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1. 发明授权

US10539581B2 Stabilization of labile analytes in reference materials 有权
公开(公告)号：US10539581B2
公开(公告)日：2020-01-21
申请号：US15331638
申请日：2016-10-21
申请人： Bio-Rad Laboratories, Inc.
发明人： Alireza Ebrahim , Karl De Vore , Christopher Spates
IPC分类号： G01N33/96 , F26B5/06
摘要： Provided herein are assay control materials comprising stable analytes and lyophilized unstable analytes, and methods of making and using the same.

2. 发明申请

US20160054339A1 VALUE ASSIGNMENT FOR CUSTOMIZABLE QUALITY CONTROLS 有权
标题翻译：可定制质量控制的价值分配
公开(公告)号：US20160054339A1
公开(公告)日：2016-02-25
申请号：US14831765
申请日：2015-08-20
申请人： Bio-Rad Laboratories, Inc.
发明人： Alireza Ebrahim , Karl De Vore , Christopher Spates
IPC分类号： G01N33/78
CPC分类号： G01N33/78 , G01N33/48 , G01N33/96
摘要： Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.
摘要翻译：为最终用户提供诊断测量程序的方法，以制备具有所需分析物回收率的质量控制，估计已经制备的质量控制的回收率，并比较估计和测量的回收率。为了制备含有特定分析物的质量控制，可以通过相关因子来缩放分析物测量程序的期望回收，以获得质量控制中分析物的目标标称浓度。或者，质量控制中的分析物的标称浓度可以通过相关因子来缩放，以获得对分析物的测量程序的预测回收。相关因子可以基于先前使用测量程序获得的恢复数据和可选的一个或多个参考程序，并且可以使用这些数据的回归分析来计算。每个质量控制可以通过将包含目标分析物的许多固体珠溶解在一定体积的基质中来制备。

3. 发明授权

US11385245B2 Value assignment for customizable quality controls 有权
公开(公告)号：US11385245B2
公开(公告)日：2022-07-12
申请号：US16880705
申请日：2020-05-21
申请人： Bio-Rad Laboratories, Inc.
发明人： Alireza Ebrahim , Karl De Vore , Christopher Spates
IPC分类号： G01N33/96 , G01N33/78 , G01N33/48
摘要： Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.

4. 发明申请

US20200284809A1 VALUE ASSIGNMENT FOR CUSTOMIZABLE QUALITY CONTROLS 审中-公开
公开(公告)号：US20200284809A1
公开(公告)日：2020-09-10
申请号：US16880705
申请日：2020-05-21
申请人： Bio-Rad Laboratories, Inc.
发明人： Alireza Ebrahim , Karl De Vore , Christopher Spates
IPC分类号： G01N33/78 , G01N33/96
摘要： Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.

5. 发明授权

US10697981B2 Value assignment for customizable quality controls 有权
公开(公告)号：US10697981B2
公开(公告)日：2020-06-30
申请号：US15849514
申请日：2017-12-20
申请人： Bio-Rad Laboratories, Inc.
发明人： Alireza Ebrahim , Karl De Vore , Christopher Spates
IPC分类号： G01N33/96 , G01N33/78 , G01N33/48
摘要： Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.

6. 发明申请

US20180203023A1 VALUE ASSIGNMENT FOR CUSTOMIZABLE QUALITY CONTROLS 审中-公开
公开(公告)号：US20180203023A1
公开(公告)日：2018-07-19
申请号：US15849514
申请日：2017-12-20
申请人： Bio-Rad Laboratories, Inc.
发明人： Alireza Ebrahim , Karl De Vore , Christopher Spates
IPC分类号： G01N33/78 , G01N33/96
摘要： Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.

7. 发明申请

US20170131302A1 STABILIZATION OF LABILE ANALYTES IN REFERENCE MATERIALS 审中-公开
公开(公告)号：US20170131302A1
公开(公告)日：2017-05-11
申请号：US15411775
申请日：2017-01-20
申请人： Bio-Rad Laboratories, Inc.
发明人： Alireza Ebrahim , Karl De Vore , Christopher Spates
IPC分类号： G01N33/96
摘要： Provided herein are assay control materials comprising stable analytes and lyophilized unstable analytes, and methods of making and using the same.

8. 发明授权

US09885728B2 Value assignment for customizable quality controls 有权
公开(公告)号：US09885728B2
公开(公告)日：2018-02-06
申请号：US14831765
申请日：2015-08-20
申请人： Bio-Rad Laboratories, Inc.
发明人： Alireza Ebrahim , Karl De Vore , Christopher Spates
IPC分类号： G01N33/96 , G01N33/78 , G01N33/48
CPC分类号： G01N33/78 , G01N33/48 , G01N33/96
摘要： Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.

9. 发明申请

US20170122970A1 STABILIZATION OF LABILE ANALYTES IN REFERENCE MATERIALS 审中-公开
公开(公告)号：US20170122970A1
公开(公告)日：2017-05-04
申请号：US15331638
申请日：2016-10-21
申请人： Bio-Rad Laboratories, Inc.
发明人： Alireza Ebrahim , Karl De Vore , Christopher Spates
IPC分类号： G01N33/96
摘要： Provided herein are assay control materials comprising stable analytes and lyophilized unstable analytes, and methods of making and using the same.

10. 发明授权

US09599543B2 Customized quality controls for analytical assays 有权
公开(公告)号：US09599543B2
公开(公告)日：2017-03-21
申请号：US14938780
申请日：2015-11-11
申请人： Bio-Rad Laboratories, Inc. QSD
发明人： Alireza Ebrahim , Christopher Spates , Karl De Vore
IPC分类号： G01N33/00 , G01N1/28 , G01N33/96 , C12Q1/32 , G01N21/91
CPC分类号： G01N1/28 , C12Q1/32 , G01N21/91 , G01N33/96 , G01N2001/2893 , G01N2333/765 , G01N2496/00 , G01N2496/80
摘要： Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay.

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