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    • 7. 发明授权
    • Composite material
    • 复合材料
    • US08110222B2
    • 2012-02-07
    • US10295461
    • 2002-11-15
    • Stacy A. HutchensJonathan WoodwardBarbara R. EvansHugh M. O'Neill
    • Stacy A. HutchensJonathan WoodwardBarbara R. EvansHugh M. O'Neill
    • A61K9/14A61F13/00
    • A61K47/38A61K9/5078A61K33/42A61L27/46A61L27/52A61L27/56A61L2430/02
    • A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.
    • 复合生物相容性水凝胶材料包括多孔聚合物基质,聚合物基质包括多个孔并提供至少10GPa的杨氏模量。 包含盐的钙被设置在至少一些孔中。 多孔聚合物基质可以包括纤维素,包括细菌纤维素。 复合材料可用作骨移植材料。 动物体内组织修复的方法包括提供包括多孔聚合物基质的复合生物相容性水凝胶材料的步骤,所述聚合物基质包括多个孔并提供至少10GPa的杨氏模量,并将水凝胶材料 进入动物的软骨或骨组织,其中所述水凝胶材料在体外支持细胞定植以进行自体细胞接种。