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1. 发明申请

US20050261313A1 Substituted alkylamine derivatives and methods of use 失效
标题翻译：取代的烷基胺衍生物和使用方法
公开(公告)号：US20050261313A1
公开(公告)日：2005-11-24
申请号：US11014184
申请日：2004-12-15
申请人： Benny Askew , Jeffrey Adams , Shon Booker , Guoqing Chen , Lucian DiPietro , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Gregory Habgood , Michael Handley , Qi Huang , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Rana Nomak , Vinod Patel , Babak Riahi , Joseph Kim , Ning Xi , Kevin Yang , Chester Yuan
发明人： Benny Askew , Jeffrey Adams , Shon Booker , Guoqing Chen , Lucian DiPietro , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Gregory Habgood , Michael Handley , Qi Huang , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Rana Nomak , Vinod Patel , Babak Riahi , Joseph Kim , Ning Xi , Kevin Yang , Chester Yuan
IPC分类号： A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P9/10 , A61P11/06 , A61P15/08 , A61P17/06 , A61P19/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/02 , C07D471/04 , C07D491/02 , C07D41/02 , C07D43/02
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：选择的胺对于预防和治疗疾病如血管生成介导的疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

2. 发明授权

US06878714B2 Substituted alkylamine derivatives and methods of use 有权
公开(公告)号：US06878714B2
公开(公告)日：2005-04-12
申请号：US10197974
申请日：2002-07-17
申请人： Benny Askew , Jeffrey Adams , Shon Booker , Guoqing Chen , Lucian V. DiPietro , Daniel Elbaum , Julie Germain , Stephanie D. Geuns-Meyer , Gregory J. Habgood , Michael Handley , Qi Huang , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Rana Nomak , Vinod F. Patel , Babak Riahi , Joseph L. Kim , Ning Xi , Kevin Yang , Chester Chenguang Yuan
发明人： Benny Askew , Jeffrey Adams , Shon Booker , Guoqing Chen , Lucian V. DiPietro , Daniel Elbaum , Julie Germain , Stephanie D. Geuns-Meyer , Gregory J. Habgood , Michael Handley , Qi Huang , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Rana Nomak , Vinod F. Patel , Babak Riahi , Joseph L. Kim , Ning Xi , Kevin Yang , Chester Chenguang Yuan
IPC分类号： A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P9/10 , A61P11/06 , A61P15/08 , A61P17/06 , A61P19/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/02 , C07D471/04 , C07D491/02 , A61K31/4427
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

3. 发明申请

US20060040956A1 Substituted alkylamine derivatives and methods of use 有权
公开(公告)号：US20060040956A1
公开(公告)日：2006-02-23
申请号：US11234713
申请日：2005-09-23
申请人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod Patel , Leon Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan
发明人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod Patel , Leon Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan
IPC分类号： A61K31/506 , C07D403/02
CPC分类号： C07D213/82 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

4. 发明申请

US20120065185A1 SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE 有权
标题翻译：取代的烷基胺衍生物及其使用方法
公开(公告)号：US20120065185A1
公开(公告)日：2012-03-15
申请号：US13297213
申请日：2011-11-15
申请人： Guoqing CHEN , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan
发明人： Guoqing CHEN , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan
IPC分类号： A61K31/4436 , A61K31/4709 , A61K31/4725 , A61P3/00 , A61P7/00 , A61P35/00 , A61P31/00 , A61K31/444 , A61K31/5377
CPC分类号： C07D213/82 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.
摘要翻译：所选择的杂环化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。本发明包括新型化合物，类似物，前药及其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。

5. 发明授权

US06995162B2 Substituted alkylamine derivatives and methods of use 有权
公开(公告)号：US06995162B2
公开(公告)日：2006-02-07
申请号：US10046681
申请日：2002-01-10
申请人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan
发明人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan
IPC分类号： A61K31/435 , C07D213/82
CPC分类号： C07D213/82 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

6. 发明申请

US20050054670A1 Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use 有权
标题翻译：取代的2,3-二氢-1,5-异吲哚-1-酮衍生物及其使用方法
公开(公告)号：US20050054670A1
公开(公告)日：2005-03-10
申请号：US10926238
申请日：2004-08-24
申请人： Christopher Tegley , Jeffrey Adams , Benny Askew , Michael Croghan , Daniel Elbaum , Julie Germain , Gregory Habgood , Scott Harried , Aiwen Li , Nobuko Nishimura , Rana Nomak , Andrew Tasker , Kevin Yang
发明人： Christopher Tegley , Jeffrey Adams , Benny Askew , Michael Croghan , Daniel Elbaum , Julie Germain , Gregory Habgood , Scott Harried , Aiwen Li , Nobuko Nishimura , Rana Nomak , Andrew Tasker , Kevin Yang
IPC分类号： A61P29/00 , A61P35/00 , C07D401/12 , C07D401/14 , C07D471/02 , A61K31/4035 , A61K31/4745
CPC分类号： C04B35/632 , C07D401/12 , C07D401/14
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

7. 发明申请

US20060194848A1 Substituted amine derivatives and methods of use 失效
公开(公告)号：US20060194848A1
公开(公告)日：2006-08-31
申请号：US11417329
申请日：2006-05-02
申请人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph Kim , Xiaohu Ouyang , Vinod Patel , Leon Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan , Tae-Seong Kim
发明人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph Kim , Xiaohu Ouyang , Vinod Patel , Leon Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan , Tae-Seong Kim
IPC分类号： A61K31/44 , A61K31/40
CPC分类号： C07D401/14 , A61K31/00 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , Y02A50/401
摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

8. 发明授权

US07514564B2 Substituted amine derivatives and methods of use 失效
标题翻译：取代的胺衍生物和使用方法
公开(公告)号：US07514564B2
公开(公告)日：2009-04-07
申请号：US11417329
申请日：2006-05-02
申请人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph L. Kim , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan , Tae-Seong Kim
发明人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph L. Kim , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan , Tae-Seong Kim
IPC分类号： C07D211/94 , C07D211/98 , A61K31/44
CPC分类号： C07D401/14 , A61K31/00 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , Y02A50/401
摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：选择的胺对于预防和治疗疾病如血管生成介导的疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

9. 发明授权

US07105682B2 Substituted amine derivatives and methods of use 有权
公开(公告)号：US07105682B2
公开(公告)日：2006-09-12
申请号：US10046622
申请日：2002-01-10
申请人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph L. Kim , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan , Tae-Seong Kim
发明人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph L. Kim , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan , Tae-Seong Kim
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D401/14 , A61K31/00 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , Y02A50/401
摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

10. 发明申请

US20060145080A1 Density detection using real time discrete photon counting for fast moving targets 有权
标题翻译：使用实时离散光子计数的快速移动目标的密度检测
公开(公告)号：US20060145080A1
公开(公告)日：2006-07-06
申请号：US11292093
申请日：2005-12-02
申请人： Victor Verbinski , Scott Smith , Kenneth Valentine , Judith Maxwell , Jeffrey Adams , Ryan Shyffer
发明人： Victor Verbinski , Scott Smith , Kenneth Valentine , Judith Maxwell , Jeffrey Adams , Ryan Shyffer
IPC分类号： G01N23/08
CPC分类号： G01V5/0016 , G01N23/02 , G01V5/0066
摘要： A system for detecting and graphically displaying a contents of a fast-moving target object comprises: a radiation source, having a position such that at least a portion of radiation emitted from the radiation source passes through the fast-moving target object, the fast-moving target object having a variable velocity and acceleration while maintaining a substantially constant distance from the radiation source and being selected from the group consisting of: a vehicle, a cargo container and a railroad car; a velocity measuring device configured to measure the variable velocity of the fast-moving target object; a detector array comprising a plurality of photon detectors, having a position such that at least some of the at least a portion of the radiation passing through the target object is received thereby, the detector array having a variable count time according to the variable velocity and a grid unit size; a counter circuit coupled to the detector array for discretely counting a number of photons entering individual photon detectors, the counter circuit measuring a count rate according to a contents within the fast-moving target object; a high baud-rate interface coupled to the counter circuit for sending count information from the counter circuit at a rate fast enough to support real-time data transfer therethrough; and a processor coupled to the velocity measuring device and to the high-baud-rate interface, receiving count information from the high baud-rate interface and generating distortion-free image data in real time as a function of the count information and the variable velocity. A method for using the system is also disclosed.
摘要翻译：一种用于检测和图形显示快速移动的目标物体的内容的系统包括：辐射源，具有这样的位置，使得从辐射源发出的辐射的至少一部分通过快速移动的目标物体，具有可变速度和加速度的移动目标物体，同时保持与辐射源基本恒定的距离，并且从包括车辆，货物集装箱和铁路车辆的组中选择; 速度测量装置，被配置为测量所述快速移动的目标物体的可变速度; 包括多个光子检测器的检测器阵列，具有这样的位置，使得穿过目标物体的至少一部分辐射被接收，检测器阵列根据可变速度具有可变计数时间，网格单位大小; 耦合到所述检测器阵列的计数器电路，用于对进入各个光子检测器的多个光子进行离散计数，所述计数器电路根据所述快速移动目标对象内的内容来测量计数率; 耦合到计数器电路的高波特率接口，用于以足以支持实时数据传输的速率从计数器电路发送计数信息; 以及耦合到速度测量装置和高波特率接口的处理器，从高波特率接口接收计数信息，并且作为计数信息和可变速度的函数实时生成无失真图像数据。还公开了一种使用该系统的方法。

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