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1. 发明授权

US5705154A Humanized monoclonal antibodies against human interleukin-4 失效
标题翻译：针对人白细胞介素-4的人源化单克隆抗体
公开(公告)号：US5705154A
公开(公告)日：1998-01-06
申请号：US704744
申请日：1996-09-06
申请人： Barbara Dalie , Kenneth Miller , Nicholas Murgolo , Stephen Tindall
发明人： Barbara Dalie , Kenneth Miller , Nicholas Murgolo , Stephen Tindall
IPC分类号： C07K16/24 , C07K16/42 , A61K39/395 , C07H21/04
CPC分类号： C07K16/4241 , C07K16/247 , C07K2317/24 , C07K2319/00
摘要： Humanized monoclonal antibodies are provided which are specific for human IL-4 and have properties unexpectedly superior to other, previously available humanized antibodies. Single-chain binding proteins, fusion proteins, and antigenic or IL-4 binding fragments of such antibodies are also provided by this invention. Also provided are nucleic acids which encode the heavy and light chain variable regions of such monoclonal antibodies or antigenic fragments thereof; anti-idiotypic antibodies; and methods for detecting, measuring and immunopurifying human IL-4, and for blocking or mimicking the biological activity of human IL-4.
摘要翻译： PCT No.PCT / US95 / 02400 Sec。 371日期1996年9月6日 102（e）1996年9月6日PCT PCT 1995年3月8日PCT公布。出版物WO95 / 24481 日期1995年9月14日提供人类单克隆抗体，其对于人IL-4是特异性的，并且具有出乎意料地优于其他先前可获得的人源化抗体的性质。本发明还提供了这种抗体的单链结合蛋白，融合蛋白和抗原或IL-4结合片段。还提供编码这种单克隆抗体或其抗原性片段的重链和轻链可变区的核酸; 抗独特型抗体; 以及用于检测，测量和免疫人IL-4并用于阻断或模拟人IL-4的生物活性的方法。

2. 发明授权

US5597710A Humanized monoclonal antibodies against human interleukin-4 失效
标题翻译：针对人白细胞介素-4的人源化单克隆抗体
公开(公告)号：US5597710A
公开(公告)日：1997-01-28
申请号：US208886
申请日：1994-03-10
申请人： Barbara Dalie , Kenneth Miller , Nicholas Murgolo , Stephen Tindall
发明人： Barbara Dalie , Kenneth Miller , Nicholas Murgolo , Stephen Tindall
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P35/00 , A61P37/00 , A61P43/00 , C07K16/24 , C12N5/10 , C12P21/08 , C12R1/91 , C07H21/04 , C07K16/46 , C12N1/20 , C12N15/00
CPC分类号： C07K16/247 , A61K38/00 , C07K2319/00
摘要： Humanized monoclonal antibodies are provided which are specific for human IL-4 and have properties unexpectedly superior to other, previously available humanized antibodies. Also provided are nucleic acids which encode the heavy and light chain variable regions of such monoclonal antibodies or antigenic fragments thereof; anti-idiotypic antibodies; and methods for detecting, measuring and immunopurifying human IL-4, and for blocking or mimicking the biological activity of human IL-4.
摘要翻译：提供对人IL-4特异的人源化单克隆抗体，并具有出乎意料地优于其他先前可获得的人源化抗体的性质。还提供编码这种单克隆抗体或其抗原性片段的重链和轻链可变区的核酸; 抗独特型抗体; 以及用于检测，测量和免疫人IL-4并用于阻断或模拟人IL-4的生物活性的方法。

3. 发明授权

US5863537A Humanized monoclonal antibodies against human interleukin-4 失效
标题翻译：针对人白细胞介素-4的人源化单克隆抗体
公开(公告)号：US5863537A
公开(公告)日：1999-01-26
申请号：US290793
申请日：1994-08-16
申请人： Barbara Dalie , Hung V. Le , Kenneth Miller , Nicholas J. Murgolo , Hanh Nguyen , Stephen Tindall , Paul J. Zavodny
发明人： Barbara Dalie , Hung V. Le , Kenneth Miller , Nicholas J. Murgolo , Hanh Nguyen , Stephen Tindall , Paul J. Zavodny
IPC分类号： A61K38/00 , A61K39/395 , A61P43/00 , C07K14/47 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/24 , C07K16/46 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/13 , C12P21/02 , C12P21/08 , C12R1/91 , A61K39/40
CPC分类号： C07K16/465 , C07K16/247 , A61K38/00 , C07K2317/24 , C07K2319/00 , C07K2319/02
摘要： Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal antibodies and complementarity determining regions from such DNAs; and kits and methods for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4.
摘要翻译： PCT No.PCT / US93 / 01301 Sec。 371日期：1994年8月16日 102（e）日期1994年8月16日PCT提交1993年2月18日PCT公布。出版物WO93 / 17106 日期1993年9月2日提供对人白细胞介素-4特异性的单克隆抗体。还提供了编码这些单克隆抗体的重链和轻链可变区和来自这些DNA的互补决定区的互补DNA; 以及用于检测，测量和免疫人白细胞介素-4并用于阻断人白细胞介素-4的生物活性的试剂盒和方法。

4. 发明授权

US5770403A Cloning and exprssion of humanized monoclonal antibodies against human interluekin-4 失效
标题翻译：人源化单克隆抗体针对人类interluekin-4的克隆和表达
公开(公告)号：US5770403A
公开(公告)日：1998-06-23
申请号：US469557
申请日：1995-06-06
申请人： Barbara Dalie , Hung V. Le , Kenneth Miller , Nicholas J. Murgolo , Hanh Nguyen , Stephen Tindall , Paul J. Zavodny
发明人： Barbara Dalie , Hung V. Le , Kenneth Miller , Nicholas J. Murgolo , Hanh Nguyen , Stephen Tindall , Paul J. Zavodny
IPC分类号： A61K38/00 , A61K39/395 , A61P43/00 , C07K14/47 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/24 , C07K16/46 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/13 , C12P21/02 , C12P21/08 , C12R1/91 , C12P21/04 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C07K16/465 , C07K16/247 , A61K38/00 , C07K2317/24 , C07K2319/00 , C07K2319/02
摘要： Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal antibodies and complementarity determining regions from such DNAs; and kits and methods for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4.
摘要翻译：提供对人白细胞介素-4特异的单克隆抗体。还提供了编码这些单克隆抗体的重链和轻链可变区和来自这些DNA的互补决定区的互补DNA; 以及用于检测，测量和免疫人白细胞介素-4并用于阻断人白细胞介素-4的生物活性的试剂盒和方法。

5. 发明授权

US08677993B2 Humidifier for breathing gas heating and humidification system 有权
标题翻译：加湿器用于呼吸气体加热和加湿系统
公开(公告)号：US08677993B2
公开(公告)日：2014-03-25
申请号：US12175888
申请日：2008-07-18
申请人： Felino V. Cortez, Jr. , William F. Niland , George McGarrity , Carl Buyer , Kenneth Miller , Peter Boyd
发明人： Felino V. Cortez, Jr. , William F. Niland , George McGarrity , Carl Buyer , Kenneth Miller , Peter Boyd
IPC分类号： A61M11/02 , A61M15/00 , A61M16/00 , A61M16/10 , H05B3/00 , B01F3/04 , C10K1/08 , B05B7/26 , B05B7/28 , B05B9/04 , F23D11/10
CPC分类号： A61M16/162 , A61M16/0051 , A61M16/0066 , A61M16/022 , A61M16/08 , A61M16/0875 , A61M16/107 , A61M16/1075 , A61M16/109 , A61M16/142 , A61M16/16
摘要： A humidification canister for humidifying a breathing gas, the humidification canister includes a fluid supply configured to supply a fluid and a first gas flow path in fluid communication with the fluid supply. A first gas flow path is configured to humidify the breathing gas with the fluid. A second gas flow path at least partially surrounds the first gas flow path. A method of insulating a breathing gas in a humidification canister using a gas is also disclosed.
摘要翻译：一种用于加湿呼吸气体的加湿罐，所述加湿罐包括被配置为供应流体的流体供应源和与所述流体供应源流体连通的第一气体流动路径。第一气体流路被配置成用流体对呼吸气体进行加湿。第二气体流动路径至少部分地围绕第一气体流动路径。还公开了使用气体使加湿罐中的呼吸气体绝缘的方法。

6. 发明申请

US20090056713A1 SYSTEM AND METHOD FOR DELIVERING A HEATED AND HUMIDIFIED GAS 有权
标题翻译：用于输送加热和加湿气体的系统和方法
公开(公告)号：US20090056713A1
公开(公告)日：2009-03-05
申请号：US12175861
申请日：2008-07-18
申请人： Felino V. Cortez, JR. , Owen S. Bamford , William F. Niland , George McGarrity , Carl Buyer , Kenneth Miller , Peter Boyd
发明人： Felino V. Cortez, JR. , Owen S. Bamford , William F. Niland , George McGarrity , Carl Buyer , Kenneth Miller , Peter Boyd
IPC分类号： A61M16/16
CPC分类号： A61M16/162 , A61M16/0051 , A61M16/0066 , A61M16/022 , A61M16/08 , A61M16/0875 , A61M16/107 , A61M16/1075 , A61M16/109 , A61M16/142 , A61M16/16
摘要： An apparatus for providing breathing gas to a patient that includes a base unit to provide a first flow of gas and a second flow of gas and a humidification canister to be coupled to the base unit is described. The humidification canister includes a first gas flow path to receive and humidify the first flow of gas. A delivery tube assembly includes a first lumen configured for fluid communication with the first gas flow path to receive the humidified first flow of gas and a second lumen to receive the second flow of gas. A method of heating and humidifying the first flow of gas and insulating the first flow of gas with the second flow of gas is also described.
摘要翻译：一种用于向患者提供呼吸气体的装置，其包括基本单元以提供第一气体流和第二气体流，以及要耦合到基座单元的加湿罐。加湿罐包括用于接收和加湿第一气体流的第一气体流路。输送管组件包括构造成与第一气体流动路径流体连通以接收加湿的第一气体流动的第一腔室和用于接收第二气体流的第二腔室。还描述了加热和加湿第一气体流并且使第一气体流与第二气体流绝缘的方法。

7. 发明申请

US20070275242A1 ARTICLES DERIVED FROM COMPOSITIONS CONTAINING MODIFIED POLYBUTYLENE TEREPHTHALATE (PBT) RANDOM COPOLYMERS DERIVED FROM POLYETHYLENE TEREPHTHALATE (PET) 有权
标题翻译：由含有改性聚苯乙烯（PBT）的聚苯乙烯（PET）衍生的随机共聚物的组合物衍生的制品
公开(公告)号：US20070275242A1
公开(公告)日：2007-11-29
申请号：US11668189
申请日：2007-01-29
申请人： Vikram Gopal , Ganesh Kannan , Kenneth Miller , Dhaval Shah
发明人： Vikram Gopal , Ganesh Kannan , Kenneth Miller , Dhaval Shah
IPC分类号： C08L67/03 , C08G63/60
CPC分类号： C08J11/24 , C08J2367/02 , C08L67/02 , Y02W30/706 , Y10T428/298 , C08L2666/02
摘要： Compositions of matter including articles derived from (a) from 5 to 99.99 wt % of a modified polybutylene terephthalate random copolymer that (1) is derived from polyethylene terephthalate and (2) contains a at least one residue derived from polyethylene terephthalate selected from the group consisting of antimony, germanium, diethylene glycol groups, isophthalic acid groups, cis isomer of cyclohexane dimethanol, trans isomer of cyclohexane dimethanol, sodium benzoate, alkali salts, napthalane dicarboxylic acids, 1,3-propane diols, cobalt, cobalt-containing compounds, and combinations thereof, and (b) from 0.01 to 95 wt. % of a member selected from the group consisting of (1) fillers, (2) a carboxy reactive component, (3) polyethyelene terephthalate, (4) a component including a polycarbonate and an impact modifier. The articles may be derived from various conversion processes, e.g., injection molding processes, extrusion processes, thermoforming processes, melt-blown process.
摘要翻译：包括衍生自（a）5至99.99重量％的改性聚对苯二甲酸丁二醇酯无规共聚物的物质组合物，（1）衍生自聚对苯二甲酸乙二醇酯和（2）含有至少一种衍生自聚对苯二甲酸乙二醇酯的残基，由锑，锗，二甘醇基，间苯二甲酸基，环己烷二甲醇的顺式异构体，环己烷二甲醇的反式异构体，苯甲酸钠，碱金属盐，萘二甲酸，1,3-丙二醇，钴，含钴化合物，及其组合，和（b）0.01至95wt。选自（1）填料，（2）羧基反应性组分，（3）聚对苯二甲酸乙二醇酯，（4）包含聚碳酸酯和抗冲改性剂的组分的组分的％。制品可以衍生自各种转化方法，例如注射成型工艺，挤出工艺，热成型工艺，熔喷工艺。

8. 发明申请

US20070225474A1 COPOLYETHERESTERS DERIVED FROM POLYETHYLENE TEREPHTHALATE 有权
标题翻译：聚苯乙烯衍生自聚乙烯三癸酸酯的共聚物
公开(公告)号：US20070225474A1
公开(公告)日：2007-09-27
申请号：US11627745
申请日：2007-01-26
申请人： Michael Determan , Ganesh Kannan , Kenneth Miller , Dhaval Shah
发明人： Michael Determan , Ganesh Kannan , Kenneth Miller , Dhaval Shah
IPC分类号： C08G63/02
CPC分类号： C08G63/672 , C08J11/24 , C08J2367/02 , Y02W30/706
摘要： The invention relates to a composition comprising a modified, random copolyetherester containing a modified, random polybutylene terephthalate copolymer block that is derived from a polyethylene terephthalate component selected from the group consisting of polyethylene terephthalate and polyethylene terephthalate copolymers and combinations thereof, and contains at least one residue derived from the polyethylene terephthalate component; and a polyalkylene oxide copolymer block that is derived from a polyethylene terephthalate component and polyalkylene oxide glycol, and contains polyalkylene oxide and at least one residue derived from the polyethylene terephthalate component. Advantageously, the composition has a modulus of elasticity that is at least 80%, as compared to the modulus of elasticity of a copolyetherester derived from (1) polybutylene terephthalate derived from a monomer component selected from the group consisting of terephthalic acid, isophthalic acid, alkyl esters of terephthalic acid, hydroalkyl esters of terephthalic acid, alkyl esters of isophthalic acid, 1,4-butanediol, (2) polyalkylene oxide glycol, and (3) combinations thereof. The invention also relates to articles made from the composition, methods of making the composition. The invention also relates to copolyetherester containing: a modified, random polytrimethylene terephthalate copolymer blocks, articles made from the compositions, and methods for making such materials.
摘要翻译：本发明涉及一种组合物，其包含改性的无规共聚醚酯，该改性的无规共聚醚酯包含衍生自聚对苯二甲酸乙二醇酯组分的聚对苯二甲酸乙二醇酯组分的选自聚对苯二甲酸乙二醇酯和聚对苯二甲酸乙二醇酯共聚物及其组合的改性随机聚对苯二甲酸丁二醇酯共聚物嵌段，衍生自聚对苯二甲酸乙二醇酯组分的残基; 和衍生自聚对苯二甲酸乙二醇酯组分和聚环氧烷二醇的聚环氧烷共聚物嵌段，并且含有聚环氧烷和至少一种衍生自聚对苯二甲酸乙二醇酯组分的残基。有利的是，与来自（1）聚对苯二甲酸丁二醇酯的共聚醚酯的弹性模量相比，组合物的弹性模量为至少80％，所述聚对苯二甲酸丁二醇酯衍生自选自对苯二甲酸，间苯二甲酸，对苯二甲酸的烷基酯，对苯二甲酸的烷基酯，间苯二甲酸的烷基酯，1,4-丁二醇，（2）聚环氧烷二醇，和（3）它们的组合。本发明还涉及由该组合物制成的制品，以及制备该组合物的方法。本发明还涉及共聚醚酯，其包含：改性的无规聚对苯二甲酸丙二醇酯共聚物嵌段，由组合物制成的制品，以及制备这种材料的方法。

9. 发明申请

US20070192258A1 Method for controlling when mail is received by a recipient 审中-公开
标题翻译：用于控制邮件被收件人接收的方法
公开(公告)号：US20070192258A1
公开(公告)日：2007-08-16
申请号：US11372809
申请日：2006-03-10
申请人： James Norris , John Winkelman , Kenneth Miller , John Rojas , Alla Tsipenyuk
发明人： James Norris , John Winkelman , Kenneth Miller , John Rojas , Alla Tsipenyuk
IPC分类号： B65B35/00
CPC分类号： G06Q30/02 , G06Q10/04 , G06Q10/06 , G06Q10/06312 , G06Q10/08 , G06Q10/0833 , G06Q20/102 , H04M3/51 , H04M2203/402
摘要： A computer controlled method that enables a mailer to control when recipients will receive mail mailed by the mailer. The method involves receiving a mailing composition, the desired mailing in home delivery date ranges and carrier schedules; utilizing a prediction model built from historical delivery data to predict when the quantities of mail will arrive for the mailing; and using the prediction model to determine preferred induction dates for the mailing.
摘要翻译：一种计算机控制的方法，使邮件程序能够控制收件人何时接收邮件发送的邮件。该方法包括接收邮寄作品，在本地传送日期范围和载体日程表中所需的邮寄; 利用从历史交货数据构建的预测模型来预测邮件的数量何时到达邮寄的时间; 并使用预测模型确定邮寄的优选诱导日期。

10. 发明申请

US20060264579A1 Low gloss thermoplastic composition 有权
标题翻译：低光泽热塑性组合物
公开(公告)号：US20060264579A1
公开(公告)日：2006-11-23
申请号：US11316227
申请日：2005-12-22
申请人： Donald Ellington , Kenneth Miller , Yantao Zhu , Claire Yu
发明人： Donald Ellington , Kenneth Miller , Yantao Zhu , Claire Yu
IPC分类号： C08L67/00 , C08L69/00 , B32B27/36
CPC分类号： C08L55/02 , C08K5/1515 , C08K5/5435 , C08L23/0884 , C08L67/02 , C08L69/00 , C08L2666/14 , C08L2666/02
摘要： A composition comprising a) about 30 to 80 wt. % of a polycarbonate, b) about 5 to about 50 wt. % of a polyester, c) about 2 to about 25 wt. % of an impact modifier and d) a gloss reducing effective amount of a multifunctional additive comprising at least one epoxy group.
摘要翻译：一种组合物，其包含a）约30至80wt。％的聚碳酸酯，b）约5至约50wt。％的聚酯，c）约2至约25wt。％的抗冲改性剂和d）光泽度降低有效量的包含至少一个环氧基团的多功能添加剂。

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