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    • 5. 发明授权
    • Shear-sensitive injectable delivery system
    • 剪切敏感的注射输送系统
    • US08845580B2
    • 2014-09-30
    • US10757159
    • 2004-01-14
    • Barry N. Gellman
    • Barry N. Gellman
    • A61M5/14A61M5/315A61M5/20A61M5/31
    • A61M5/2066A61M5/31596A61M2005/3139
    • A delivery system for delivering a shear-sensitive injectable material into the body of a mammal, such as a human being, acts as a mechanical feed that continuously mixes a shear-sensitive injectable material as it delivers the shear-sensitive injectable material to a target tissue, or to a site adjacent a target tissue. In one embodiment of the invention, the delivery system comprises an injector system including a rotatable mixing member coupled to a driving system. The injector system comprises a housing defining a lumen and having an output end and a driving system connection end and includes a rotatable mixing member for coupling to the driving system and for mixing and delivering the shear-sensitive injectable material. The driving system comprises a drive mechanism, an actuator capable of actuating the drive mechanism, and an interfacing member coupled to the drive mechanism for coupling with the mixing member to rotate the mixing member when the interfacing member is driven by the drive mechanism.
    • 用于将剪切敏感的可注射材料递送到哺乳动物(例如人)的体内的输送系统用作机械进料,其将剪切敏感的可注射材料连续混合,因为其将剪切敏感的可注射材料输送到靶 组织或邻近靶组织的部位。 在本发明的一个实施例中,输送系统包括喷射器系统,其包括联接到驱动系统的可旋转的混合部件。 注射器系统包括限定内腔并具有输出端和驱动系统连接端的壳体,并且包括用于联接到驱动系统并用于混合和输送剪切敏感的可注射材料的可旋转的混合构件。 所述驱动系统包括驱动机构,能够致动所述驱动机构的致动器,以及联接到所述驱动机构的接合构件,用于在所述接合构件被所述驱动机构驱动时与所述混合构件联接以旋转所述混合构件。