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1. 发明授权

US10441635B2 Methods of treating pain using protein solutions 有权
公开(公告)号：US10441635B2
公开(公告)日：2019-10-15
申请号：US14937241
申请日：2015-11-10
申请人： Biomet Biologics, LLC
发明人： Krista Toler , William King , Jennifer E. Woodell-May
IPC分类号： A61K38/00 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/20 , G01N33/68 , G01N33/50 , A61K35/15
摘要： Methods and compositions for treating pain in mammalian subjects are provided. The methods include obtaining blood or a fraction of blood from the subject, measuring a therapeutic indicator in the blood or in the fraction blood, and administering an anti-inflammatory composition to the subject if the therapeutic indicator is equal to or above a threshold level. The anti-inflammatory composition comprises a protein solution including interleukin-1 receptor antagonist. The protein solution may be prepared from the blood or blood fraction obtained from the subject.

2. 发明申请

US20180243376A1 METHODS AND NON-IMMUNOGENIC COMPOSITIONS FOR TREATING INFLAMMATORY DISORDERS 审中-公开
公开(公告)号：US20180243376A1
公开(公告)日：2018-08-30
申请号：US15885432
申请日：2018-01-31
申请人： Biomet Biologics, LLC
发明人： Jeffrey R. Binder , Joel C. Higgins , Michael D. Leach , Krista Toler , Jennifer E. Woodell-May
IPC分类号： A61K38/19 , A61K38/17 , A61K45/06 , A61M1/36 , A61K35/14
CPC分类号： A61K38/19 , A61K35/14 , A61K38/1703 , A61K38/1793 , A61K45/06 , A61M1/3693
摘要： Methods for making non-immunogenic anti-inflammatory cytokine compositions, comprising (a) obtaining a liquid comprising cytokine producing cells from a mammalian donor; (b) contacting the liquid with a solid extraction material to generate a composition rich in interleukin-1 receptor antagonist; and performing one or both of (i) removing cells from the composition and (ii) freezing the composition. The compositions comprise two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII. Compositions may also contain white blood cells and platelets.

3. 发明授权

US10441634B2 Treatment of peripheral vascular disease using protein solutions 有权
公开(公告)号：US10441634B2
公开(公告)日：2019-10-15
申请号：US15836249
申请日：2017-12-08
申请人： Biomet Biologics, LLC
发明人： Matthew D. Landrigan , Krista Toler , Jennifer E. Woodell-May , David L. Suter
IPC分类号： A61K38/19 , A61K35/15 , A61K35/19 , A61K38/17 , A61K35/14 , A61K38/18
摘要： Methods of treating peripheral vascular disease comprising administering a protein solution site of a defect at least two proteins from the group IL-1ra, sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII. The solution may also comprise white blood cells, platelets, concentrated bone marrow aspirate, and combinations thereof.

4. 发明申请

US20180099026A1 TREATMENT OF PERIPHERAL VASCULAR DISEASE USING PROTEIN SOLUTIONS 审中-公开
公开(公告)号：US20180099026A1
公开(公告)日：2018-04-12
申请号：US15836249
申请日：2017-12-08
申请人： Biomet Biologics,LLC.
发明人： Matthew D. Landrigan , Krista Toler , Jennifer E. Woodell-May , David L. Suter
IPC分类号： A61K38/19 , A61K38/18 , A61K35/14 , A61K38/17 , A61K35/19 , A61K35/15
CPC分类号： A61K38/19 , A61K35/14 , A61K35/15 , A61K35/19 , A61K38/1703 , A61K38/1793 , A61K38/1808 , A61K38/1858
摘要： Methods of treating peripheral vascular disease comprising administering a protein solution site of a defect at least two proteins from the group IL-1ra, sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII. The solution may also comprise white blood cells, platelets, concentrated bone marrow aspirate, and combinations thereof.

5. 发明申请

US20170128538A1 METHODS FOR ASSESSING THE EFFICACY OF ANTI-INFLAMMATORY CYTOKINE COMPOSITIONS 审中-公开
公开(公告)号：US20170128538A1
公开(公告)日：2017-05-11
申请号：US15322585
申请日：2014-06-30
申请人： BIOMET BIOLOGICS, LLC
发明人： Krista Toler , William King , Jennifer E. Woodell-May
IPC分类号： A61K38/20 , G01N33/68
CPC分类号： A61K38/2006 , G01N33/502 , G01N33/6863 , G01N2333/52
摘要： Methods for generating an anti-inflammatory compositions. Methods include obtaining a biological material, determining input concentrations of an anti-inflammatory cytokine and of an inflammatory cytokine in the biological material wherein the anti-inflammatory cytokine inhibits the activity of the inflammatory cytokine; processing the biological material, and determining output concentrations of the anti-inflammatory cytokine and the inflammatory cytokine in the anti-inflammatory composition. The input and output concentrations are used to calculate a ratio of anti-inflammatory cytokines to inflammatory cytokines in both the output and the input. A ratio of at least 1 indicates that the anti-inflammatory composition is suitable for treating an inflammatory disorder.

6. 发明申请

US20150141332A1 METHODS FOR DIAGNOSING OSTEOARTHRITIS 审中-公开
标题翻译：诊断OSTEOARTHRITIS的方法
公开(公告)号：US20150141332A1
公开(公告)日：2015-05-21
申请号：US14405726
申请日：2013-06-04
申请人： Biomet Biologics, LLC
发明人： Krista Toler
IPC分类号： G01N33/68
CPC分类号： G01N33/6863 , G01N33/6887 , G01N2333/485 , G01N2333/49 , G01N2800/105 , G01N2800/52
摘要： Methods for managing osteoarthritis, in a human or other mammalian subject, comprising the measurement of certain cytokines and growth factors in a tissue sample of a subject, including one or more of platelet-derived growth factor AB (PDGF-AB), platelet-derived growth factor BB (PDGF-BB), and epidermal growth factor (EGF). Tissue samples may be whole blood, blood fractions, urine, saliva, and synovial fluid. Methods include diagnosing osteoarthritis, and methods for assessing the severity of osteoarthritis, such as in subject that have been diagnosed with osteoarthritis using radiographic or other methods. Methods may also include comparison of measured cytokine levels to a reference level. Methods of managing the clinical progression of osteoarthritis include initiating a clinical action based on the difference between the measured cytokine level and a reference level.
摘要翻译：在人或其他哺乳动物受试者中管理骨关节炎的方法，包括在受试者的组织样品中测量某些细胞因子和生长因子，包括一种或多种血小板衍生生长因子AB（PDGF-AB），血小板衍生的生长因子BB（PDGF-BB）和表皮生长因子（EGF）。组织样品可以是全血，血液分数，尿液，唾液和滑液。方法包括诊断骨关节炎，以及评估骨关节炎严重程度的方法，例如使用放射照相法或其他方法诊断为骨关节炎的受试者。方法还可以包括将测量的细胞因子水平与参考水平的比较。管理骨关节炎临床进展的方法包括基于测量的细胞因子水平与参考水平之间的差异来启动临床行为。

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