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1. 发明申请

US20120021077A1 SYNERGISTIC HERBAL COMPOSITION FOR TREATMENT OF RHEUMATIC AND MUSCULO-SKELETAL DISORDERS (RMSDS) 审中-公开
标题翻译：用于治疗感染和肌肉 - 脊髓疾病（RMSDS）的协同草本组合物
公开(公告)号：US20120021077A1
公开(公告)日：2012-01-26
申请号：US12669643
申请日：2008-07-18
申请人： Bhushan Patwardhan , Arvind Chopra , Gumdal Narsimulu , Rohini Handa , Lata S. Bichile , Ghulam Nabi Qazi , Arvind Manohar Mujumdar , Venil N. Sumantran , Palpu Pushpangadam , Shanta Mehrotra , Ajay Kumar Singh Rawat , Sayyada Khatoon , Subha Rastogi , Govindarajan Raghavan , Ashwinikumar Raut
发明人： Bhushan Patwardhan , Arvind Chopra , Gumdal Narsimulu , Rohini Handa , Lata S. Bichile , Ghulam Nabi Qazi , Arvind Manohar Mujumdar , Venil N. Sumantran , Palpu Pushpangadam , Shanta Mehrotra , Ajay Kumar Singh Rawat , Sayyada Khatoon , Subha Rastogi , Govindarajan Raghavan , Ashwinikumar Raut
IPC分类号： A61K36/9068 , A61P21/00 , A61P19/00 , A61P39/06 , A61K36/81 , A61P29/00
CPC分类号： A61K36/185 , A61K36/324 , A61K36/47 , A61K36/59 , A61K36/81 , A61K36/9068 , A61K2300/00
摘要： The present invention deals with a synergistic herbal composition useful for treatment of rheumatic and musculo-skeletal disorders (RMSDs) comprising a base formulation (50-60%) and plant parts and/or extracts of the plant (40-50%) selected from the group consisting of Withania somnifera, Tribulus terrestris, Phyllanthus emblica and Boswellia serrata optionally along with pharmaceutically acceptable excipients. The herbal formulation is capable of causing simultaneous long term decrease in glycosaminoglycan (GAG) release and aggrecan by cartilage explants resulting in reduction of pain, inflammation, stiffness and low degeneration of bones, joints, muscles and other connective tissues. The present invention further deals with a process for the preparation of the said herbal formulation and a method of treating RMSDs using the formulation up to a high safety level and stable for a long durations.
摘要翻译：本发明涉及用于治疗风湿性和肌肉 - 骨骼疾病（RMSDs）的协同草药组合物，其包含基础制剂（50-60％）和植物部分和/或植物提取物（40-50％），选自该组包括有睡莲，Trib藜，竹a和芥子草，任选地与药学上可接受的赋形剂。草药制剂能够通过软骨外植体同时长期降低糖胺聚糖（GAG）释放和聚集蛋白聚糖，导致骨骼，关节，肌肉和其他结缔组织的疼痛，炎症，僵硬和变性降低。本发明进一步涉及制备所述草药制剂的方法和使用该制剂治疗RMSD的方法，该方法达到高安全性水平并且在长时间内稳定。

2. 发明授权

US08445700B2 Process for the preparation of optically active N-benzyl-3 hydroxypyrrolidines 有权
标题翻译：光学活性N-苄基-3-羟基吡咯烷的制备方法
公开(公告)号：US08445700B2
公开(公告)日：2013-05-21
申请号：US13130702
申请日：2009-11-24
申请人： Subhash Chandra Taneja , Mushtaq Ahmad Aga , Brijesh Kumar , Vijay Kumar Sethi , Samar Singh Andotra , Ghulam Nabi Qazi
发明人： Subhash Chandra Taneja , Mushtaq Ahmad Aga , Brijesh Kumar , Vijay Kumar Sethi , Samar Singh Andotra , Ghulam Nabi Qazi
IPC分类号： C07D207/12 , C07D471/02
CPC分类号： C07D207/12
摘要： The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)—N-benzyl-3-hydroxypyrrolidine and (R)—N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)—N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.
摘要翻译：本发明涉及从天然存在的生物碱催化剂以高产率制备光学活性N-苄基-3-羟基吡咯烷的简便，高效和经济的方法。使用天然生物碱维生素作为（S）-N-苄基-3-羟基吡咯烷和（R）-N-苄基-3-羟基吡咯烷的前体，其可以通过以下方法容易地从药用植物金丝桃源中获得并通过本发明所述的方法转化成光学异构体（R）和（S）-N-苄基-3-羟基吡咯烷。

3. 发明申请

US20120251464A1 CHALCONES AS ENHANCER OF ANTIMICROBIAL AGENTS 有权
标题翻译：作为抗病毒剂增强剂的混合物
公开(公告)号：US20120251464A1
公开(公告)日：2012-10-04
申请号：US13515836
申请日：2009-12-18
申请人： Ravi Subramanyam , Laurence Du-Thumm , Ghulam Nabi Qazi , Inshad Ali Khan , Krishan Avtar Suri , Naresh Kumar Satti , Furqan Ali , Nitin Pal Kalia
发明人： Ravi Subramanyam , Laurence Du-Thumm , Ghulam Nabi Qazi , Inshad Ali Khan , Krishan Avtar Suri , Naresh Kumar Satti , Furqan Ali , Nitin Pal Kalia
IPC分类号： A61K31/12 , A61K31/40 , A61K31/496 , A61K31/194 , A61K31/7048 , A61K9/68 , A61K8/35 , A61K8/49 , A61P31/04 , A61Q11/00 , A61K31/341 , A61K31/4425
CPC分类号： A61K31/122 , A61K31/00 , A61K31/341 , A61K31/40 , A61K45/06 , C07D207/00 , Y02A50/473 , A61K2300/00
摘要： Compounds are described that are effective in enhancing the efficacy of antimicrobial agents. Also described are methods of using such compounds and compositions that include such compounds. The composition includes a chalcone compound and, optionally, an antimicrobial agent.
摘要翻译：描述了有效提高抗微生物剂功效的化合物。还描述了使用这些化合物和包含这些化合物的组合物的方法。该组合物包括查耳酮化合物和任选的抗微生物剂。

4. 发明授权

US06593127B1 Composition for early and profuse sporulation in fungi and a method thereof 有权
标题翻译：早期和大量真菌孢子的组成及其方法
公开(公告)号：US06593127B1
公开(公告)日：2003-07-15
申请号：US10067132
申请日：2002-02-04
申请人： Rajinder Kumar Khajuria , Ram Vilas Parsad Sinha , Vijeshwar Verma , Ghulam Nabi Qazi , Sukhdev Swami Handa
发明人： Rajinder Kumar Khajuria , Ram Vilas Parsad Sinha , Vijeshwar Verma , Ghulam Nabi Qazi , Sukhdev Swami Handa
IPC分类号： C12N116
CPC分类号： C12N3/00 , C12N1/14
摘要： The present invention relates to a composition useful for early and profuse sporulation in fungi with about 100 fold increase in spore count within 48 hours of inoculation, said composition comprising molasses ranging between 5-20 g/L, Corn Steep Liquor (CSL) ranging between 10-25 g/L, Sodium chloride (NaCl) ranging between 5-15 g/L, calcium sulphate (CaSO4) ranging between 0.1-0.5 g/L, Potassium dihydrogen phosphate (KH2PO4) ranging between 0.001-0.01 g/L, Magnesium sulphate (MgSO4.7 H2O) ranging between 0.001-0.01 g/L, Copper sulphate (CuSO4) ranging between 0.001-0.0050 g/L, Ferrous sulphate (FeSO4) ranging between 0.0009-0.005 g/L, an anti-foam agent, and optionally solidifying agent and a method thereof.
摘要翻译：本发明涉及用于早期和大量真菌孢子成分的组合物，其接种48小时内孢子数量增加约100倍，所述组合物包含范围在5-20g / L之间的糖蜜，玉米eep酒（CSL）的范围介于 10-25g / L，氯化钠（NaCl）为5-15g / L，硫酸钙（CaSO 4）为0.1-0.5g / L，磷酸二氢钾（KH 2 PO 4）为0.001-0.01g / L，范围在0.001-0.01g / L之间的硫酸镁（MgSO 4·7H 2 O），0.001-0.0050g / L范围内的硫酸铜（CuSO 4），0.0009-0.005g / L范围内的硫酸亚铁（FeSO 4），防沫剂，和任选的固化剂及其方法。

5. 发明授权

US08580752B2 Aromatic amides as potentiators of bioefficacy of anti-infective drugs 有权
标题翻译：芳香酰胺作为抗感染药物生物功效的增强剂
公开(公告)号：US08580752B2
公开(公告)日：2013-11-12
申请号：US11391391
申请日：2006-03-29
申请人： Surrinder Koul , Jawahir Lal Koul , Subhash Chandra Taneja , Pankaj Gupta , Inshad Ali Khan , Zahid Mehmood Mirza , Ashwani Kumar , Rakesh Kamal Johri , Monika Pandita , Anita Khosa , Ashok Kumar Tikoo , Subhash Chander Sharma , Vijeshwar Verma , Ghulam Nabi Qazi
发明人： Surrinder Koul , Jawahir Lal Koul , Subhash Chandra Taneja , Pankaj Gupta , Inshad Ali Khan , Zahid Mehmood Mirza , Ashwani Kumar , Rakesh Kamal Johri , Monika Pandita , Anita Khosa , Ashok Kumar Tikoo , Subhash Chander Sharma , Vijeshwar Verma , Ghulam Nabi Qazi
IPC分类号： A61K31/70
CPC分类号： C07D211/46 , A61K31/351 , A61K31/445 , A61K31/4525 , A61K31/453 , A61K31/496 , A61K31/7036 , C07D295/108 , C07D311/58 , C07D317/60 , C07D319/16 , C07D319/18 , Y02A50/473 , Y02A50/481
摘要： The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.
摘要翻译：本发明涉及芳族取代的戊二烯酸酰胺，并且其中使用特定量的芳族酰胺，即4-烷基-5-（取代的苯基）-2（E），4（E） - 戊二烯酸酰胺，其几何形状异构体或其二氢或四氢衍生物和用于增强抗感染药物生物功效的抗感染药物。本发明的组合可用于治疗抑制微生物菌株生长所必需的较低浓度抗感染剂的某些感染和疾病，并且还可用于降低微生物的抗性。

6. 发明申请

US20120101285A1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3 HYDROXYPYRROLIDINES 有权
标题翻译：制备光活性N-苯甲基-3羟基吡咯烷酮的方法
公开(公告)号：US20120101285A1
公开(公告)日：2012-04-26
申请号：US13130702
申请日：2009-11-24
申请人： Subhash Chandra Taneja , Mushtaq Ahmad Aga , Brijesh Kumar , Vijay Kumar Sethi , Samar Singh Andotra , Ghulam Nabi Qazi
发明人： Subhash Chandra Taneja , Mushtaq Ahmad Aga , Brijesh Kumar , Vijay Kumar Sethi , Samar Singh Andotra , Ghulam Nabi Qazi
IPC分类号： C07D207/12
CPC分类号： C07D207/12
摘要： The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)—N-benzyl-3-hydroxypyrrolidine and (R)—N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)—N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.
摘要翻译：本发明涉及从天然存在的生物碱催化剂以高产率制备光学活性N-苄基-3-羟基吡咯烷的简便，高效和经济的方法。使用天然生物碱维生素作为（S）-N-苄基-3-羟基吡咯烷和（R）-N-苄基-3-羟基吡咯烷的前体，其可以通过以下方法容易地从药用植物金丝桃源中获得并通过本发明所述的方法转化成光学异构体（R）和（S）-N-苄基-3-羟基吡咯烷。

7. 发明授权

US07378268B2 Endophytic camptothecin and camptothecinoid producing fungi and process of producing the same 有权
标题翻译：内生喜树碱和喜树碱产生真菌及其生产过程
公开(公告)号：US07378268B2
公开(公告)日：2008-05-27
申请号：US11020075
申请日：2004-12-21
申请人： Satish Chander Puri , Vijeshwar Verma , Touseef Amna , Geeta Handa , Vinay Gupta , Neelam Verma , Ravi Kant Khajuria , Ajit Kumar Saxena , Ghulam Nabi Qazi , Michael Spiteller
发明人： Satish Chander Puri , Vijeshwar Verma , Touseef Amna , Geeta Handa , Vinay Gupta , Neelam Verma , Ravi Kant Khajuria , Ajit Kumar Saxena , Ghulam Nabi Qazi , Michael Spiteller
IPC分类号： C12N1/14 , C12N1/00 , C12P17/00 , C12P17/14 , C12P17/16
CPC分类号： C12P17/188 , C12R1/645
摘要： The present invention relates to a novel source of microorganism for production of Camptothecin and related camptothecinoids. The invention also discloses its isolation, screening for Camptothecin production, growth, fermentation requirements and chemical analysis of Camptothecin (camptothecinoids).
摘要翻译：本发明涉及一种用于生产喜树碱和相关喜树碱的新型微生物来源。本发明还公开了喜树碱（喜树碱）的喜树碱生产，生长，发酵要求和化学分析的分离，筛选。

8. 发明授权

US07119075B2 Use of herbal agents for potentiation of bioefficacy of anti infectives 有权
标题翻译：使用草药增强抗感染药物的生物功效
公开(公告)号：US07119075B2
公开(公告)日：2006-10-10
申请号：US10404014
申请日：2003-03-31
申请人： Ghulam Nabi Qazi , Om Parkash Suri , Kasturi Lal Bedi , Inshad Ali Khan , Vijeshwar Verma , Rakesh Kamal Johri , Krishan Avtar Suri , Bishan Datt Gupta , Naresh Kumar Satti , Manoj Kumar Tikoo , Subhash Chander Sharma , Ashok Kumar Tikoo
发明人： Ghulam Nabi Qazi , Om Parkash Suri , Kasturi Lal Bedi , Inshad Ali Khan , Vijeshwar Verma , Rakesh Kamal Johri , Krishan Avtar Suri , Bishan Datt Gupta , Naresh Kumar Satti , Manoj Kumar Tikoo , Subhash Chander Sharma , Ashok Kumar Tikoo
IPC分类号： A61K31/70
CPC分类号： A61K45/06 , A61K31/00 , A61K31/4525 , A61K31/455 , A61K31/7048 , A61K2300/00
摘要： The present invention relates to the use of bioenhancers to decrease the resistance of microbial strains to anti-infective such an antibiotics and antifungals by potentiating the activities of anti-infective. This may be useful to reduce resistance in bacteria and yeast to aid in the treatment of certain infections and disease and to lower the concentration of antiinfectives necessary to inhibit the growth of microbial strains.
摘要翻译：本发明涉及通过增强抗感染活性来降低微生物菌株对抗感染性抗生素和抗真菌剂的抗性的用途。这可能有助于降低细菌和酵母中的抗性，以帮助治疗某些感染和疾病，并降低抑制微生物菌株生长所必需的抗感染药物的浓度。

9. 发明授权

US06855547B2 Methods and compositions for rapid in vitro propagation of Swertia chirata 有权
标题翻译： Swertia chirata快速体外繁殖的方法和组成
公开(公告)号：US06855547B2
公开(公告)日：2005-02-15
申请号：US10011208
申请日：2001-11-30
申请人： Ashok Ahuja , Sushma Koul , Brij Lal Kaul , Navin Kumar Verma , Mahrak Krishen Kaul , Ravinder Kumar Raina , Ghulam Nabi Qazi
发明人： Ashok Ahuja , Sushma Koul , Brij Lal Kaul , Navin Kumar Verma , Mahrak Krishen Kaul , Ravinder Kumar Raina , Ghulam Nabi Qazi
IPC分类号： A01H4/00 , C12N5/02 , C12N5/00
CPC分类号： A01H4/005
摘要： The present disclosure relates to methods and compositions for in vitro cultivation of species of Swertia, e.g. Swertia chirata (Ham.). The disclosure provides culture media comprising Murashige and Skoog (MS) basal culture medium, plant hormones preferably selected from the group consisting of benzyladenine (BAP), gibberellic acid (GA3), and auxins, and other additives, e.g. sucrose and agar. Preferably, auxins are selected from the group consisting of indole acetic acid (IAA), indole butyric acid (IBA), and naphthalene acetic acid (NAA). Individual plant hormone concentrations are preferably from about 0.5 mg/L to about 5.0 mg/L. The disclosure provides methods of in vitro cultivation of Swertia chirata comprising contacting preferably axillary bud and/or shoot apex explants with an initiation medium comprising a modified MS basal culture medium, BAP, IAA, IBA, and NAA to produce a primary explant, contacting the primary explant with a shoot propagation medium comprising, a modified MS basal culture medium, BAP, GA3, and IAA to produce a secondary explant, contacting a secondary explant with a rooting medium comprising a modified MS basal culture medium, IAA, IBA, and NAA. The methods and compositions of the invention are capable of inducing extraordinarily rapid in vitro propagation of Swertia chirata. The methods and compositions of the disclosure may be useful for conservation of this threatened species as well as producing bulk quantities, e.g. gram, kilogram or more, of plant material for medicinal applications.
摘要翻译：本公开涉及用于体外培养Swertia物种的方法和组合物，例如芝士（火鸡）。本公开提供包含Murashige和Skoog（MS）基础培养基的培养基，优选选自苄基腺嘌呤（BAP），赤霉酸（GA3）和生长素等的植物激素和其它添加剂，例如，蔗糖和琼脂。优选地，生长素选自吲哚乙酸（IAA），吲哚丁酸（IBA）和萘乙酸（NAA）。个体植物激素浓度优选为约0.5mg / L至约5.0mg / L。本公开提供了Swertia chirata的体外培养方法，其包括优选使腋芽和/或茎顶端外植体与包含修饰的MS基础培养基BAP，IAA，IBA和NAA的起始培养基接触以产生初级外植体，初级外植体，其具有包含修饰的MS基础培养基，BAP，GA3和IAA的芽繁殖培养基，以产生第二外植体，使次生外植体与包含修饰的MS基础培养基，IAA，IBA和NAA的生根培养基接触。本发明的方法和组合物能够诱导Swertia chirata的异常快速的体外繁殖。本公开的方法和组合物可用于保护该受威胁的物种以及产生大量的物质，例如，克，千克或更多的药用植物材料。

10. 发明授权

US09192589B2 Chalcones as enhancer of antimicrobial agents 有权
标题翻译：查尔酮作为抗微生物剂的增强剂
公开(公告)号：US09192589B2
公开(公告)日：2015-11-24
申请号：US13515836
申请日：2009-12-18
申请人： Ravi Subramanyam , Laurence Du-Thumm , Ghulam Nabi Qazi , Inshad Ali Khan , Krishan Avtar Suri , Naresh Kumar Satti , Furqan Ali , Nitin Pal Kalia
发明人： Ravi Subramanyam , Laurence Du-Thumm , Ghulam Nabi Qazi , Inshad Ali Khan , Krishan Avtar Suri , Naresh Kumar Satti , Furqan Ali , Nitin Pal Kalia
IPC分类号： A61K36/00 , A61K31/122 , A61K31/00 , A61K31/341 , A61K31/40 , A61K45/06 , C07D207/00
CPC分类号： A61K31/122 , A61K31/00 , A61K31/341 , A61K31/40 , A61K45/06 , C07D207/00 , Y02A50/473 , A61K2300/00
摘要： Compounds are described that are effective in enhancing the efficacy of antimicrobial agents. Also described are methods of using such compounds and compositions that include such compounds. The composition includes a chalcone compound and, optionally, an antimicrobial agent.
摘要翻译：描述了有效提高抗微生物剂功效的化合物。还描述了使用这些化合物和包含这些化合物的组合物的方法。该组合物包括查耳酮化合物和任选的抗微生物剂。

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