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1. 发明申请

US20090326385A1 OBTAINING OPTICAL TISSUE PROPERTIES 审中-公开
标题翻译：获得光学组织特性
公开(公告)号：US20090326385A1
公开(公告)日：2009-12-31
申请号：US12517249
申请日：2007-11-29
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper , Ruth Wilhelmine Ireen De Boer , Augustinus Laurentius Braun , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper , Ruth Wilhelmine Ireen De Boer , Augustinus Laurentius Braun , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
IPC分类号： A61B6/00
CPC分类号： A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/6848
摘要： This application describes a medical device (230) for obtaining optical tissue properties of a target material. The medical device (230) comprises an elongated body (231) having a longitudinal axis (232) and an optical fiber being integrated within the elongated body (231). The optical fiber has a second fiber end (242, 242a, 242b), which is arranged at a side wall (233) of the elongated body (231) and which provides a lateral field of view with respect to the longitudinal axis (232). According to an embodiment many optical fibers are integrated each having an optical outlet (242, 242a, 242b) around the elongated body (231). Using the outlets (242, 242a, 242b) to do diffuse optical tomography and also use optical fibers to do an optical inspection, one can get information on the presence of tumors in a volume around the medical device (230) and a tissue characterization in the vicinity of the medical device (230). Thereby, an optical biopsy may be carried out, wherein no real tissue is removed. According to another embodiment an optical detection system is integrated into a real biopsy needle (330) allowing inspection and taking real biopsy simultaneously.
摘要翻译：本申请描述了用于获得目标材料的光学组织性质的医疗装置（230）。医疗装置（230）包括具有纵向轴线（232）的细长主体（231）和整合在细长主体（231）内的光纤。光纤具有第二光纤端（242,242a，242b），其被布置在细长主体（231）的侧壁（233）处，并且相对于纵向轴线（232）提供横向视场，。根据实施例，许多光纤被集成为每个都具有围绕细长主体（231）的光学出口（242,242a，242b）。使用出口（242,242a，242b）进行漫射光学层析成像，并且还使用光纤进行光学检查，可以获得关于医疗装置周围的体积肿瘤的存在的信息（230）和组织表征医疗装置（230）的附近。因此，可以进行光学活检，其中不去除真实的组织。根据另一个实施例，光学检测系统被集成到实际的活检针（330）中，允许同时进行检查和进行实际的活检。

2. 发明申请

US20100105022A1 ANALYZING BIOLOGICAL CELL MATERIAL BASED ON DIFFERENT INTERACTIONS BETWEEN ILLUMINATION LIGHT AND CELL COMPONENTS 审中-公开
标题翻译：基于照明光和细胞成分之间的不同相互作用分析生物细胞材料
公开(公告)号：US20100105022A1
公开(公告)日：2010-04-29
申请号：US12530787
申请日：2008-03-10
申请人： Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Ruth Wilhelmine Ireen De Boer , Gert Hooft
发明人： Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Ruth Wilhelmine Ireen De Boer , Gert Hooft
IPC分类号： C12Q1/00 , C12M1/34
CPC分类号： G01N21/645 , G01N21/31 , G01N21/6428
摘要： It is described a device (100) for analyzing biological cell material (115). The device (100) comprises a light source arrangement (120), which is adapted for directing a first (131) and a second illumination light (132) towards the cell material (115), wherein the first (131) and the second (132) illumination light comprises a first and a second spectral radiation component, respectively. The device (100) further comprises a detector arrangement (170), which is adapted for receiving a first measurement light (151) based on a first interaction of the first illumination light (131) with the cell material (115) and a second measurement light (152) based on a second interaction of the second illumination light (152) with the cell material (115). Further, the device (100) comprises an evaluation unit (180), which is coupled the detector arrangement (170) and which is adapted to evaluate a first signal (171a) and a second signal (171b) being indicative for the first (151) and the second measurement light (151), respectively. The device (100) may be used for accomplishing ultraviolet DNA image cytometryin combination with autofluorescence measurements of NAD(P)H.
摘要翻译：描述了用于分析生物细胞材料（115）的装置（100）。所述装置（100）包括光源装置（120），其适于将第一（131）和第二照明光（132）引向所述电池材料（115），其中所述第一（131）和所述第二（131） 132）照明光分别包括第一和第二光谱辐射分量。装置（100）还包括检测器装置（170），其适于基于第一照明光（131）与电池材料（115）的第一相互作用接收第一测量光（151）和第二测量基于第二照明光（152）与电池材料（115）的第二相互作用的光（152）。此外，设备（100）包括评估单元（180），其耦合检测器装置（170）并且适于评估第一信号（171a）和第二信号（171b），其指示第一（151））和第二测量光（151）。装置（100）可用于实现与NAD（P）H的自发荧光测量结合的紫外线DNA图像细胞计数法。

3. 发明授权

US07405825B2 Optical analysis system 失效
标题翻译：光学分析系统
公开(公告)号：US07405825B2
公开(公告)日：2008-07-29
申请号：US10539540
申请日：2003-12-19
申请人： Frank Jeroen Pieter Schuurmans , Michael Cornelis Van Beek , Levinus Pieter Bakker , Wouter Harry Jacinth Rensen , Bernardus Hendrikus Wilhelmus Hendriks , Robert Frans Maria Hendriks , Thomas Steffen
发明人： Frank Jeroen Pieter Schuurmans , Michael Cornelis Van Beek , Levinus Pieter Bakker , Wouter Harry Jacinth Rensen , Bernardus Hendrikus Wilhelmus Hendriks , Robert Frans Maria Hendriks , Thomas Steffen
IPC分类号： G01J3/32 , G01J3/457 , G02B26/02
CPC分类号： G01J3/02 , G01J3/0205 , G01J3/021 , G01J3/10 , G01J3/28 , G01J3/36 , G01N21/274 , G01N21/31 , G01N2021/3196 , G01N2201/129
摘要： The optical analysis system (20) for determining an amplitude of a principal component of an optical signal comprises a multivariate optical element (10) for reflecting the optical signal and thereby weighing the optical signal by a spectral weighing function, and a detector (9, 9P, 9N) for detecting the weighed optical signal. The optical analysis system (20) may further comprise a dispersive element (2) for spectrally dispersing the optical signal, the multivariate optical element being arranged to receive the dispersed optical signal. The blood analysis system (40) comprises the optical analysis system (20) according to the invention.
摘要翻译：用于确定光信号的主分量的幅度的光学分析系统（20）包括用于反射光信号并由此通过光谱称重功能称重光信号的多元光学元件（10） 9 P，9 N），用于检测加权的光信号。光学分析系统（20）还可以包括用于光谱分散光学信号的色散元件（2），所述多元光学元件被布置成接收分散的光信号。血液分析系统（40）包括根据本发明的光学分析系统（20）。

4. 发明授权

US08450703B2 Method and system for imaging samples 有权
标题翻译：成像样本的方法和系统
公开(公告)号：US08450703B2
公开(公告)日：2013-05-28
申请号：US12678781
申请日：2008-07-23
申请人： Ruth Wilhelmine Ireen De Boer , Bernardus Hendrikus Wilhelmus Hendriks
发明人： Ruth Wilhelmine Ireen De Boer , Bernardus Hendrikus Wilhelmus Hendriks
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G02B21/16 , G02B21/244
摘要： The invention provides a method for imaging samples, at least comprising: —staining of a sample with a first marker material and with a second marker material; —utilizing the first marker material in a focusing step for focusing an imaging device with respect to the sample; and —utilizing the second marker material and the imaging device, which has been focused in the focusing step, in an imaging step to acquire an image of the sample. The invention also relates to a system for imaging samples.
摘要翻译：本发明提供了一种用于成像样品的方法，至少包括：用第一标记材料和第二标记材料染色样品; - 在聚焦步骤中利用所述第一标记材料，用于相对于所述样品聚焦成像装置; 并且在成像步骤中利用聚焦在聚焦步骤中的第二标记材料和成像装置来获取样本的图像。本发明还涉及用于成像样本的系统。

5. 发明申请

US20100214430A1 METHOD AND SYSTEM FOR IMAGING SAMPLES 有权
标题翻译：用于成像样本的方法和系统
公开(公告)号：US20100214430A1
公开(公告)日：2010-08-26
申请号：US12678781
申请日：2008-07-23
申请人： Ruth Wilhelmine Ireen De Boer , Bernardus Hendrikus Wilhelmus Hendriks
发明人： Ruth Wilhelmine Ireen De Boer , Bernardus Hendrikus Wilhelmus Hendriks
IPC分类号： H04N5/228 , G06K9/62
CPC分类号： G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G02B21/16 , G02B21/244
摘要： The invention provides a method for imaging samples, at least comprising:—staining of a sample with a first marker material and with a second marker material;—utilizing the first marker material in a focusing step for focusing an imaging device with respect to the sample; and—utilizing the second marker material and the imaging device, which has been focused in the focusing step, in an imaging step to acquire an image of the sample. The invention also relates to a system for imaging samples.
摘要翻译：本发明提供了一种用于成像样品的方法，至少包括： - 用第一标记材料和第二标记材料染色样品; - 在聚焦步骤中利用第一标记材料，用于相对于样品聚焦成像装置 ; 并且利用已经聚焦在聚焦步骤中的第二标记材料和成像装置在获取样本的图像的成像步骤中。本发明还涉及用于成像样本的系统。

6. 发明申请

US20120029360A1 NEEDLE WITH INTEGRATED FIBERS IN THE CUTTING FACETS OF THE BEVEL 审中-公开
标题翻译：带有整体纤维的针在水平切割面上
公开(公告)号：US20120029360A1
公开(公告)日：2012-02-02
申请号：US13264388
申请日：2010-04-12
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Rik Habers , Marjolein Van Der Voort , Adrien Desjardins , Rami Nachabe
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Rik Habers , Marjolein Van Der Voort , Adrien Desjardins , Rami Nachabe
IPC分类号： A61B6/00
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/6848
摘要： A needle comprises a tip part, a holder part, a shaft, and fibers capable of transmitting light, wherein the shaft comprises a distal end connected to the tip part, and a proximal end connected to the holder part, wherein the tip part comprises a bevel, cutting facets, and at least one channel for accommodating a fiber, and wherein an end section of the fiber is located in the channel and an end surface of the fiber is located at one of the cutting facets. By way of the facets an introduction of the needle into tissue may be facilitated. A further aspect of the invention is a method for producing such a needle.
摘要翻译：针包括尖端部分，保持器部分，轴和能够透射光的光纤，其中所述轴包括连接到所述尖端部分的远端以及连接到所述保持器部分的近端，其中所述尖端部分包括斜面，切割面和用于容纳纤维的至少一个通道，并且其中光纤的端部位于通道中，并且光纤的端表面位于一个切割平面上。通过这些方面，可以促进将针引入组织中。本发明的另一方面是制造这种针的方法。

7. 发明申请

US20110251494A1 NEEDLE WITH OPTICAL FIBERS 审中-公开
标题翻译：带有光纤的针
公开(公告)号：US20110251494A1
公开(公告)日：2011-10-13
申请号：US13129171
申请日：2009-11-18
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Rik Harbers , Marjolein Van Der Voort , Adrien Desjardins , Rami Nachabe
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Rik Harbers , Marjolein Van Der Voort , Adrien Desjardins , Rami Nachabe
IPC分类号： A61B6/00
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/1459 , A61B5/6848 , A61B10/0233 , A61B10/0283 , A61B17/3401 , A61B18/1477 , A61B2017/00057 , A61B2018/1425
摘要： Needle interventions are widely used in the field of oncology for taking biopsies of tissue in order to inspect whether tissue is cancerous or not. To make these interventions more reliable feedback of what kind of tissue is in front of the needle is required. A way to achieve this is by making use of optical spectroscopy. This requires integration of fibers into the needle. These fibers are used to deliver light to illuminate the tissue in front of the needle and to collect back the reflected light from the tissue. The present invention proposes to integrate the fiber distal ends in the slanted bevel of the needle in such a way that at least one source-detector fiber pair has a distance that is larger than the outer diameter of the needle.
摘要翻译：针刺干预广泛用于肿瘤学领域，用于检查组织的活组织检查，以检查组织是否癌变。要使这些干预措施更为可靠，就需要在针前方使用什么样的组织。实现这一目标的一个方法是利用光谱学。这需要将纤维整合到针中。这些纤维用于传递光以照射针前面的组织并收集来自组织的反射光。本发明提出将光纤远端集成在针的倾斜斜面中，使得至少一个源 - 检测器光纤对的距离大于针的外径。

8. 发明授权

US09131846B2 Optical scanning probe assembly 有权
标题翻译：光学扫描探头组件
公开(公告)号：US09131846B2
公开(公告)日：2015-09-15
申请号：US13125392
申请日：2009-10-19
申请人： Franciscus Martinus Antonius Maria Van Gaal , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Cornelius Antonius Hezemans , Waltherus Cornelis Jozef Bierhoff
发明人： Franciscus Martinus Antonius Maria Van Gaal , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Cornelius Antonius Hezemans , Waltherus Cornelis Jozef Bierhoff
IPC分类号： A61B6/00 , A61B5/00 , G02B23/24 , G02B26/10
CPC分类号： A61B5/0062 , A61B5/0084 , G02B23/2461 , G02B26/103
摘要： An optical scanning probe assembly for microscopic guide optic scanning and inspection of tissues includes an outer housing having a spring element for a scanning motor. The spring element is formed as a hollow tube configured to receive an optical guide, where the hollow tube has a mechanical stiffness larger than the optical guide to be received. The assembly further includes a lens system and a deflector configured to deflect the distal end of the hollow tube in directions transverse to the longitudinal extension of the hollow tube, so as to form an optical scan pattern.
摘要翻译：用于微小导向光学扫描和组织检查的光学扫描探针组件包括具有用于扫描电机的弹簧元件的外壳。弹簧元件形成为构造成接收光导的中空管，其中中空管具有比要接收的光导更大的机械刚度。组件还包括透镜系统和偏转器，其被配置为使中空管的远端沿垂直于中空管的纵向延伸的方向偏转，以形成光学扫描图案。

9. 发明授权

US08717654B2 Optical probe with feedback correction 失效
标题翻译：具有反馈校正的光学探头
公开(公告)号：US08717654B2
公开(公告)日：2014-05-06
申请号：US13320601
申请日：2010-05-10
申请人： Cornelius Antonius Hezemans , Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Augustinus Laurentius Braun , Nenad Mihajlovic
发明人： Cornelius Antonius Hezemans , Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Augustinus Laurentius Braun , Nenad Mihajlovic
IPC分类号： G02B26/08 , A61B5/05
CPC分类号： A61B5/6848 , A61B5/0068 , A61B5/0084 , G02B21/0012 , G02B21/0036 , G02B23/2423 , G02B23/26 , G02B26/103
摘要： The present invention relates to an optical probe (1) suitable for miniature applications. An example application is a fiber-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system (9, 10) comprising drive coils (9) capable of displacing the distal end (3) of an optical guide (2) housed (4) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set-point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.
摘要翻译：本发明涉及适合于微型应用的光学探头（1）。一个示例应用是基于光纤的共聚焦微型显微镜。光探头包括基于线圈的致动系统（9,10），其包括驱动线圈（9），该驱动线圈能够移动由光学探头容纳（4）的光导（2）的远端（3）。探头利用反馈回路，通过驱动通过驱动线圈的电流驱动光导的位移和切断通过驱动线圈的电流之间的交替，并且当驱动电流被切断时，测量速度光导的远端。将测量的速度与设定点速度进行比较，并且如果检测到差异，则调节驱动电流以消除或至少降低该差异。

10. 发明申请

US20100207015A1 FIBER-OPTIC SCANNER 有权
标题翻译：光纤扫描仪
公开(公告)号：US20100207015A1
公开(公告)日：2010-08-19
申请号：US12668905
申请日：2008-07-14
申请人： Waltherus Cornelis Jozef Bierhoff , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Nanad Mihajlovic
发明人： Waltherus Cornelis Jozef Bierhoff , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Nanad Mihajlovic
IPC分类号： G02B26/10
CPC分类号： G02B26/101 , A61B5/0062 , A61B5/0084
摘要： A fiber scanning system is provided comprising a housing (102) with a fiber (13), the fiber (13) comprising a fixed part and a free end, the fixed part being attached to a bottom of the housing (102) and the fiber (13) extending parallel to the wall of the housing (102). At least one electrical coil (12) is attached to the wall at a position in between the fixed part and the free end of the fiber (13), a winding of the electrical coil (12) being in a plane parallel to the fiber (13). A magnet (11) is attached to the fiber (13), such that the electrical coil (12) may induce a force on the magnet (11). The magnet (11) is attached to the fiber (13) at a position just before or after the electrical coil (12), a width of the magnet (11) being such that the magnet (11) extends over the electrical coil (12).
摘要翻译：提供一种纤维扫描系统，其包括具有纤维（13）的壳体（102），所述纤维（13）包括固定部分和自由端，所述固定部分附接到所述壳体（102）的底部，并且所述纤维（13）平行于壳体（102）的壁延伸。至少一个电线圈（12）在所述固定部分和所述光纤（13）的所述自由端之间的位置处附接到所述壁，所述电线圈（12）的绕组处于与所述光纤平行的平面（ 13）。磁体（11）附着在光纤（13）上，使得电线圈（12）可以在磁铁（11）上产生一个力。磁体（11）在刚好在电线圈（12）之前或之后的位置处附接到光纤（13），磁体（11）的宽度使得磁体（11）在电线圈（12）上方延伸）。

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