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1. 发明申请

US20140005133A1 KETOLIDE COMPOUNDS 有权
标题翻译：胶体化合物
公开(公告)号：US20140005133A1
公开(公告)日：2014-01-02
申请号：US13991762
申请日：2011-02-03
申请人： Bharat Trivedi , Prasad Deshpande , Ravikumar Tadiparthi , Sunil Gupta , Santosh Diwakar , Shivaji Pawar , Vijay Patil , Deepak Dekhane , Mahesh Patel , Satish Bhavsar , Amit Mishra , Manish Solanki , Mohammad Jafri , Sachin Bhagwat
发明人： Bharat Trivedi , Prasad Deshpande , Ravikumar Tadiparthi , Sunil Gupta , Santosh Diwakar , Shivaji Pawar , Vijay Patil , Deepak Dekhane , Mahesh Patel , Satish Bhavsar , Amit Mishra , Manish Solanki , Mohammad Jafri , Sachin Bhagwat
IPC分类号： C07H17/08 , C07D417/04
CPC分类号： C07H17/08 , C07D417/04 , C07H23/00
摘要： The invention relates to ketolide compounds of Formula (I) and their pharmaceutically acceptable salts, solvates, hydrates, polymorphs and stereoisomers having antimicrobial activity. The invention also provides pharmaceutical compositions containing the compounds of invention and methods of treating or preventing microbial infections with the compounds of invention, wherein, T is —C*H(R1)—P-Q; R1 is hydrogen; unsubstituted or substituted lower alkyl, cycloalkyl or aryl; P is heteroaryl ring; Q is unsubstituted or substituted aryl or heteroaryl ring; and P is attached to Q via carbon-carbon link; and R3 is hydrogen or fluorine, With the provision that when R1 is hydrogen, R3 is fluorine.
摘要翻译：本发明涉及具有抗微生物活性的式（I）的酮内酯化合物及其药学上可接受的盐，溶剂合物，水合物，多晶型物和立体异构体。本发明还提供含有本发明化合物的药物组合物和本发明化合物治疗或预防微生物感染的方法，其中T为-C * H（R 1）-P-Q; R1是氢; 未取代或取代的低级烷基，环烷基或芳基; P是杂芳基环; Q是未取代或取代的芳基或杂芳基环; P通过碳 - 碳键连接到Q上; 并且R 3是氢或氟，条件是当R 1是氢时，R 3是氟。

2. 发明授权

US09175031B2 Ketolide compounds 有权
标题翻译：酮酯化合物
公开(公告)号：US09175031B2
公开(公告)日：2015-11-03
申请号：US13991762
申请日：2011-02-03
申请人： Bharat Trivedi , Prasad Deshpande , Ravikumar Tadiparthi , Sunil Gupta , Santosh Diwakar , Shivaji Pawar , Vijay Patil , Deepak Dekhane , Mahesh Patel , Satish Bhavsar , Amit Mishra , Manish Solanki , Mohammad Jafri , Sachin Bhagwat
发明人： Bharat Trivedi , Prasad Deshpande , Ravikumar Tadiparthi , Sunil Gupta , Santosh Diwakar , Shivaji Pawar , Vijay Patil , Deepak Dekhane , Mahesh Patel , Satish Bhavsar , Amit Mishra , Manish Solanki , Mohammad Jafri , Sachin Bhagwat
IPC分类号： A61K31/70 , C07H17/08 , C07H23/00 , C07D417/04
CPC分类号： C07H17/08 , C07D417/04 , C07H23/00
摘要： The invention relates to ketolide compounds of Formula (I) and their pharmaceutically acceptable salts, solvates, hydrates, polymorphs and stereoisomers having antimicrobial activity. The invention also provides pharmaceutical compositions containing the compounds of invention and methods of treating or preventing microbial infections with the compounds of invention, wherein, T is —C*H(R1)—P-Q; R1 is hydrogen; unsubstituted or substituted lower alkyl, cycloalkyl or aryl; P is heteroaryl ring; Q is unsubstituted or substituted aryl or heteroaryl ring; and P is attached to Q via carbon-carbon link; and R3 is hydrogen or fluorine, With the provision that when R1 is hydrogen, R3 is fluorine.
摘要翻译：本发明涉及具有抗微生物活性的式（I）的酮内酯化合物及其药学上可接受的盐，溶剂合物，水合物，多晶型物和立体异构体。本发明还提供含有本发明化合物的药物组合物和本发明化合物治疗或预防微生物感染的方法，其中T为-C * H（R 1）-P-Q; R1是氢; 未取代或取代的低级烷基，环烷基或芳基; P是杂芳基环; Q是未取代或取代的芳基或杂芳基环; P通过碳 - 碳键连接到Q上; 并且R 3是氢或氟，条件是当R 1是氢时，R 3是氟。

3. 发明申请

US20050143421A1 Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy 失效
标题翻译：具有抗菌活性并具有改善的体内功效的取代的哌啶子基苯基恶唑烷酮
公开(公告)号：US20050143421A1
公开(公告)日：2005-06-30
申请号：US10935708
申请日：2004-09-07
申请人： Prasad Deshpande , Milind Sindkhedkar , Mahesh Phansalkar , Ravindra Yeole , Shrikant Gupte , Yati Chugh , Nitin Shetty , Sachin Bhagwat , Milind Shukla , Noel De Souza , Mahesh Patel
发明人： Prasad Deshpande , Milind Sindkhedkar , Mahesh Phansalkar , Ravindra Yeole , Shrikant Gupte , Yati Chugh , Nitin Shetty , Sachin Bhagwat , Milind Shukla , Noel De Souza , Mahesh Patel
IPC分类号： C07D413/10 , C07D413/14 , C07D491/10 , C07D495/10 , C07D497/10 , C07D498/10 , C07D513/10 , C07D413/02 , A61K31/422 , A61K31/454
CPC分类号： C07D491/10 , C07D413/10 , C07D413/14 , C07D495/10 , C07D497/10 , C07D513/10
摘要： The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.
摘要翻译：本发明提供具有预防和治疗感染性疾病的抗微生物活性的试剂。因此，本发明提供新的取代的哌啶子基苯基恶唑烷酮衍生物，制备化合物的方法以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。

4. 发明申请

US20050065164A1 Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments 失效
公开(公告)号：US20050065164A1
公开(公告)日：2005-03-24
申请号：US10945504
申请日：2004-09-20
申请人： Noel De Souza , Mahesh Patel , Prasad Deshpande , Shiv Agarwal , Kandepu Sreenivas , Sheela Nair , Yati Chugh , Milind Shukla
发明人： Noel De Souza , Mahesh Patel , Prasad Deshpande , Shiv Agarwal , Kandepu Sreenivas , Sheela Nair , Yati Chugh , Milind Shukla
IPC分类号： A61K31/47 , A61K45/06 , C07D215/22 , C07D215/233 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08 , C07D519/00 , C07D471/02 , A61K31/4709 , A61K31/4745 , A61K31/496
CPC分类号： A61K31/47 , A61K45/06 , C07D215/233 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08 , Y10S514/859
摘要： This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

5. 发明申请

US20070219227A1 Prodrugs of benzoquinolizine-2-carboxylic acid 有权
标题翻译：苯喹啉-2-羧酸的前药
公开(公告)号：US20070219227A1
公开(公告)日：2007-09-20
申请号：US11715921
申请日：2007-03-09
申请人： Mahesh Patel , Vijaya Desai , Prasad Deshpande , Ravindra Yeole , Rajesh Kale
发明人： Mahesh Patel , Vijaya Desai , Prasad Deshpande , Ravindra Yeole , Rajesh Kale
IPC分类号： A61K31/4745 , C07D455/06
CPC分类号： C07D455/04
摘要： The instant invention relates to novel prodrugs of optically pure benzoquinolizine-2-carboxylic acid and pharmaceutical compositions that include the prodrugs. In particular, the present invention relates to the sulfonic acid salts of L-alanine and L-valine prodrugs of S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid. The compounds and compositions of the invention can be used to treat bacterial Gram-positive, Gram-negative and anaerobic infections, especially infections caused by resistant Gram-positive organism and Gram-negative organism, mycobacterial infections and emerging nosocomial pathogen infections.
摘要翻译：本发明涉及光学纯苯醌喹唑啉-2-羧酸的新型前体药物和包含前药的药物组合物。特别地，本发明涉及L-丙氨酸的磺酸盐和S - （ - ） - 9-氟-6,7-二氢-8-（4-羟基哌啶-1-基） - 5-甲基-1-氧代-1H，5H-苯并[i，j]喹嗪-2羧酸。本发明的化合物和组合物可用于治疗细菌革兰氏阳性，革兰氏阴性和厌氧感染，特别是由抗性革兰氏阳性生物和革兰氏阴性生物，分枝杆菌感染和新出现的医院病原体感染引起的感染。

6. 发明申请

US20070167627A1 Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate 审中-公开
标题翻译：苯并喹啉-2-羧酸精氨酸盐四水合物
公开(公告)号：US20070167627A1
公开(公告)日：2007-07-19
申请号：US11594349
申请日：2006-11-08
申请人： Prasad Deshpande , Vijaya Desai , Ravindra Yeole , Shrikant Gupte , Mahesh Patel , Noel de Souza
发明人： Prasad Deshpande , Vijaya Desai , Ravindra Yeole , Shrikant Gupte , Mahesh Patel , Noel de Souza
IPC分类号： C07D451/00
CPC分类号： C07D471/06
摘要： The invention relates to crystalline S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt tetrahydrate, a process for its preparation and pharmaceutical formulations incorporating it as the active ingredient for use in treating microbial infections.
摘要翻译：本发明涉及结晶S - （ - ） - 9-氟-6,7-二氢-8-（4-羟基哌啶-1-基）-5-甲基-1-氧代-1H，5H-苯并[i，j ]喹嗪-2羧酸L-精氨酸盐四水合物，其制备方法和将其作为用于治疗微生物感染的活性成分的药物制剂。

7. 发明申请

US20050054666A1 Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate 有权
标题翻译：苯并喹啉-2-羧酸精氨酸盐四水合物
公开(公告)号：US20050054666A1
公开(公告)日：2005-03-10
申请号：US10749932
申请日：2003-12-31
申请人： Prasad Deshpande , Vijaya Desai , Ravindra Yeole , Shrikant Gupte , Mahesh Patel , Noel de Souza
发明人： Prasad Deshpande , Vijaya Desai , Ravindra Yeole , Shrikant Gupte , Mahesh Patel , Noel de Souza
IPC分类号： A61P31/04 , C07D471/06 , C07D471/04 , A61K31/4745
CPC分类号： C07D471/06
摘要： The invention relates to crystalline S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt tetrahydrate, a process for its preparation and pharmaceutical formulations incorporating it as the active ingredient for use in treating microbial infections.
摘要翻译：本发明涉及结晶S - （ - ） - 9-氟-6,7-二氢-8-（4-羟基哌啶-1-基）-5-甲基-1-氧代-1H，5H-苯并[i，j ]喹嗪-2羧酸L-精氨酸盐四水合物，其制备方法和将其作为用于治疗微生物感染的活性成分的药物制剂。

8. 发明申请

US20150038475A1 TESTOSTERONE UNDECANOATE COMPOSITIONS 审中-公开
标题翻译：未成熟组合物的TESTOSTERONE
公开(公告)号：US20150038475A1
公开(公告)日：2015-02-05
申请号：US14500438
申请日：2014-09-29
申请人： Basawaraj Chickmath , Chandrashekar Giliyar , Chidambaram Nachiappan , Mahesh Patel , Srinivasan Venkateshwaran
发明人： Basawaraj Chickmath , Chandrashekar Giliyar , Chidambaram Nachiappan , Mahesh Patel , Srinivasan Venkateshwaran
IPC分类号： A61K9/20 , A61K47/10 , A61K47/36 , A61K31/568
CPC分类号： A61K9/2031 , A61K9/14 , A61K9/146 , A61K9/148 , A61K9/1652 , A61K9/1676 , A61K9/1694 , A61K9/2013 , A61K9/2018 , A61K9/205 , A61K9/2054 , A61K9/282 , A61K9/2853 , A61K9/286 , A61K9/2866 , A61K9/4866 , A61K9/4875 , A61K31/568 , A61K47/10 , A61K47/36 , A61K47/38 , A61K47/40
摘要： The present disclosure is drawn to pharmaceutical compositions and oral dosage forms containing testosterone undecanoate, as well as related methods of treatment. In one embodiment, the oral dosage form can include a therapeutically effective amount of testosterone undecanoate and a pharmaceutically acceptable carrier. The dosage form can be formulated such that, when measured using a USP Type II apparatus in 1000 mL of 8 wt % Triton X-100 in water at 37° C. and 100 rpm, the oral dosage form releases at least 20% more testosterone undecanoate after the first 120 minutes than an equivalent dose testosterone undecanoate containing oral dosage form without the pharmaceutically acceptable carrier.
摘要翻译：本公开涉及含有十一酸睾酮的药物组合物和口服剂型，以及相关的治疗方法。在一个实施方案中，口服剂型可以包括治疗有效量的十一酸睾酮和药学上可接受的载体。可以配制剂型，使得当使用USP II型装置在1000mL的8重量％Triton X-100在水中在37℃和100rpm下测量时，口服剂型释放至少20％以上的睾酮十一酸十一酸酯比不含药学上可接受的载体的含有口服剂型的等效剂量十一酸睾酮。

9. 发明申请

US20100177680A1 SYSTEM AND METHOD OF DELIVERING CONTENT USING NETWORKED WIRELESS COMMUNICATION UNITS 审中-公开
标题翻译：使用网络无线通信单元传送内容的系统和方法
公开(公告)号：US20100177680A1
公开(公告)日：2010-07-15
申请号：US12351048
申请日：2009-01-09
申请人： Larry G. Fischer , Jamie Brown , Mahesh Patel , Tony Lefebvre
发明人： Larry G. Fischer , Jamie Brown , Mahesh Patel , Tony Lefebvre
IPC分类号： H04W4/00
CPC分类号： H04L67/2842 , H04L65/1026
摘要： A wireless network comprises a plurality of areas of interest and a core network coupled to each of the plurality of areas of interest to route real-time data from each of the plurality of areas of interest. Each of the plurality of areas of interest includes a plurality of wireless communication units. Each wireless communication unit comprises a local cache to store non-real-time data; and a gateway to process non-real-time data requests and provide an interface to a packet network. The plurality of wireless communication units in each of the plurality of areas of interest are networked together such that each wireless communication unit has access to data stored on the local cache of another of the plurality of wireless communication units, wherein the gateway in each of the plurality of wireless communication units is operable to provide the requested non-real-time data, if available, from one of its local cache and the cache of other wireless communication units prior to passing the non-real-time data request to the packet network.
摘要翻译：无线网络包括多个感兴趣的区域和耦合到所述多个感兴趣区域中的每一个的核心网络以从多个感兴趣区域中的每一个区域路由实时数据。多个感兴趣区域中的每一个包括多个无线通信单元。每个无线通信单元包括本地高速缓存以存储非实时数据; 以及用于处理非实时数据请求并向分组网络提供接口的网关。多个感兴趣区域中的每一个中的多个无线通信单元被联网在一起，使得每个无线通信单元能够访问存储在多个无线通信单元中的另一个的本地高速缓存上的数据，其中每个多个无线通信单元可操作以在将非实时数据请求传递到分组网络之前提供所请求的非实时数据（如果可用）从其本地高速缓存和其它无线通信单元的高速缓存提供。

10. 发明申请

US20060261000A1 Filter cartridge and method of construction thereof 审中-公开
标题翻译：滤芯及其构造方法
公开(公告)号：US20060261000A1
公开(公告)日：2006-11-23
申请号：US11429711
申请日：2006-05-08
申请人： Laurence Bassett , William Contaxis , Karl Fritze , Mahesh Patel
发明人： Laurence Bassett , William Contaxis , Karl Fritze , Mahesh Patel
IPC分类号： B01D35/28
CPC分类号： B01D39/2079 , B01D35/30 , B01D39/1661 , B01D2201/02 , B01D2201/302 , B01D2201/4015 , C02F1/001 , C02F1/283 , C02F2201/006
摘要： A filter cartridge includes a one-piece housing having a port and a filtration element disposed in the housing. The filtration element is a coherent filter block that can be, but is not necessarily, larger in cross dimension than the port. In one embodiment, the filtration element is a coherent filter block that generally conforms to the shape of the hollow interior, but is slightly smaller than the hollow interior so as to define a gap between the filtration element and the inner surface. One method for constructing a filter cartridge includes providing a housing having a hollow interior and at least one port, introducing a granular material into the hollow interior via the port, and transforming the granular material in the hollow material into a coherent filter block. Another method for constructing a filter cartridge includes providing a filtration element in the form of a coherent filter block, and overmolding a housing around the filtration element.
摘要翻译：滤筒包括具有端口的一体式壳体和设置在壳体中的过滤元件。过滤元件是相干过滤器块，其可以但并不一定比端口的交叉尺寸更大。在一个实施例中，过滤元件是通常符合中空内部形状但是略小于中空内部的相干过滤块，以便限定过滤元件和内表面之间的间隙。一种用于构造过滤器滤芯的方法包括提供具有中空内部和至少一个端口的壳体，通过该端口将颗粒材料引入中空内部，并将中空材料中的颗粒材料转化为相干过滤块。用于构造过滤器滤芯的另一种方法包括提供呈粘性过滤块形式的过滤元件，以及围绕过滤元件的壳体包覆模制。

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