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1. 发明申请

US20070105176A1 Method and apparatus for glucose monitoring 有权
标题翻译：用于葡萄糖监测的方法和装置
公开(公告)号：US20070105176A1
公开(公告)日：2007-05-10
申请号：US11529280
申请日：2006-09-28
申请人： Bennett Ibey , Vamsi Yadavalli , Rebecca Rounds , Hope Beier , Gerard Cote , Michael Pishko
发明人： Bennett Ibey , Vamsi Yadavalli , Rebecca Rounds , Hope Beier , Gerard Cote , Michael Pishko
IPC分类号： C12Q1/54 , C12M3/00
CPC分类号： C12Q1/54 , G01N33/53 , G01N33/54366
摘要： This disclosure relates to systems, devices, and methods of sensing an analyte. An implantable sensor may be contacted with a test sample under conditions that permit a binding protein and a ligand of the sensor to interact in an analyte-dependent manner to produce an analyte-dependent signal, and (b) detecting the analyte-dependent signal with a detector. A binding protein may reversibly bind an analyte and/or a ligand. A binding protein may have a higher binding affinity for an analyte than for a ligand. A binding protein and a ligand may each include a fluorophore, the absorption and/or emission properties of which may change in an analyte-dependent manner. A binding protein and/or a ligand may be bound to an active or inactive substrate. Some embodiments of systems, devices, and methods may be practiced in vitro, in situ, and/or in vivo. Systems and/or devices of the disclosure may be configured to be wearable.
摘要翻译：本公开涉及感测分析物的系统，装置和方法。在允许结合蛋白和传感器的配体以分析物依赖的方式相互作用以产生分析物相关信号的条件下，可植入传感器可以与测试样品接触，并且（b）用分析物依赖的信号检测检测器结合蛋白质可以可逆地结合分析物和/或配体。结合蛋白质可能对分析物具有比配体更高的结合亲和力。结合蛋白和配体可以各自包括荧光团，其吸收和/或发射性质可以以分析物依赖的方式改变。结合蛋白和/或配体可以与活性或非活性底物结合。系统，装置和方法的一些实施方案可以在体外，原位和/或体内实践。本公开的系统和/或设备可以被配置为可穿戴的。

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