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1. 发明申请

US20160287615A1 NOVEL ENCAPSULATION OF FLUORESCENT, PHOTO-SENSITIVE, OR OXYGEN-SENSITIVE ACTIVE INGREDIENT FOR TOPICAL APPLICATION 审中-公开
标题翻译：用于局部应用的荧光，光敏性或氧气敏感性成分的新颖包封
公开(公告)号：US20160287615A1
公开(公告)日：2016-10-06
申请号：US15090595
申请日：2016-04-04
申请人： BioPharmX, Inc.
发明人： Kin F. Chan , Anja B. Krammer , Douglas W. Thomas
IPC分类号： A61K31/65 , A61K9/50 , A61K31/66 , A61K9/00
CPC分类号： A61K31/65 , A61K9/14
摘要： A topical composition for treatment of a skin condition comprising a fluorescent, photosensitive, or oxygen sensitive active ingredient encapsulated in a plurality of tubular microparticles for pharmaceutical use in humans is described. Some embodiments comprise a topical composition for treatment of acne that comprises an encapsulation of a tetracycline class drug, such as crystalline minocycline, in a plurality of microparticles, wherein the microparticles comprise a divalent cation, such as Mg2+ or Zn2+. The tubular microparticles may comprise Mg2CO3. Benefits of various embodiments include the lack of visible fluorescence from a fluorescent active ingredient, reduced UV degradation of a photosensitive active ingredient, reduced UV degradation of an oxygen sensitive active ingredient, sun protection factor for the skin, and sustained delivery of a therapeutic dose.
摘要翻译：描述了用于治疗皮肤病症的局部组合物，其包含包封在用于人类药物的多个管状微粒中的荧光，感光或氧敏感性活性成分。一些实施方案包括用于治疗痤疮的局部组合物，其包含将四环素类药物如结晶米诺环素包封在多个微粒中，其中所述微粒包含二价阳离子，例如Mg 2+或Zn 2+。管状微粒可以包含Mg 2 CO 3。各种实施方案的优点包括缺乏来自荧光活性成分的可见荧光，光敏活性成分的UV降解降低，氧敏感性成分的UV降解，皮肤的防晒因子和治疗剂量的持续递送。

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