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1. 发明授权

US5395614A Protective Plasmodium falciparum hybrid proteins which contain part-sequences of the malaria antigens HRPII and SERP, the preparation and use thereof 失效
标题翻译：含有疟疾抗原HRPII和SERP的部分序列的恶性疟原虫杂合蛋白的制备和应用
公开(公告)号：US5395614A
公开(公告)日：1995-03-07
申请号：US152922
申请日：1993-11-16
申请人： Bernhard Knapp , Erika Hundt , Burkhard Enders , Hans Kupper
发明人： Bernhard Knapp , Erika Hundt , Burkhard Enders , Hans Kupper
IPC分类号： A61K39/015 , A61K39/00 , A61P31/00 , C07K14/00 , C07K14/435 , C07K14/44 , C07K14/445 , C07K19/00 , C12N15/09 , C12N15/30 , C12N15/63 , C12P21/02 , C12R1/19 , G01N33/53 , G01N33/569 , C07K15/08
CPC分类号： C07K14/445 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , Y10S530/806
摘要： Protective Plasmodium falciparum hybrid proteins which contain part-sequences of the malaria antigens HRPII and SERP, the preparation and use thereof.The invention relates to hybrid proteins composed of part-sequences of the malaria antigens HRPII and SERP. The HRPII sequence has already proven protective in the monkey model (EP-A2-0 315 085), where a C-terminal region of 189 amino acids has been used in the present invention in the same way as in the preceding protection experiment. SERP was identified with the aid of an antiserum against a protective protein band (EP-A1-0 283 882); the part-sequence used (amino acids (AA) 631-892 or 630-764) contains at least two T-cell epitopes (Roussilhon et al. (1990), Immunol. Letters 25, 149-154). In preferred embodiments, further T-cell epitope-containing regions of other P. falciparum proteins such as merozoite surface antigen I (MSA I or else "195 kd antigen"), amino acids from 100 to 300, are incorporated (Crisanti et al. (1988), Science 240, 324-326). The property common to all the hybrid components is that they represent highly conserved peptide sequences. Protection against a malaria infection is generated by immunization with abovementioned hybrid proteins.
摘要翻译：保护性恶性疟原虫杂交蛋白，其含有疟疾抗原HRPII和SERP的部分序列，其制备和应用。本发明涉及由疟疾抗原HRPII和SERP的部分序列组成的杂合蛋白。 HRPII序列已经证明在猴模型（EP-A2-0 315 085）中具有保护作用，其中本发明中已经使用了189个氨基酸的C-末端区域，与前述保护实验相同。借助于抗保护性蛋白质条带的抗血清鉴定了SERP（EP-A1-0 283 882）; 使用的部分序列（氨基酸（AA）631-892或630-764）含有至少两个T细胞表位（Roussilhon等人（1990），Immunol.Letters 25,149-154）。在优选的实施方案中，引入其它恶性疟原虫蛋白质的其它T细胞表位含有区域，例如裂殖子表面抗原I（MSA I或其他“195kd抗原”），100至300的氨基酸（Crisanti等人（1988），Science 240,324-326）。所有混合组分共有的性质是它们代表高度保守的肽序列。通过用上述杂交蛋白免疫产生抗疟疾感染的保护。

2. 发明授权

US5194587A Malaria-specific DNA sequences, expression products thereof, and the use thereof 失效
标题翻译：疟疾特异性DNA序列，其表达产物及其用途
公开(公告)号：US5194587A
公开(公告)日：1993-03-16
申请号：US723668
申请日：1991-06-27
申请人： Bernhard Knapp , Erika Hundt , Burkhard Enders , Hans Kupper
发明人： Bernhard Knapp , Erika Hundt , Burkhard Enders , Hans Kupper
IPC分类号： A61K39/00 , C07K14/445
CPC分类号： C07K14/445 , A61K39/00 , C07K2319/02 , Y10S530/806 , Y10S530/82
摘要： The invention relates to malaria-specific DNA sequences, to the expression products thereof, and to the use thereof.A combination of three of the expression proteins whose DNA sequences were isolated by screening a lambda gt11 gene bank with a monospecific antiserum against the protective 41kD antigen bend from P. falciparum protects Aotus monkeys completely from a P. falciparum infection in model experiments.
摘要翻译：本发明涉及疟疾特异性DNA序列，其表达产物及其用途。通过用针对恶性疟原虫的保护性41kD抗原弯曲的单特异性抗血清筛选λgt11基因库来分离其DNA序列的三种表达蛋白质的组合在模型实验中完全保护Aotus猴子免受恶性疟原虫感染。

3. 发明授权

US5393523A Plasmodium falciparum vaccine comprising a recombinant histidine-rich protein-HRP-II 失效
标题翻译：重组恶性疟原虫组氨酸富集蛋白，其制备及应用。
公开(公告)号：US5393523A
公开(公告)日：1995-02-28
申请号：US109478
申请日：1993-08-20
申请人： Bernard Knapp , Erika Hundt , Burkhard Enders , Hans Kupper
发明人： Bernard Knapp , Erika Hundt , Burkhard Enders , Hans Kupper
IPC分类号： A61K39/015 , A61K39/00 , A61K39/395 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/41 , C07K14/445 , C07K16/00 , C07K16/20 , C07K19/00 , C12N15/02 , C12N15/09 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C12R1/91 , A61K35/66
CPC分类号： C07K14/445 , C07K16/205 , C12Q1/6893 , A61K39/00 , C07K2319/02 , Y10S530/855
摘要： Recombinant histidine-rich protein of Plasmodium falciparum, its preparation and use. It was possible, by screening two different Plasmodium falciparum cDNA gene banks with an antiserum against a 41 kD protein and by cross-hybridization with the insert DNA of a clone obtained therewith, to isolate a gene which codes for a Histidine-Alanine-rich protein (HRP-II). This protein protects aotus monkeys from infection with P. falciparum and is thus a suitable constituent of a malaria vaccine.
摘要翻译：重组组氨酸富含恶性疟原虫蛋白，其制备及应用。可以通过用针对41kD蛋白的抗血清筛选两种不同的恶性疟原虫cDNA基因库，并通过与其获得的克隆的插入DNA进行交叉杂交来分离编码组氨酸 - 富含丙氨酸的蛋白质的基因（HRP-II）。这种蛋白质保护aotus猴免受恶性疟原虫的感染，因此是疟疾疫苗的合适成分。

4. 发明授权

US5585268A Malaria-specific DNA sequences, expression products thereof, and the use thereof 失效
标题翻译：疟疾特异性DNA序列，其表达产物及其用途
公开(公告)号：US5585268A
公开(公告)日：1996-12-17
申请号：US128269
申请日：1993-09-29
申请人： Bernhard Knapp , Erika Hundt , Burkhard Enders , Hans K upper
发明人： Bernhard Knapp , Erika Hundt , Burkhard Enders , Hans K upper
IPC分类号： A61K39/00 , C07K14/445 , C12N1/21 , C07H21/04
CPC分类号： C07K14/445 , A61K39/00 , C07K2319/02
摘要： The invention relates to malaria-specific nucleic acid sequences, to the expression products thereof, and to the use thereof. A combination of three of the expression proteins whose nucleic acid sequences were isolated by screening a lambda gt11 gene bank with a monospecific antiserum against the protective 41 kD antigen band from P. falciparum protects Aotus monkeys from a P. falciparum infection in model experiments.
摘要翻译：本发明涉及疟疾特异性核酸序列，其表达产物及其用途。通过用针对恶性疟原虫的保护性41kD抗原带的单特异性抗血清筛选λgt11基因库来分离其核酸序列的三种表达蛋白质的组合在模型实验中保护了恶性疟原虫感染的Aotus猴。

5. 发明申请

US20050063987A1 Proteins, in particular membrane proteins, of Helicobacter pylori, their preparation and use 审中-公开
标题翻译：幽门螺杆菌的蛋白质，特别是膜蛋白，其制备和用途
公开(公告)号：US20050063987A1
公开(公告)日：2005-03-24
申请号：US10662126
申请日：2003-09-12
申请人： Bernhard Knapp , Erika Hundt , Karl-Heinz Schmidt
发明人： Bernhard Knapp , Erika Hundt , Karl-Heinz Schmidt
IPC分类号： A61K38/00 , A61K39/00 , C07K14/205 , A61K39/02 , C07K14/195
CPC分类号： C07K14/205 , A61K38/00 , A61K39/00 , A61K2039/51
摘要： The present invention relates to novel proteins, in particular membrane proteins or proteins which are firmly associated with the membrane, which are derived from Helicobacter pylori (H. pylori) and which contain the peptide sequence SEQ ID NO:37 according to Tables 1a-1c, or to parts or homologues thereof having a minimum length of ten amino acids, and to their preparation and use as pharmaceutical compositions, in particular as vaccines, or as a diagnostic agent. Based on these data, the gene coding for this protein was also isolated as shown in SEQ ID NO: 36.
摘要翻译：本发明涉及与幽门螺杆菌（幽门螺杆菌）有关的新型蛋白质，特别是与蛋白质牢固相关的蛋白质或蛋白质，其含有根据表1a-1c的肽序列SEQ ID NO：37 或其具有最小长度为10个氨基酸的部分或同系物，以及其制备和用作药物组合物，特别是疫苗或诊断剂。基于这些数据，编码该蛋白质的基因也如SEQ ID NO：36所示分离。

6. 发明申请

US20050227346A1 Cultivation of dispersed mycobacteria 审中-公开
标题翻译：培养分散型分枝杆菌
公开(公告)号：US20050227346A1
公开(公告)日：2005-10-13
申请号：US10490266
申请日：2002-09-25
申请人： Guido Dietrich , Erika Hundt , Heinz Weber
发明人： Guido Dietrich , Erika Hundt , Heinz Weber
IPC分类号： C12N1/20 , C12Q1/04
CPC分类号： C12Q1/045 , C12N1/20 , G01N2333/35
摘要： The present invention relates to a culture medium for disperse mycobacteria comprising at least one detergent and an antifoam agent, whereby said antifoam agent is a member of the silicone family. In addition, the invention provides for methods for the activation of dipressed mycobacteria, for obtaining a standardized mycobyterial culture or for the production of (a), purified protein derivates(s) (PDD) which comprise the cultivation of mycobacteria in the active medium disclosed herein. Furthermore, the use of standardized mycobacterial cultures obtained by the method of the invention for the preparation of pharmaceutical or diagnostic compositions is described.
摘要翻译：本发明涉及一种用于分散分枝杆菌的培养基，其包含至少一种洗涤剂和消泡剂，其中所述消泡剂是硅酮族的成员。此外，本发明提供了激活被分解细菌的方法，用于获得标准化的骨髓间充质培养物或用于（a）纯化的蛋白质衍生物（PDD）的生产，所述纯化蛋白质衍生物（PDD）包括在所述活性培养基中培养分枝杆菌这里。此外，描述了通过本发明的方法获得的用于制备药物或诊断组合物的标准化分枝杆菌培养物的使用。

7. 发明申请

US20130059364A1 CULTIVATION OF DISPERSED MYCOBACTERIA 审中-公开
标题翻译：分解的MYCOBACTERIA的培养
公开(公告)号：US20130059364A1
公开(公告)日：2013-03-07
申请号：US13541644
申请日：2012-07-03
申请人： Guido Dietrich , Erika Hundt , Heinz Weber
发明人： Guido Dietrich , Erika Hundt , Heinz Weber
IPC分类号： C12N1/20
CPC分类号： C12N1/20
摘要： The present invention relates to a culture medium for disperse mycobacteria comprising at least one detergent and an antifoam agent, whereby said antifoam agent is a member of the silicone family. In addition, the invention provides for methods for the activation of dipressed mycobacteria, for obtaining a standardized mycobyterial culture or for the production of (a), purified protein derivates(s) (PDD) which comprise the cultivation of mycobacteria in the active medium disclosed herein. Furthermore, the use of standardized mycobacterial cultures obtained by the method of the invention for the preparation of pharmaceutical or diagnostic compositions is described.
摘要翻译：本发明涉及一种用于分散分枝杆菌的培养基，其包含至少一种洗涤剂和消泡剂，其中所述消泡剂是硅酮族的成员。此外，本发明提供了激活被分解细菌的方法，用于获得标准化的骨髓间充质培养物或用于（a）纯化的蛋白质衍生物（PDD）的生产，所述纯化蛋白质衍生物（PDD）包括在所述活性培养基中培养分枝杆菌这里。此外，描述了通过本发明的方法获得的用于制备药物或诊断组合物的标准化分枝杆菌培养物的使用。

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