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1. 发明授权

US5935945A Methods of treating or preventing cardiac arrhythmia 失效
标题翻译：治疗或预防心律失常的方法
公开(公告)号：US5935945A
公开(公告)日：1999-08-10
申请号：US959392
申请日：1997-10-28
申请人： Joseph J. Lynch, Jr. , Richard J. Swanson , Joseph J. Salata , Bernard Fermini
发明人： Joseph J. Lynch, Jr. , Richard J. Swanson , Joseph J. Salata , Bernard Fermini
IPC分类号： C07D237/24 , A61K31/00 , A61K31/50 , A61K31/66 , A61K31/664 , A61K45/00 , A61P9/06
CPC分类号： A61K31/664 , A61K31/00 , A61K31/50 , A61K31/66 , Y10S514/821
摘要： A method of treating or preventing supraventricular tachyarrhythmias is disclosed which comprises the use of a compound which selectively blocks the ultra-rapidly-activating delayed rectifier K.sup.+ current (I.sub.Kur) of the human atrium.
摘要翻译：公开了一种治疗或预防室上性快速性心律失常的方法，其包括使用选择性阻断人类心房的超快速活化延迟整流K +电流（IKur）的化合物。

2. 发明授权

US06214810B1 Methods of treating or preventing cardiac arrhythmia 有权
标题翻译：治疗或预防心律失常的方法
公开(公告)号：US06214810B1
公开(公告)日：2001-04-10
申请号：US09284705
申请日：1999-04-19
申请人： Bernard Fermini , Joseph J. Lynch, Jr. , Joseph J. Salata , Richard J. Swanson
发明人： Bernard Fermini , Joseph J. Lynch, Jr. , Joseph J. Salata , Richard J. Swanson
IPC分类号： A61K3166
CPC分类号： A61K31/664 , A61K31/00 , A61K31/50 , A61K31/66 , Y10S514/821
摘要： This application discloses a method of treating or preventing atrial arrhythmias which utilizes compounds which are blockers of the ultra-rapidly-activating delayed rectifier K+ current (IKur) of the human atrium in a use-dependent and/or rate dependent manner, and which provide the selective block preferentially at fast heart rates so that the effect is realized or maximized when required.
摘要翻译：本申请公开了一种治疗或预防心房心律失常的方法，该方法利用作为人类心房的超快速激活延迟整流K +电流（IKur）的阻断剂的化合物，其依赖于和/或速率依赖的方式，其提供选择性阻断优先以快速心率，使得当需要时实现或最大化效果。

3. 发明授权

US06214809B1 Methods of treating or preventing cardiac arrhythmia 有权
标题翻译：治疗或预防心律失常的方法
公开(公告)号：US06214809B1
公开(公告)日：2001-04-10
申请号：US09284704
申请日：1999-04-19
申请人： Bernard Fermini , Joseph J. Lynch, Jr. , Joseph J. Salata , Richard J. Swanson
发明人： Bernard Fermini , Joseph J. Lynch, Jr. , Joseph J. Salata , Richard J. Swanson
IPC分类号： A61K3166
CPC分类号： A61K31/664 , A61K31/00 , A61K31/50 , A61K31/66 , Y10S514/821
摘要： A method of treating or preventing supraventricular tachyarrhythmias is disclosed which comprises the use of a compound which selectively blocks the ultra-rapidly-activating delayed rectifier K+ current (IKur) of the human atrium.
摘要翻译：公开了一种治疗或预防室上性快速性心律失常的方法，其包括使用选择性阻断人类心房的超快速活化延迟整流K +电流（IKur）的化合物。

4. 发明授权

US5969017A Methods of treating or preventing cardiac arrhythmia 失效
标题翻译：治疗或预防心律失常的方法
公开(公告)号：US5969017A
公开(公告)日：1999-10-19
申请号：US958958
申请日：1997-10-28
申请人： Joseph J. Lynch, Jr. , Richard J. Swanson , Joseph J. Salata , Bernard Fermini
发明人： Joseph J. Lynch, Jr. , Richard J. Swanson , Joseph J. Salata , Bernard Fermini
IPC分类号： C07D237/24 , A61K31/00 , A61K31/50 , A61K31/66 , A61K45/00 , A61P9/00 , A61P9/06 , A61P43/00 , C07F9/53 , C08J5/52 , A01N57/18 , A01N57/34 , C08K5/51
CPC分类号： C07F9/5333 , A61K31/00 , A61K31/50 , A61K31/66 , C07D237/24 , C07F9/532 , C07F9/5325
摘要： This application discloses a method of treating or preventing atrial arrhythmias which utilizes compounds which are blockers of the ultra-rapidly-activating delayed rectifier K.sup.+ current (I.sub.Kur) of the human atrium in a use-dependent and/or rate dependent manner, and which provide the selective block preferentially at fast heart rates so that the effect is realized or maximized when required.
摘要翻译：本申请公开了一种治疗或预防心房心律失常的方法，该方法利用作为人类心房的超快速激活延迟整流K +电流（IKur）的阻断剂的化合物，其依赖于和/或速率依赖的方式，其提供选择性阻断优先以快速心率，使得当需要时实现或最大化效果。

5. 发明授权

US5503960A Millimeter wave device and method of making 失效
标题翻译：毫米波装置及其制作方法
公开(公告)号：US5503960A
公开(公告)日：1996-04-02
申请号：US42449
申请日：1993-04-01
申请人： Garry N. Hulderman , Eugene Phillips , Richard J. Swanson
发明人： Garry N. Hulderman , Eugene Phillips , Richard J. Swanson
IPC分类号： H03B9/14 , H03D9/06 , H04B1/38 , H05K3/06 , H05K3/20 , G03F7/00
CPC分类号： H03B9/14 , H03B9/147 , H03D9/06 , H04B1/38 , H05K3/06 , H05K3/20 , H05K3/202
摘要： A method for making a millimeter wave device having a dielectric substrate with a pair of substantially parallel planar surfaces with at least one predetermined millimeter wave circuit pattern formed in a conductive layer located on at least one of the substrate surfaces. A substantially planar conductive channel plate is mounted adjacent the conductive layer on one substrate surface with the channel plate having an aperture overlying each circuit pattern formed in the conductive layer. A substantially planar conductive cover plate is mounted adjacent one of the channel plates so as to form a first cavity in the region defined by the substrate surface, the channel plate aperture and the cover plate. The device may further include a second substantially planar conductive channel plate mounted adjacent the other one of the substrate surfaces with the second channel plate having an aperture corresponding to and aligned with the first channel plate aperture. A second substantially planar conductive cover plate is mounted adjacent the second channel plate so as to form a second cavity in the region defined by the other substrate surface, the second channel plate aperture and the second cover place. A substantially planar conductive back place may be mounted adjacent each cover plate to provide support to the device structure. For the production of large quantity, high yield devices, the channel places, cover plates, and back plates are fabricated by photolithography with chemical milling, to achieve device high performance operation. Alternatively the channel plates and back plates are integrally formed by combining photolithography and electroforming techniques.
摘要翻译：一种用于制造具有介电基片的毫米波器件的方法，所述电介质基片具有一对具有至少一个预定的毫米波电路图形的基本上平行的平坦表面，所述至少一个预定的毫米波电路图形成在位于至少一个基底表面上的导电一个基本上平面的导电通道板被安装在一个衬底表面上与导电层相邻，沟道板具有覆盖在导电层中形成的每个电路图案的孔。基本上平面的导电盖板安装在一个通道板附近，以便在由基板表面，通道板孔和盖板限定的区域中形成第一腔。该装置还可以包括邻近另一个衬底表面安装的第二基本上平面的导电通道板，其中第二通道板具有与第一通道板孔对应并对准的孔。安装在第二通道板附近的第二基本上平面的导电盖板，以便在由另一个基板表面，第二通道板孔和第二盖位置限定的区域中形成第二腔。基本上平面的导电后部位置可以安装在每个盖板附近以提供对器件结构的支撑。为了生产大量，高产量的装置，通过化学铣削的光刻制造通道，盖板和背板，以实现器件的高性能操作。或者，通过组合光刻和电铸技术将通道板和背板一体地形成。

6. 发明授权

US5545511A Millimeter wave device and method of making 失效
标题翻译：毫米波装置及其制作方法
公开(公告)号：US5545511A
公开(公告)日：1996-08-13
申请号：US394517
申请日：1995-02-27
申请人： Garry N. Hulderman , Eugene Phillips , Richard J. Swanson
发明人： Garry N. Hulderman , Eugene Phillips , Richard J. Swanson
IPC分类号： H03B9/14 , H03D9/06 , H04B1/38 , H05K3/06 , H05K3/20 , G03F7/20
CPC分类号： H03B9/14 , H03B9/147 , H03D9/06 , H04B1/38 , H05K3/06 , H05K3/20 , H05K3/202
摘要： A millimeter wave device having a dielectric substrate with a pair of substantially parallel planar surfaces with at least one predetermined millimeter wave circuit pattern formed in a conductive layer located on at least one of the substrate surfaces. A substantially planar conductive channel plate is mounted adjacent the conductive layer on one substrate surface with the channel plate having an aperture overlying each circuit pattern formed in the conductive layer. A substantially planar conductive cover plate is mounted adjacent one of the channel plates so as to form a first cavity in the region defined by the substrate surface, the channel plate aperture and the cover plate. The device may further include a second substantially planar conductive channel plate mounted adjacent the other one of the substrate surfaces with the second channel plate having an aperture corresponding to and aligned with the first channel plate aperture. A second substantially planar conductive cover plate is mounted adjacent the second channel plate so as to form a second cavity in the region defined by the other substrate surface, the second channel plate aperture and the second cover plate. A substantially planar conductive back plate may be mounted adjacent each cover plate to provide support to the device structure. For the production of large quantity, high yield devices, the channel plates, cover plates, and back plates are fabricated by precision techniques such as by photolithography with chemical milling, or electrodischarge machine wire saw fabrication techniques to achieve device high performance operation. In an alternate embodiment of the invention the channel plates, cover plates and back plates are integrally formed by combining photolithography and electroforming techniques.
摘要翻译：一种毫米波器件，具有具有一对基本上平行的平坦表面的电介质基底，该平坦表面具有形成在位于至少一个基底表面上的导电层中的至少一个预定毫米波电路图案。一个基本上平面的导电通道板被安装在一个衬底表面上与导电层相邻，沟道板具有覆盖在导电层中形成的每个电路图案的孔。基本上平面的导电盖板安装在一个通道板附近，以便在由基板表面，通道板孔和盖板限定的区域中形成第一腔。该装置还可以包括邻近另一个衬底表面安装的第二基本上平面的导电通道板，其中第二通道板具有与第一通道板孔对应并对准的孔。安装在第二通道板附近的第二基本上平面的导电盖板，以便在由另一个基板表面，第二通道板孔和第二盖板限定的区域中形成第二腔。基本上平面的导电背板可以安装在每个盖板附近以提供对器件结构的支撑。为了生产大量，高产量的装置，通过精密技术制造通道板，盖板和背板，例如通过化学铣削的光刻或电镀放电机线锯制造技术来实现器件高性能操作。在本发明的替代实施例中，通过组合光刻和电铸技术将通道板，盖板和背板一体地形成。

7. 发明授权

US5776734A DNA encoding the .beta. subunit of a mammalian maxi-K potassium channel 失效
标题翻译：编码哺乳动物maxi-K钾通道的β亚基的DNA
公开(公告)号：US5776734A
公开(公告)日：1998-07-07
申请号：US732506
申请日：1996-11-12
申请人： Gregory J. Kaczorowski , Maria L. Garcia , Reid J. Leonard , Owen B. McManus , Richard J. Swanson , Kimberly L. Folander
发明人： Gregory J. Kaczorowski , Maria L. Garcia , Reid J. Leonard , Owen B. McManus , Richard J. Swanson , Kimberly L. Folander
IPC分类号： C12N15/09 , A61K38/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , A61P21/02 , A61P25/04 , A61P29/00 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/19 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/865 , C12R1/91
CPC分类号： C07K14/705 , A61K38/00 , C12N2799/026
摘要： This invention relates to a heteromultimer and its use in screening pharmaceutically active compounds for modulators of maxi-K channel activity. Such modulators are useful in treating asthma, pregnant human myometrium, hypertension and angina, cerebral ischemia and in conditions where stimulation of neurotransmitter release is desired such as Alzheimer's disease and stimulation of damaged nerves.
摘要翻译： PCT No.PCT / US95 / 05768 Sec。 371日期：1996年11月12日 102（e）日期1996年11月12日PCT提交1995年5月9日PCT公布。公开号WO95 / 31543 日期1995年11月23日本发明涉及异源多聚体及其用于筛选药物活性化合物用于maxi-K通道活性调节剂的用途。这种调节剂可用于治疗哮喘，怀孕的人肌层，高血压和心绞痛，脑缺血以及需要刺激神经递质释放的疾病如阿尔茨海默病和刺激受损的神经。

8. 发明授权

US5936493A Low cost, one-shot switch waveguide window 失效
标题翻译：低成本，单向开关波导窗口
公开(公告)号：US5936493A
公开(公告)日：1999-08-10
申请号：US977388
申请日：1997-11-24
申请人： Garry N. Hulderman , Richard J. Swanson
发明人： Garry N. Hulderman , Richard J. Swanson
IPC分类号： H01P1/08 , H01P1/10
CPC分类号： H01P1/08
摘要： Inexpensive and reliable apparatus for blanking the signal path between an antenna and a transmitter or a receiver to protect them from harmful radiation in the absence of power forms supplied thereto. The apparatus is preferably formed as a printed circuit waveguide switch window having a plurality of parallel conductors, such as metal wires or printed circuit traces, disposed on a dielectric substrate. The waveguide switch window is secured between two sections of waveguide. The conductors have a predetermined separation and width that are designed to appear as a solid metal surface that rejects radiation over a wide bandwidth. A bias terminal is coupled to the plurality of conductors, and insulating material is disposed between the bias terminal and the conductors to insulate the top portion of the grid array from the adjacent waveguide. The lower portion of the grid array is grounded to the adjacent waveguide. When the waveguide switch window is in its protective, blanked state, it blocks undesired radiation from entering the antenna and destroying sensitive components in the receiver. When a predetermined voltage is supplied to the bias terminal, it vaporizes the grid array and opens the waveguide switch window to allow normal operation of the antenna and receiver. As proven by tests, the waveguide switch window provides radiation immunity against high level input radiation power and high isolation (30 dB) for receiver protection in the blanked state, and with no measurable loss in the unblanked state.
摘要翻译：用于消除天线和发射机或接收机之间的信号路径的廉价可靠的设备，以在没有提供给其的电力形式的情况下保护它们免受有害辐射。该装置优选地形成为布置在介质基板上的具有多个平行导体（例如金属线或印刷电路迹线）的印刷电路波导开关窗口。波导开关窗固定在波导的两个部分之间。导体具有预定的分离宽度，被设计成出现为在宽带宽上抑制辐射的固体金属表面。偏置端子耦合到多个导体，并且绝缘材料设置在偏置端子和导体之间，以将栅格阵列的顶部部分与相邻的波导绝缘。栅格阵列的下部接地到相邻的波导。当波导开关窗处于保护状态时，阻挡不需要的辐射进入天线，并破坏接收器中的敏感元件。当向偏置端子提供预定电压时，它使电网阵列蒸发并打开波导开关窗口以允许天线和接收器的正常操作。通过测试证明，波导开关窗口在消隐状态下提供高电平输入辐射功率和高隔离度（30 dB）的辐射抗扰度，并且在未钝化状态下没有可测量的损耗。

9. 发明授权

US5688618A Millimeter wave device and method of making 失效
标题翻译：毫米波装置及其制作方法
公开(公告)号：US5688618A
公开(公告)日：1997-11-18
申请号：US446025
申请日：1995-05-19
申请人： Garry N. Hulderman , Eugene Phillips , Richard J. Swanson
发明人： Garry N. Hulderman , Eugene Phillips , Richard J. Swanson
IPC分类号： H03B9/14 , H03D9/06 , H04B1/38 , H05K3/06 , H05K3/20 , G03F7/00 , G03F9/00
CPC分类号： H03B9/14 , H03B9/147 , H03D9/06 , H04B1/38 , H05K3/06 , H05K3/20 , H05K3/202
摘要： A millimeter wave device having a dielectric substrate with a pair of substantially parallel planar surfaces with at least one predetermined millimeter wave circuit pattern formed in a conductive layer located on at least one of the substrate surfaces. A substantially planar conductive channel plate is mounted adjacent the conductive layer on one substrate surface with the channel plate having an aperture overlying each circuit pattern formed in the conductive layer. A substantially planar conductive cover plate is mounted adjacent one of the channel plates so as to form a first cavity in the region defined by the substrate surface, the channel plate aperture and the cover plate The device may further include a second substantially planar conductive channel plate mounted adjacent the other one of the substrate surfaces with the second channel plate having an aperture corresponding to and aligned with the first channel plate aperture. A second substantially planar conductive cover plate is mounted adjacent the second channel plate so as to form a second cavity in the region defined by the other substrate surface, the second channel plate aperture and the second cover plate. A substantially planar conductive back plate may be mounted adjacent each cover plate to provide support to the device structure. For the production at large quantity, high yield devices, the channel plates, cover plates, and back plates are fabricated by precision techniques such as by photolithography with chemical milling, or electrodischarge machine wire saw fabrication techniques to achieve device high performance operation. In an alternate embodiment of the invention the channel plates, cover plates and back plates are integrally formed for combining photolithography and electroforming techniques.
摘要翻译：一种毫米波器件，具有具有一对基本上平行的平坦表面的电介质基底，该平坦表面具有形成在位于至少一个基底表面上的导电层中的至少一个预定毫米波电路图案。一个基本上平面的导电通道板被安装在一个衬底表面上与导电层相邻，沟道板具有覆盖在导电层中形成的每个电路图案的孔。基本上平面的导电盖板安装在一个通道板附近，以便在由基板表面，通道板孔和盖板限定的区域中形成第一空腔。该装置还可包括第二基本上平面的导电通道板安装在另一个衬底表面上，其中第二通道板具有与第一通道板孔对应并对准的孔。安装在第二通道板附近的第二基本上平面的导电盖板，以便在由另一个基板表面，第二通道板孔和第二盖板限定的区域中形成第二腔。基本上平面的导电背板可以安装在每个盖板附近以提供对器件结构的支撑。对于大批量生产高产量装置，通过精密技术制造通道板，盖板和背板，例如通过化学铣削的光刻或电镀放电机线锯制造技术来实现器件高性能操作。在本发明的替代实施例中，通道板，盖板和背板是一体形成的，用于组合光刻和电铸技术。

10. 发明授权

US5637470A Screening array using cells expressing recombinant .alpha. and .beta. subunits of the mammalian large-conductance (maxi-K) potassium channel 失效
标题翻译：筛选阵列使用表达哺乳动物大电导（maxi-K）钾通道的重组α和β亚基的细胞
公开(公告)号：US5637470A
公开(公告)日：1997-06-10
申请号：US389668
申请日：1995-02-16
申请人： Gregory J. Kaczorowski , Maria L. Garcia , Reid J. Leonard , Owen B. McManus , Richard J. Swanson , Kimberly L. Folander
发明人： Gregory J. Kaczorowski , Maria L. Garcia , Reid J. Leonard , Owen B. McManus , Richard J. Swanson , Kimberly L. Folander
IPC分类号： C12N15/09 , A61K38/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , A61P21/02 , A61P25/04 , A61P29/00 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/19 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/865 , C12R1/91 , G01N33/50
CPC分类号： C07K14/705 , A61K38/00 , C12N2799/026
摘要： Disclosed are nucleic acids encoding the .beta. subunit of the mammalian large-conductance ("maxi-K") potassium channel, cells transformed with such nucleic acids, and .beta. subunit proteins produced by the transformed cells. Within the invention are recombinant host cells expressing .alpha..beta. heteromultimers. Such cells or preparations made from them may be used to screen for pharmacologically active modulators of maxi-K channel activity. Such modulators are potentially useful in treating asthma, pregnant human myometrium, hypertension and angina, cerebral ischemia, and conditions where stimulation of neurotransmitter release is desired, such as in Alzheimer's disease and stimulation of damaged nerves.
摘要翻译：公开了编码哺乳动物大电导（“maxi-K”）钾通道的β亚单位，用这种核酸转化的细胞和由转化细胞产生的β亚基蛋白的核酸。在本发明内是表达αβ异复合体的重组宿主细胞。这些由其制备的细胞或制剂可用于筛选具有maxi-K通道活性的药理活性调节剂。这种调节剂可能用于治疗哮喘，怀孕的人类子宫肌层，高血压和心绞痛，脑缺血以及需要刺激神经递质释放的疾病，例如阿尔茨海默病和刺激受损神经。

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