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1. 发明申请

US20130296408A1 MEDULLOBLASTOMA GENES AS TARGETS FOR DIAGNOSIS AND THERAPEUTICS 有权
标题翻译： MEDULLOBLASTOMA基因作为诊断和治疗药物的目标
公开(公告)号：US20130296408A1
公开(公告)日：2013-11-07
申请号：US13884154
申请日：2011-11-08
申请人： Bert Vogelstein , Kenneth Kinzler , Nickolas Papadopoulos , Donald Williams Parsons , Rebecca J. Leary , Meng Li , Xiaosong Zhang , Sian Jones , Gregory J. Riggins , Victor Velculescu
发明人： Bert Vogelstein , Kenneth Kinzler , Nickolas Papadopoulos , Donald Williams Parsons , Rebecca J. Leary , Meng Li , Xiaosong Zhang , Sian Jones , Gregory J. Riggins , Victor Velculescu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , G01N33/57407
摘要： Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations, markedly fewer than in common adult cancers. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone H3K4 trimethylase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.
摘要翻译：成神经管细胞瘤（MB）是儿童最常见的恶性脑肿瘤。为了鉴定这种肿瘤类型的遗传改变，我们使用高密度微阵列搜索拷贝数变化，并使用Sanger测序对所有已知的蛋白质编码基因和miRNA基因进行测序。我们发现平均每个肿瘤有11个基因改变，明显少于普通成年癌症。除了Hedgehog和Wnt途径的改变之外，我们的分析导致了以前未知在MB中被改变的基因的发现。最明显的是，在16％的MB患者中鉴定了组蛋白H3K4三甲基酶基因MLL2或MLL3的失活突变。这些结果显示了成年和儿童期癌症遗传景观之间的关键差异，突出了发育途径的失调作为MBs的重要机制，并确定了特定类型的组蛋白甲基化在人类肿瘤发生中的作用。

2. 发明授权

US09695479B2 Medulloblastoma genes as targets for diagnosis and therapeutics 有权
公开(公告)号：US09695479B2
公开(公告)日：2017-07-04
申请号：US13884154
申请日：2011-11-08
申请人： Bert Vogelstein , Kenneth Kinzler , Nickolas Papadopoulos , Donald Williams Parsons , Rebecca J. Leary , Meng Li , Xiaosong Zhang , Sian Jones , Gregory J. Riggins , Victor Velculescu , Darell Bigner , Hai Yan
发明人： Bert Vogelstein , Kenneth Kinzler , Nickolas Papadopoulos , Donald Williams Parsons , Rebecca J. Leary , Meng Li , Xiaosong Zhang , Sian Jones , Gregory J. Riggins , Victor Velculescu , Darell Bigner , Hai Yan
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , G01N33/57407
摘要： Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations, markedly fewer than in common adult cancers. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone H3K4 trimethylase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.

3. 发明申请

US20120164638A1 Digital Quantification of DNA Methylation 审中-公开
标题翻译： DNA甲基化的数字定量
公开(公告)号：US20120164638A1
公开(公告)日：2012-06-28
申请号：US13263020
申请日：2010-04-06
申请人： Bert Vogelstein , Kenneth W. Kinzler , Meng Li , Luis Diaz , Nickolas Papadopoulos , Sanford Markowitz
发明人： Bert Vogelstein , Kenneth W. Kinzler , Meng Li , Luis Diaz , Nickolas Papadopoulos , Sanford Markowitz
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6816 , C12Q1/6886 , C12Q2600/154 , C12Q2565/501 , C12Q2527/125 , C12Q2523/125
摘要： Abnormal DNA methylation can be used as a biomarker in cancer patients. For such purposes, it is important to determine precisely the fraction of methylated molecules in an analyzed sample. A technology we term Methyl-BEAMing achieves this goal. Individual bisulfite-treated DNA molecules can be PCR-amplified within aqueous nanocompartments containing beads, resulting in a population of beads each containing thousands of copies of the template molecule. After hybridization with probes specific for methylated sequences, the beads can be analyzed by flow cytometry. This approach enables detection and enumeration of one methylated molecule in a population of ˜5000 unmethylated molecules. Methyl-BEAMing provides digital quantification of rare methylation events and is generally applicable to the assessment of methylated genes in clinical samples.
摘要翻译： DNA甲基化异常可用作癌症患者的生物标志物。为此目的，重要的是精确测定分析样品中甲基化分子的分数。我们称之为甲基BEAMing的技术实现了这一目标。单独的亚硫酸氢盐处理的DNA分子可以在含有珠粒的含水纳米间隔内进行PCR扩增，导致每个珠粒群含有数千份拷贝的模板分子。与特异于甲基化序列的探针杂交后，可以通过流式细胞术分析珠粒。这种方法能够检测和计数一个约5000个非甲基化分子的群体中的一个甲基化分子。甲基BEAMing提供罕见甲基化事件的数字量化，通常适用于临床样品中甲基化基因的评估。

4. 发明授权

US09360526B2 Methods for beaming 有权
标题翻译：辐射方法
公开(公告)号：US09360526B2
公开(公告)日：2016-06-07
申请号：US12091395
申请日：2006-10-20
申请人： Bert Vogelstein , Frank Diehl , Kenneth W Kinzler , Meng Li
发明人： Bert Vogelstein , Frank Diehl , Kenneth W Kinzler , Meng Li
IPC分类号： C12Q1/68 , C12P19/34 , G01R31/327 , G01R31/02
CPC分类号： C12Q1/6858 , G01R31/025 , G01R31/3277 , C12Q2565/537 , C12Q2563/155 , C12Q2527/125
摘要： Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various DNA polymerases and have permitted the detection of rare and subtle mutations in DNA isolated from plasma of cancer patients.
摘要翻译：用于BEAMing的基本方法的改进提高了灵敏度并提高了信噪比。这些改进允许确定各种DNA聚合酶的固有错误率，并允许检测从癌症患者血浆中分离的DNA中罕见且微妙的突变。

5. 发明申请

US20130040300A9 Methods for Beaming 有权
标题翻译： Beaming方法
公开(公告)号：US20130040300A9
公开(公告)日：2013-02-14
申请号：US12091395
申请日：2006-10-20
申请人： Bert Vogelstein , Frank Diehl , Kenneth W. Kinzler , Meng Li
发明人： Bert Vogelstein , Frank Diehl , Kenneth W. Kinzler , Meng Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , G01R31/025 , G01R31/3277 , C12Q2565/537 , C12Q2563/155 , C12Q2527/125
摘要： Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various DNA polymerases and have permitted the detection of rare and subtle mutations in DNA isolated from plasma of cancer patients.
摘要翻译：用于BEAMing的基本方法的改进提高了灵敏度并提高了信噪比。这些改进允许确定各种DNA聚合酶的固有错误率，并允许检测从癌症患者血浆中分离的DNA中罕见且微妙的突变。

6. 发明申请

US20220194354A1 METHOD OF SUPERVISORY CONTROL FOR POWER MANAGEMENT OF A PARALLEL TWO MOTOR HYBRID POWERTRAIN 有权
公开(公告)号：US20220194354A1
公开(公告)日：2022-06-23
申请号：US17128594
申请日：2020-12-21
申请人： Meng Li , Yang Liang
发明人： Meng Li , Yang Liang
IPC分类号： B60W20/13 , B60W10/06 , B60W10/10 , B60W10/26 , B60W10/08 , B60W10/02 , F02N11/08 , B60W30/18
摘要： A hybrid electric vehicle and method of its control include a parallel hybrid powertrain including an engine, a transmission, a battery system, a first electric motor coupled to the engine by a first clutch between the engine and the first electric motor, a second electric motor coupled to the transmission and to the first electric motor by a second clutch between the first and second electric motors, and a controller configured to control the parallel hybrid powertrain for optimal operation across a plurality of different propulsion and charging modes, including calculating cost values for each of the engine and the first and second electric motors and selecting optimal propulsion and charging modes based on the calculated cost values.

7. 发明申请

US20160352876A1 Mobile Terminal 审中-公开
标题翻译：移动终端
公开(公告)号：US20160352876A1
公开(公告)日：2016-12-01
申请号：US15004973
申请日：2016-01-24
申请人： Yongli Chen , Meng Li
发明人： Yongli Chen , Meng Li
IPC分类号： H04M1/02 , H04B5/02
CPC分类号： H04M1/026 , H04B5/0081 , H04B5/02 , H04M2250/04
摘要： A mobile terminal is disclosed. The mobile terminal includes a metal back cover; an NFC coil located under the metal cover; a first slot set on the metal cover, the first slot including a plurality of slot cells set intervally along a same straight line, the slot cells dividing the metal back cover into a top and a body portion; and a second slot set on the top. A part of the NFC coil is located within a projection area of the top.
摘要翻译：公开了一种移动终端。移动终端包括金属后盖; 位于金属盖下方的NFC线圈; 设在所述金属盖上的第一槽，所述第一槽包括沿相同直线横向设置的多个槽单元，所述槽单元将所述金属后盖分成顶部和主体部分; 并在顶部设置第二个插槽。 NFC线圈的一部分位于顶部的投影区域内。

8. 发明授权

US09251750B2 LCD module and manufacturing method thereof 有权
标题翻译： LCD模块及其制造方法
公开(公告)号：US09251750B2
公开(公告)日：2016-02-02
申请号：US13379650
申请日：2011-12-02
申请人： Ming-Hung Shih , Meng Li
发明人： Ming-Hung Shih , Meng Li
IPC分类号： G02F1/13 , G09G3/36 , G09G3/00 , G02F1/1362 , G02F1/1333
CPC分类号： G09G3/3648 , G02F1/1303 , G02F1/1309 , G02F2001/133302 , G02F2001/136254 , G02F2201/54 , G09G3/006
摘要： A liquid crystal display (LCD) module is disclosed, which comprises: a thin film transistor (TFT) substrate and a color filter (CF) substrate disposed opposite to each other, and a liquid crystal layer sandwiched between the TFT substrate and the CF substrate. The TFT substrate comprises a plurality of wires including at least a first group of wires and a second group of wires, and the second group of wires comprises at least two wires. The CF substrate comprises first curing test units and second curing test units insulated from each other. The first curing test units are electrically connected with the first group of wires, and the second curing test units are electrically connected with all the wires of the second group of wires. A manufacturing method of an LCD module is further disclosed. The LCD module and the manufacturing method thereof of the present disclosure can avoid occurrence of arcing in the TFT substrate during the CVD process, thereby improving the product yield and reducing the manufacturing cost.
摘要翻译：公开了一种液晶显示器（LCD）模块，其包括：彼此相对布置的薄膜晶体管（TFT）基板和滤色器（CF）基板，以及夹在TFT基板和CF基板之间的液晶层。 TFT基板包括包括至少第一组导线和第二组导线的多个导线，并且第二组导线包括至少两根导线。 CF基板包括彼此绝缘的第一固化测试单元和第二固化测试单元。第一固化测试单元与第一组导线电连接，第二固化测试单元与第二组导线的所有导线电连接。进一步公开了一种LCD模块的制造方法。本公开的LCD模块及其制造方法可以避免在CVD工艺期间在TFT基板中产生电弧，从而提高产品产量并降低制造成本。

9. 发明授权

US08802359B2 UV glass production method 有权
标题翻译： UV玻璃生产方法
公开(公告)号：US08802359B2
公开(公告)日：2014-08-12
申请号：US13380191
申请日：2011-12-04
申请人： Minghung Shih , Mingwen Lin , Meng Li , Weichen Lin
发明人： Minghung Shih , Mingwen Lin , Meng Li , Weichen Lin
IPC分类号： G03F7/00
CPC分类号： G03F1/60 , G03F1/54 , G03F1/68
摘要： The present invention discloses a UV glass production method, comprising the steps: arranging a blade on an exposure stage; controlling the position of an exposure area on a glass substrate by regulating the position of the blade; removing a film layer from the area to be transparent; and forming a UV mask in the area to be shaded. In the present invention, a mask blade is adopted, can individually move and be accurately controlled individually; thus, rays of an exposure machine can be accurately positioned for producing a UV glass which meets standards. Moreover, in the present invention, there is no need to design a light cover especially so as to save the design and production cost of the light cover; thus, the present invention can ensure the production accuracy and effectively save the production cost.
摘要翻译：本发明公开了一种紫外线玻璃制造方法，其特征在于，包括以下步骤：在曝光台上配置叶片; 通过调节叶片的位置来控制玻璃基板上曝光区域的位置; 从所述区域去除膜层是透明的; 并在要遮蔽的区域中形成UV掩模。在本发明中，采用了掩模刀片，可单独移动并被精确地控制; 因此，可以精确地定位曝光机的光线，以制造符合标准的UV玻璃。此外，在本发明中，不需要特别设计光罩，以节省灯罩的设计和制造成本; 因此，本发明可以确保生产准确性并有效地节省生产成本。

10. 发明授权

US08648630B2 Systems and methods for driving transistors with high threshold voltages 有权
标题翻译：用于驱动具有高阈值电压的晶体管的系统和方法
公开(公告)号：US08648630B2
公开(公告)日：2014-02-11
申请号：US13297085
申请日：2011-11-15
申请人： Jiqing Yang , Meng Li , Qiang Luo , Lieyi Fang
发明人： Jiqing Yang , Meng Li , Qiang Luo , Lieyi Fang
IPC分类号： H03B1/00 , H03K3/00
CPC分类号： H03K17/302 , H03K17/063 , H03K2217/0081
摘要： System and method are provided for driving a transistor. The system includes a floating-voltage generator, a first driving circuit, and a second driving circuit. The floating-voltage generator is configured to receive a first bias voltage and generate a floating voltage, the floating-voltage generator being further configured to change the floating voltage if the first bias voltage changes and to maintain the floating voltage to be lower than the first bias voltage by a first predetermined value in magnitude. The first driving circuit is configured to receive an input signal, the first bias voltage and the floating voltage. The second driving circuit is configured to receive the input signal, a second bias voltage and a third bias voltage, the first driving circuit and the second driving circuit being configured to generate an output signal to drive a transistor.
摘要翻译：提供了用于驱动晶体管的系统和方法。该系统包括浮置电压发生器，第一驱动电路和第二驱动电路。浮置电压发生器被配置为接收第一偏置电压并产生浮置电压，该浮动电压发生器进一步被配置为如果第一偏置电压改变则改变浮动电压，并且将浮置电压保持为低于第一偏置电压偏置电压大小为第一预定值。第一驱动电路被配置为接收输入信号，第一偏置电压和浮置电压。第二驱动电路被配置为接收输入信号，第二偏置电压和第三偏置电压，第一驱动电路和第二驱动电路被配置为产生驱动晶体管的输出信号。

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