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1. 发明授权

US09738676B2 Selected macrolides with PDE4-inhibiting activity 有权
公开(公告)号：US09738676B2
公开(公告)日：2017-08-22
申请号：US14653928
申请日：2013-12-27
申请人： Basilea Pharmaceutica AG
发明人： Johannes Laurenz Kellenberger , Jürg Dreier
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： The application relates to the macrolide compound of the formula (I): wherein * indicates a stereocentre which is in (R) or (S) configuration, or a pharmaceutically acceptable salt or ester thereof and their use as PDE4 inhibitors.

2. 发明授权

US08933073B2 Macrolides and their use 有权
标题翻译：大环内酯类及其用途
公开(公告)号：US08933073B2
公开(公告)日：2015-01-13
申请号：US14163683
申请日：2014-01-24
申请人： Basilea Pharmaceutica AG
发明人： Johannes Laurenz Kellenberger , Jürg Dreier
IPC分类号： A61K31/706 , C07D498/04 , C07H17/08
CPC分类号： C07D498/04 , C07H17/08
摘要： The invention relates to macrolide compounds of formula (I), the use of said compounds as medicaments, in particular for the treatment or prevention of inflammatory and allergic diseases, pharmaceutical compositions containing said compounds and to processes for their preparation. The invention relates in particular to macrolide compounds with antiinflammatory activity mediated primarily through inhibition of phosphodiesterase 4 (PDE4) which makes them useful for the treatment and/or prevention of inflammatory and allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, atopic dermatitis or inflammatory bowel disease or proliferative diseases such as cancer.
摘要翻译：本发明涉及式（I）的大环内酯类化合物，所述化合物作为药物的用途，特别是用于治疗或预防炎性和过敏性疾病，含有所述化合物的药物组合物及其制备方法。本发明特别涉及主要通过抑制磷酸二酯酶4（PDE4）介导的具有抗炎活性的大环内酯类化合物，其使它们可用于治疗和/或预防炎性和过敏性疾病如慢性阻塞性肺疾病（COPD），哮喘，类风湿关节炎，特应性皮炎或炎症性肠病或增殖性疾病如癌症。

3. 发明授权

US10221206B2 Selected macrolides with PDE4-inhibiting activity 有权
公开(公告)号：US10221206B2
公开(公告)日：2019-03-05
申请号：US15667894
申请日：2017-08-03
申请人： Basilea Pharmaceutica AG
发明人： Johannes Laurenz Kellenberger , Jürg Dreier
IPC分类号： C07H17/08
摘要： The application relates to the macrolide compound of the formula (I): wherein * indicates a stereocentre which is in (R) or (S) configuration, or a pharmaceutically acceptable salt or ester thereof.

4. 发明申请

US20150344515A1 SELECTED MACROLIDES WITH PDE4-INHIBITING ACTIVITY 有权
标题翻译：具有PDE4抑制活性的选择性抗体
公开(公告)号：US20150344515A1
公开(公告)日：2015-12-03
申请号：US14653928
申请日：2013-12-27
申请人： BASILEA PHARMACEUTICA AG
发明人： Johannes Laurenz Kellenberger , Jürg Dreier
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： The application relates to the macrolide compound of the formula (I): wherein * indicates a stereocentre which is in (R) or (S) configuration, or a pharmaceutically acceptable salt or ester thereof and their use as PDE4 inhibitors.
摘要翻译：本申请涉及式（I）的大环内酯类化合物：其中*表示具有（R）或（S）构型的立体中心或其药学上可接受的盐或酯，以及它们作为PDE4抑制剂的用途。

5. 发明申请

US20170327525A1 SELECTED MACROLIDES WITH PDE4-INHIBITING ACTIVITY 审中-公开
公开(公告)号：US20170327525A1
公开(公告)日：2017-11-16
申请号：US15667894
申请日：2017-08-03
申请人： Basilea Pharmaceutica AG
发明人： Johannes Laurenz Kellenberger , Jürg Dreier
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： The application relates to the macrolide compound of the formula (I): wherein * indicates a stereocentre which is in (R) or (S) configuration, or a pharmaceutically acceptable salt or ester thereof.

6. 发明申请

US20140142100A1 NEW MACROLIDES AND THEIR USE 有权
标题翻译：新的MACROLIDES及其使用
公开(公告)号：US20140142100A1
公开(公告)日：2014-05-22
申请号：US14163683
申请日：2014-01-24
申请人： BASILEA PHARMACEUTICA AG
发明人： Johannes Laurenz Kellenberger , Jürg Dreier
IPC分类号： C07D498/04
CPC分类号： C07D498/04 , C07H17/08
摘要： The invention relates to macrolide compounds of formula (I), the use of said compounds as medicaments, in particular for the treatment or prevention of inflammatory and allergic diseases, pharmaceutical compositions containing said compounds and to processes for their preparation. The invention relates in particular to macrolide compounds with antiinflammatory activity mediated primarily through inhibition of phosphodiesterase 4 (PDE4) which makes them useful for the treatment and/or prevention of inflammatory and allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, atopic dermatitis or inflammatory bowel disease or proliferative diseases such as cancer.
摘要翻译：本发明涉及式（I）的大环内酯类化合物，所述化合物作为药物的用途，特别是用于治疗或预防炎性和过敏性疾病，含有所述化合物的药物组合物及其制备方法。本发明特别涉及主要通过抑制磷酸二酯酶4（PDE4）介导的具有抗炎活性的大环内酯类化合物，其使它们可用于治疗和/或预防炎性和过敏性疾病如慢性阻塞性肺疾病（COPD），哮喘，类风湿关节炎，特应性皮炎或炎症性肠病或增殖性疾病如癌症。

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