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1. 发明申请

US20050135887A1 Twist drill 有权
标题翻译：麻花钻
公开(公告)号：US20050135887A1
公开(公告)日：2005-06-23
申请号：US10738469
申请日：2003-12-17
申请人： Bernhard Borschert , Jerome Hanna , Tilo Krieg , Larry Meenan , Michael Shultz
发明人： Bernhard Borschert , Jerome Hanna , Tilo Krieg , Larry Meenan , Michael Shultz
IPC分类号： B23B51/00 , B23B51/02
CPC分类号： B23B51/02 , B23B2250/12 , B23B2251/046 , B23B2251/402 , B23B2251/50 , Y10T408/9097
摘要： A twist drill including a cutting tip having a front flank face, a substantially cylindrical tool body extending rearwardly from the cutting tip, and a shank. The tool body includes a rotational axis therethrough and at least one flute formed on an outer peripheral surface thereof and extending to the front flank face. The at least one flute includes a first helical portion opening to the front flank face and a second helical portion extending from the rear end of the first helical portion toward the rear portion of the tool body. The second helical portion twists in a direction opposite of the first helical portion.
摘要翻译：一种麻花钻，包括具有前侧面的切割尖端，从切割尖端向后延伸的大致圆柱形的工具主体和柄。工具主体包括穿过其中的旋转轴线和至少一个形成在其外周表面上的并且延伸到前侧面的凹槽。所述至少一个凹槽包括通向所述前侧面的第一螺旋部分和从所述第一螺旋部分的后端朝向所述工具主体的后部延伸的第二螺旋部分。第二螺旋部分在与第一螺旋部分相反的方向上扭转。

2. 发明申请

US20050084352A1 Rotary cutting tool, such as a drill, comprising an exchangeable cutting insert, and an exchangeable cutting insert 有权
标题翻译：旋转切削工具，例如钻头，其包括可更换的切削刀片和可更换的切削刀片
公开(公告)号：US20050084352A1
公开(公告)日：2005-04-21
申请号：US10921781
申请日：2004-08-19
申请人： Bernhard Borschert , Dieter Muhlfriedel , Jurgen Schwagerl , Ruy De Souza Filho , Michael Shultz , Michael McCormick , Robert Erickson
发明人： Bernhard Borschert , Dieter Muhlfriedel , Jurgen Schwagerl , Ruy De Souza Filho , Michael Shultz , Michael McCormick , Robert Erickson
IPC分类号： B23B51/00 , B23B51/02 , B23C5/10 , B23D77/02
CPC分类号： B23B51/00 , B23B51/02 , B23B2205/02 , B23B2251/02 , B23B2251/50 , B23C5/109 , B23D77/025 , B23D2277/02 , Y10S408/713 , Y10T408/892 , Y10T408/907 , Y10T408/909 , Y10T408/9095 , Y10T408/9097 , Y10T408/9098
摘要： A rotary cutting tool that is composed of a tool shank with at least one chucking groove or chip flute and one exchangeable cutting insert. At the tip of the shank a recess for accommodating the cutting insert is provided. The tool shank, on its circumference, has a limb with a bearing surface that is inclined relative to the tool axis and that corresponds to a likewise inclined bearing surface on a wing of the cutting insert. The inclination of the bearing surfaces produces an axial force that retains the cutting insert on the tool shank. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. §1.72(b). As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.
摘要翻译：一种旋转切削工具，其由具有至少一个夹紧槽或切屑槽的工具柄和一个可更换的切削刀片组成。在柄的尖端处设置有用于容纳切削刀片的凹部。工具柄在其圆周上具有带有相对于工具轴线倾斜的支承表面的肢体，并且其对应于在切削刀片的机翼上同样倾斜的支承表面。轴承表面的倾斜产生将切削刀片保持在工具柄上的轴向力。披露摘要根据37 C.F.R.的要求提交。 §1.72（b）。如37 C.F.R. §1.72（b）：说明书中技术性披露的简要摘要必须在单独的表格上开始，优选按照权利要求，在“披露摘要”标题下。摘要的目的是使专利商标局和公众一般能够从粗略检查中快速确定技术披露的性质和要点。摘要不得用于解释权利要求书的范围。因此，与摘要有关的任何陈述不旨在以任何方式限制权利要求，也不应被解释为以任何方式限制权利要求。

3. 发明申请

US20070022724A1 Method, system and apparatus for detecting defects in a honeycomb body using a particulate fluid 有权
标题翻译：使用微粒流体检测蜂窝体中的缺陷的方法，系统和装置
公开(公告)号：US20070022724A1
公开(公告)日：2007-02-01
申请号：US11494880
申请日：2006-07-28
申请人： Patrick Gargano , Babak Raj , William Ryszytiwskyj , Michael Shultz , David Worthey , Leon Zoeller
发明人： Patrick Gargano , Babak Raj , William Ryszytiwskyj , Michael Shultz , David Worthey , Leon Zoeller
IPC分类号： B01D46/00
CPC分类号： B01D46/0086 , B01D46/2418 , B01D46/2474 , B01D46/44 , B01D2046/2477 , B01D2046/2481 , B01D2046/2488 , B01D2273/18 , B01D2279/30 , F01N3/0222 , F01N2450/10 , G01N21/95692 , Y10S55/30
摘要： A system, apparatus and method for detecting defects in a honeycomb body. The system and apparatus include a fixture adapted to hold the honeycomb body, a particulate fluid source, a pipe which defines a flow path between the particulate fluid source and a first end face of the honeycomb body thereby allowing particulate fluid to flow from the particulate fluid source to the first end face of the honeycomb body. The particulate fluid emerges at a second end face of the honeycomb body through defects, if any, in the honeycomb body where the positions of such defects may be monitored. The system and apparatus includes a flow straightener disposed in the flow path to minimize boundary layer influence of the pipe on the flow of the particulate fluid. A substantially uniform velocity flow profile is provided to the first end face of the honeycomb body.
摘要翻译：一种用于检测蜂窝体中的缺陷的系统，装置和方法。该系统和装置包括适于保持蜂窝体的夹具，颗粒流体源，限定了颗粒流体源与蜂窝体的第一端面之间的流动路径的管，从而允许颗粒流体从颗粒流体源于蜂窝体的第一端面。微粒流体在蜂窝体中的缺陷（如果有的话）在蜂窝体的第二端面处露出，可以监测这些缺陷的位置。该系统和装置包括设置在流路中的流动矫直机，以最小化管道对颗粒流体流动的边界层影响。向蜂窝体的第一端面提供基本均匀的速度流动分布。

4. 发明申请

US20120258954A1 ArylSulfonamide Based Matrix Metalloprotease Inhibitors 有权
标题翻译：芳基磺酰胺基基质金属蛋白酶抑制剂
公开(公告)号：US20120258954A1
公开(公告)日：2012-10-11
申请号：US13481983
申请日：2012-05-29
申请人： Claus Ehrhardt , Leslie Wighton McQuire , Pascal Rigollier , Olivier Rogel , Michael Shultz , Ruben Alberto Tommasi
发明人： Claus Ehrhardt , Leslie Wighton McQuire , Pascal Rigollier , Olivier Rogel , Michael Shultz , Ruben Alberto Tommasi
IPC分类号： A61K31/18 , A61K31/402 , A61K31/451 , A61K31/495 , A61K31/40 , A61K31/381 , A61K31/437 , A61K31/55 , A61K31/404 , A61K31/4439 , A61K31/416 , A61P11/06 , A61P11/00 , A61P19/02 , A61P9/10 , A61P35/00 , A61P35/04 , A61P9/04 , A61P25/28 , A61P25/00 , A61K31/4402
CPC分类号： C07D333/22 , A61K31/18 , A61K31/381 , A61K31/402 , A61K31/416 , A61K31/437 , A61K31/4402 , A61K31/4409 , A61K31/451 , A61K31/495 , A61K31/5375 , A61K31/55 , A61K45/06 , C07C311/16 , C07C311/29 , C07C311/39 , C07C311/46 , C07C317/24 , C07C323/67 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/20 , C07D207/30 , C07D207/333 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/80 , C07D209/82 , C07D211/06 , C07D211/14 , C07D211/24 , C07D213/40 , C07D213/50 , C07D213/61 , C07D221/16 , C07D223/04 , C07D231/56 , C07D235/06 , C07D235/08 , C07D241/04 , C07D265/30 , C07D295/112 , C07D295/116 , C07D295/192 , C07D333/18 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D487/04
摘要： The present invention provides a compound of formula (I): said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译：本发明提供式（I）化合物：所述化合物是MMP-2和/或MMP-8和/或MMP-9和/或MMP-12和/或MMP-13的抑制剂，因此可以用于治疗以MMP-2，/或MMP-8和/或MMP-9，和/或MMP-12和/或MMP-13异常活性为特征的疾病或疾病。因此，式（I）化合物可用于治疗由MMP-2和/或MMP-8和/或MMP-9和/或MMP-12和/或MMP- 13。最后，本发明还提供药物组合物。

5. 发明申请

US20100008923A1 Organic Compounds 审中-公开
标题翻译：有机化合物
公开(公告)号：US20100008923A1
公开(公告)日：2010-01-14
申请号：US12305427
申请日：2007-06-25
申请人： Michael Shultz
发明人： Michael Shultz
IPC分类号： A61K31/714 , A61K31/525 , A61K31/51 , A61P35/00 , A61K38/02 , A61K31/4415 , A61K39/395
CPC分类号： A61K31/51 , A61K31/00 , A61K31/195 , A61K31/4415 , A61K31/445 , A61K31/525 , A61K31/714 , A61K45/06 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions containing inhibitors of histone deacetylase and B vitamins and methods of use thereof, in the treatment of HDAC dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases.
摘要翻译：本发明涉及含有组蛋白脱乙酰酶和B族维生素抑制剂的药物组合物及其使用方法，用于治疗HDAC依赖性疾病和用于制备用于治疗所述疾病的药物制剂。

6. 发明授权

US08841291B2 Selective hydroxamic acid based MMP-12 and MMP-13 inhibitors 有权
标题翻译：选择性异羟肟酸基MMP-12和MMP-13抑制剂
公开(公告)号：US08841291B2
公开(公告)日：2014-09-23
申请号：US14042652
申请日：2013-09-30
申请人： Leslie Wighton McQuire , Michael Shultz , Ruben Alberto Tommasi , Sven Weiler
发明人： Leslie Wighton McQuire , Olivier Rogel , Michael Shultz , Ruben Alberto Tommasi , Sven Weiler
IPC分类号： A01N43/00 , A61K31/55
CPC分类号： C07C311/29 , A61K31/18 , C07C311/19 , C07C311/42 , C07C311/46 , C07C323/60 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/48 , C07D211/60 , C07D211/92 , C07D211/96 , C07D213/42 , C07D213/74 , C07D213/89 , C07D215/36 , C07D223/06 , C07D277/06 , C07D277/80 , C07D279/12 , C07D295/13 , C07D309/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D453/06 , C07D471/08 , C07D487/08
摘要： The present invention provides a compound of formula (I): said compound is inhibitor of MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-12 and/or MMP-13. Finally, the present invention also provides pharmaceutical composition that include the compound of formula (I).
摘要翻译：本发明提供式（I）化合物：所述化合物是MMP-12和/或MMP-13的抑制剂，因此可用于治疗特征为MMP-12异常活性和/ 或MMP-13。因此，式（I）化合物可用于治疗由MMP-12和/或MMP-13介导的病症或疾病。最后，本发明还提供了包含式（I）化合物的药物组合物。

7. 发明授权

US08362063B2 Arylsulfonamide based matrix metalloprotease inhibitors 有权
公开(公告)号：US08362063B2
公开(公告)日：2013-01-29
申请号：US13481983
申请日：2012-05-29
申请人： Ruben Alberto Tommasi , Michael Shultz , Leslie Wighton McQuire , Pascal Rigollier , Olivier Rogel , Claus Ehrhardt
发明人： Ruben Alberto Tommasi , Michael Shultz , Leslie Wighton McQuire , Pascal Rigollier , Olivier Rogel , Claus Ehrhardt
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D333/22 , A61K31/18 , A61K31/381 , A61K31/402 , A61K31/416 , A61K31/437 , A61K31/4402 , A61K31/4409 , A61K31/451 , A61K31/495 , A61K31/5375 , A61K31/55 , A61K45/06 , C07C311/16 , C07C311/29 , C07C311/39 , C07C311/46 , C07C317/24 , C07C323/67 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/20 , C07D207/30 , C07D207/333 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/80 , C07D209/82 , C07D211/06 , C07D211/14 , C07D211/24 , C07D213/40 , C07D213/50 , C07D213/61 , C07D221/16 , C07D223/04 , C07D231/56 , C07D235/06 , C07D235/08 , C07D241/04 , C07D265/30 , C07D295/112 , C07D295/116 , C07D295/192 , C07D333/18 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D487/04
摘要： The present invention provides a compound of formula (I): said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.

8. 发明申请

US20100022514A1 Heterocycle Compounds and Methods of Use Thereof 审中-公开
标题翻译：杂环化合物及其使用方法
公开(公告)号：US20100022514A1
公开(公告)日：2010-01-28
申请号：US12519319
申请日：2007-12-17
申请人： Young Shin Cho , Lei Jiang , Michael Shultz
发明人： Young Shin Cho , Lei Jiang , Michael Shultz
IPC分类号： A61K31/4035 , C07D209/44 , C07D403/06 , C07D401/12 , C07D471/04 , C07D217/04 , A61K31/55 , A61K31/4439 , A61K31/4178 , A61K31/437 , A61K31/472 , A61K31/4725 , A61P35/00 , A61P37/00 , A61P25/00
CPC分类号： A61K31/165
摘要： The invention relates to the use of compounds in the treatment of deacetylase-associated diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases.
摘要翻译：本发明涉及化合物在治疗脱乙酰酶相关疾病中的用途以及制备用于治疗所述疾病的药物制剂。

9. 发明申请

US20070160437A1 Drill For Making Flat Bottom Hole 有权
标题翻译：钻平底孔钻
公开(公告)号：US20070160437A1
公开(公告)日：2007-07-12
申请号：US11564112
申请日：2006-11-28
申请人： Michael Shultz , Stephen George , Raymond Moring , David Ford
发明人： Michael Shultz , Stephen George , Raymond Moring , David Ford
IPC分类号： B23B51/00
CPC分类号： B23B51/02 , B23B2251/14 , B23B2251/18 , B23B2251/44 , Y10T408/906 , Y10T408/9065 , Y10T408/9097
摘要： The present invention is directed to a helical drill configuration that allows substantially flat bottomed holes to be machined. At the cutting end of the body member, there are at least two cutting edges that are symmetrically oriented on opposing sides of the rotational axis of the drill. In an embodiment of the invention, first and second cutting edge portions form a continuous surface which provides strength and tool stability. The height of the second portions of each of the cutting edges remains relatively consistent along the horizontal for formation of a generally flat bottom hole. In the embodiment, a center point is defined by two sloped peak surfaces. A central straight chisel edge is formed by the intersection of the two sloped peak surfaces. The first cutting edge section extends from the chisel edge to the second cutting edge section. The first cutting edge section for both cutting edges is formed by symmetrically thinning the two peak surface. In the invention, stress at the center portion of the helical cutting tool is limited by the chisel edge and first sections of the cutting edge near the center portion having a balanced geometry. The balanced geometry of the helical drill also prevents the drill from wobbling and creating deviations in the hole being formed. The chisel edge may blend with a first curvilinear cutting edge and the first curvilinear cutting edge may also have a positive rake to promote cutting.
摘要翻译：本发明涉及一种允许基本平坦的有底孔加工的螺旋钻构型。在主体构件的切割端处，至少有两个切削刃对称地定向在钻头的旋转轴线的相对侧上。在本发明的一个实施例中，第一和第二切削刃部分形成一个提供强度和刀具稳定性的连续表面。每个切削刃的第二部分的高度沿着水平线保持相对一致以形成大致平坦的底部孔。在本实施例中，中心点由两个倾斜的峰面限定。中心的直凿边缘由两个倾斜的峰面相交而形成。第一切削刃部分从凿子边缘延伸到第二切削刃部分。用于两个切削刃的第一切削刃部分通过对称地使两个峰值表面变薄而形成。在本发明中，螺旋切削工具的中心部分处的应力受到凿子边缘和靠近中心部分具有平衡几何形状的切削刃的第一部分的限制。螺旋钻的平衡几何形状还可防止钻头摆动并产生正在形成的孔中的偏差。凿子边缘可以与第一曲线切割边缘混合，并且第一曲线切割边缘也可以具有正耙子以促进切割。

10. 发明申请

US20050084058A1 Method and apparatus for reactor monolith loading 失效
标题翻译：反应堆整料装载方法和装置
公开(公告)号：US20050084058A1
公开(公告)日：2005-04-21
申请号：US10670865
申请日：2003-09-25
申请人： Gilbert Deangelis , Jerome Firlik , Michael Shultz
发明人： Gilbert Deangelis , Jerome Firlik , Michael Shultz
IPC分类号： B01J20060101 , G21C19/00
CPC分类号： B01J8/002 , B01J8/003 , B01J19/2485 , B01J19/30 , B01J2208/00752 , B01J2208/00778 , B01J2219/30246 , B01J2219/30416 , B01J2219/30475 , B01J2219/3085 , B01J2219/3086 , B01J2219/31
摘要： A method for delivering a plurality of reactor monoliths into an interior of a reactor includes providing at least one tubular member having an outer wall defining an interior space adapted to allow sliding movement of reactor monolith therethrough, and providing a plurality of engagement members located within the interior space of the at least one tubular member and spaced along a length thereof, wherein each engagement member is actuable between an extended position and a retracted position. The at least one tubular member is extended into an interior of a reactor such that a first end of the at least one tubular member is located near an opening in the reactor, and a second end of the at least one tubular member is insert into the interior of the reactor. The plurality of engagement members may be controlled such that each engagement member actuates between the extended position, thereby preventing sliding movement of the monolith through the tube, and the retracted position, thereby allowing the monolith to slide past the engagement member within the tube.
摘要翻译：用于将多个反应堆整料输送到反应器内部的方法包括提供至少一个管状构件，其具有限定适于允许反应堆整体滑动通过其的内部空间的外壁，并且提供多个接合构件，所述至少一个管状构件的内部空间并沿着其长度间隔开，其中每个接合构件在延伸位置和缩回位置之间是致动的。至少一个管状构件延伸到反应器的内部，使得至少一个管状构件的第一端位于反应器中的开口附近，并且至少一个管状构件的第二端插入到反应堆内部。可以控制多个接合构件，使得每个接合构件在延伸位置之间致动，从而防止整体通过管的滑动运动和缩回位置，从而允许整体滑动通过管内的接合构件。

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