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1. 发明授权

US08000773B2 Radioimaging 有权
标题翻译：放射成像
公开(公告)号：US08000773B2
公开(公告)日：2011-08-16
申请号：US11980617
申请日：2007-10-31
申请人： Benny Rousso , Shlomo Ben-Haim , Michael Nagler , Omer Ziv , Ran Ravhon , Dalia Dickman , Yoel Zilberstein , Eli Dichterman , Simona Ben-Haim , Shankar Vallabhajosula , Daniel Berman , Zohar Bronshtine , Ziv Popper , Nir Weissberg , Nathaniel Roth , Haim Melman
发明人： Benny Rousso , Shlomo Ben-Haim , Michael Nagler , Omer Ziv , Ran Ravhon , Dalia Dickman , Yoel Zilberstein , Eli Dichterman , Simona Ben-Haim , Shankar Vallabhajosula , Daniel Berman , Zohar Bronshtine , Ziv Popper , Nir Weissberg , Nathaniel Roth , Haim Melman
IPC分类号： A61B5/00
CPC分类号： G01T1/161 , A61B5/4076 , A61B5/415 , A61B5/417 , A61B5/418 , A61B6/037 , A61B6/4258 , A61B6/507 , A61B6/583
摘要： A method of imaging, including receiving radioactive radiation from a body; reconstructing a 3D SPECT image of a distribution of radiation in at least one voxel of said body; and reconstructing a dynamic change in radiation in said voxel, as an updated image, at a rate of faster than one change per 5 minutes, wherein said reconstructed image is a clinically useful image including a resolution of 10 mm or better for a voxel volume of at least 5 cm in diameter and a contrast to background ratio of radiation of at least 2:1.
摘要翻译：一种成像方法，包括从身体接收放射性辐射; 重建在所述身体的至少一个体素中的辐射分布的3D SPECT图像; 以及以每5分钟快于一次更新的速率，将所述体素中的辐射的动态变化重建为更新的图像，其中所述重建的图像是临床有用的图像，其包括对于体素体积为10mm或更大的分辨率直径至少为5厘米，与背景比的比例至少为2：1。

2. 发明授权

US07705316B2 Dynamic SPECT camera 有权
标题翻译：动态SPECT相机
公开(公告)号：US07705316B2
公开(公告)日：2010-04-27
申请号：US12084559
申请日：2006-11-09
申请人： Benny Rousso , Omer Ziv , Michael Nagler , Shlomo Ben-Haim
发明人： Benny Rousso , Omer Ziv , Michael Nagler , Shlomo Ben-Haim
IPC分类号： G01T1/24
CPC分类号： G01T1/161 , A61B6/037 , G01T1/166 , G01T1/2985
摘要： A dynamic SPECT camera is provided, comprising, a plurality of single-pixel detectors, a timing mechanism, in communication with each single-pixel detector, configured for enabling time-binning of the radioactive emissions impinging upon each single-pixel detector to time periods not greater than substantially 30 seconds, and a position-tracker, configured for providing information on the position and orientation of each detecting unit, with respect to the overall structure, substantially at all times, during the individual motion, the dynamic SPECT camera being configured for acquiring a tomographic reconstruction image of a region of interest of about 15×15×15 cubic centimeters, during an acquisition time of 30 seconds, at a spatial resolution of at least 10×10×10 cubic millimeter. The dynamic camera is configured for very short damping time, and may further acquire images in a stationary mode, with no motion. It is further configured for time binning at dynamically varying time-bin lengths, dynamically determining a spectral energy bin for each detecting unit, and employing an anatomic construction of voxels in the imaging and reconstruction.
摘要翻译：提供了一种动态SPECT相机，包括多个单像素检测器，与每个单像素检测器通信的定时机构，其被配置为使得能够将入射到每个单像素检测器上的放射性发射器的时间分级到时间段不大于大约30秒的位置跟踪器，以及位置跟踪器，被配置为基本上在所述单独运动期间总是提供关于每个检测单元的位置和方位的信息，所述动态SPECT相机被配置用于在30秒的获取时间内以至少10×10×10立方毫米的空间分辨率获取约15×15×15立方厘米的感兴趣区域的断层重建图像。动态相机被配置为非常短的阻尼时间，并且可以在没有运动的情况下进一步以静止模式获取图像。它还被配置为在动态变化的时间段长度上进行时间分档，动态地确定每个检测单元的频谱能量仓，并且在成像和重构中采用体素的解剖构造。

3. 发明申请

US20070156047A1 Radioactive-emission-measurement optimization to specific body structures 有权
标题翻译：放射性 - 排放测量优化到特定的身体结构
公开(公告)号：US20070156047A1
公开(公告)日：2007-07-05
申请号：US11607075
申请日：2006-12-01
申请人： Michael Nagler , Eli Dichterman , Yoel Zilberstein , Ran Ravhon , Omer Ziv , Benny Rousso , Shlomo Ben-Haim
发明人： Michael Nagler , Eli Dichterman , Yoel Zilberstein , Ran Ravhon , Omer Ziv , Benny Rousso , Shlomo Ben-Haim
IPC分类号： A61B6/00
CPC分类号： A61B6/481 , A61B6/00 , A61B6/02 , A61B6/06 , A61B6/4258 , A61B6/4266 , A61B6/54 , G01T1/1642 , G01T1/1644 , G06T7/0012 , G06T2207/10072
摘要： Systems, methods, and probes are provided for functional imaging by radioactive-emission-measurements, specific to body structures, such as the prostate, the esophagus, the cervix, the uterus, the ovaries, the heart, the breast, the brain, and the whole body, and other body structures. The nuclear imaging may be performed alone, or together with structural imaging, for example, by x-rays, ultrasound, or MRI. Preferably, the radioactive-emission-measuring probes include detectors, which are adapted for individual motions with respect to the probe housings, to generate views from different orientations and to change their view orientations. These motions are optimized with respect to functional information gained about the body structure, by identifying preferred sets of views for measurements, based on models of the body structures and information theoretic measures. A second iteration, for identifying preferred sets of views for measurements of a portion of a body structure, based on models of a location of a pathology that has been identified, makes it possible, in effect, to zoom in on a suspected pathology. The systems are preprogrammed to provide these motions automatically.
摘要翻译：提供了系统，方法和探针，用于通过放射性 - 发射测量，特异于身体结构，例如前列腺，食管，子宫颈，子宫，卵巢，心脏，乳房，大脑和全身等身体结构。核成像可以单独进行，或者与结构成像一起进行，例如通过X射线，超声或MRI进行。优选地，放射性发射测量探针包括适于相对于探针外壳的单独运动的检测器，以从不同取向产生视图并改变其视图取向。通过基于身体结构和信息理论测量的模型，通过识别用于测量的优选视图集合来优化关于身体结构获得的功能信息的这些运动。基于已经识别的病理学位置的模型，用于识别体部结构的一部分的测量的优选视图组的第二迭代使得实际上可以放大可疑的病理学。这些系统是预编程的，以自动提供这些运动。

5. 发明授权

US07968851B2 Dynamic spect camera 有权
标题翻译：动态光学相机
公开(公告)号：US07968851B2
公开(公告)日：2011-06-28
申请号：US12728383
申请日：2010-03-22
申请人： Benny Rousso , Omer Ziv , Michael Nagler , Shlomo Ben-Haim
发明人： Benny Rousso , Omer Ziv , Michael Nagler , Shlomo Ben-Haim
IPC分类号： H01L27/146
CPC分类号： G06T11/006 , A61B5/055 , A61B5/7289 , A61B6/032 , A61B6/037 , A61B6/503 , A61B6/5288 , A61B8/13 , A61B8/5284 , G01T1/161 , G01T1/1644 , G01T1/243 , G01T1/247 , G01T1/249 , G06T7/0012 , G06T7/62 , G06T2207/10088 , G06T2207/10108 , G06T2207/10116 , G06T2207/10132 , G06T2207/10136 , G06T2207/30048
摘要： A method of reconstruction of a radioactive emission image. The method comprises providing a first system of voxels for a region of interest, obtaining radioactive-emission data from the region of interest, performing a first reconstruction, based on the radioactive-emission data and the first system of voxels, to obtain a first image, correcting the first system of voxels, by aligning voxel boundaries with object boundaries, based on the first image; thus obtaining a second system of voxels, and performing a second reconstruction, based on the radioactive-emission data and the second system of voxels, thus obtaining a second image.
摘要翻译：一种重建放射性发射图像的方法。该方法包括提供用于感兴趣区域的体素的第一系统，从感兴趣区域获得放射性发射数据，基于放射性发射数据和第一体素体素执行第一重建，以获得第一图像基于第一个图像，通过将体素边界与对象边界对齐来校正体素的第一系统; 从而获得体素的第二系统，并且基于放射性发射数据和第二体素体系执行第二重建，从而获得第二图像。

6. 发明授权

US08606349B2 Radioimaging using low dose isotope 有权
标题翻译：使用低剂量同位素进行放射成像
公开(公告)号：US08606349B2
公开(公告)日：2013-12-10
申请号：US11980653
申请日：2007-10-31
申请人： Benny Rousso , Shlomo Ben-Haim , Michael Nagler , Omer Ziv , Ran Ravhon , Dalia Dickman , Yoel Zilberstein , Eli Dichterman , Simona Ben-Haim , Shankar Vallabhajosula , Daniel Berman , Zohar Bronshtine , Ziv Popper , Nir Weissberg , Nathaniel Roth , Haim Melman
发明人： Benny Rousso , Shlomo Ben-Haim , Michael Nagler , Omer Ziv , Ran Ravhon , Dalia Dickman , Yoel Zilberstein , Eli Dichterman , Simona Ben-Haim , Shankar Vallabhajosula , Daniel Berman , Zohar Bronshtine , Ziv Popper , Nir Weissberg , Nathaniel Roth , Haim Melman
IPC分类号： A61B6/00
CPC分类号： A61B6/44 , A61B5/06 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/7285 , A61B6/037 , A61B6/0414 , A61B6/425 , A61B6/4258 , A61B6/4266 , A61B6/4275 , A61B6/4291 , A61B6/488 , A61B6/501 , A61B6/502 , A61B6/507 , A61B6/541 , A61B6/547 , A61B6/548 , A61B6/583 , A61B8/0808 , A61B8/0825 , A61B8/12 , A61B8/4416 , A61B8/543 , A61K51/00 , A61K51/0478 , A61K51/1048 , G01R33/481 , G01T1/1615 , G01T1/1642 , G01T1/2985
摘要： A method of imaging, comprising: (a) providing an isotope at a low dosage in a body of a patient; (b) receiving radiation generated by said isotope from said body using a radiation camera; and (c) reconstructing a 3D distribution of said isotope from said received radiation, wherein the dosage is less than ⅓ of a standard dose set forth in Table 5.
摘要翻译：一种成像方法，包括：（a）在患者体内以低剂量提供同位素; （b）使用辐射照相机从所述身体接收由所述同位素产生的辐射; 和（c）从所述接收的辐射重建所述同位素的3D分布，其中所述剂量小于表5中列出的标准剂量的1/3。

7. 发明授权

US08423125B2 Radioimaging 有权
公开(公告)号：US08423125B2
公开(公告)日：2013-04-16
申请号：US11980690
申请日：2007-10-31
申请人： Benny Rousso , Shlomo Ben-Haim , Michael Nagler , Omer Ziv , Ran Ravhon , Dalia Dickman , Yoel Zilberstein , Eli Dichterman , Simona Ben-Haim , Shankar Vallabhajosula , Daniel Berman , Zohar Bronshtine , Ziv Popper , Nir Weissberg , Nathaniel Roth , Haim Melman
发明人： Benny Rousso , Shlomo Ben-Haim , Michael Nagler , Omer Ziv , Ran Ravhon , Dalia Dickman , Yoel Zilberstein , Eli Dichterman , Simona Ben-Haim , Shankar Vallabhajosula , Daniel Berman , Zohar Bronshtine , Ziv Popper , Nir Weissberg , Nathaniel Roth , Haim Melman
IPC分类号： A61B6/00
CPC分类号： G01T1/161 , A61B5/4076 , A61B5/415 , A61B5/417 , A61B5/418 , A61B6/037 , A61B6/4258 , A61B6/507 , A61B6/583
摘要： Radioimaging methods, devices and radiopharmaceuticals therefor.

8. 发明申请

US20100245354A1 DYNAMIC SPECT CAMERA 有权
标题翻译：动态影像相机
公开(公告)号：US20100245354A1
公开(公告)日：2010-09-30
申请号：US12728383
申请日：2010-03-22
申请人： Benny Rousso , Omer Ziv , Michael Nagler , Shlomo Ben-Haim
发明人： Benny Rousso , Omer Ziv , Michael Nagler , Shlomo Ben-Haim
IPC分类号： G06T17/00 , G01T1/166
CPC分类号： G06T11/006 , A61B5/055 , A61B5/7289 , A61B6/032 , A61B6/037 , A61B6/503 , A61B6/5288 , A61B8/13 , A61B8/5284 , G01T1/161 , G01T1/1644 , G01T1/243 , G01T1/247 , G01T1/249 , G06T7/0012 , G06T7/62 , G06T2207/10088 , G06T2207/10108 , G06T2207/10116 , G06T2207/10132 , G06T2207/10136 , G06T2207/30048
摘要： A dynamic SPECT camera is provided, comprising, a plurality of single-pixel detectors, a timing mechanism, in communication with each single-pixel detector, configured for enabling time-binning of the radioactive emissions impinging upon each single-pixel detector to time periods not greater than substantially 30 seconds, and a position-tracker, configured for providing information on the position and orientation of each detecting unit, with respect to the overall structure, substantially at all times, during the individual motion, the dynamic SPECT camera being configured for acquiring a tomographic reconstruction image of a region of interest of about 15×15×15 cubic centimeters, during an acquisition time of 30 seconds, at a spatial resolution of at least 10×10×10 cubic millimeter. The dynamic camera is configured for very short damping time, and may further acquire images in a stationary mode, with no motion. It is further configured for time binning at dynamically varying time-bin lengths, dynamically determining a spectral energy bin for each detecting unit, and employing an anatomic construction of voxels in the imaging and reconstruction.
摘要翻译：提供了一种动态SPECT相机，包括多个单像素检测器，与每个单像素检测器通信的定时机构，其被配置为使得能够将入射到每个单像素检测器上的放射性发射器的时间分级到时间段不大于大约30秒的位置跟踪器，以及位置跟踪器，被配置为基本上在所述单独运动期间总是提供关于每个检测单元的位置和方位的信息，所述动态SPECT相机被配置用于在30秒的获取时间内以至少10×10×10立方毫米的空间分辨率获取约15×15×15立方厘米的感兴趣区域的断层重建图像。动态相机被配置为非常短的阻尼时间，并且可以在没有运动的情况下进一步以静止模式获取图像。它还被配置为在动态变化的时间段长度上进行时间分档，动态地确定每个检测单元的频谱能量仓，并且在成像和重构中采用体素的解剖构造。

9. 发明申请

US20090152471A1 Dynamic Spect Camera 有权
标题翻译：动态光谱相机
公开(公告)号：US20090152471A1
公开(公告)日：2009-06-18
申请号：US12084559
申请日：2006-11-09
申请人： Benny Rousso , Omer Ziv , Michael Nagler , Shlomo Ben-Haim
发明人： Benny Rousso , Omer Ziv , Michael Nagler , Shlomo Ben-Haim
IPC分类号： G01T1/166
CPC分类号： G01T1/161 , A61B6/037 , G01T1/166 , G01T1/2985
摘要： A dynamic SPECT camera is provided, comprising, a plurality of single-pixel detectors, a timing mechanism, in communication with each single-pixel detector, configured for enabling time-binning of the radioactive emissions impinging upon each single-pixel detector to time periods not greater than substantially 30 seconds, and a position-tracker, configured for providing information on the position and orientation of each detecting unit, with respect to the overall structure, substantially at all times, during the individual motion, the dynamic SPECT camera being configured for acquiring a tomographic reconstruction image of a region of interest of about 15×15×15 cubic centimeters, during an acquisition time of 30 seconds, at a spatial resolution of at least 10×10×10 cubic millimeter. The dynamic camera is configured for very short damping time, and may further acquire images in a stationary mode, with no motion. It is further configured for time binning at dynamically varying time-bin lengths, dynamically determining a spectral energy bin for each detecting unit, and employing an anatomic construction of voxels in the imaging and reconstruction.
摘要翻译：提供了一种动态SPECT相机，包括多个单像素检测器，与每个单像素检测器通信的定时机构，其被配置为使得能够将入射到每个单像素检测器上的放射性发射器的时间分级到时间段不大于大约30秒的位置跟踪器，以及位置跟踪器，被配置为基本上在所述单独运动期间总是提供关于每个检测单元的位置和方位的信息，所述动态SPECT相机被配置用于在30秒的采集时间期间以至少10×10 10立方毫米的空间分辨率获取约15×15×15立方厘米的感兴趣区域的断层重建图像。动态相机被配置为非常短的阻尼时间，并且可以在没有运动的情况下进一步以静止模式获取图像。它还被配置为在动态变化的时间段长度上进行时间分档，动态地确定每个检测单元的频谱能量仓，并且在成像和重构中采用体素的解剖构造。

10. 发明申请

US20080230705A1 Radioimaging 有权
标题翻译：放射成像
公开(公告)号：US20080230705A1
公开(公告)日：2008-09-25
申请号：US11980690
申请日：2007-10-31
申请人： Benny Rousso , Shlomo Ben-Haim , Michael Nagler , Omer Ziv , Ran Ravhon , Dalia Dickman , Yoel Zilberstein , Eli Dichterman , Simona Ben-Haim , Shankar Vallabhajosula , Daniel Berman , Zohar Bronshtine , Ziv Popper , Nir Weissberg , Nathaniel Roth , Haim Melman
发明人： Benny Rousso , Shlomo Ben-Haim , Michael Nagler , Omer Ziv , Ran Ravhon , Dalia Dickman , Yoel Zilberstein , Eli Dichterman , Simona Ben-Haim , Shankar Vallabhajosula , Daniel Berman , Zohar Bronshtine , Ziv Popper , Nir Weissberg , Nathaniel Roth , Haim Melman
IPC分类号： G01T1/166
CPC分类号： G01T1/161 , A61B5/4076 , A61B5/415 , A61B5/417 , A61B5/418 , A61B6/037 , A61B6/4258 , A61B6/507 , A61B6/583
摘要： Radioimaging methods, devices and radiopharmaceuticals therefor.
摘要翻译：放射成像方法，装置和放射性药物。

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