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1. 发明授权

US06961490B2 Waveguide plate and process for its production and microtitre plate 失效
标题翻译：波导板及其生产工艺及微量滴定板
公开(公告)号：US06961490B2
公开(公告)日：2005-11-01
申请号：US09916114
申请日：2001-07-27
申请人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine-Kempkens , Michael Pawlak , Gert Duveneck
发明人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine-Kempkens , Michael Pawlak , Gert Duveneck
IPC分类号： G01N21/55 , G01N21/77 , G02B6/12 , G02B6/124 , G02B6/34
CPC分类号： G01N21/7743 , G01N21/552 , G01N21/648 , G02B6/124 , G02B6/136 , G02B6/34 , G02B2006/12107 , G02B2006/12147
摘要： A waveguide plate and a process for making the waveguide plate with a plate-like glass substrate (1), carrying a waveguiding layer (2), with at least one coupling grating on the surface carrying said waveguiding layer (2), which coupling grating is formed as a grating of lines with a period between 150 nm and 1000 nm, the extension of said grating being at least 5 cm with lines parallel to one another, wherein the coupling angle () varies by not more than 0.1_/cm along a line of said grating and wherein the absolute value of the deviation of the coupling angle () on said waveguide plate, from a predefined desired value, does not exceed 0.5_. The deviation from the average value of the coupling angle does not exceed 0.3_, preferably not 0.15_ on the whole waveguide plate. The waveguide plate is suitable as part of a sensor platform and of an arrangement of sample compartments for chemo-and bioanalytical investigations in order to produce a coupling grating formed as a line grating with a grating period between 100 nm and 2500 nm
摘要翻译：波导板和用于制造具有板状玻璃基板（1）的波导板的工艺，其在承载所述波导层（2）的表面上具有带有至少一个耦合光栅的波导层（2），该耦合光栅形成为具有150nm至1000nm之间的周期的线的光栅，所述光栅的延伸至少5cm，线彼此平行，其中耦合角（）沿着所述光栅的直线比0.1_ / cm，并且其中耦合角度的偏差的绝对值（）在预定的期望值上不超过0.5_。在整个波导板上与耦合角的平均值的偏差不超过0.3_，最好不超过0.15_。波导板适合作为传感器平台的一部分和用于化学和生物分析研究的样品室的布置的一部分，以便产生形成为具有在100nm和2500nm之间的光栅周期的线光栅的耦合光栅

2. 发明申请

US20060008206A1 Waveguide plate and process for its production and microtitre plate 有权
标题翻译：波导板及其生产工艺及微量滴定板
公开(公告)号：US20060008206A1
公开(公告)日：2006-01-12
申请号：US11208765
申请日：2005-08-23
申请人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine-Kempkens , Michael Pawlak , Gert Duveneck
发明人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine-Kempkens , Michael Pawlak , Gert Duveneck
IPC分类号： G02B6/34
CPC分类号： G01N21/7743 , G01N21/552 , G01N21/648 , G02B6/124 , G02B6/136 , G02B6/34 , G02B2006/12107 , G02B2006/12147
摘要： A waveguide plate and a process for making the waveguide plate with a plate-like glass substrate (1), carrying a waveguiding layer (2), with at least one coupling grating on the surface carrying said waveguiding layer (2), which coupling grating is formed as a grating of lines with a period between 150 nm and 1000 nm, the extension of said grating being at least 5 cm with lines parallel to one another, wherein the coupling angle (θ) varies by not more than 0.1°/cm along a line of said grating and wherein the absolute value of the deviation of the coupling angle (θ) on said waveguide plate, from a predefined desired value, does not exceed 0.5°. The deviation from the average value of the coupling angle does not exceed 0.3°, preferably not 0.15° on the whole waveguide plate. The waveguide plate is suitable as part of a sensor platform and of an arrangement of sample compartments for chemo-and bioanalytical investigations in order to produce a coupling grating formed as a line grating with a grating period between 100 nm and 2500 nm.
摘要翻译：波导板和用于制造具有板状玻璃基板（1）的波导板的工艺，其在承载所述波导层（2）的表面上具有带有至少一个耦合光栅的波导层（2），该耦合光栅形成为具有150nm和1000nm之间的周期的线的光栅，所述光栅的延伸至少5cm，线彼此平行，其中耦合角（θ）变化不超过0.1°/ cm 沿着所述光栅的线，并且其中所述波导板上的耦合角（θ）与预定的期望值的偏差的绝对值不超过0.5°。与整个波导板的耦合角度的平均值的偏差不超过0.3°，最好不超过0.15°。波导板适合作为传感器平台的一部分和用于化学和生物分析研究的样品室的布置的一部分，以便产生形成为具有在100nm和2500nm之间的光栅周期的线光栅的耦合光栅。

3. 发明授权

US07215850B2 Waveguide plate and process for its production and microtitre plate 有权
标题翻译：波导板及其生产工艺及微量滴定板
公开(公告)号：US07215850B2
公开(公告)日：2007-05-08
申请号：US11208765
申请日：2005-08-23
申请人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine , Michael Pawlak , Gert Duveneck
发明人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine , Michael Pawlak , Gert Duveneck
IPC分类号： G02B6/34
CPC分类号： G01N21/7743 , G01N21/552 , G01N21/648 , G02B6/124 , G02B6/136 , G02B6/34 , G02B2006/12107 , G02B2006/12147
摘要： A waveguide plate and a process for making the waveguide plate with a plate-like glass substrate (1), carrying a waveguiding layer (2), with at least one coupling grating on the surface carrying said waveguiding layer (2), which coupling grating is formed as a grating of lines with a period between 150 nm and 1000 nm, the extension of said grating being at least 5 cm with lines parallel to one another, wherein the coupling angle (θ) varies by not more than 0.1°/cm along a line of said grating and wherein the absolute value of the deviation of the coupling angle (θ) on said waveguide plate, from a predefined desired value, does not exceed 0.5°. The deviation from the average value of the coupling angle does not exceed 0.3°, preferably not 0.15° on the whole waveguide plate. The waveguide plate is suitable as part of a sensor platform and of an arrangement of sample compartments for chemo-and bioanalytical investigations in order to produce a coupling grating formed as a line grating with a grating period between 100 nm and 2500 nm.
摘要翻译：波导板和用于制造具有板状玻璃基板（1）的波导板的工艺，其在承载所述波导层（2）的表面上具有带有至少一个耦合光栅的波导层（2），该耦合光栅形成为具有150nm和1000nm之间的周期的线的光栅，所述光栅的延伸至少5cm，线彼此平行，其中耦合角（θ）变化不超过0.1°/ cm 沿着所述光栅的线，并且其中所述波导板上的耦合角（θ）与预定的期望值的偏差的绝对值不超过0.5°。与整个波导板的耦合角度的平均值的偏差不超过0.3°，最好不超过0.15°。波导板适合作为传感器平台的一部分和用于化学和生物分析研究的样品室的布置的一部分，以便产生形成为具有在100nm和2500nm之间的光栅周期的线光栅的耦合光栅。

4. 发明授权

US06873764B2 METHOD FOR PRODUCING A GRID STRUCTURE, AN OPTICAL ELEMENT, AN EVANESCENCE FIELD SENSOR PLATE, MICROTITRE PLATE AND AN OPTICAL COMMUNICATION ENGINEERING COUPLER AS WELL AS A DEVICE FOR MONITORING A WAVELENGTH 有权
标题翻译：网格结构的生产方法，光学元件，变化现场传感器板，微型板和光通信工程耦合器，作为用于监测波长的装置
公开(公告)号：US06873764B2
公开(公告)日：2005-03-29
申请号：US10182247
申请日：2001-01-26
申请人： Bernd Maisenholder , Johannes Edlinger , Claus Heine , Michael Pawlak , Gert Duveneck
发明人： Bernd Maisenholder , Johannes Edlinger , Claus Heine , Michael Pawlak , Gert Duveneck
IPC分类号： G01N21/64 , G01N21/552 , G01N21/77 , G01N33/53 , G01N37/00 , G02B5/18 , G02B6/02 , G02B6/12 , G02B6/122 , G02B6/124 , G02B6/13 , G02B6/34
CPC分类号： G01N21/7703 , G01N21/552 , G01N21/648 , G01N21/7743 , G01N2021/7776 , G02B6/02138 , G02B6/12007 , G02B6/124 , G02B6/34 , G02B2006/12107
摘要： A coupling grating formed as a line grating with a grating period between 100 nm and 2500 nm, a substrate (1) is covered with a photoresist layer (10) and exposed for instance at the Lithrow angle (ΘL) or at 0° to a mercury-vapour lamp (11) via a folding mirror (13, 13′) through a phase mask (14) in the near field of which the photoresist layer is arranged, then structured by reactive ion etching and provided with a transparent layer by reactive DC magnetron sputtering, particularly pulsed DC sputtering or AC-superimposed DC sputtering. The phase mask (14) is structured in advance with the laser two-beam interference method. The process is particularly suited for the production of optical elements, particularly evane-scent field sensor plates and optical couplers for communications technology which can be employed in particular as filters for wavelength multiplexing in fibre-optic networks.
摘要翻译：形成为具有100nm和2500nm之间的光栅周期的线光栅的耦合光栅，衬底（1）被光致抗蚀剂层（10）覆盖并且例如以Lithrow角（ThetaL）或0°暴露于通过折射镜（13,13'）穿过其中布置光致抗蚀剂层的近场中的相位掩模（14）的汞蒸气灯（11），然后通过反应离子蚀刻构造并且通过反应性设置有透明层 DC磁控溅射，特别是脉冲DC溅射或AC叠加DC溅射。预先利用激光二光束干涉法构成相位掩模（14）。该方法特别适用于生产光学元件，特别是用于通信技术的示范性场传感器板和光耦合器，其特别可用作光纤网络中的波长复用滤波器。

5. 发明申请

US20050163659A1 Kit for assay development and serial analysis 审中-公开
标题翻译：用于测定开发和连续分析的试剂盒
公开(公告)号：US20050163659A1
公开(公告)日：2005-07-28
申请号：US10514166
申请日：2003-05-06
申请人： Gert Duveneck , Peter Oroszlan , Michael Pawlak
发明人： Gert Duveneck , Peter Oroszlan , Michael Pawlak
IPC分类号： G01N33/543 , G01N21/00
CPC分类号： G01N33/54353 , G01N33/54366
摘要： The invention relates to a kit for assay development and for carrying out a plurality of analyses, comprising a carrier substrate and a placement body jointly forming an arrangement of a plurality of sample compartments comprising said carrier substrate as a base plate, in addition to a plurality of immobilized binding partners for the detection of one or more analytes in one or more samples in a bioaffinity assay, said binding partners being arranged and immobilized on the carrier substrate inside the sample containers always in two-dimensional arrays of discrete measuring areas, wherein always at least one measuring area of an array or a partial surface inside an array or sample compartment, respectively, is provided on the carrier substrate for referencing purposes, and the surface density of the immobilized binding partners, in relation to the surface of the measurement areas, is less than the surface density of a full, i.e. extensive, monolayer of said binding partners. The composition of the inventive kit is such that, surprisingly, it enables a full series of measurements to be carried out on an individual carrier substrate. The invention also relates to an analytical system wherein the inventive kit is used, and to analytical detection methods based thereon and the use thereof.
摘要翻译：本发明涉及用于测定开发和用于进行多个分析的试剂盒，其包括载体基底和放置体，该载体基底和放置体除了多个之外，共同形成包括所述载体基底作为基板的多个样品室的布置用于在生物亲和力测定中检测一个或多个样品中的一种或多种分析物的固定化结合配偶体，所述结合伙伴被布置和固定在样品容器内的载体基质上，总是在离散测量区域的二维阵列中，其中总是为了参考目的，在载体基底上分别提供阵列或样品室内的阵列或部分表面的至少一个测量区域，并且固定的结合物的表面密度相对于测量区域的表面小于所述结合配偶体的完整的，即广泛的单层的表面密度。本发明的试剂盒的组成使得令人惊奇的是，它使得能够在单个载体基底上进行全系列的测量。本发明还涉及其中使用本发明的试剂盒的分析系统，以及基于其的分析检测方法及其用途。

6. 发明申请

US20060291772A1 Analytical system and method for analyzing nonlinear optical signals 失效
标题翻译：用于分析非线性光信号的分析系统和方法
公开(公告)号：US20060291772A1
公开(公告)日：2006-12-28
申请号：US10565909
申请日：2003-07-01
申请人： Markus Haiml , Laurent Balet , Gert Duveneck , Gerd Marowsky
发明人： Markus Haiml , Laurent Balet , Gert Duveneck , Gerd Marowsky
IPC分类号： G02B6/26
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/6452 , G01N21/6456
摘要： The invention relates to a method for the ultrasensitive simultaneous measurement of nonlinear optical emission signals in one or two local dimensions. Said method comprises the following steps: the excitation light is irradiated in a power-modulated or pulse-modulated form from at least one light source into an interactive volume or onto an interactive area or layer (hereafter called interactive spaces) in which one or several emissions that are nonlinearly correlated with the excitement light can be excited; the light emanating from said interactive spaces is measured by means of a one-dimensional or two-dimensional detector array; the measured data is transmitted from said detector array to a computer, and said data is formatted in a one-dimensional or two-dimensional data matrix. The inventive method is characterized in that non-correlated portions of the light emanating from the interactive spaces or the portions thereof that are linearly proportionate to the intensity of the excitement light available in said interactive spaces are separated from portions of the light emanating from the interactive spaces, which are not linearly proportionate to the intensity of the available excitement light. The invention further relates to an analytical system that is suitable for carrying out the inventive method.
摘要翻译：本发明涉及用于在一个或两个局部维度上的非线性光发射信号的超灵敏同时测量的方法。所述方法包括以下步骤：将激发光以功率调制或脉冲调制形式从至少一个光源照射到交互式卷或交互式区域或层（以下称为交互空间），其中一个或几个可以激发与兴奋光线非线性相关的排放; 通过一维或二维检测器阵列测量从所述交互空间发出的光; 测量数据从所述检测器阵列发送到计算机，并且所述数据被格式化为一维或二维数据矩阵。本发明的方法的特征在于，从与交互空间中可用的兴奋光的强度成线性成比例的交互空间或其部分发出的光的非相关部分与从交互式中发出的光的部分分离空间，其与可用的兴奋光的强度不成线性比例。本发明还涉及适用于实施本发明方法的分析系统。

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