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1. 发明授权

US5723316A .alpha.-1-antichymotrypsin analogues having chymase inhibiting activity 失效
标题翻译：具有糜酶抑制活性的α-1抗胰凝乳蛋白酶类似物
公开(公告)号：US5723316A
公开(公告)日：1998-03-03
申请号：US221171
申请日：1994-03-31
申请人： Barry S. Cooperman , Harvey Rubin , Norman Schechter , Zhi Mei Wang
发明人： Barry S. Cooperman , Harvey Rubin , Norman Schechter , Zhi Mei Wang
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61P7/02 , A61P9/00 , A61P29/00 , A61P31/04 , C07H21/04 , C07K14/81 , C12N1/21 , C12N5/10 , C12N9/99 , C12P21/02 , C12R1/19 , C12N15/00 , A61K38/43
CPC分类号： C07K14/8121 , C07K14/8125 , A61K38/00
摘要： The invention provides analogues of .alpha.-1-antichymotrypsin having amino acid substitutions at position 358. .alpha.-1-antichymotrypsin analogues having amino acid substitutions at positions 356-361 and analogues having amino acid substitutions at positions 356-361 wherein the amino acid at position 358 is substituted are also within the scope of the invention. These analogues exhibit chymase inhibitory activity. Also provided are novel .alpha.-1-antichymotrypsins having an N-terminal extension of methionine-alanine-serine or alanine-serine. Expression vectors for the production of .alpha.-1-antichymotrypsins are also provided. The present invention also provides host cells and cell cultures capable of expressing analogues of .alpha.-1-antichymotrypsin, as well as protein preparations from the host cells. Methods of producing and using the analogues of .alpha.-1-antichymotrypsin to inhibit chymase activity are also provided.
摘要翻译：本发明提供了在358位具有氨基酸取代的α-1-抗胰凝乳蛋白酶的类似物。在356-361位具有氨基酸取代的α1-抗胰凝乳蛋白酶类似物和在位置356-361处具有氨基酸取代的类似物，其中位置处的氨基酸 358也在本发明的范围内。这些类似物表现出糜酶抑制活性。还提供了具有甲硫氨酸 - 丙氨酸 - 丝氨酸或丙氨酸 - 丝氨酸的N-末端延伸的新型α-1抗胰凝乳蛋白。还提供了用于产生α-1抗胰凝乳蛋白的表达载体。本发明还提供能够表达α-1-胰凝乳蛋白酶类似物的宿主细胞和细胞培养物，以及来自宿主细胞的蛋白质制剂。还提供了产生和使用α-1抗胰凝乳蛋白酶类似物以抑制胃促胰酶活性的方法。

2. 发明授权

US5674708A .alpha.-1-antichymotrypsin analogues having elastase inhibitory activity 失效
标题翻译：具有弹性蛋白酶抑制活性的α-1抗胰凝乳蛋白酶类似物
公开(公告)号：US5674708A
公开(公告)日：1997-10-07
申请号：US221078
申请日：1994-03-31
申请人： Barry S. Cooperman , Harvey Rubin , Norman Schechter , Zhi Mei Wang
发明人： Barry S. Cooperman , Harvey Rubin , Norman Schechter , Zhi Mei Wang
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K38/55 , A61P1/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P29/00 , A61P31/04 , A61P43/00 , C07H21/04 , C07K14/81 , C12N1/21 , C12N9/99 , C12P21/02 , C12R1/19 , C12N15/15
CPC分类号： C07K14/8121 , C07K14/8125 , A61K38/00
摘要： The present invention provides an analogue of human .alpha.-1-antichymotrypsin wherein the amino acid at position 358 is selected from the group consisting of isoleucine, valine, alanine, aspattic acid, threonine, and glutamic acid.
摘要翻译：本发明提供人α1-抗胰凝乳蛋白酶的类似物，其中位置358处的氨基酸选自异亮氨酸，缬氨酸，丙氨酸，天冬氨酸，苏氨酸和谷氨酸。

3. 发明授权

US5367064A .alpha.-1-antichymotrypsin, analogues and methods of production 失效
标题翻译： α-1抗胰凝乳蛋白酶，类似物和生产方法
公开(公告)号：US5367064A
公开(公告)日：1994-11-22
申请号：US5908
申请日：1993-01-15
申请人： Harvey Rubin , Zhi M. Wang , Barry S. Cooperman , Norman Schechter
发明人： Harvey Rubin , Zhi M. Wang , Barry S. Cooperman , Norman Schechter
IPC分类号： A61K38/00 , C07K14/81 , C07H21/04 , C07K13/00 , C12N15/22
CPC分类号： C07K14/8125 , A61K38/00
摘要： The invention provides .alpha.-1-antichymotrypsin and protein preparations comprising human .alpha.-1-antichymotrypsin produced by E. coli cells transformed with a DNA sequence encoding human .alpha.-1-antichymotrypsin. The invention also provides methods for producing .alpha.-1-antichymotrypsin. The invention further provides analogues of .alpha.-1-antichymotrypsin that exhibit antichymotrypsin, anti-trypsin and anti-thrombin activity and methods of producing the analogues.
摘要翻译：本发明提供了包含用编码人α1-抗胰凝乳蛋白酶的DNA序列转化的大肠杆菌细胞产生的人α1-抗胰凝乳蛋白酶的α-1抗胰凝乳蛋白酶和蛋白质制剂。本发明还提供了生产α-1抗胰凝乳蛋白酶的方法。本发明还提供表现出抗胰凝乳蛋白酶，抗胰蛋白酶和抗凝血酶活性的α-1-抗胰凝乳蛋白酶的类似物和产生类似物的方法。

4. 发明授权

US5827662A Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies 失效
标题翻译：检测导致蛋白酶抑制剂不足的遗传突变的方法
公开(公告)号：US5827662A
公开(公告)日：1998-10-27
申请号：US722268
申请日：1996-12-18
申请人： Harvey Rubin , Barry Cooperman , Norman Schechter , Michael Plotnick , Zhi Mei Wang
发明人： Harvey Rubin , Barry Cooperman , Norman Schechter , Michael Plotnick , Zhi Mei Wang
IPC分类号： C12N15/15 , C12Q1/68 , C12Q1/00 , C07K14/81 , C12N15/70
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： A method of producing a recombinant serine protease inhibitor capable of effectively modulating serine protease activity is provided. Compositions capable of modulating serine protease activity and use of such compositions to regulate inflammatory processes in cells are also provided.
摘要翻译：提供了能够有效调节丝氨酸蛋白酶活性的重组丝氨酸蛋白酶抑制剂的制备方法。还提供能够调节丝氨酸蛋白酶活性的组合物和这种组合物用于调节细胞中的炎症过程的组合物。

5. 发明授权

US5266465A .alpha.-1-antichymotrypsin, analogues and methods of production 失效
标题翻译： α-1抗胰凝乳蛋白酶，类似物和生产方法
公开(公告)号：US5266465A
公开(公告)日：1993-11-30
申请号：US735322
申请日：1991-07-24
申请人： Harvey Rubin , Zhi M. Wang , Barry S. Cooperman , Norman Schecter
发明人： Harvey Rubin , Zhi M. Wang , Barry S. Cooperman , Norman Schecter
IPC分类号： A61K38/00 , C07K14/81 , C07K3/00 , A61K45/05 , C12N15/09 , C12P21/02
CPC分类号： C07K14/8125 , A61K38/00
摘要： The invention provides .alpha.-1-antichymotrypsin and protein preparations comprising human .alpha.-1-antichymotrypsin produced by E. coli cells transformed with a DNA sequence encoding human .alpha.-1-antichymotrypsin. The invention also provides methods for producing .alpha.-1-antichymotrypsin. The invention further provides analogues of .alpha.-1-antichymotrypsin that exhibit antichymotrypsin, anti-trypsin and anti-thrombin activity and methods of producing the analogues.
摘要翻译：本发明提供了包含用编码人α1-抗胰凝乳蛋白酶的DNA序列转化的大肠杆菌细胞产生的人α1-抗胰凝乳蛋白酶的α-1抗胰凝乳蛋白酶和蛋白质制剂。本发明还提供了生产α-1抗胰凝乳蛋白酶的方法。本发明还提供表现出抗胰凝乳蛋白酶，抗胰蛋白酶和抗凝血酶活性的α-1-抗胰凝乳蛋白酶的类似物和产生类似物的方法。

6. 发明授权

US5459063A Plasmodium falciparum ribonucleotide reductase DNA 失效
标题翻译：恶性疟原虫核糖核苷酸还原酶DNA
公开(公告)号：US5459063A
公开(公告)日：1995-10-17
申请号：US136743
申请日：1993-10-14
申请人： Barry S. Cooperman , Harvey Rubin , Jerome Salem , Alison L. Fisher
发明人： Barry S. Cooperman , Harvey Rubin , Jerome Salem , Alison L. Fisher
IPC分类号： A61K38/00 , C07K14/445 , C12N9/02 , C12N15/53
CPC分类号： C12N9/0093 , C07K14/445 , A61K38/00
摘要： This invention relates to the ribonucleotide reductase of Plasmodium falciparum (Pf RR), to the subunits of Pf RR (Pf R1 and Pf R2), and to compounds comprising peptides derived from the Pf R2 C-terminus sequence that inhibit the action of protozoal RR. The invention provides a method for the prevention and treatment of malaria caused by P. falciparum by controlling the proliferation of P. falciparum comprising administering to a patient at least one peptide according to the invention. Antimalarial compositions are provided which comprise a pharmaceutically acceptable carrier and at least one peptide according to the invention which inhibits the P. falciparum ribonucleotide reductase reduction of ribonucleotides to 2'-deoxyribonucleotides. Also provided are methods for diagnosing malaria and for screening potential antimalarial agents.
摘要翻译：本发明涉及恶性疟原虫（Pf RR）对Pf RR（Pf R1和Pf R2）的亚基的核糖核苷酸还原酶，以及包含抑制原生动物RR作用的Pf R2 C-末端序列的肽的化合物。本发明提供了通过控制恶性疟原虫的增殖来预防和治疗由恶性疟原虫引起的疟疾的方法，其包括向患者施用至少一种本发明的肽。提供了抗疟组合物，其包含药学上可接受的载体和根据本发明的至少一种肽，其将核糖核苷酸的恶性疟原虫核糖核苷酸还原酶还原成2'-脱氧核糖核苷酸。还提供了诊断疟疾和筛选潜在抗疟药物的方法。

7. 发明授权

US5612194A Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors 失效
标题翻译：生产有效的重组丝氨酸蛋白酶抑制剂的方法和这些抑制剂的用途
公开(公告)号：US5612194A
公开(公告)日：1997-03-18
申请号：US276936
申请日：1994-07-19
申请人： Harvey Rubin , Barry Cooperman , Norman Schechter , Michael Plotnick , Zhi M. Wang
发明人： Harvey Rubin , Barry Cooperman , Norman Schechter , Michael Plotnick , Zhi M. Wang
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61P9/08 , A61P9/10 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/81 , C12N1/00 , C12N5/00 , C12N9/99 , C12P21/02 , A61K38/57 , C12N15/15
CPC分类号： C07K14/8121 , C07K14/8125 , A61K38/00
摘要： A method of producing a recombinant serine protease inhibitor capable of effectively modulating serine protease activity is provided. Compositions capable of modulating serine protease activity and use of such compositions to regulate inflammatory processes in cells are also provided.
摘要翻译：提供了能够有效调节丝氨酸蛋白酶活性的重组丝氨酸蛋白酶抑制剂的制备方法。还提供能够调节丝氨酸蛋白酶活性的组合物和这种组合物用于调节细胞中的炎症过程的组合物。

8. 发明授权

US09648488B2 Methods and systems for providing user information in telecommunications networks 有权
公开(公告)号：US09648488B2
公开(公告)日：2017-05-09
申请号：US12289298
申请日：2008-10-24
申请人： Christopher F. Mooney , Harvey Rubin
发明人： Christopher F. Mooney , Harvey Rubin
IPC分类号： H04W84/00 , H04W8/02 , H04L29/06 , H04W12/06 , H04W76/02
CPC分类号： H04W8/02 , H04L63/0892 , H04W12/06 , H04W76/12
摘要： Example embodiments and methods are directed to providing and otherwise handling user information within telecommunications networks, including wireless telecommunications networks. Example embodiments may include wireless networks having a Correlation Data Records Store (CDRS) that may store and update all user data needed by applications and services operating in example networks. Example methods may provide for collection and handling in the CDRS of all user information relied upon by applications and services operating in wireless networks, so as to reduce resource consumption by such applications and services.

9. 发明授权

US09107032B2 Method of collecting per-user performance data 有权
标题翻译：收集每个用户的性能数据的方法
公开(公告)号：US09107032B2
公开(公告)日：2015-08-11
申请号：US12545607
申请日：2009-08-21
申请人： Harvey Rubin , Jean-Michel Pugeat , Baoling S. Sheen , Dennis J. Wiest
发明人： Harvey Rubin , Jean-Michel Pugeat , Baoling S. Sheen , Dennis J. Wiest
IPC分类号： H04L12/50 , H04W8/02 , H04W80/04 , H04W24/08
CPC分类号： H04W8/02 , H04W24/08 , H04W80/04
摘要： The present invention provides a method for implementation in a wireless communication system including a plurality of base stations, a plurality of gateways, and a plurality of mobility management entities. The method includes receiving, at a first mobility management entity and from a first base station, measurement data collected by the first base station for a first mobile unit having a connection to the wireless communication system via the first base station. The measurement data includes a temporary identifier associated with the first mobile unit for the duration of the connection. The method also includes identifying the first mobile unit using the temporary identifier and forming a first record associated with the first mobile unit. The first record includes the measurement data collected by the first base station for the first mobile unit and previously collected measurement data for the first mobile unit.
摘要翻译：本发明提供一种在包括多个基站，多个网关和多个移动性管理实体的无线通信系统中实现的方法。该方法包括在第一移动性管理实体和第一基站处接收由第一基站收集的用于具有经由第一基站与无线通信系统的连接的第一移动单元的测量数据。测量数据包括在连接期间与第一移动单元相关联的临时标识符。该方法还包括使用临时标识符识别第一移动单元并形成与第一移动单元相关联的第一记录。第一记录包括由第一移动单元的第一基站收集的测量数据和第一移动单元的先前收集的测量数据。

10. 发明申请

US20110044283A1 METHOD OF COLLECTING PER-USER PERFORMANCE DATA 有权
标题翻译：收集性能数据的方法
公开(公告)号：US20110044283A1
公开(公告)日：2011-02-24
申请号：US12545607
申请日：2009-08-21
申请人： Harvey Rubin , Jean-Michel Pugeat , Baoling S. Sheen , Dennis J. Wiest
发明人： Harvey Rubin , Jean-Michel Pugeat , Baoling S. Sheen , Dennis J. Wiest
IPC分类号： H04W36/00 , H04W16/00
CPC分类号： H04W8/02 , H04W24/08 , H04W80/04
摘要： The present invention provides a method for implementation in a wireless communication system including a plurality of base stations, a plurality of gateways, and a plurality of mobility management entities. The method includes receiving, at a first mobility management entity and from a first base station, measurement data collected by the first base station for a first mobile unit having a connection to the wireless communication system via the first base station. The measurement data includes a temporary identifier associated with the first mobile unit for the duration of the connection. The method also includes identifying the first mobile unit using the temporary identifier and forming a first record associated with the first mobile unit. The first record includes the measurement data collected by the first base station for the first mobile unit and previously collected measurement data for the first mobile unit.
摘要翻译：本发明提供一种在包括多个基站，多个网关和多个移动性管理实体的无线通信系统中实现的方法。该方法包括在第一移动性管理实体和第一基站处接收由第一基站收集的用于具有经由第一基站与无线通信系统的连接的第一移动单元的测量数据。测量数据包括在连接期间与第一移动单元相关联的临时标识符。该方法还包括使用临时标识符识别第一移动单元并形成与第一移动单元相关联的第一记录。第一记录包括由第一移动单元的第一基站收集的测量数据和第一移动单元的先前收集的测量数据。

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