专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08921362B2 6,7-dialkoxy quinazoline derivatives and methods of treating drug resistant and other tumors 有权
标题翻译： 6,7-二烷氧基喹唑啉衍生物和治疗耐药性等肿瘤的方法
公开(公告)号：US08921362B2
公开(公告)日：2014-12-30
申请号：US12833789
申请日：2010-07-09
申请人： Bhujanga rao Adibhatla Kali Satya , Ramanadham Jyothi Prasad , Bollepalli Nageshwara Rao , Nannapaneni Venkaiah Chowdary
发明人： Bhujanga rao Adibhatla Kali Satya , Ramanadham Jyothi Prasad , Bollepalli Nageshwara Rao , Nannapaneni Venkaiah Chowdary
IPC分类号： A61K31/535 , A61K31/497 , C07D239/94
CPC分类号： A61K31/5377 , C07D239/94
摘要： Compounds of formula (I) in which: R1 is: R2 is —CH3 or —CH2CH3; or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions including the compound of formula (I) and a pharmaceutically acceptable carrier. Processes for preparing the compound of formula (I). Methods of inhibiting a receptor tyrosine kinase in a subject in need thereof. Methods of inhibiting the growth of a tumor cell in a subject in need thereof. Methods of treating pancreatic cancer in a subject in need of treatment for pancreatic cancer. Methods of treating HER2 positive breast cancer in a subject in need of treatment for HER2 positive breast cancer. Methods of treating drug resistant non-small cell lung cancer in a subject in need of treatment for drug resistant non-small cell lung cancer. Each of these methods can include administering to the subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）化合物，其中：R1为：R2为-CH3或-CH2CH3; 或其药学上可接受的盐。药物组合物，包括式（I）化合物和药学上可接受的载体。制备式（I）化合物的方法。在有需要的受试者中抑制受体酪氨酸激酶的方法。抑制有需要的受试者中肿瘤细胞生长的方法。在需要胰腺癌治疗的受试者中治疗胰腺癌的方法。在需要治疗HER2阳性乳腺癌的个体中治疗HER2阳性乳腺癌的方法。在需要治疗耐药性非小细胞肺癌的受试者中治疗耐药性非小细胞肺癌的方法。这些方法中的每一种可以包括向受试者施用有效量的式（I）化合物或其药学上可接受的盐。

2. 发明授权

US08143250B2 6-7,dialkoxy quinazoline derivatives useful for treatment of cancer related disorders 有权
标题翻译： 6-7，可用于治疗癌症相关疾病的二烷氧基喹唑啉衍生物
公开(公告)号：US08143250B2
公开(公告)日：2012-03-27
申请号：US12812726
申请日：2008-01-18
申请人： Ramanadham Jyothi Prasad , Bhujanga Rao Adibhatla Kali Satya , Bollepalli Nageshwara Rao , Nannapaneni Venkaiah Chowdary
发明人： Ramanadham Jyothi Prasad , Bhujanga Rao Adibhatla Kali Satya , Bollepalli Nageshwara Rao , Nannapaneni Venkaiah Chowdary
IPC分类号： A61K31/5377 , C07D413/12 , A61P35/00
CPC分类号： A61K31/5377 , C07D239/94
摘要： In view of the great potential the quinazoline class of compounds offer, we started the synthesis and screening of a large number of new chemical entities with novel structural features. It has been surprisingly and unexpectedly found that quinazolines having 3-Ethynyl anilino group at the 4th position and specifically substituted alkoxy groups in the 6 and 7 positions, impart much enhanced and special anti-proliferative properties when compared to other prominent members of the quinazoline class of drugs. Also, surprisingly the compounds of this invention are much less toxic and the safety profile is exceedingly beneficial for therapeutic applications. The novel chemical entities described in this invention are designated by the general structure (I) and have not been synthesized earlier nor investigated for their therapeutic benefits and safety profile. Compound (I) is NRC-2694, when structure (A).
摘要翻译：鉴于喹唑啉类化合物具有巨大的潜力，我们开始对大量具有新型结构特征的新化学物质进行合成和筛选。出人意料地发现，与喹唑啉类的其他显着成分相比，在第4位具有3-乙炔基苯胺基的6和7位上具有特异性取代的烷氧基的喹唑啉具有很强的增强和特殊的抗增殖特性的药物。此外，令人惊讶的是，本发明的化合物毒性远低于安全性，对于治疗应用是非常有益的。本发明中描述的新颖化学实体由通式结构（I）表示，并没有早期合成，也没有对其治疗益处和安全性进行调查。当结构（A）时，化合物（I）是NRC-2694。

3. 发明申请

US20110034459A1 6,7-DIALKOXY QUINAZOLINE DERIVATIVES AND METHODS OF TREATING DRUG RESISTANT AND OTHER TUMORS 有权
标题翻译： 6,7-二盐酸喹唑啉衍生物及其抗肿瘤剂及其它肿瘤的治疗方法
公开(公告)号：US20110034459A1
公开(公告)日：2011-02-10
申请号：US12833789
申请日：2010-07-09
申请人： Bhujanga rao ADIBHATLA KALI SATYA , Ramanadham Jyothi Prasad , Bollepalli Nageshwara Rao , Nannapaneni Venkaiah Chowdary
发明人： Bhujanga rao ADIBHATLA KALI SATYA , Ramanadham Jyothi Prasad , Bollepalli Nageshwara Rao , Nannapaneni Venkaiah Chowdary
IPC分类号： A61K31/5377 , A61P35/00 , C07D413/10 , C07D403/10 , A61K31/496 , A61K31/517
CPC分类号： A61K31/5377 , C07D239/94
摘要： Compounds of formula (I) in which: R1 is: R2 is —CH3 or —CH2CH3; or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions including the compound of formula (I) and a pharmaceutically acceptable carrier. Processes for preparing the compound of formula (I).Methods of inhibiting a receptor tyrosine kinase in a subject in need thereof. Methods of inhibiting the growth of a tumor cell in a subject in need thereof. Methods of treating pancreatic cancer in a subject in need of treatment for pancreatic cancer. Methods of treating HER2 positive breast cancer in a subject in need of treatment for HER2 positive breast cancer. Methods of treating drug resistant non-small cell lung cancer in a subject in need of treatment for drug resistant non-small cell lung cancer. Each of these methods can include administering to the subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）化合物，其中：R1为：R2为-CH3或-CH2CH3; 或其药学上可接受的盐。药物组合物，包括式（I）化合物和药学上可接受的载体。制备式（I）化合物的方法。在有需要的受试者中抑制受体酪氨酸激酶的方法。抑制有需要的受试者中肿瘤细胞生长的方法。在需要胰腺癌治疗的受试者中治疗胰腺癌的方法。在需要治疗HER2阳性乳腺癌的受试者中治疗HER2阳性乳腺癌的方法。在需要治疗耐药性非小细胞肺癌的受试者中治疗耐药性非小细胞肺癌的方法。这些方法中的每一种可以包括向受试者施用有效量的式（I）化合物或其药学上可接受的盐。

4. 发明授权

US09050341B2 Methods of treating drug resistant and other tumors by administering 6,7-dialkoxy quinazoline derivatives 有权
标题翻译：通过施用6,7-二烷氧基喹唑啉衍生物治疗耐药性和其它肿瘤的方法
公开(公告)号：US09050341B2
公开(公告)日：2015-06-09
申请号：US12833733
申请日：2010-07-09
申请人： Bhujanga rao Abidhatla Kali Satya , Ramanadham Jyothi Prasad , Bollepalli Nageshwara Rao , Nannapaneni Venkaiah Chowdary
发明人： Bhujanga rao Abidhatla Kali Satya , Ramanadham Jyothi Prasad , Bollepalli Nageshwara Rao , Nannapaneni Venkaiah Chowdary
IPC分类号： A61K31/535 , A61K31/497 , A61K31/517
CPC分类号： A61K31/517
摘要： Methods employing and uses of a compound of formula (I) in inhibiting the growth of a tumor cell in a subject in need thereof. Methods employing and uses of a compound of formula (I) in treating pancreatic cancer in a subject in need of treatment for pancreatic cancer. Methods employing and uses of a compound of formula (I) in treating HER-2 positive breast cancer in a subject in need of treatment for HER-2 positive breast cancer. Methods employing and uses of a compound of formula (I) in treating drug resistant non-small cell lung cancer in a subject in need of treatment for drug resistant non-small cell lung cancer. Each of these methods can include administering to the subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.Method of manufacturing a medicament including a compound of formula (I) for treating a subject suffering from growth of a tumor cell; for treating a subject suffering from pancreatic cancer; for treating a subject suffering from HER-2 positive breast cancer; or for treating a subject suffering from drug resistant non-small cell lung cancer.
摘要翻译：使用和使用式（I）化合物抑制有需要的受试者中肿瘤细胞生长的方法。在需要治疗胰腺癌的受试者中使用和使用式（I）化合物治疗胰腺癌的方法。在需要治疗HER-2阳性乳腺癌的受试者中使用和使用式（I）化合物治疗HER-2阳性乳腺癌的方法。在需要治疗耐药性非小细胞肺癌的受试者中使用和使用式（I）化合物在治疗耐药性非小细胞肺癌中的方法。这些方法中的每一种可以包括向受试者施用有效量的式（I）化合物或其药学上可接受的盐。制备药物的方法，所述药物包括用于治疗患有肿瘤细胞生长的受试者的式（I）化合物; 用于治疗患有胰腺癌的受试者; 用于治疗患有HER-2阳性乳腺癌的受试者; 或用于治疗患有耐药非小细胞肺癌的受试者。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式