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1. 发明授权

US08553839B2 System and method for generating images of a patient's interior and exterior 有权
标题翻译：用于产生患者内部和外部的图像的系统和方法
公开(公告)号：US08553839B2
公开(公告)日：2013-10-08
申请号：US13134537
申请日：2009-12-04
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Adrien Desjardins , Drazenko Babic
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Adrien Desjardins , Drazenko Babic
IPC分类号： G01N23/04
CPC分类号： A61B6/5235 , A61B6/4423 , A61B6/4441 , A61B6/5247 , A61B90/361 , A61B2090/364 , A61B2090/366 , A61B2090/371 , A61B2090/376
摘要： A system for generating an image including information of both an interior and an exterior of a patient. The system includes an X ray device for providing an X ray image of a patient's interior, and a camera responsive to a wavelength for providing a camera image of a patient's exterior. The camera may be supported by the X ray device for establishing a determined spatial relationship between the camera and the X ray device. The system further includes a spatial reference for spatially correlating the X ray image and the camera image, where the spatial reference is detectable in the X ray image and in the camera image. A data processor configured for rendering the camera image and the X ray image into a composite image on the basis of the spatial reference.
摘要翻译：一种用于生成包括患者的内部和外部的信息的图像的系统。该系统包括用于提供患者内部的X射线图像的X射线装置和响应于用于提供患者外部的照相机图像的波长的照相机。照相机可以由X射线装置支持，以建立照相机和X射线装置之间确定的空间关系。该系统还包括用于空间上相关X射线图像和相机图像的空间参考，其中空间参考在X射线图像和相机图像中是可检测的。一种数据处理器，被配置为基于空间参考将相机图像和X射线图像渲染成合成图像。

2. 发明申请

US20120008741A1 System and method for generating images of a patient's interior and exterior 有权
标题翻译：用于产生患者内部和外部的图像的系统和方法
公开(公告)号：US20120008741A1
公开(公告)日：2012-01-12
申请号：US13134537
申请日：2011-06-09
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Adrien Desjardins , Drazenko Babic
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Adrien Desjardins , Drazenko Babic
IPC分类号： A61B6/00 , G01N23/04
CPC分类号： A61B6/5235 , A61B6/4423 , A61B6/4441 , A61B6/5247 , A61B90/361 , A61B2090/364 , A61B2090/366 , A61B2090/371 , A61B2090/376
摘要： A system for generating an image including information of both an interior and an exterior of a patient. The system includes an X ray device for providing an X ray image of a patient's interior, and a camera responsive to a wavelength for providing a camera image of a patient's exterior. The camera may be supported by the X ray device for establishing a determined spatial relationship between the camera and the X ray device. The system further includes a spatial reference for spatially correlating the X ray image and the camera image, where the spatial reference is detectable in the X ray image and in the camera image. A data processor configured for rendering the camera image and the X ray image into a composite image on the basis of the spatial reference.
摘要翻译：一种用于生成包括患者的内部和外部的信息的图像的系统。该系统包括用于提供患者内部的X射线图像的X射线装置和响应于用于提供患者外部的照相机图像的波长的照相机。照相机可以由X射线装置支持，以建立照相机和X射线装置之间确定的空间关系。该系统还包括用于空间上相关X射线图像和相机图像的空间参考，其中空间参考在X射线图像和相机图像中是可检测的。一种数据处理器，被配置为基于空间参考将相机图像和X射线图像渲染成合成图像。

3. 发明授权

US08812080B2 Algorithm for photonic needle console 有权
标题翻译：光子针控制器算法
公开(公告)号：US08812080B2
公开(公告)日：2014-08-19
申请号：US13376702
申请日：2010-06-07
申请人： Rami Nachabe , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Marjolein Van Der Voort , Adrien Desjardins , Drazenko Babic , Nenad Mihajlovic
发明人： Rami Nachabe , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Marjolein Van Der Voort , Adrien Desjardins , Drazenko Babic , Nenad Mihajlovic
IPC分类号： A61B5/05
CPC分类号： G06F19/321 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/14503 , A61B5/6848 , A61B5/7435 , A61B5/7475 , A61B6/467 , A61B6/469 , A61B6/545 , A61B8/0833 , A61B8/461 , A61B8/467 , A61B8/469 , A61B8/585 , A61B17/3401 , A61B17/3403 , A61B34/20 , A61B90/92 , A61B90/96 , A61B90/98 , A61B2017/00199 , A61B2017/00225 , A61B2034/2055 , A61B2090/376 , A61B2090/3908 , A61B2090/3945 , A61B2562/08 , G06F19/00 , G16H40/63
摘要： Needles are widely used in interventional radiology. Each medical application requires a specific needle type. The same holds for the photonic needles which analysis depends on the type of application the clinician aims for. Therefore, it is relevant to have the X-ray machine recognize the type of needle that is being used and to load the required software for the tissue analysis. It is therefore proposed to have a data link established between the imaging modality used for the acquisition of the patient anatomy (X-ray, CT, MR or US) and the system that processes optical data from the needle, so that the information from this imaging modality can be used to guide the processing. In a preferred embodiment the selection is made by reading out the code present in the disposable needle when it is connected to the console.
摘要翻译：针头广泛用于介入放射学。每个医疗应用都需要特殊的针型。同样适用于光子针，分析取决于临床医生的应用类型。因此，使X射线机器识别正在使用的针的类型并加载组织分析所需的软件是相关的。因此，建议在用于获取患者解剖结构（X射线，CT，MR或US）的成像模式和处理来自针的光学数据的系统之间建立数据链路，使得来自该信息的信息成像模式可用于指导处理。在优选实施例中，通过在连接到控制台时读出一次性针头中存在的代码来进行选择。

4. 发明申请

US20120088991A1 ALGORITHM FOR PHOTONIC NEEDLE CONSOLE 有权
标题翻译： PHOTONIC NEEDLE CONSOLE算法
公开(公告)号：US20120088991A1
公开(公告)日：2012-04-12
申请号：US13376702
申请日：2010-06-07
申请人： Rami Nachabe , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Marjolein Van Der Voort , Adrien Desjardins , Drazenko Babic , Nenad Mihajlovic
发明人： Rami Nachabe , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Marjolein Van Der Voort , Adrien Desjardins , Drazenko Babic , Nenad Mihajlovic
IPC分类号： A61B5/1455 , A61B5/055 , A61B5/05
CPC分类号： G06F19/321 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/14503 , A61B5/6848 , A61B5/7435 , A61B5/7475 , A61B6/467 , A61B6/469 , A61B6/545 , A61B8/0833 , A61B8/461 , A61B8/467 , A61B8/469 , A61B8/585 , A61B17/3401 , A61B17/3403 , A61B34/20 , A61B90/92 , A61B90/96 , A61B90/98 , A61B2017/00199 , A61B2017/00225 , A61B2034/2055 , A61B2090/376 , A61B2090/3908 , A61B2090/3945 , A61B2562/08 , G06F19/00 , G16H40/63
摘要： Needles are widely used in interventional radiology. Each medical application requires a specific needle type. The same holds for the photonic needles which analysis depends on the type of application the clinician aims for. Therefore, it is relevant to have the X-ray machine recognize the type of needle that is being used and to load the required software for the tissue analysis. It is therefore proposed to have a data link established between the imaging modality used for the acquisition of the patient anatomy (X-ray, CT, MR or US) and the system that processes optical data from the needle, so that the information from this imaging modality can be used to guide the processing. In a preferred embodiment the selection is made by reading out the code present in the disposable needle when it is connected to the console.
摘要翻译：针头广泛用于介入放射学。每个医疗应用都需要特殊的针型。同样适用于光子针，分析取决于临床医生的应用类型。因此，使X射线机器识别正在使用的针的类型并加载组织分析所需的软件是相关的。因此，建议在用于获取患者解剖结构（X射线，CT，MR或US）的成像模式和处理来自针的光学数据的系统之间建立数据链路，使得来自该信息的信息成像模式可用于指导处理。在优选实施例中，通过在连接到控制台时读出一次性针头中存在的代码来进行选择。

5. 发明授权

US09179985B2 Biopsy guidance by electromagnetic tracking and photonic needle 有权
标题翻译：电磁跟踪和光子针穿刺活检
公开(公告)号：US09179985B2
公开(公告)日：2015-11-10
申请号：US12867267
申请日：2009-02-27
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Guy Shechter , Drazenko Babic , Wim Crooijmans
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Guy Shechter , Drazenko Babic , Wim Crooijmans
IPC分类号： A61B5/06 , A61B19/00 , A61B10/04 , A61B5/00 , A61B10/02 , A61B17/34 , A61B17/00
CPC分类号： A61B5/6848 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B10/0275 , A61B10/04 , A61B17/3403 , A61B17/3421 , A61B34/20 , A61B2017/00061 , A61B2017/00066 , A61B2034/2051 , A61B2090/306 , A61B2090/378 , A61B2576/00
摘要： A system for providing integrated guidance for positioning a needle in a body has two levels of guidance: a coarse guidance and a fine guidance. The system includes a non-invasive tracking system for tracing the biopsy device in the body, for providing the coarse guidance. Furthermore, the system includes an optical detector mounted on the needle for obtaining optical information discriminating tissue in the body, for providing the fine guidance.
摘要翻译：用于提供用于将针定位在身体中的集成指导的系统具有两个指导级别：粗略的引导和精细的引导。该系统包括用于跟踪身体中活检装置的非侵入性跟踪系统，用于提供粗略的引导。此外，该系统包括安装在针上的光学检测器，用于获得识别身体中的组织的光学信息，以提供精细引导。

6. 发明申请

US20120170824A1 SYSTEM FOR DETECTING GLOBAL PATIENT MOVEMENT DURING IMAGING PROCEDURES 有权
标题翻译：在成像过程中检测全球患者运动的系统
公开(公告)号：US20120170824A1
公开(公告)日：2012-07-05
申请号：US13320358
申请日：2010-05-10
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Michael Cornelis Van Beek , Peter-Andre Redert , Frederik Jan De Bruijn , Drazenko Babic , Robert Johannes Frederik Homan , Ralph Braspenning , Wei Pien Lee , Karl Catharina Van Bree , Caifeng Shan
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Michael Cornelis Van Beek , Peter-Andre Redert , Frederik Jan De Bruijn , Drazenko Babic , Robert Johannes Frederik Homan , Ralph Braspenning , Wei Pien Lee , Karl Catharina Van Bree , Caifeng Shan
IPC分类号： G06K9/00
CPC分类号： A61B6/025 , A61B6/4423 , A61B6/4441 , A61B6/5247 , A61B90/361 , A61B90/39 , A61B2090/376
摘要： The invention provides a system (102) for accurately detecting a patient's (114) movement during imaging procedures. The system comprises a camera (126) for providing a stream of camera images of a part of a patient's exterior (206). The system (102) furthermore comprises a fiducial element (116), which fiducial element (116) is mountable on said part of the patient's exterior (206), and which fiducial element (116) is detectable in the stream of camera images, and an image processor (128) for detecting a displacement of the fiducial element based on consecutive camera images comprised in at least the stream of camera images and for generating an output signal (129) indicative for said displacement. Herein, the fiducial element (116) has an in-plane stiffness which is substantially larger than an in-plane stiffness of said part of the patient's exterior. In addition, the fiducial element (116) and said part of the patient's exterior are provided with substantially equal outer in-plane dimensions.
摘要翻译：本发明提供一种用于在成像过程期间准确地检测患者（114）运动的系统（102）。该系统包括用于提供患者外部（206）的一部分的相机图像流的照相机（126）。所述系统（102）还包括基准元件（116），所述基准元件（116）可安装在所述患者外部部分（206）的所述部分上，并且所述基准元件（116）在相机图像流中是可检测的，以及图像处理器（128），用于基于包括在至少相机图像流中的连续相机图像来检测基准元素的位移，并且用于生成指示所述位移的输出信号（129）。这里，基准元件（116）具有的面内刚度基本上大于患者外部部分的平面内刚度。此外，基准元件（116）和患者外部的所述部分设置有基本上相等的外部平面外尺寸。

7. 发明申请

US20100317964A1 BIOPSY GUIDANCE BY ELECTROMAGNETIC TRACKING AND PHOTONIC NEEDLE 审中-公开
标题翻译：电磁跟踪和光子针的生物指导
公开(公告)号：US20100317964A1
公开(公告)日：2010-12-16
申请号：US12867267
申请日：2009-02-27
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Guy Shechter , Drazenko Babic , Wim Crooijmans
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Guy Shechter , Drazenko Babic , Wim Crooijmans
IPC分类号： A61B5/05 , A61B10/02
CPC分类号： A61B5/6848 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B10/0275 , A61B10/04 , A61B17/3403 , A61B17/3421 , A61B34/20 , A61B2017/00061 , A61B2017/00066 , A61B2034/2051 , A61B2090/306 , A61B2090/378 , A61B2576/00
摘要： A system for providing integrated guidance for positioning a needle in a body has two levels of guidance: a coarse guidance and a fine guidance. The system comprises a non-invasive tracking system (400) for tracing the biopsy device (100) in the body, for providing the coarse guidance. Furthermore, the system comprises an optical detector (101′, 102′, 103′) mounted on the needle (100) for obtaining optical information discriminating tissue in the body, for providing the fine guidance.
摘要翻译：用于提供用于将针定位在身体中的集成指导的系统具有两个指导级别：粗略的引导和精细的引导。该系统包括用于跟踪身体中的活检装置（100）的非侵入式跟踪系统（400），用于提供粗略的引导。此外，该系统包括安装在针（100）上的光学检测器（101'，102'，103'），用于获得鉴别身体中的组织的光学信息，以提供精细引导。

8. 发明申请

US20100076317A1 CATHETER WITH ULTRASOUND TRANSDUCER AND VARIABLE FOCUS LENS USED IN ANEURYSM ASSESSMENT 审中-公开
标题翻译：超声波传感器和可变焦度镜头用于防护评估的导管
公开(公告)号：US20100076317A1
公开(公告)日：2010-03-25
申请号：US12516617
申请日：2007-11-16
申请人： Drazenko Babic , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks
发明人： Drazenko Babic , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks
IPC分类号： A61B8/14
CPC分类号： A61B8/12 , A61B5/02014 , A61B8/06 , A61B8/445 , A61B8/4483 , A61B8/483 , A61B17/12113 , A61B17/1214 , A61B2017/1205 , G10K11/30
摘要： A catheter having ultrasound capability and a distal end extending along a longitudinal axis, the end being situated adjacent to a tissue of interest inside of a patient; at least one ultrasound transducer located in the end to direct ultrasound waves along the axis in a generally forward direction relative to the end; a variable-focus lens system located in the end, downstream of the transducer in the generally forward direction, the lens system being capable of variably focusing the ultrasound waves emitted by the transducer at various positions downstream of the lens and catheter end; optionally, a mirror located in the end, downstream of the transducer and the lens system in the generally forward direction, whereby the emitted ultrasound waves from the lens system are either reflected from the mirror and focused at a position substantially perpendicular to the longitudinal axis; or the emitted ultrasound waves from the lens system substantially bypass the mirror in unreflected form and are focused at a position downstream of the transducer, the lens system and the mirror in the generally forward direction along the longitudinal axis; and imaging means for translating the focused ultrasound waves from the lens system reflected and/or unreflected by the mirror into three-dimensional images and communicating the images in viewable form to a human operator that is external to the patient. A method of measuring, imaging and viewing blood flow velocity and patterns in a blood vessel and aneurysm, as well as monitoring vaso-occlusive coil placement in an aneurysm during a surgical intervention using the catheter, is also disclosed.
摘要翻译：具有超声波能力的导管和沿着纵向轴线延伸的远端，所述端部位于与患者体内的感兴趣组织相邻的位置; 位于所述端部的至少一个超声波换能器沿着所述轴线在相对于所述端部的大致向前方向上引导超声波; 可变焦距透镜系统位于传感器的大致向前方的下游，透镜系统能够在透镜和导管端的下游的各个位置处可变地聚焦由换能器发射的超声波; 可选地，位于换能器下游的镜子和大致正向的透镜系统，由此来自透镜系统的发射的超声波或者从反射镜反射并且在基本上垂直于纵向轴线的位置聚焦; 或者来自透镜系统的发射的超声波基本上以未反射的形式旁路反射镜，并且沿着纵轴在大致向前的方向上聚焦在换能器，透镜系统和反射镜的下游位置处; 以及成像装置，用于将由镜子反射和/或未反射的透镜系统的聚焦超声波转换为三维图像，并将可视形式的图像传送给患者外部的人类操作者。还公开了一种在使用导管的外科手术中测量，成像和观察血管和动脉瘤中的血流速度和图案的方法以及监测动脉瘤中的血管闭塞线圈放置。

9. 发明申请

US20110218445A1 NEEDLE WITH INTEGRATED FIBERS 审中-公开
标题翻译：带有集成纤维的针头
公开(公告)号：US20110218445A1
公开(公告)日：2011-09-08
申请号：US13129206
申请日：2009-06-15
申请人： Augustinus Laurentius Braun , Bernardus Hendrikus Wilhelmus Hendriks , Rik Harbers , Marjolein Van Der Voort , Adrien Emmanuel Desjardins , Rami Nachabe , Bernardus Wilhelmus Johannes Wassink , Franciscus Marinus Antonius Maria Van Gaal , Nenad Mihajlovic , Drazenko Babic
发明人： Augustinus Laurentius Braun , Bernardus Hendrikus Wilhelmus Hendriks , Rik Harbers , Marjolein Van Der Voort , Adrien Emmanuel Desjardins , Rami Nachabe , Bernardus Wilhelmus Johannes Wassink , Franciscus Marinus Antonius Maria Van Gaal , Nenad Mihajlovic , Drazenko Babic
IPC分类号： A61B6/00 , B21G3/18
CPC分类号： A61B5/6848 , A61B5/0075 , A61B5/0084
摘要： Needles equipped with fibres allow tissue inspection based on optical spectroscopy to diagnose whether tissue is cancerous or not. This requires integration of optical fibers into needles. The problem is how to manufacture the needle having at least one fiber exit at the distal end of the needle, where the fiber does not obstruct the hollow part of the needle if present as well as does not extend beyond the outer cylinder geometry. To solve this problem we propose to manufacture the needle consisting of four parts: an inner cylinder tube, an outer hollow cylinder tube, a needle tip part with integrated fiber exit and a holder part, wherein the hollow spacing between the inner and the outer cylinder is larger or equal to the outer diameter of the fibers, the inner and the outer cylinder are mounted in the holder part and where the tip part is mounted on the two cylinders.
摘要翻译：配备纤维的针头允许基于光谱的组织检查来诊断组织是否是癌变的。这需要将光纤集成到针中。问题是如何制造在针的远端具有至少一个纤维出口的针，其中纤维不会阻塞针的中空部分，如果存在，并且不延伸超出外筒几何形状。为了解决这个问题，我们建议制造由四部分组成的针：内筒管，外空心筒管，具有集成纤维出口的针尖部分和保持器部分，其中内筒和外筒之间的中空间隔大于或等于纤维的外径，内筒和外筒安装在保持器部分中，并且尖端部分安装在两个气缸上。

10. 发明授权

US09955927B2 System for detecting global patient movement during imaging procedures 有权
公开(公告)号：US09955927B2
公开(公告)日：2018-05-01
申请号：US13320358
申请日：2010-05-10
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Michael Cornelis Van Beek , Peter-Andre Redert , Frederik Jan De Bruijn , Drazenko Babic , Robert Johannes Frederik Homan , Ralph Braspenning , Wei Pien Lee , Karl Catharina Van Bree , Caifeng Shan
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Michael Cornelis Van Beek , Peter-Andre Redert , Frederik Jan De Bruijn , Drazenko Babic , Robert Johannes Frederik Homan , Ralph Braspenning , Wei Pien Lee , Karl Catharina Van Bree , Caifeng Shan
IPC分类号： G06K9/00 , A61B6/02 , A61B6/00 , A61B90/00
CPC分类号： A61B6/025 , A61B6/4423 , A61B6/4441 , A61B6/5247 , A61B90/361 , A61B90/39 , A61B2090/376
摘要： A system for accurately detecting a patient's movement during imaging procedures includes a camera for providing a stream of camera images of a part of a patient's exterior and a fiducial element mountable on part of the patient's exterior. The fiducial element is detectable in the stream of images. An image processor is configured to detect a displacement of the fiducial element based on consecutive images including in at least the stream of images and to generate an output signal indicative of the displacement. The fiducial element has an in-plane stiffness which is substantially larger than an in-plane stiffness of the part of the patient's exterior. In addition, the fiducial element and the part of the patient's exterior are provided with substantially equal outer in-plane dimensions.

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