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1. 发明授权

US10220045B2 Compositions and methods for forming stabilized compositions with reduced CSA agglomeration 有权
公开(公告)号：US10220045B2
公开(公告)日：2019-03-05
申请号：US14642905
申请日：2015-03-10
申请人： Benjamin J. Darien , Paul B. Savage
发明人： Benjamin J. Darien , Paul B. Savage
IPC分类号： A61K9/16 , A61K9/48 , A61K31/575 , A61K9/14 , B06B1/00 , A61K31/56
摘要： Compositions and methods for preparing stabilized CSA compositions having reduced agglomeration and increased stability. The compositions have increased efficacy in killing microbes and reduced cytotoxicity to mammals. The compositions include a liquid carrier, micelles formed from an amphiphilic material, and CSA molecules encapsulated by the micelles. The CSA compositions can be formed by blending together a solvent or liquid carrier, a plurality of CSA molecules, and a micelle-forming agent and causing or allowing the micelle-forming agent to form micelles encapsulating at least a portion of the CSA molecules so that no more than 25% of the CSA molecules form agglomerates larger than 1 μm in size. The CSA compositions can be used to treat mammals, such as mammals suffering from microbial diseases or infections.

2. 发明申请

US20150258121A1 COMPOSITIONS AND METHODS FOR FORMING STABILIZED COMPOSITIONS WITH REDUCED CSA AGGLOMERATION 审中-公开
标题翻译：用减少CSA聚集形成稳定组合物的组合物和方法
公开(公告)号：US20150258121A1
公开(公告)日：2015-09-17
申请号：US14642905
申请日：2015-03-10
申请人： Benjamin J. Darien , Paul B. Savage
发明人： Benjamin J. Darien , Paul B. Savage
IPC分类号： A61K31/575 , A61K9/48
CPC分类号： A61K31/575 , A61K9/1075 , A61K9/48 , A61K9/4833
摘要： Compositions and methods for preparing stabilized CSA compositions having reduced agglomeration and increased stability. The compositions have increased efficacy in killing microbes and reduced cytotoxicity to mammals. The compositions include a liquid carrier, micelles formed from an amphiphilic material, and CSA molecules encapsulated by the micelles. The CSA compositions can be formed by blending together a solvent or liquid carrier, a plurality of CSA molecules, and a micelle-forming agent and causing or allowing the micelle-forming agent to form micelles encapsulating at least a portion of the CSA molecules so that no more than 25% of the CSA molecules form agglomerates larger than 1 μm in size. The CSA compositions can be used to treat mammals, such as mammals suffering from microbial diseases or infections.
摘要翻译：用于制备具有降低的附聚和增加的稳定性的稳定的CSA组合物的组合物和方法。该组合物具有增加杀死微生物的功效并降低对哺乳动物的细胞毒性。组合物包括液体载体，由两亲性材料形成的胶束和由胶束包封的CSA分子。 CSA组合物可以通过将溶剂或液体载体，多个CSA分子和胶束形成剂混合在一起而形成，并使胶束形成剂形成包封至少一部分CSA分子的胶束，使得不超过25％的CSA分子形成大于1μm的团聚体。 CSA组合物可用于治疗哺乳动物，例如患有微生物疾病或感染的哺乳动物。

3. 发明授权

US11739116B2 Methods for treating inflammation, autoimmune disorders and pain 有权
公开(公告)号：US11739116B2
公开(公告)日：2023-08-29
申请号：US14208082
申请日：2014-03-13
申请人： Paul B. Savage , Carl Genberg
发明人： Paul B. Savage , Carl Genberg
IPC分类号： C07J41/00 , A61K47/10 , A61K47/42 , A61K31/575 , A61K45/06 , A61K47/69 , A61K47/64 , A61K47/60
CPC分类号： C07J41/0088 , A61K31/575 , A61K45/06 , A61K47/60 , A61K47/643 , A61K47/6921 , A61K31/575 , A61K2300/00
摘要： Compositions and methods for treating, reducing, or preventing a disease or symptom such as gingivitis, periodontitis, gastritis, colitis, ileitis, Crohn's disease, chronic inflammatory intestinal disease, inflammatory bowel syndrome, chronic inflammatory bowel disease, celiac disease, ulcerative colitis, a gastric ulcer, a peptic ulcer, a buccal ulcer, a nasopharyngeal ulcer, an esophageal ulcer, a duodenal ulcer, a gastrointestinal ulcer, an autoimmune disorder, or pain. The method includes identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

4. 发明申请

US20190076581A1 CATIONIC STEROIDAL ANTIBIOTIC COMPOSITIONS FOR THE TREATMENT OF DERMAL TISSUE 审中-公开
公开(公告)号：US20190076581A1
公开(公告)日：2019-03-14
申请号：US16184211
申请日：2018-11-08
申请人： Paul B. Savage , Carl Genberg , Ronald Bracken
发明人： Paul B. Savage , Carl Genberg , Ronald Bracken
IPC分类号： A61L27/54 , A61L24/00 , A61L27/58 , C08L5/08 , A61L27/22 , A61K31/575 , A61L27/16 , A61L27/18 , A61L24/08 , C08L83/04 , A61L24/04 , C08L67/04 , A61L24/06 , C08L33/12 , C08L35/04 , A61L26/00 , A61L24/10 , A61L27/50 , A61L27/24 , A61L27/20
摘要： This disclosure relates to dermal treatment compositions, such as dermal fillers and tissue glues, and injectable compositions that incorporate one or more cationic steroidal antimicrobials (CSAs). The CSAs are incorporated into the dermal treatment compositions to provide effective antimicrobial, anti-inflammatory, analgesic, anti-swelling and/or tissue-healing properties. A treatment composition includes a component formed from a biologically compatible material suitable for injection into and/or application onto tissue at a treatment site. One or more CSA compounds are mixed with the biologically compatible material so that the one or more CSA compounds are incorporated within the composition, forming a reservoir of CSA compounds within the resulting bolus of the treatment composition after injection and/or application.

5. 发明申请

US20180169114A1 METHODS FOR REDUCING CELLULAR PROLIFERATION AND TREATING CERTAIN DISEASES 审中-公开
公开(公告)号：US20180169114A1
公开(公告)日：2018-06-21
申请号：US15895848
申请日：2018-02-13
申请人： Carl Genberg , Paul B. Savage
发明人： Carl Genberg , Paul B. Savage
IPC分类号： A61K31/575 , A61K31/56
CPC分类号： A61K31/575 , A61K31/56
摘要： Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

6. 发明授权

US09943529B2 Methods for reducing cellular proliferation and treating certain diseases 有权
公开(公告)号：US09943529B2
公开(公告)日：2018-04-17
申请号：US14149675
申请日：2014-01-07
申请人： Carl Genberg , Paul B. Savage
发明人： Carl Genberg , Paul B. Savage
IPC分类号： A61K31/575 , A61K31/56
CPC分类号： A61K31/575 , A61K31/56
摘要： Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

7. 发明授权

US09867836B2 Lavage and/or infusion using CSA compounds for increasing fertility in a mammal 有权
公开(公告)号：US09867836B2
公开(公告)日：2018-01-16
申请号：US14644946
申请日：2015-03-11
申请人： Chad S. Beus , Paul B. Savage
发明人： Chad S. Beus , Paul B. Savage
IPC分类号： A61K31/575 , A61K9/00
CPC分类号： A61K31/575 , A61K9/0017
摘要： Increasing fertility in a mammal utilizes cationic steroidal antimicrobial (CSA) compounds and CSA-containing compositions. Such treatment in a mammal includes administering a formulation (e.g., lavage and/or infusion) including at least one CSA compound, or pharmaceutically acceptable salt thereof, to the reproductive structure(s) of the mammal (e.g., horse, dairy cow, human, etc.). The formulation may be applied topically as lavage and/or infusion to desired reproductive structures, such as the vagina, cervix, uterus, penis, or combinations thereof. The formulation may kill both planktonic and biofilm forms of sperm killing microbes, and may at least partially break up a microbial plaque or film located within any of the reproductive structures (e.g., the uterus). The CSA or pharmaceutically acceptable salt thereof may be selective or preferential in its action, so as to preferentially kill sperm killing microbes without causing harm to beneficial microbes also residing within the reproductive structure of the mammal.

8. 发明申请

US20170232004A1 METHODS FOR TREATING FUNGAL INFECTIONS 审中-公开
公开(公告)号：US20170232004A1
公开(公告)日：2017-08-17
申请号：US15585632
申请日：2017-05-03
申请人： Carl Genberg , Chad S. Beus , Paul B. Savage
发明人： Carl Genberg , Chad S. Beus , Paul B. Savage
IPC分类号： A61K31/575 , A61K9/00 , A61K45/06
CPC分类号： A61K31/575 , A61K9/0014 , A61K45/06
摘要： Disclosed herein are methods of treating fungal infections in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

9. 发明授权

US09546195B2 Hydrophobic ceragenin compounds and devices incorporating same 有权
标题翻译：疏水性ceragenin化合物和结合相同的装置
公开(公告)号：US09546195B2
公开(公告)日：2017-01-17
申请号：US14602499
申请日：2015-01-22
申请人： Paul B. Savage
发明人： Paul B. Savage
IPC分类号： A61K31/56 , A61F13/00 , C07J51/00 , C07J41/00 , A61L27/52 , A61L27/54 , A61L31/14 , A61L31/16 , A61L27/34 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , C07C211/00 , A61L27/18
CPC分类号： C07J41/0055 , A61L27/14 , A61L27/18 , A61L27/34 , A61L27/52 , A61L27/54 , A61L29/04 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/208 , A61L2300/404 , A61L2300/606 , C07C211/00
摘要： A hydrophobic cationic steroidal anti-microbial (ceragenin) compound forms an amphiphilic compound having a hydrophobic sterol face and a hydrophilic cationic face. The hydrophobic CSA also includes a hydrophobic substituent that gives the ceragenin compound a C Log P value of at least 6.0, 6.25, 6.5, 7.5, 8.5, or 10.
摘要翻译：疏水性阳离子甾族抗微生物（ceragenin）化合物形成具有疏水性固醇面和亲水性阳离子面的两亲性化合物。疏水性CSA还包括疏水性取代基，其给予cerornin化合物的C Log P值至少为6.0,6.25,6.5,7.5,8.5或10。

10. 发明申请

US20160311850A1 CATIONIC STEROIDAL ANTIMICROBIAL SALTS 审中-公开
标题翻译：阳离子灭菌抗菌素
公开(公告)号：US20160311850A1
公开(公告)日：2016-10-27
申请号：US15135928
申请日：2016-04-22
申请人： Paul B. Savage , Saurabh Shashikant Chitre , Kunal Arvind Varia , Hayley Ann Reece , Thomas E. Jacks , Ross A. Miller , Jared Lynn Randall
发明人： Paul B. Savage , Saurabh Shashikant Chitre , Kunal Arvind Varia , Hayley Ann Reece , Thomas E. Jacks , Ross A. Miller , Jared Lynn Randall
IPC分类号： C07J41/00 , C07C309/29 , C07C309/35
CPC分类号： C07J41/0088 , C07B2200/13 , C07C309/29 , C07C309/35 , C07J41/0061
摘要： Disclosed herein are acid addition salts of cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making the same. Particularly advantageous salt forms are identified, such as 1,5-naphthalenedisulfonic acid addition salts and sulfate addition salts. The acid addition salts may be formulated for treating subjects with ailments responsive to CSAs, including but not limited to treating bacterial infections. Accordingly, some embodiments include formulations and methods of administering acid addition salts of CSAs.
摘要翻译：本文公开了阳离子甾族抗微生物剂（“CSA”或“ceragenins”）的酸加成盐及其制备方法。确定了特别有利的盐形式，例如1,5-萘二磺酸加成盐和硫酸盐加成盐。可以将酸加成盐配制用于治疗对CSA有反应性疾病的受试者，包括但不限于治疗细菌感染。因此，一些实施方案包括施用CSA的酸加成盐的制剂和方法。

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