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1. 发明授权

US07547816B2 α(1,3)-galactosyltransferase knockout swine, tissues and organs 有权
标题翻译： α（1,3） - 半乳糖转移酶敲除猪，组织和器官
公开(公告)号：US07547816B2
公开(公告)日：2009-06-16
申请号：US10499407
申请日：2002-12-23
申请人： Billy N. Day , Robert J. Hawley , Randall S. Prather
发明人： Billy N. Day , Robert J. Hawley , Randall S. Prather
IPC分类号： A01K67/027 , C12N15/00 , A01N1/00
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0276 , A01K2217/075 , A01K2227/108 , A01K2267/02 , A01K2267/025 , A01K2267/03 , C12N9/1051 , C12N15/8778 , C12N2517/02 , C12N2800/60 , C12N2840/203 , C12N2840/85
摘要： The invention relates to the genetic manipulation of non-human animals. More particularly, the invention relates to genetic manipulation of non-human animals to be used for xenotransplantation. The invention provides viable gene knockout swine including swine in which the α(1,3)-galactosyltransferase gene has been disrupted, methods for making such swine, and methods of using the tissues and organs of such swine for xenotransplantation.
摘要翻译：本发明涉及非人类动物的遗传操作。更具体地说，本发明涉及用于异种移植的非人动物的遗传操作。本发明提供了可行的基因敲除猪，包括其中α（1,3） - 半乳糖转移酶基因被破坏的猪，以及制备这种猪的方法，以及使用这种猪的组织和器官进行异种移植的方法。

2. 发明授权

US5916144A System for introducing a fluid into the uterus of an animal 失效
标题翻译：将流体引入动物子宫的系统
公开(公告)号：US5916144A
公开(公告)日：1999-06-29
申请号：US964833
申请日：1997-11-05
申请人： Jiewen Li , August Rieke , Billy N. Day , Randall S. Prather
发明人： Jiewen Li , August Rieke , Billy N. Day , Randall S. Prather
IPC分类号： A61B17/42 , A61B17/43 , A61D19/02 , A61D19/04 , A61D7/00
CPC分类号： A61D19/04 , A61B17/43 , A61D19/027 , A61B17/4241
摘要： This invention relates to a system for penetrating the uterus of an animal during a non-surgical procudure, the uterus having a cervix leading to a uterus body. The system comprises a probe having a long tubular body with a central longitudinal axis, open forward and rearward ends, and a probing member projecting forward and laterally outward beyond the forward end of the probe body. The probe is inserted, forward end first, inside the cervix of said animal, and the probe body is manipulated to gently maneuver the probing member in a forward direction through the cervix to a position in which the probing member and the forward open end of the probe body are adjacent the body of the uterus.
摘要翻译：本发明涉及一种在非手术切除期间穿透动物子宫的系统，子宫具有通向子宫体的子宫颈。该系统包括具有中心纵向轴线的长管状体的探头，前端和后端的开口以及向前和向外向外突出超出探针主体前端的探测构件。探针首先在前述动物的子宫颈内插入，并且探测体被操纵以便将探测构件沿向前的方向轻轻地操纵通过子宫颈到探测构件和探针构件的向前开口端的位置探针体与子宫体相邻。

3. 发明授权

US5656010A System for effecting embryo transplant 失效
标题翻译：影响胚胎移植的系统
公开(公告)号：US5656010A
公开(公告)日：1997-08-12
申请号：US438162
申请日：1995-05-09
申请人： Jiewen Li , August Rieke , Billy N. Day , Randall S. Prather
发明人： Jiewen Li , August Rieke , Billy N. Day , Randall S. Prather
IPC分类号： A61B17/42 , A61B17/43 , A61D19/02 , A61D19/04 , A61D7/00
CPC分类号： A61D19/04 , A61B17/43 , A61D19/027 , A61B17/4241 , A61B2090/036
摘要： The invention involves a system for effecting the nonsurgical transplant of embryos into the uterus of an animal. The system comprises (1) a long tubular gripping instrument having an open forward end configured for gripping the walls of the cervix of the uterus when the instrument is inserted to a position inside the cervix, and (2) a probe having a long tubular body which extends through the tubular gripping instrument, the probe being manipulatable to effect movement of the probe relative to the gripping instrument to facilitate passage of the probe and the gripping instrument through the cervix to a position generally adjacent the body of the uterus, and (3) an embryo carrier for carrying one or more embryos to be placed in the uterus of the animal. The embryo carrier is sized for insertion in and through the tubular probe to an embryo release position for release of the embryos into the uterus.
摘要翻译：本发明涉及一种用于将胚胎非手术移植到动物子宫中的系统。该系统包括（1）一种长管状夹持器具，其具有设置成当器械插入子宫颈内部位置时夹持子宫颈的壁的开口前端，以及（2）具有长管状体的探针其延伸穿过管状夹持器械，探头可操作以实现探针相对于夹持器械的运动，以便于将探针和夹持器械通过子宫颈通过到与子宫主体相邻的位置，并且（3 ）用于携带一个或多个胚胎以放置在动物子宫中的胚胎载体。胚胎载体的尺寸适于插入并穿过管状探针至胚胎释放位置以将胚胎释放到子宫中。

4. 发明授权

US5558636A Method of effecting embryo transplant 失效
标题翻译：影响胚胎移植的方法
公开(公告)号：US5558636A
公开(公告)日：1996-09-24
申请号：US438174
申请日：1995-05-09
申请人： Jiewen Li , August Rieke , Billy N. Day , Randall S. Prather
发明人： Jiewen Li , August Rieke , Billy N. Day , Randall S. Prather
IPC分类号： A61B17/42 , A61B17/43 , A61D19/02 , A61D19/04 , A61M31/00
CPC分类号： A61D19/04 , A61B17/43 , A61D19/027 , A61B17/4241
摘要： This invention is directed to a method of effecting the non-surgical transplant of embryos into the uterus of an animal. The method involves the use of a long tubular gripping instrument having an open forward end and an external gripping formation generally adjacent its forward end. A probe with a long tubular body having an open forward end extends axially inside the gripping instrument. A probing member projects in a generally non-axial direction from the probe body generally adjacent its forward end. The method comprises the steps of inserting the gripping instrument, forward end first, into a cervix of the uterus, and establishing a grip between the walls of the cervix and the external gripping formation on the gripping instrument. While maintaining said grip, the gripping instrument is pulled in a rearward direction to straighten the cervix. At the same time the the probe is pushed in a forward direction to advance the probing member through the cervix to a position generally adjacent a body of the uterus. An embryo carrier is then placed inside the probe body and moved to an embryo release position for release of embryos from the carrier into the uterus.
摘要翻译：本发明涉及一种将胚胎非手术移植到动物子宫中的方法。该方法包括使用长管状夹持器具，其具有大致相邻于其前端的敞开的前端和外部夹持结构。具有开放的前端的长管体的探针在夹持器具内部轴向延伸。探测构件大致在非轴向方向上从探头主体突出，大致相邻其前端。该方法包括以下步骤：将握持器械首先将前端插入子宫颈，并在子宫颈壁和夹持器具上的外部夹持结构之间建立夹持。在保持所述把手的同时，夹持器械沿向后方向拉伸以使子宫颈伸直。同时，探针被向前推动以将探测构件通过子宫颈推进到大致邻近子宫体的位置。然后将胚胎载体放置在探针体内并移动到胚胎释放位置，以将胚胎从载体释放到子宫中。

5. 发明申请

US20170258495A1 MEDIUM SUPPLEMENT TO INCREASE THE EFFICIENCY OF OOCYTE MATURATION AND EMBRYO CULTURE IN VITRO 审中-公开
公开(公告)号：US20170258495A1
公开(公告)日：2017-09-14
申请号：US15445621
申请日：2017-02-28
申请人： Ye Yuan , Lee D. Spate , Randall S. Prather , R. Michael Roberts
发明人： Ye Yuan , Lee D. Spate , Randall S. Prather , R. Michael Roberts
IPC分类号： A61B17/435 , C12N5/075
CPC分类号： C12N5/0609 , C12N5/0604 , C12N2501/10 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/235 , C12N2501/31 , C12N2501/727 , C12N2517/04 , C12N2517/10
摘要： The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided.

6. 发明申请

US20120180141A1 Transgenic Animal Models of Disease 有权
标题翻译：转基因动物模型的疾病
公开(公告)号：US20120180141A1
公开(公告)日：2012-07-12
申请号：US13288720
申请日：2011-11-03
申请人： Michael J. Welsh , Christopher S. Rogers , Randall S. Prather , John Engelhardt , Ziying Yan
发明人： Michael J. Welsh , Christopher S. Rogers , Randall S. Prather , John Engelhardt , Ziying Yan
IPC分类号： A01K67/027 , C12N15/861 , A61K49/00 , C12N5/10
CPC分类号： C07K14/4712 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/052 , A01K2217/056 , A01K2217/075 , A01K2217/15 , A01K2227/108 , A01K2267/0306 , C12N15/8509
摘要： The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions.
摘要翻译：本发明提供了转基因大的非人类动物模型的疾病和病症，以及制备和使用这些动物模型来鉴定和表征疾病和病症的疗法的方法。

7. 发明申请

US20180094240A1 ARTIFICIAL OOCYTE ACTIVATION 审中-公开
公开(公告)号：US20180094240A1
公开(公告)日：2018-04-05
申请号：US15726672
申请日：2017-10-06
申请人： Kiho Lee , Randall S. Prather
发明人： Kiho Lee , Randall S. Prather
IPC分类号： C12N5/075 , C12N15/877 , A01K67/027
CPC分类号： C12N5/0609 , A01K67/0273 , A01K2227/108 , C12N15/877 , C12N15/8778 , C12N2500/14 , C12N2500/22 , C12N2501/405 , C12N2517/04 , C12N2517/10
摘要： The present invention provides novel methods for improving the efficiency of artificial activation of unfertilized mammalian oocytes by reducing the intracellular concentration of Zn2+ in the oocyte. The methods of the invention may additionally comprise a preceding step of increasing the intracellular concentration of Ca2+ in the oocyte prior to reduction of the intracellular Zn2+ concentration. The invention further provides unfertilized oocytes activated by the disclosed methods and viable mammalian animals produced from unfertilized oocytes activated by the disclosed methods.

8. 发明授权

US06211429B1 Complete oocyte activation using an oocyte-modifying agent and a reducing agent 失效
标题翻译：使用卵母细胞修饰剂和还原剂完成卵母细胞活化
公开(公告)号：US06211429B1
公开(公告)日：2001-04-03
申请号：US09100167
申请日：1998-06-18
申请人： Zoltan Machaty , Randall S. Prather
发明人： Zoltan Machaty , Randall S. Prather
IPC分类号： C12N1500
CPC分类号： C12N15/8771 , C12N5/0609 , C12N2517/10
摘要： Provided is a method of parthenogenetically activating an unfertilized mammalian oocyte, comprising contacting an unfertilized mammalian oocyte with an oocyte-modifying agent followed by a reducing agent, wherein the mammalian oocyte is in contact with the oocyte-modifying agent and reducing agent, respectively, for a time and under conditions such that the unfertilized mammalian oocyte is activated. Also provided are methods for transplanting a nucleus from a cultured mammalian cell, mammalian embryo, mammalian fetus, or an adult mammal to a recipient mammalian oocyte; producing a cloned mammalian embryo; and producing a cloned mammal, as well as the cloned products produced by these methods. Finally, a method of studying genetic imprinting in mammals is also provided.
摘要翻译：提供了一种孤雌激活未受精的哺乳动物卵母细胞的方法，包括使未受精的哺乳动物卵母细胞与卵母细胞修饰剂接触，然后还原剂接触，其中哺乳动物卵母细胞分别与卵母细胞改性剂和还原剂接触，用于时间和条件使得未受精的哺乳动物卵母细胞被激活。还提供了将细胞核从培养的哺乳动物细胞，哺乳动物胚胎，哺乳动物胎儿或成年哺乳动物移植到受体哺乳动物卵母细胞的方法; 产生克隆的哺乳动物胚胎; 并产生克隆的哺乳动物，以及通过这些方法产生的克隆产物。最后还提供了一种研究哺乳动物遗传印记的方法。

9. 发明授权

US09820475B2 Porcine reproductive and respiratory syndrome virus resistant animals 有权
公开(公告)号：US09820475B2
公开(公告)日：2017-11-21
申请号：US14117943
申请日：2012-05-16
申请人： Randall S. Prather , Kevin D. Wells , Kristin M. Whitworth
发明人： Randall S. Prather , Kevin D. Wells , Kristin M. Whitworth
IPC分类号： A01K67/027 , C12N15/85 , C07K14/705
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2217/15 , A01K2227/108 , A01K2267/02 , C07K14/7056 , C07K14/70596 , C12N15/8509
摘要： The disclosure relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles CD 163 gene inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSV). Methods for producing such transgenic swine are also provided.

10. 发明授权

US08912386B2 Transgenic pig model of cystic fibrosis 有权
标题翻译：囊性纤维化转基因猪模型
公开(公告)号：US08912386B2
公开(公告)日：2014-12-16
申请号：US13288720
申请日：2011-11-03
申请人： Michael J. Welsh , Christopher S. Rogers , Randall S. Prather , John Engelhardt , Ziying Yan
发明人： Michael J. Welsh , Christopher S. Rogers , Randall S. Prather , John Engelhardt , Ziying Yan
IPC分类号： A01K67/00 , A01K67/033 , A01K67/027
CPC分类号： C07K14/4712 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/052 , A01K2217/056 , A01K2217/075 , A01K2217/15 , A01K2227/108 , A01K2267/0306 , C12N15/8509
摘要： The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions.
摘要翻译：本发明提供了转基因大的非人类动物模型的疾病和病症，以及制备和使用这些动物模型来鉴定和表征疾病和病症的疗法的方法。

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