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1. 发明申请

US20200292548A1 MARKERS FOR THE DIAGNOSIS OF BIOCHEMICAL RECURRENCE IN PROSTATE CANCER 审中-公开
公开(公告)号：US20200292548A1
公开(公告)日：2020-09-17
申请号：US16783238
申请日：2020-02-06
申请人： Berg LLC , The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
发明人： Michael Andrew Kiebish , Niven Rajin Narain , Rangaprasad Sarangarajan , Viatcheslav R. Akmaev , Leonardo Rodrigues , Lixia Zhang , Eric Milliman , Shiv Srivastava , Albert Dobi , Jennifer Cullen
IPC分类号： G01N33/574
摘要： Methods for diagnosing the presence of BCR in prostate cancer in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of BCR. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

2. 发明申请

US20220107322A1 LIPID, PROTEIN, AND METABOLITE MARKERS FOR THE DIAGNOSIS AND TREATMENT OF PROSTATE CANCER 有权
公开(公告)号：US20220107322A1
公开(公告)日：2022-04-07
申请号：US17343538
申请日：2021-06-09
申请人： Berg LLC , The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
发明人： Michael Andrew Kiebish , Niven Rajin Narain , Rangaprasad Sarangarajan , Viatcheslav R. Akmaev , Leonardo Rodrigues , Yezhou Sun , Shiv Srivastava , Albert Dobi
IPC分类号： G01N33/574 , A61K31/00 , C12Q1/6886 , G01R33/46 , G01N21/31 , G01N30/02 , C07C229/12
摘要： Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of prostate cancer. The invention also provides methods of treating prostate cancer by administering a biomarker or an agent that modulates a biomarker of prostate cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

3. 发明申请

US20210080466A1 MARKERS FOR THE DIAGNOSIS OF PROSTATE CANCER 有权
公开(公告)号：US20210080466A1
公开(公告)日：2021-03-18
申请号：US16913775
申请日：2020-06-26
申请人： Berg LLC , The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
发明人： Michael Andrew Kiebish , Niven Rajin Narain , Rangaprasad Sarangarajan , Viatcheslav R. Akmaev , Leonardo Rodrigues , Lixia Zhang , Shiv Srivastava , Albert Dobi , Jennifer Cullen
IPC分类号： G01N33/574
摘要： Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of prostate cancer. The invention also provides methods of treating prostate cancer by administering a biomarker or an agent that modulates a biomarker of prostate cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

4. 发明申请

US20180024132A1 LIPID, PROTEIN, AND METABOLITE MARKERS FOR THE DIAGNOSIS AND TREATMENT OF PROSTATE CANCER 审中-公开
公开(公告)号：US20180024132A1
公开(公告)日：2018-01-25
申请号：US15644095
申请日：2017-07-07
申请人： Berg LLC , The Henry M. Jackson Foundation for The Advancement of Military Medicine, Inc.
发明人： Michael Andrew Kiebish , Niven Rajin Narain , Rangaprasad Sarangarajan , Viatcheslav R. Akmaev , Leonardo Rodrigues , Yezhou Sun , Shiv Srivastava , Albert Dobi
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57434 , A61K31/00 , C07C229/12 , C12Q1/6886 , G01N2021/3155 , G01N2030/027 , G01N2500/10 , G01N2800/60 , G01R33/46
摘要： Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of prostate cancer. The invention also provides methods of treating prostate cancer by administering a biomarker or an agent that modulates a biomarker of prostate cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

5. 发明申请

US20200176118A1 METHODS AND SYSTEMS FOR SEPTIC SHOCK RISK ASSESSMENT 审中-公开
公开(公告)号：US20200176118A1
公开(公告)日：2020-06-04
申请号：US16673885
申请日：2019-11-04
申请人： Berg LLC
发明人： Vijetha Vemulapalli , Niven Rajin Narain , Viatcheslav R. Akmaev
IPC分类号： G16H50/30 , G16H10/60 , G16H40/63 , G16H40/67 , A61B5/145 , A61B5/00
摘要： Provided herein are methods and systems for determining the risk of a septic shock in a patient or for identifying a patient at high risk if septic shock. In some embodiment a method includes accessing and/or receiving information regarding a patient, the information including an indication of whether a measured level of mean corpuscular hemoglobin for the patient fell outside a normal range for the patient, and an indication of whether a measured level of whole blood potassium for the patient fell outside a normal range for the patient. In some embodiments, the method includes determining an estimated risk of the patient experiencing septic shock within a specified time period based on, at least, the indication of whether the measured level of mean corpuscular hemoglobin fell outside the normal range and the indication of whether the measured level of whole blood potassium fell outside the normal range.

6. 发明申请

US20160258958A1 USE OF MARKERS INCLUDING FILAMIN A IN THE DIAGNOSIS AND TREATMENT OF PROSTATE CANCER 审中-公开
标题翻译：使用包括FILAMIN A在内的标记物进行诊断和治疗前列腺癌
公开(公告)号：US20160258958A1
公开(公告)日：2016-09-08
申请号：US14962966
申请日：2015-12-08
申请人： Berg LLC
发明人： Niven Rajin Narain , Vivek K. Vishnudas , Rangaprasad Sarangarajan , Viatcheslav R. Akmaev
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N2333/47 , G01N2333/4742
摘要： Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of variety of biomarkers diagnostic of prostate cancer, including filamin A alone, or in combination with one or more additional biomarkers of prostate cancer, including, PSA, keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3, filamin B, and LY9. Additionally, age can be used as a predictor variable. The invention also provides methods of treating prostate cancer which rely on diagnostic information obtained based on the detection of biomarkers of prostate cancer, including filamin A alone, or in combination with one or more additional biomarkers of prostate cancer, including, PSA, keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3, filamin B, LY9, and/or age. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.
摘要翻译：提供了用于诊断受试者中前列腺癌存在的方法，所述方法包括检测前列腺癌诊断的生物标志物的多样性水平，包括单独的丝氨酸A或与一种或多种另外的前列腺癌生物标志物组合， PSA，角蛋白4，角蛋白7，角蛋白8，角蛋白15，角蛋白18，角蛋白19，微管蛋白β3，丝氨蛋白B和LY9。此外，年龄可以用作预测变量。本发明还提供了依赖于基于前列腺癌生物标志物的检测而获得的诊断信息的方法，所述诊断信息包括单独的丝氨酸A或与一种或多种另外的前列腺癌生物标志物组合，包括PSA，角蛋白4，角蛋白7，角蛋白8，角蛋白15，角蛋白18，角蛋白19，微管蛋白β3，丝氨蛋白B，LY9和/或年龄。还提供了用于检测本发明的生物标志物的试剂盒和试剂盒形式的组合物。

7. 发明授权

US10539566B2 Use of markers including filamin A in the diagnosis and treatment of prostate cancer 有权
公开(公告)号：US10539566B2
公开(公告)日：2020-01-21
申请号：US14962966
申请日：2015-12-08
申请人： Berg LLC
发明人： Niven Rajin Narain , Vivek K. Vishnudas , Rangaprasad Sarangarajan , Viatcheslav R. Akmaev
IPC分类号： G01N33/574 , C12Q1/6886
摘要： Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of variety of biomarkers diagnostic of prostate cancer, including filamin A alone, or in combination with one or more additional biomarkers of prostate cancer, including, PSA, keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3, filamin B, and LY9. Additionally, age can be used as a predictor variable. The invention also provides methods of treating prostate cancer which rely on diagnostic information obtained based on the detection of biomarkers of prostate cancer, including filamin A alone, or in combination with one or more additional biomarkers of prostate cancer, including, PSA, keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3, filamin B, LY9, and/or age. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

8. 发明公开

US20230274799A1 SYSTEMS AND METHODS FOR PATIENT STRATIFICATION AND IDENTIFICATION OF POTENTIAL BIOMARKERS 审中-公开
公开(公告)号：US20230274799A1
公开(公告)日：2023-08-31
申请号：US17953075
申请日：2022-09-26
申请人： Berg LLC
发明人： Niven Rajin Narain , Viatcheslav R. Akmaev , Leonardo Rodrigues , Gregory Mark Miller
IPC分类号： G16B50/30 , G16H50/50 , G16H50/70 , G16B25/10 , G16B40/00 , G16B45/00 , G16B20/00 , G16B20/20
CPC分类号： G16B50/30 , G16H50/50 , G16H50/70 , G16B25/10 , G16B40/00 , G16B45/00 , G16B20/00 , G16B20/20
摘要： Disclosed herein are methods and systems for identifying one or more potential biomarkers for a clinical outcome related to administration of an agent. The method includes processing molecular profile data for a plurality of subjects where the molecular profile data includes data obtained before, during and/or after administration of an agent to the plurality of subjects. The method also includes processing clinical records data for the subjects, where the clinical records data includes clinical outcome data, integrating the processed molecular profile data and the processed clinical records data for the subjects and storing in a database as merged data, selecting two or more subsets of the merged data using one or more criteria based on the clinical records data to generate two or more selected data sets, and analyzing one or more of the selected data sets to identify one or more potential biomarkers for a clinical outcome related to administration of the agent.

9. 发明申请

US20200333344A1 USE OF MARKERS INCLUDING FILAMIN A IN THE DIAGNOSIS AND TREATMENT OF PROSTATE CANCER 审中-公开
公开(公告)号：US20200333344A1
公开(公告)日：2020-10-22
申请号：US16688266
申请日：2019-11-19
申请人： Berg LLC
发明人： Niven Rajin Narain , Vivek K. Vishnudas , Rangaprasad Sarangarajan , Viatcheslav R. Akmaev
IPC分类号： G01N33/574 , C12Q1/6886
摘要： Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of variety of biomarkers diagnostic of prostate cancer, including filamin A alone, or in combination with one or more additional biomarkers of prostate cancer, including, PSA, keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3, filamin B, and LY9. Additionally, age can be used as a predictor variable. The invention also provides methods of treating prostate cancer which rely on diagnostic information obtained based on the detection of biomarkers of prostate cancer, including filamin A alone, or in combination with one or more additional biomarkers of prostate cancer, including, PSA, keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3, filamin B, LY9, and/or age. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

10. 发明授权

US10759850B2 Filamin A binding proteins and uses thereof 有权
公开(公告)号：US10759850B2
公开(公告)日：2020-09-01
申请号：US15801093
申请日：2017-11-01
申请人： Berg LLC
发明人： Wenfang Sybil Wu , Shobha Ravipaty , Tracey Friss , Viatcheslav R. Akmaev , Nikunj Narendra Tanna
IPC分类号： C07K16/18 , C07K16/30 , A61K39/395 , G01N33/574 , A01K67/027 , G01N3/50
摘要： The present invention encompasses filamin A (FLNA) binding proteins. Specifically, the invention relates to antibodies to FLNA. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention in methods of diagnosis, monitoring and prognosis of prostate cancer are also provided.

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