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1. 发明授权

US5592388A Method of and apparatus for analyzing internal combustion engine speed data 失效
标题翻译：分析内燃机转速数据的方法和装置
公开(公告)号：US5592388A
公开(公告)日：1997-01-07
申请号：US825048
申请日：1992-01-24
申请人： Benjamin J. Bradshaw , Michael Holmes , Russell W. Jones
发明人： Benjamin J. Bradshaw , Michael Holmes , Russell W. Jones
IPC分类号： F02D45/00 , F02P11/06 , G01M15/11 , G01M15/00 , G06F17/00
CPC分类号： G01M15/11 , F02P11/06
摘要： Variations in the speed of an internal combustion engine are measured and the distribution of the variations is analyzed for asymmetry, which indicates engine misfire. A threshold is generated as a function of engine speed increases and compared with engine speed decreases to detect asymmetry in the distribution.
摘要翻译：测量内燃机速度的变化，并分析变化的分布不对称性，这表明发动机失火。作为发动机转速增加的函数产生阈值，并与发动机转速相比较，以检测分布中的不对称性。

2. 发明授权

US5237504A Method of and apparatus for detecting misfire 失效
标题翻译：用于检测MISFIRE的方法和装置
公开(公告)号：US5237504A
公开(公告)日：1993-08-17
申请号：US655568
申请日：1991-02-13
申请人： Michael Holmes , Benjamin J. Bradshaw
发明人： Michael Holmes , Benjamin J. Bradshaw
IPC分类号： F02D45/00 , F02P17/12 , G01M15/11
CPC分类号： G01M15/11
摘要： In order to detect misfire in an internal combustion engine, engine speed is determined by measuring the time of passage of a crankshaft disc from a first position to a second position during every revolution. A detection circuit takes the reciprocal of the measured times of passage to form a series of engine speeds and forms the difference between consecutive engine speeds. These differences are compared with a threshold to signal a misfire when the threshold is exceeded.

3. 发明授权

US08683997B2 Portable ventilator system 有权
标题翻译：便携式呼吸机系统
公开(公告)号：US08683997B2
公开(公告)日：2014-04-01
申请号：US11979142
申请日：2007-10-31
申请人： Douglas F. DeVries , David Boyle , Michael Holmes , Malcolm Williams
发明人： Douglas F. DeVries , David Boyle , Michael Holmes , Malcolm Williams
IPC分类号： A61M16/00 , H02P5/00
CPC分类号： F04C18/126 , A61M11/00 , A61M16/0051 , A61M16/0057 , A61M16/0063 , A61M16/0066 , A61M16/0069 , A61M16/026 , A61M16/107 , A61M16/12 , A61M16/202 , A61M16/205 , A61M16/206 , A61M16/209 , A61M2016/0021 , A61M2016/0036 , A61M2016/1025 , A61M2202/0208 , A61M2205/16 , A61M2205/3317 , A61M2205/3365 , A61M2205/3368 , A61M2205/3553 , A61M2205/3569 , A61M2205/3584 , A61M2205/42 , A61M2205/505 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/70 , A61M2205/8206 , A61M2205/8237 , A61M2205/8262 , A61M2209/086 , A61M2230/205 , A61M2230/432 , A61M2230/435 , F04C29/0035 , H02P6/17
摘要： A portable ventilator uses a ROOTS-type blower as a compressor to reduce both the size and power consumption of the ventilator. Various functional aspects of the ventilator are delegated to multiple subassemblies having dedicated controllers and software that interact with a ventilator processor to provide user interface functions, exhalation control and flow control servos, and monitoring of patient status. The ventilator overcomes noise problems through the use of noise reducing pressure compensating orifices on the ROOTS-type blower housing and multiple baffling chambers. The ventilator is configured with a highly portable form factor, and may be used as a stand-alone device or as a docked device having a docking cradle with enhanced interface and monitoring capabilities.
摘要翻译：便携式呼吸机使用ROOTS型鼓风机作为压缩机，以减小呼吸机的尺寸和功率消耗。将呼吸机的各个功能方面委托给具有专用控制器和软件的多个子组件，所述专用控制器和软件与通气机处理器相互作用以提供用户界面功能，呼气控制和流量控制伺服以及对患者状态的监视。呼吸机通过在ROOTS型鼓风机壳体和多个挡板室上使用减噪压力补偿孔来克服噪音问题。通风机配置有高度便携的外形尺寸，可用作独立设备或具有扩展接口和监控功能的对接支架的对接设备。

4. 发明授权

US08677995B2 Compressor control system for a portable ventilator 有权
标题翻译：便携式呼吸机的压缩机控制系统
公开(公告)号：US08677995B2
公开(公告)日：2014-03-25
申请号：US11877117
申请日：2007-10-23
申请人： David Boyle , Michael Holmes , Malcolm Williams
发明人： David Boyle , Michael Holmes , Malcolm Williams
IPC分类号： A61M16/00 , H02P5/00
CPC分类号： A61M16/206 , A61M11/00 , A61M16/0057 , A61M16/0063 , A61M16/0066 , A61M16/0069 , A61M16/026 , A61M16/107 , A61M16/12 , A61M16/202 , A61M16/205 , A61M16/209 , A61M2016/0021 , A61M2016/0036 , A61M2016/1025 , A61M2202/0208 , A61M2205/16 , A61M2205/3317 , A61M2205/3365 , A61M2205/3368 , A61M2205/3553 , A61M2205/3569 , A61M2205/3584 , A61M2205/42 , A61M2205/505 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/70 , A61M2205/8206 , A61M2205/8237 , A61M2205/8262 , A61M2209/086 , A61M2230/205 , A61M2230/432 , A61M2230/435 , H02P6/17
摘要： A method and apparatus for controlling a brushless DC (BLDC) motor over a wide range of angular speeds is presented. Analog magnetic sensors provide continuous signal measurements related to the rotor angular position at a sample rate independent of rotor angular speed. In one embodiment, analog signal measurements are subsequently processed using an arctangent function to obtain the rotor angular position. The arctangent may be computed using arithmetic computation, a small angle approximation, a polynomial evaluation approach, a table lookup approach, or a combination of various methods. In one embodiment, the BLDC rotor is used to drive a Roots blower used as a compressor in a portable mechanical ventilator system.
摘要翻译：提出了一种用于在宽范围的角速度下控制无刷DC（BLDC）电动机的方法和装置。模拟磁传感器以独立于转子角速度的采样速率提供与转子角位置相关的连续信号测量。在一个实施例中，随后使用反正切函数来处理模拟信号测量以获得转子角位置。可以使用算术计算，小角度近似，多项式评估方法，表查找方法或各种方法的组合来计算反正切。在一个实施例中，BLDC转子用于驱动用作便携式机械通气机系统中的压缩机的罗茨鼓风机。

5. 发明申请

US20080033661A1 METHOD AND APPARATUS FOR MONITORING ANESTHESIA DRUG DOSAGES, CONCENTRATIONS, AND EFFECTS USING N-DIMENSIONAL REPRESENTATIONS OF CRITICAL FUNCTIONS 审中-公开
标题翻译：用于监测麻醉药物剂量，浓度和效果的方法和装置，使用关键功能的三维表示
公开(公告)号：US20080033661A1
公开(公告)日：2008-02-07
申请号：US11843524
申请日：2007-08-22
申请人： Noah Syroid , Dwayne Westenskow , Julio Bermudez , James Agutter , David Strayer , Robert Albert , Michael Holmes , Frank Drews , Haunke Prenzel
发明人： Noah Syroid , Dwayne Westenskow , Julio Bermudez , James Agutter , David Strayer , Robert Albert , Michael Holmes , Frank Drews , Haunke Prenzel
IPC分类号： G06F19/00
CPC分类号： G09B23/28 , A61B5/00 , A61M5/142 , A61M16/021 , A61M2202/048 , A61M2205/3576 , A61M2205/6072 , G06F19/3456 , G16H50/50
摘要： A method, system and apparatus for the monitoring, diagnosis and evaluation of the state of a dynamic system is disclosed. This method and system provides the processing means for receiving sensed and/or simulated data, converting such data into a displayable object format and displaying such objects in a manner such that the interrelationships between the respective variables can be correlated and identified by a user. This invention provides for the rapid cognitive grasp of the overall state of a critical function with respect to a dynamic system. The system provides for displayed objects, which change in real-time to show the changes of the functions of the system. It is a highly flexible system which works with a wide variety of applications, including biological systems, environmental systems, engineering systems, economic systems, mechanical systems, chemical systems and the like. In particular, this invention is directed to the processing and display of drug data for the use of doctors in the process of monitoring or administering drugs to patients.
摘要翻译：公开了一种用于动态系统状态的监视，诊断和评估的方法，系统和装置。该方法和系统提供了用于接收感测和/或模拟数据的处理装置，将这些数据转换成可显示对象格式，并以这样一种方式显示这些对象，使得各个变量之间的相互关系可以由用户相关和识别。本发明提供了关于动态系统的关键功能的总体状态的快速认知掌握。系统提供显示对象，实时更改以显示系统功能的更改。它是一个高度灵活的系统，适用于各种应用，包括生物系统，环境系统，工程系统，经济系统，机械系统，化学系统等。特别地，本发明涉及在向患者监测或给予药物的过程中使用医生的药物数据的处理和显示。

6. 发明申请

US20070051239A1 High energy dissociation for mercury control systems 有权
标题翻译：汞控制系统的高能量解离
公开(公告)号：US20070051239A1
公开(公告)日：2007-03-08
申请号：US11220810
申请日：2005-09-07
申请人： Michael Holmes , John Pavlish , Edwin Olson , Ye Zhuang
发明人： Michael Holmes , John Pavlish , Edwin Olson , Ye Zhuang
IPC分类号： B01D53/02
CPC分类号： B01D53/64 , B01D2257/602
摘要： An apparatus and method for controlling mercury emissions in the gas stream from a fuel fired system includes a chamber for creating dissociated halogen to be supplied to the gas stream, with or without carbonaceous material.
摘要翻译：用于控制来自燃料燃烧系统的气流中的汞排放的装置和方法包括用于产生将被供应到气流的离解的卤素的室，具有或不具有碳质材料。

7. 发明申请

US20050064474A1 Methods and compositions for targeted cleavage and recombination 有权
标题翻译：用于靶向切割和重组的方法和组合物
公开(公告)号：US20050064474A1
公开(公告)日：2005-03-24
申请号：US10912932
申请日：2004-08-06
申请人： Fyodor Urnov , Michael Holmes , Jeffrey Miller , Carl Pabo
发明人： Fyodor Urnov , Michael Holmes , Jeffrey Miller , Carl Pabo
IPC分类号： C07K14/435 , C07K14/47 , C07K14/715 , C12N9/14 , C12N9/22 , C12N15/62 , C12P19/34 , C12Q1/68
CPC分类号： A61K35/12 , C07K14/43595 , C07K14/4717 , C07K14/715 , C07K2319/00 , C07K2319/09 , C07K2319/81 , C12N9/14 , C12N9/22 , C12N15/62 , C12N15/85 , C12N2800/80
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.
摘要翻译：本文公开了用于基因组序列的靶向切割，基因组序列的靶向改变以及基因组区域和与该基因组区域同源的外源多核苷酸之间的靶向重组的方法和组合物。组合物包括包含切割结构域（或切割半结构域）和工程化锌指结构域的融合蛋白和编码它们的多核苷酸。用于靶向切割的方法包括将这种融合蛋白或其编码的多核苷酸引入细胞。用于靶向重组的方法另外包括将与基因组区域同源的外源多核苷酸引入包含所公开的融合蛋白的细胞中。

8. 发明申请

US20050015755A1 System and method for automatically generating a hierarchical register consolidation structure 有权
标题翻译：自动生成分层寄存器整合结构的系统和方法
公开(公告)号：US20050015755A1
公开(公告)日：2005-01-20
申请号：US10801792
申请日：2004-03-16
申请人： Michael Holmes , Gerald Williams
发明人： Michael Holmes , Gerald Williams
IPC分类号： G06F9/45
CPC分类号： G06F17/5045
摘要： A system for, and method of, automatically generating a hierarchical register consolidation structure. In one embodiment, the system includes: (1) a graph generator that parses a High-level Design Language (HDL) file to generate an intermediate graph containing definitions of microprocessor-accessible registers, node interrelationships and summary bits and masks associated with alarm registers, (2) a graph converter, associated with the graph generator, that selectively adds virtual elements and nodes to the intermediate graph to transform the intermediate graph into a mathematical tree and (3) a description generator, associated with the graph converter, that employs the mathematical tree to generate a static tree description in a programming language suitable for use by a device-independent condition management structure.
摘要翻译：一种自动生成分层寄存器整合结构的系统和方法。在一个实施例中，系统包括：（1）图形生成器，其解析高级设计语言（HDL）文件以生成包含微处理器可访问寄存器，节点相互关系和与报警寄存器相关联的摘要位和掩码的定义的中间图，（2）与图形生成器相关联的图形转换器，其选择性地将虚拟元素和节点添加到中间图，以将中间图变换成数学树;以及（3）与图形转换器相关联的描述生成器，其使用数学树在适合于与设备无关的条件管理结构使用的编程语言中生成静态树描述。

9. 发明授权

US4915079A Adaptive control system for an internal combustion engine and method of operating an internal combustion engine 失效
标题翻译：用于内燃机的自适应控制系统和操作内燃机的方法
公开(公告)号：US4915079A
公开(公告)日：1990-04-10
申请号：US347116
申请日：1989-05-01
申请人： Michael Holmes
发明人： Michael Holmes
IPC分类号： F02D41/34 , F02D41/14 , F02D45/00 , F02M25/022 , F02M25/07 , F02P5/145 , F02P5/15
CPC分类号： F02D41/1408 , F02D41/1498 , F02P5/1455 , F02D2200/1015 , Y02T10/46
摘要： An adaptive control system for an internal combustion engine has a mixture control device and an ignition timing control device. Combustion performance, such as engine roughness is measured and mixture varied about a base value to achieve a desired performance. Ignition timing is compensated for the mixture variation by perturbing ignition timing about a base valve, detecting the slope of engine output with respect to ignition timing and varying the timing to achieve a desired slope.

10. 发明申请

US20070144521A1 Portable drag compressor powered mechanical ventilator 审中-公开
公开(公告)号：US20070144521A1
公开(公告)日：2007-06-28
申请号：US11644801
申请日：2006-12-22
申请人： Douglas DeVries , Michael Cegielski , Warner Graves , Malcolm Williams , Michael Holmes
发明人： Douglas DeVries , Michael Cegielski , Warner Graves , Malcolm Williams , Michael Holmes
IPC分类号： A61M16/00 , A62B7/00
CPC分类号： A61M16/206 , A61M16/0051 , A61M16/0057 , A61M16/0063 , A61M16/0069 , A61M16/024 , A61M16/0833 , A61M16/1015 , A61M16/107 , A61M16/12 , A61M16/125 , A61M16/20 , A61M16/202 , A61M16/205 , A61M16/208 , A61M16/209 , A61M2016/0021 , A61M2016/0027 , A61M2016/0036 , A61M2016/0039 , A61M2016/0042 , A61M2202/0208 , A61M2205/16 , A61M2205/18 , A61M2205/3331 , A61M2205/3365 , A61M2205/3561 , A61M2205/3569 , A61M2205/3592 , A61M2205/42 , A61M2205/502 , A61M2205/581 , A61M2205/587 , A61M2205/70 , A61M2205/8206 , A61M2205/8212 , A61M2230/46 , G01F1/40 , G01F1/42
摘要： A ventilator device and system comprising a rotating compressor, preferably a drag compressor, which, at the beginning of each inspiratory ventilation phase, is accelerated to a sufficient speed to deliver the desired inspiratory gas flow, and is subsequently stopped or decelerated to a basal flow level to permit the expiratory ventilation phase to occur. The ventilator device is small and light weight enough to be utilized in portable applications. The ventilator device is power efficient enough to operate for extended periods of time on internal or external batteries. Also provided is an oxygen blending apparatus which utilizes solenoid valves having specific orifice sizes for blending desired amounts of oxygen into the inspiratory gas flow. Also provided is an exhalation valve having an exhalation flow transducer which incorporates a radio frequency data base to provide an attendant controller with specific calibration information for the exhalation flow transducer.

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