2-氨基苯并咪唑衍生物及其作为小肠钙激活钾通道的调节剂
公开(公告)号：US20100035951A1
公开(公告)日：2010-02-11
申请号：US12307083
申请日：2007-07-05
申请人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strøbaek , Tina Holm Johansen , Palle Christophersen
发明人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strøbaek , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/4184 , C07D235/00
CPC分类号： C07D235/30
摘要： This invention relates to 2-amino benzimidazole derivatives of Formula 1a or 1b: which are useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及式1a或1b的2-氨基苯并咪唑衍生物：其可用作小电导钙激活钾通道（SK通道）的调节剂。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

8. 发明申请

US20100035924A1 NOVEL 4-AMINO-PYRIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译：新型4-氨基吡啶衍生物及其作为钾通道调节剂的用途
公开(公告)号：US20100035924A1
公开(公告)日：2010-02-11
申请号：US12514284
申请日：2007-11-13
申请人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strøbæk , Tina Holm Johansen , Palle Christophersen
发明人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strøbæk , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/47 , C07D211/72 , A61K31/44 , C07D215/38
CPC分类号： C07D213/74 , C07D215/44
摘要： This invention relates to novel 4-amino-pyridine derivative useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型4-氨基 - 吡啶衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

9. 发明申请

US20100152210A1 PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
公开(公告)号：US20100152210A1
公开(公告)日：2010-06-17
申请号：US12593218
申请日：2008-03-27
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Tina Holm Johansen , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/52 , C07D473/40 , A61P11/00 , A61P25/00 , A61P25/08 , A61P13/00 , A61P15/00 , A61P9/00 , A61P1/00 , A61P3/10 , A61P37/00 , A61P25/30 , A61P25/28
CPC分类号： C07D473/16 , C07D473/24
摘要： This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

10. 发明申请

US20090325989A1 INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS 有权
标题翻译：有用的盐酸衍生物作为钾通道调节剂
公开(公告)号：US20090325989A1
公开(公告)日：2009-12-31
申请号：US12444344
申请日：2007-10-03
申请人： Birgitte L. Eriksen , Ulrik Svane Sorensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Palle Christophersen , Tina Holm Johansen
发明人： Birgitte L. Eriksen , Ulrik Svane Sorensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Palle Christophersen , Tina Holm Johansen
IPC分类号： A61K31/506 , C07D401/04 , A61P9/10
CPC分类号： C07D403/04 , C07D401/04
摘要： This invention relates to novel indazolyl derivatives useful as potassium channel modulating agents, and their use in the preparation of pharmaceutical compositions.Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, in particular respiratory diseases, epilepsy, convulsions, seizures, absence seizures, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, erectile dysfunction, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, autism, ataxia, traumatic brain injury, Parkinson's disease, bipolar disorder, psychosis, schizophrenia, anxiety, depression, mania, mood disorders, dementia, memory and attention deficits, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, arrhythmia, hypertension, myotonic muscle dystrophia, spasticity, xerostomi, diabetes type II, hyperinsulinemia, premature labour, baldness, cancer, irritable bowel syndrome, immune suppression, migraine and pain.
摘要翻译：本发明涉及可用作钾通道调节剂的新的吲唑基衍生物及其在制备药物组合物中的用途。此外，本发明涉及可用于治疗或减轻与钾通道活性相关的疾病或病症的药物组合物，特别是呼吸系统疾病，癫痫，抽搐，癫痫发作，不发作，痉挛，血管痉挛，冠状动脉痉挛，肾脏疾病，多囊肾病，膀胱痉挛，尿失禁，膀胱流出阻塞，勃起功能障碍，胃肠功能障碍，分泌性腹泻，局部缺血，脑局部缺血，缺血性心脏病，心绞痛，冠心病，自闭症，共济失调，创伤性脑损伤，帕金森病，双相障碍，精神病，精神分裂症，焦虑症，抑郁症，躁狂症，情绪障碍，痴呆，记忆和注意力缺陷，阿尔茨海默病，肌萎缩性侧索硬化（ALS），痛经，发作性睡眠，雷诺病，间歇性跛行，Sjorgren综合征，心律失常，高血压，肌筋膜肌营养不良，痉挛，x 老年糖尿病，II型糖尿病，高胰岛素血症，早产，秃发，癌症，肠易激综合征，免疫抑制，偏头痛和疼痛。

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