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    • 10. 发明申请
    • PROCESS FOR PREPARING ALPHA-HYDROXYCARBOXYLIC ESTERS
    • 制备α-羟基羧酸酯的方法
    • US20090182167A1
    • 2009-07-16
    • US12298034
    • 2007-03-28
    • Alexander MayBernd VogelHermann SiegertJochen AckermannSönke Bröcker
    • Alexander MayBernd VogelHermann SiegertJochen AckermannSönke Bröcker
    • C07C67/20C07C67/54
    • C07C67/20C07C67/54C07C69/675
    • Continuous process for preparing alpha-hydroxycarboxylic esters, in which the reactants reacted are alpha-hydroxycarboxamide with an alcohol in the presence of a catalyst to obtain a product mixture which comprises alpha-hydroxycarboxylic ester, ammonia, unconverted alpha-hydroxycarboxamide and alcohol, and catalyst; wherein reactant streams comprising, as reactants, an alpha-hydroxycarboxamide, an alcohol and a catalyst are fed into a pressure reactor; the reactant streams are reacted with one another in the pressure reactor at a pressure in the range of 1 bar to 100 bar; and the product mixture is depleted in alcohol and ammonia by distilling off ammonia at a pressure which is constantly kept greater than 1 bar without the aid of additional stripping media. The continuous process can be employed particularly advantageously on the industrial scale.
    • 制备α-羟基羧酸酯的连续方法,其中反应物在催化剂存在下与醇反应为α-羟基甲酰胺,得到包含α-羟基羧酸酯,氨,未转化的α-羟基甲酰胺和醇的产物混合物,以及催化剂 ; 其中包含作为反应物的α-羟基甲酰胺,醇和催化剂的反应物流被加入到压力反应器中; 反应物流在压力反应器中在1巴至100巴的压力下彼此反应; 并且通过在不经额外的剥离介质的帮助下,在恒定地保持大于1巴的压力下蒸馏掉氨,产物混合物就会耗尽醇和氨。 该连续方法可以在工业规模上特别有利地使用。