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1. 发明授权

US5534409A Cytokine regulated transcription factor 失效
标题翻译：细胞因子调节转录因子
公开(公告)号：US5534409A
公开(公告)日：1996-07-09
申请号：US366276
申请日：1994-12-29
申请人： Bernd Groner , Fabrice Gouilleux , Hiroshi Wakao
发明人： Bernd Groner , Fabrice Gouilleux , Hiroshi Wakao
IPC分类号： C07K14/47 , C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C07K14/4702
摘要： The present invention discloses isolated nucleic acids encoding MGF and recombinant proteins encoded thereby. In addition to being useful for the production of recombinant MGF, these nucleic acids are also useful as probes. In a further aspect of the invention, transfected host cells, particularly eukaryotic cells, containing and expressing such nucleic acids are provided. Furthermore, the present invention relates to methods for using such MGF proteins to identify and characterize compounds which affect the intracellular signal transduction of a lactogenic hormone.
摘要翻译：本发明公开了分离的编码MGF的核酸和由此编码的重组蛋白。除了可用于生产重组MGF之外，这些核酸还可用作探针。在本发明的另一方面，提供了含有和表达该核酸的转染宿主细胞，特别是真核细胞。此外，本发明涉及使用这样的MGF蛋白来鉴定和表征影响产生泌激素的细胞内信号转导的化合物的方法。

2. 发明授权

US06984382B1 Bifunctional protein, preparation and use 失效
标题翻译：双功能蛋白，制备和使用
公开(公告)号：US06984382B1
公开(公告)日：2006-01-10
申请号：US09596774
申请日：2000-06-19
申请人： Bernd Groner , Dirk Moritz
发明人： Bernd Groner , Dirk Moritz
IPC分类号： A61K35/12 , A61K35/14 , C12N5/10
CPC分类号： C07K14/7051 , A61K38/00 , C07K14/70517 , C07K16/32 , C07K19/00 , C07K2319/00
摘要： A bifunctional protein comprising: 1) a single-chain antibody directed against a suitable antigen on a tumour cell, 2) a hinge region comprising from about 40 to about 200 amino acids joined to the VL domain of the single chain antibody, and 3) a functional zeta (ζ) chain from the T-cell antigen receptor (TCR) joined to the hinge region, wherein the hinge region is an immunoglobin-like hinge region which is joined to the C-terminus of the VL domain of the single-chain antibody. The functional zeta (ζ) chain comprises the transmembrane and the cytoplasmic domain. The bifunctional protein can be expressed using a cytotoxic lymphocyte (CTL) expressing DNA encoding it.
摘要翻译：一种双功能蛋白质，包括：1）针对肿瘤细胞上的合适抗原的单链抗体，2）包含约40至约200个氨基酸的铰链区，其连接到V L 所述单链抗体和3）来自所述T细胞抗原受体（TCR）的功能性ζ（ζ）链连接到所述铰链区，其中所述铰链区是免疫球蛋白样铰链区，其连接到所述C末端的单链抗体的V L结构域。功能ζ（ζ）链包含跨膜和胞质结构域。可以使用表达编码它的DNA的细胞毒性淋巴细胞（CTL）来表达双功能蛋白。

3. 发明申请

US20050038113A1 Valproic acid and derivatives for the combinatorial therapeutic treatment of human cancers and for the treatment of tumor metastasis and minimal residual disease 审中-公开
标题翻译：丙戊酸及其衍生物用于人类癌症的组合治疗和治疗肿瘤转移和微小残留疾病
公开(公告)号：US20050038113A1
公开(公告)日：2005-02-17
申请号：US10489770
申请日：2002-09-17
申请人： Bernd Groner , Thorsten Heinzel , Bernd Hentsch , Winfried Wels , Peter Herrlich , Saverio Minucci , Pier Pelicci , Martin Gott Icher
发明人： Bernd Groner , Thorsten Heinzel , Bernd Hentsch , Winfried Wels , Peter Herrlich , Saverio Minucci , Pier Pelicci , Martin Gott Icher
IPC分类号： G01N33/50 , A61K31/19 , A61K31/20 , A61K31/203 , A61K31/28 , A61K31/59 , A61K31/593 , A61K39/00 , A61K39/395 , A61K45/00 , A61K45/06 , A61P35/00 , A61P43/00 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/574 , A61K31/22
CPC分类号： A61K45/06 , A61K31/19 , A61K31/20 , A61K31/28 , A61K31/59 , A61K2300/00
摘要： The present invention relates to the use of the drug valproic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase for the sensitizing treatment of human cancers in combination with established therapeutic principles. The invention also relates to the use of those compounds for the treatment of tumor metastasis and minimal residual disease. The invention includes the manufacture of a clinically used substance for the treatment of human cancers.
摘要翻译：本发明涉及药物丙戊酸及其衍生物作为具有组蛋白脱乙酰酶的酶抑制剂用于人类癌症敏化治疗以及既定治疗原理的用途。本发明还涉及这些化合物用于治疗肿瘤转移和最小残留疾病的用途。本发明包括制备用于治疗人类癌症的临床用途物质。

4. 发明申请

US20070232696A1 Valproic acid and derivatives thereof as histone deacetylase inhibitors 审中-公开
标题翻译：丙戊酸及其衍生物作为组蛋白脱乙酰酶抑制剂
公开(公告)号：US20070232696A1
公开(公告)日：2007-10-04
申请号：US11653855
申请日：2007-01-17
申请人： Martin Gottlicher , Thorsten Heinzel , Bernd Groner , Peter Herrlich
发明人： Martin Gottlicher , Thorsten Heinzel , Bernd Groner , Peter Herrlich
IPC分类号： A61K31/22 , G01N33/574 , A61K31/16 , C12Q1/68
CPC分类号： A61K31/19
摘要： The present invention relates to the use of the drug valproic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase activity. The invention also relates to the use of those compounds for the manufacture of a medicament for the treatment of diseases which are associated with hypoacetylation of histones or in which induction of hyperacetylation has a beneficial effect for example by induction of differentiation and/or apoptosis in transformed cells.
摘要翻译：本发明涉及药物丙戊酸及其衍生物作为具有组蛋白脱乙酰酶活性的酶的抑制剂的用途。本发明还涉及这些化合物在制备用于治疗与组蛋白的低乙酰化相关的疾病或其中诱导高乙酰化具有有益作用的药物的用途，例如通过诱导转化的分化和/或细胞凋亡细胞。

5. 发明授权

US07265154B2 Valproic acid and derivatives thereof as histone deacetylase inhibitors 失效
公开(公告)号：US07265154B2
公开(公告)日：2007-09-04
申请号：US10332353
申请日：2001-07-05
申请人： Martin Göttlicher , Thorsten Heinzel , Bernd Groner , Peter Herrlich
发明人： Martin Göttlicher , Thorsten Heinzel , Bernd Groner , Peter Herrlich
IPC分类号： A01N37/00
CPC分类号： A61K31/19
摘要： The present invention relates to the use of the drug valproic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase activity. The invention also relates to the use of those compounds for the manufacture of a medicament for the treatment of diseases which are associated with hypoacetylation of histones or in which induction of hyperacetylation has a beneficial effect for example by induction of differentiation and/or apoptosis in transformed cells.

6. 发明授权

US5939531A Recombinant antibodies specific for a growth factor receptor 失效
标题翻译：对生长因子受体特异的重组抗体
公开(公告)号：US5939531A
公开(公告)日：1999-08-17
申请号：US465473
申请日：1995-06-05
申请人： Winfried Stephan Wels , Nancy E. Hynes , Ina-Maria Harwerth , Bernd Groner , Norman Hardman , Markus Zwickl
发明人： Winfried Stephan Wels , Nancy E. Hynes , Ina-Maria Harwerth , Bernd Groner , Norman Hardman , Markus Zwickl
IPC分类号： A61K38/00 , C07K16/32 , C07K16/30 , C07K16/46
CPC分类号： C07K16/32 , A61K38/00 , C07K2317/24 , C07K2317/622 , C07K2319/00
摘要： The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies directed to c-erbB-2 themselves, a method of manufacture of said recombinant antibodies and said monoclonal antibodies, hybridoma cells secreting said monoclonal antibodies, a method of manufacture of said hybridoma cells, DNA coding for the heavy chain variable domain, for the light chain variable domain and for the recombinant antibody, a method of manufacture of said DNA, hybrid vectors suitable for expression of said DNA, host cells transformed with said DNA, and the use of said recombinant antibodies and said monoclonal antibodies in the diagnosis and treatment of tumors.
摘要翻译：本发明涉及针对人生长因子受体c-erbB-2细胞外结构域的重组抗体，其包含轻链可变结构域和单克隆抗体的重链可变区，针对c-erbB-2本身的单克隆抗体，所述重组抗体和所述单克隆抗体的制备方法，分泌所述单克隆抗体的杂交瘤细胞，所述杂交瘤细胞的制备方法，编码轻链可变结构域的DNA，重链可变结构域和重组抗体的编码方法所述DNA的制备方法，适于表达所述DNA的杂交载体，用所述DNA转化的宿主细胞，以及所述重组抗体和所述单克隆抗体在诊断和治疗肿瘤中的用途。

7. 发明授权

US5571894A Recombinant antibodies specific for a growth factor receptor 失效
标题翻译：对生长因子受体特异的重组抗体
公开(公告)号：US5571894A
公开(公告)日：1996-11-05
申请号：US235838
申请日：1994-04-29
申请人： Winfried S. Wels , Nancy E. Hynes , Ina-Maria Harweth , Bernd Groner , Norman Hardman , Markus Zwickl
发明人： Winfried S. Wels , Nancy E. Hynes , Ina-Maria Harweth , Bernd Groner , Norman Hardman , Markus Zwickl
IPC分类号： A61K38/00 , C07K16/32 , C07K16/28 , C07K16/46 , C12N15/62
CPC分类号： C07K16/32 , A61K38/00 , C07K2317/24 , C07K2317/622 , C07K2319/00
摘要： The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies directed to c-erbB-2 themselves, a method of manufacturing those recombinant and monoclonal antibodies, hybridoma cells secreting those monoclonal antibodies, a method of manufacturing those hybridoma cells, DNAs encoding the heavy and light chain variable domains and the recombinant antibody, a method of manufacturing that DNA, hybrid vectors suitable for the expression of that DNA, host cells transformed with that DNA, and processes of using those recombinant and monoclonal antibodies in the diagnosis and treatment of tumors.
摘要翻译：本发明涉及针对人生长因子受体c-erbB-2细胞外结构域的重组抗体，其包含轻链可变结构域和单克隆抗体的重链可变区，针对c-erbB-2本身的单克隆抗体，制备这些重组和单克隆抗体的方法，分泌这些单克隆抗体的杂交瘤细胞，制备这些杂交瘤细胞的方法，编码重链和轻链可变区的DNA和重组抗体，制备该DNA的方法，适用于该DNA的表达，用该DNA转化的宿主细胞，以及使用这些重组和单克隆抗体进行肿瘤诊断和治疗的过程。

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