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1. 发明授权

US08652838B2 Platensimycin biosynthetic gene cluster of Streptomyces platensis 有权
标题翻译：链霉菌的Platensimycin生物合成基因簇
公开(公告)号：US08652838B2
公开(公告)日：2014-02-18
申请号：US12179406
申请日：2008-07-24
申请人： Ben Shen , Michael J. Smanski
发明人： Ben Shen , Michael J. Smanski
IPC分类号： C12N15/00 , C12N1/20
CPC分类号： C12P13/02 , C12N9/1085 , C12N9/88 , C12N15/52 , C12P17/02
摘要： The present invention relates to the cloning and sequence of a biosynthetic gene cluster from Streptomyces platensis that produces platensimycin and platencin. Also provided are engineered micro-organisms for the production of these compounds, and analogs thereto, as well as methods of screening for compounds with anti-bacterial activity.
摘要翻译：本发明涉及产生拉米霉素和平板菌素的来自Plreptomyces platensis的生物合成基因簇的克隆和序列。还提供了用于生产这些化合物的工程微生物及其类似物，以及筛选具有抗细菌活性的化合物的方法。

2. 发明申请

US20050059122A1 Targeted carrier fusions for delivery of chemotherapeutic agents 有权
标题翻译：靶向载体融合用于递送化学治疗剂
公开(公告)号：US20050059122A1
公开(公告)日：2005-03-17
申请号：US10912764
申请日：2004-08-05
申请人： Ben Shen
发明人： Ben Shen
IPC分类号： A61K47/48 , C07K14/36 , C12N1/21 , C07H21/04 , C07K14/195 , C12N9/88 , C12P21/04
CPC分类号： C07K14/36 , A61K47/64 , C07K2319/01 , C07K2319/20 , G01N2500/04
摘要： The present invention provides for fusion proteins that act as targeted drug carries. The proteins are derived from molecules that possess natural drug-binding capabilities that are further engineered to target specific cell types, and optionally to have altered/improved drug binding characteristics. These fusion proteins are useful in, for example, delivery of chemotherapeutic compounds to cancer cells.
摘要翻译：本发明提供用作靶向药物载体的融合蛋白。蛋白质衍生自具有天然药物结合能力的分子，其进一步工程化以靶向特定细胞类型，并且任选具有改变/改善的药物结合特征。这些融合蛋白可用于例如将化疗化合物递送至癌细胞。

3. 发明申请

US20060211736A1 GLUTARIMIDE-CONTAINING POLYKETIDE ANALOGS AND METHODS THEREOF 审中-公开
标题翻译：含谷氨酰胺的聚合物模拟物及其方法
公开(公告)号：US20060211736A1
公开(公告)日：2006-09-21
申请号：US11275556
申请日：2006-01-13
申请人： Ben Shen
发明人： Ben Shen
IPC分类号： A61K31/452 , A61K31/445 , C07H21/04 , C12P17/00 , C07D405/02 , C12N1/21 , C07D211/76
CPC分类号： C12P17/02 , C07D211/88 , C07D405/06 , C12P7/42 , C12P17/16
摘要： The present invention provides library of glutarimide-containing polyketide analogs, such as analogs of migrastatin, iso-migrastatin, dorrigocin A and B, epi-dorrigocin, NK30424 A and B and lactimidomycin, methods of synthesizing and using these analogs and further methods of creating a combinatorial library of these compounds through chemical modifications.
摘要翻译：本发明提供了含有戊二酰亚胺的聚酮化合物类似物的文库，例如migrastatin，异伐米他汀，dorrigocin A和B，epi-dorrigocin，NK30424A和B以及类似物的类似物，合成和使用这些类似物的方法以及进一步的创造方法这些化合物的组合文库通过化学修饰。

4. 发明申请

US20050080247A1 Leinamycin biosynthesis gene cluster and its components and their uses 审中-公开
标题翻译：雷尼霉素生物合成基因簇及其成分及其用途
公开(公告)号：US20050080247A1
公开(公告)日：2005-04-14
申请号：US10473193
申请日：2002-03-22
申请人： Ben Shen , Yi-qiang Cheng , Gong-li Tang
发明人： Ben Shen , Yi-qiang Cheng , Gong-li Tang
IPC分类号： C12N15/09 , C07H21/04 , C07K14/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N9/00 , C12N9/02 , C12N9/10 , C12N15/52 , C12N15/74 , C12P17/16 , C12P17/18 , C12P19/60 , C12P21/02
CPC分类号： C12N15/52 , C12P17/185
摘要： This invention provides detailed sequence analysis and characterization of the gene cluster responsible for the synthesis of leinamycin in Streptomyces atroolivaceus. The leinamycin gene cluster provides a hybrid polyketide synthase/nonribosomal peptide synthetase pathway. Elucidation of the various modules and enzymatic domains characterizing the pathway provides convenient synthetic routes for leinamycins, leinamycin analogs, and various other polyketides, peptides, and hybrid peptide-polyketide natural products.
摘要翻译：本发明提供了负责合成链霉菌（Streptomyces atroolivaceus）中的莱茵霉素的基因簇的详细序列分析和表征。 leinamycin基因簇提供了一种杂合聚酮化合物合酶/非核糖体肽合成酶途径。阐明该途径表征的各种模块和酶结构域为莱米霉素，莱茵霉素类似物和各种其他聚酮化合物，肽和杂合肽 - 聚酮化合物天然产物提供了方便的合成途径。

5. 发明授权

US06254760B1 Electro-chemical deposition system and method 失效
标题翻译：电化学沉积系统及方法
公开(公告)号：US06254760B1
公开(公告)日：2001-07-03
申请号：US09263649
申请日：1999-03-05
申请人： Ben Shen , Yezdi Dordi , George Birkmaier
发明人： Ben Shen , Yezdi Dordi , George Birkmaier
IPC分类号： G01F164
CPC分类号： C25D7/12 , C25D17/001 , H01L21/2885 , H05K3/241
摘要： The present invention generally provides an electro-chemical deposition system that is designed with a flexible architecture that is expandable to accommodate future designs rules and gap fill requirements and provides satisfactory throughput to meet the demands of other processing systems. The electro-chemical deposition system generally comprises a front-end loading station, a mainframe including one or more processing cells, and an electrolyte replenishing system fluidly connected to the one or more electrical processing cells. The electrolyte replenishing system comprises a main electrolyte supply tank and an analyzer module and dosing module coupled thereto. The analyzer module includes one or more chemical analyzers to monitor the concentrations of various chemicals in the main electrolyte supply tank. Information provided by the analyzer module is transmitted via a central control system to the dosing module. Source tanks in the dosing module communicate with the main supply tank to deliver the desired proportions of chemicals thereto. Preferably, the electrolyte analysis is performed continuously during processing to provide real-time data and electrolyte adjustments.
摘要翻译：本发明通常提供一种电化学沉积系统，其被设计成具有可扩展以适应未来设计规则和间隙填充要求的柔性结构，并提供令人满意的吞吐量以满足其它处理系统的需求。电化学沉积系统通常包括前端加载站，包括一个或多个处理单元的主框架和与该一个或多个电处理单元流体连接的电解质补充系统。电解质补充系统包括主要电解质供应罐和与其耦合的分析器模块和计量模块。分析仪模块包括一个或多个化学分析仪，用于监测主要电解质供应罐中各种化学物质的浓度。由分析器模块提供的信息经由中央控制系统传送到计量模块。计量模块中的来源罐与主供应罐连通，以将所需比例的化学品运送到其上。优选地，在处理期间连续执行电解质分析以提供实时数据和电解质调节。

6. 发明授权

US08580977B2 Tautomycetin and tautomycetin analog biosynthesis 有权
标题翻译： Tautomycetin和tautomycetin类似物生物合成
公开(公告)号：US08580977B2
公开(公告)日：2013-11-12
申请号：US13101624
申请日：2011-05-05
申请人： Ben Shen
发明人： Ben Shen
IPC分类号： C07D303/00 , C12P17/04
CPC分类号： C12P17/04 , C07D307/58
摘要： The present invention relates to the biosynthetic gene cluster for tautomycetin (TTN) produces tautomycetin. Also provided are engineered micro-organisms for the production of TTN and analogs thereof, as well as methods of screening for compounds for activity.
摘要翻译：本发明涉及抗菌素（TTN）的生物合成基因簇产生抗菌素。还提供了用于生产TTN及其类似物的工程微生物以及筛选用于活性的化合物的方法。

7. 发明授权

US07153667B2 Discrete acyltransferases associated with type I polyketide synthases and methods of use 失效
公开(公告)号：US07153667B2
公开(公告)日：2006-12-26
申请号：US10314657
申请日：2002-12-09
申请人： Ben Shen , Yi-Qiang Cheng , Gong-Li Tang
发明人： Ben Shen , Yi-Qiang Cheng , Gong-Li Tang
IPC分类号： C12P21/06 , C12N9/10
CPC分类号： C12N15/52 , C12P17/185
摘要： Genetic and biochemical characterization of the leinamycin biosynthesis gene cluster from Streptomyces atroolivaceus S-140 revealed two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of which contains a cognate AT domain. The AT activity is provided in trans by a discrete protein, LnmG, which loads the malonyl coenzyme A extender unit onto the ACP domains of all six PKS modules. This finding provides a basis for methods of engineering modular polyketide synthases and polyketide synthase/nonribosomal peptide synthetases.

8. 发明授权

US08637684B2 Tautomycetin and tautomycetin analog biosynthesis 有权
标题翻译： Tautomycetin和tautomycetin类似物生物合成
公开(公告)号：US08637684B2
公开(公告)日：2014-01-28
申请号：US13101612
申请日：2011-05-05
申请人： Ben Shen , Zhong-Yin Zhang
发明人： Ben Shen , Zhong-Yin Zhang
IPC分类号： C07D303/00 , C12P17/04
CPC分类号： C07D307/58 , A61K31/225 , A61K31/365 , A61K45/06 , A61K2300/00
摘要： The present invention relates to tautomycetin (TTN) and analogs thereof. Also provided are methods of using TTN and analogs thereof in the treatment of various diseases relating to SHP2 function.
摘要翻译：本发明涉及抗菌素（TTN）及其类似物。还提供了使用TTN及其类似物治疗与SHP2功能有关的各种疾病的方法。

9. 发明授权

US07452693B2 Discrete acyltransferases associated with type I polyketide synthases and methods of use 失效
标题翻译：与I型聚酮化合物合酶相关的离散酰基转移酶及其使用方法
公开(公告)号：US07452693B2
公开(公告)日：2008-11-18
申请号：US11550703
申请日：2006-10-18
申请人： Ben Shen , Yi-Qiang Cheng , Gong-Li Tang
发明人： Ben Shen , Yi-Qiang Cheng , Gong-Li Tang
IPC分类号： C12P21/06 , C12N9/10
CPC分类号： C12N15/52 , C12P17/185
摘要： Genetic and biochemical characterization of the leinamycin biosynthesis gene cluster from Streptomyces atroolivaceus S-140 revealed two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of which contains a cognate AT domain. The AT activity is provided in trans by a discrete protein, LnmG, which loads the malonyl coenzyme A extender unit onto the ACP domains of all six PKS modules. This finding provides a basis for methods of engineering modular polyketide synthases and polyketide synthase/nonribosomal peptide synthetases.
摘要翻译：来自Streptomyces atroolivaceus S-140的leinamycin生物合成基因簇的遗传和生物化学表征揭示了编码六个PKS模块的两个PKS基因lnmI和lnmJ，其中没有一个包含同源AT结构域。 AT活性由离散的蛋白质LnmG反向提供，LnmG将丙二酰辅酶A延伸剂单元加载到所有六个PKS模块的ACP结构域上。该发现为工程化聚酮化合物合成酶和聚酮化合物合酶/非核糖体肽合成酶的方法提供了基础。

10. 发明申请

US20050277684A1 Oxidative activation and episulfonium ion-mediated DNA alkylation-based anticancer 失效
标题翻译：氧化活化和锍离子介导的基于DNA烷基化的抗癌剂
公开(公告)号：US20050277684A1
公开(公告)日：2005-12-15
申请号：US11097972
申请日：2005-04-01
申请人： Ben Shen
发明人： Ben Shen
IPC分类号： A61K31/428 , C07D513/08
CPC分类号： A61K31/428 , C07D513/08
摘要： The present invention relates to TG-25 and/or analogs thereof and their use of TG-25 in the treatment of cancer. TG-25 inhibits the growth of prostate cells by inhibiting DNA synthesis, more particularly by DNA cleavage.
摘要翻译：本发明涉及TG-25和/或其类似物及其在治疗癌症中的用途。 TG-25通过抑制DNA合成来抑制前列腺细胞的生长，更特别地通过DNA裂解来抑制前列腺细胞的生长。

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