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1. 发明授权

US09423336B2 Systems and methods for particle sensing and characterization 有权
标题翻译：用于粒子感测和表征的系统和方法
公开(公告)号：US09423336B2
公开(公告)日：2016-08-23
申请号：US14160465
申请日：2014-01-21
申请人： Beckman Coulter, Inc.
发明人： Marshall Donnie Graham
IPC分类号： G01N27/00 , G01R27/08 , G01N15/12 , G01M1/00
CPC分类号： G01N15/12 , G01M1/00 , G01N1/00
摘要： Systems and methods are provided for sensing and characterizing small particles, and in particular blood cells suspended in a liquid medium. Exemplary systems include a volumeter conduit having a central region of higher electrical resistivity disposed between a first and second distal region of lower electrical resistivity, and a current source and sensing circuit module in electrical connectivity with the first and second distal regions. The module provides an electrical excitation current to the first and second distal regions to establish a particle-sensitive zone within the conduit, and detects current changes occasioned by particles of the biological sample passing through the particle-sensitive zone.
摘要翻译：提供了用于感测和表征小颗粒，特别是悬浮在液体介质中的血液细胞的系统和方法。示例性系统包括体积计导管，其具有设置在具有较低电阻率的第一和第二远端区域之间的较高电阻率的中心区域，以及与第一和第二远端区域电连接的电流源和感测电路模块。该模块向第一和第二远侧区域提供电激励电流，以在导管内建立颗粒敏感区域，并且检测由通过颗粒敏感区域的生物样品颗粒引起的电流变化。

2. 发明授权

US10466165B2 Compound optical flow cells and method of manufacture and use 有权
公开(公告)号：US10466165B2
公开(公告)日：2019-11-05
申请号：US15714473
申请日：2017-09-25
申请人： Beckman Coulter, Inc.
发明人： Marshall Donnie Graham , William Gerry Graham , James P. Clarkin , Mark A. Wells , Jose M. Cano , Carlos Alberto Arboleda , Armando J. Sanchez
IPC分类号： G01N21/05 , C03B23/047 , G01N15/14 , C03C27/00 , G01N15/10
摘要： An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship.

3. 发明申请

US20140203825A1 SYSTEMS AND METHODS FOR PARTICLE SENSING AND CHARACTERIZATION 有权
标题翻译：颗粒感测和表征的系统和方法
公开(公告)号：US20140203825A1
公开(公告)日：2014-07-24
申请号：US14160465
申请日：2014-01-21
申请人： Beckman Coulter, Inc.
发明人： Marshall Donnie Graham
IPC分类号： G01N33/483 , G01N27/06
CPC分类号： G01N15/12 , G01M1/00 , G01N1/00
摘要： Systems and methods are provided for sensing and characterizing small particles, and in particular blood cells suspended in a liquid medium. Exemplary systems include a volumeter conduit having a central region of higher electrical resistivity disposed between a first and second distal region of lower electrical resistivity, and a current source and sensing circuit module in electrical connectivity with the first and second distal regions. The module provides an electrical excitation current to the first and second distal regions to establish a particle-sensitive zone within the conduit, and detects current changes occasioned by particles of the biological sample passing through the particle-sensitive zone.
摘要翻译：提供了用于感测和表征小颗粒，特别是悬浮在液体介质中的血液细胞的系统和方法。示例性系统包括体积计导管，其具有设置在具有较低电阻率的第一和第二远端区域之间的较高电阻率的中心区域，以及与第一和第二远端区域电连接的电流源和感测电路模块。该模块向第一和第二远侧区域提供电激励电流，以在导管内建立颗粒敏感区域，并且检测由通过颗粒敏感区域的生物样品颗粒引起的电流变化。

4. 发明申请

US20180188154A1 COMPOUND OPTICAL FLOW CELLS AND METHOD OF MANUFACTURE AND USE 审中-公开
公开(公告)号：US20180188154A1
公开(公告)日：2018-07-05
申请号：US15714473
申请日：2017-09-25
申请人： Beckman Coulter, Inc.
发明人： Marshall Donnie Graham , William Gerry Graham , James P. Clarkin , Mark A. Wells , Jose M. Cano , Carlos Alberto Arboleda , Armando J. Sanchez
IPC分类号： G01N21/05 , C03B23/047
CPC分类号： G01N21/05 , C03B23/047 , C03C27/00 , G01N15/1434 , G01N2015/1006 , G01N2015/1452 , G01N2015/1486 , G01N2015/149 , G01N2201/02 , Y02P40/57
摘要： An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship. Preferably, such first element is formed by a glass-drawing process in which a relatively large glass preform having a rectilinear internal channel of a desired cross-sectional shape is heated and drawn to achieve a desired cross-sectional area of reduced size. Preferably, such second element is provided by through-boring a suitable commercial optical component to conform to such first element. Also disclosed are preferred methods for differentiating formed bodies using the flow cell of the invention.

5. 发明授权

US09772274B2 Compound optical flow cells and method of manufacture and use 有权
公开(公告)号：US09772274B2
公开(公告)日：2017-09-26
申请号：US14770930
申请日：2014-03-14
申请人： BECKMAN COULTER, INC.
发明人： Marshall Donnie Graham , William Gerry Graham , James P. Clarkin , Mark A. Wells , Jose M. Cano , Carlos Alberto Arboleda , Armando J. Sanchez
IPC分类号： G01N21/05 , C03B23/047 , C03C27/00 , G01N15/14 , G01N15/10
CPC分类号： G01N21/05 , C03B23/047 , C03C27/00 , G01N15/1434 , G01N2015/1006 , G01N2015/1452 , G01N2015/1486 , G01N2015/149 , G01N2201/02 , Y02P40/57
摘要： An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship.

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