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1. 发明授权

US08617820B2 Use of glycosaminoglycans to reduce non-specific binding in immunoassays 有权
标题翻译：使用糖胺聚糖来减少免疫测定中的非特异性结合
公开(公告)号：US08617820B2
公开(公告)日：2013-12-31
申请号：US11846390
申请日：2007-08-28
申请人： Banumathi Sankaran , Sheryl S. Sullivan , Darrell C. Haynes , Philip C. Hosimer , Graham Yearwood
发明人： Banumathi Sankaran , Sheryl S. Sullivan , Darrell C. Haynes , Philip C. Hosimer , Graham Yearwood
IPC分类号： C12Q1/00 , G01N33/00 , G01N33/53 , C12N5/07
CPC分类号： G01N33/54393 , G01N33/5306 , G01N33/6887 , Y10T436/25
摘要： An immunoassay reagent is provided which comprises an analyte binding agent in a diluent, and a glycosaminoglycan in an amount sufficient to reduce non-specific binding in an assay of a sample for the analyte. Provided is such an immunoassay reagent in which the analyte is troponin I, the analyte binding agent is a biotinylated anti-troponin I antibody, and the glycosaminoglycan is chondroitin sulfate. A sample composition is also provided which comprises a sample to be assayed for the presence of an analyte, an analyte binding agent, and a glycosaminoglycan other than heparin. Further provided is a method of detecting an analyte in a sample, in which non-specific binding is reduced in the method using a glycosaminoglycan.
摘要翻译：提供了一种免疫测定试剂，其包含稀释剂中的分析物结合剂和足以在分析物样品测定中减少非特异性结合量的糖胺聚糖。提供了这样的免疫测定试剂，其中分析物是肌钙蛋白I，分析物结合剂是生物素化的抗肌钙蛋白I抗体，并且糖胺聚糖是硫酸软骨素。还提供了一种样品组合物，其包含要分析待分析物，分析物结合剂和除肝素以外的糖胺聚糖的存在的样品。还提供了检测样品中分析物的方法，其中使用糖胺聚糖的方法中非特异性结合被还原。

2. 发明申请

US20090061455A1 Use of Glycosaminoglycans to Reduce Non-Specific Binding in Immunoassays 有权
标题翻译：使用糖胺聚糖来减少免疫测定中的非特异性结合
公开(公告)号：US20090061455A1
公开(公告)日：2009-03-05
申请号：US11846390
申请日：2007-08-28
申请人： Banumathi Sankaran , Sheryl S. Sullivan , Darrell C. Haynes , Phillp C. Hosimer , Graham Yearwood
发明人： Banumathi Sankaran , Sheryl S. Sullivan , Darrell C. Haynes , Phillp C. Hosimer , Graham Yearwood
IPC分类号： G01N33/53
CPC分类号： G01N33/54393 , G01N33/5306 , G01N33/6887 , Y10T436/25
摘要： An immunoassay reagent is provided which comprises an analyte binding agent in a diluent, and a glycosaminoglycan in an amount sufficient to reduce non-specific binding in an assay of a sample for the analyte. Provided is such an immunoassay reagent in which the analyte is troponin I, the analyte binding agent is a biotinylated anti-troponin I antibody, and the glycosaminoglycan is chondroitin sulfate. A sample composition is also provided which comprises a sample to be assayed for the presence of an analyte, an analyte binding agent, and a glycosaminoglycan other than heparin. Further provided is a method of detecting an analyte in a sample, in which non-specific binding is reduced in the method using a glycosaminoglycan.
摘要翻译：提供了一种免疫测定试剂，其包含稀释剂中的分析物结合剂和足以在分析物样品测定中减少非特异性结合量的糖胺聚糖。提供了这样的免疫测定试剂，其中分析物是肌钙蛋白I，分析物结合剂是生物素化的抗肌钙蛋白I抗体，并且糖胺聚糖是硫酸软骨素。还提供了一种样品组合物，其包含要分析待分析物，分析物结合剂和除肝素以外的糖胺聚糖的存在的样品。还提供了检测样品中分析物的方法，其中使用糖胺聚糖的方法中非特异性结合被还原。

3. 发明授权

US07601531B2 Chlamydia pneumoniae polynucleotides and uses thereof 失效
标题翻译：肺炎衣原体多核苷酸及其用途
公开(公告)号：US07601531B2
公开(公告)日：2009-10-13
申请号：US11366942
申请日：2006-03-02
申请人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
发明人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
IPC分类号： C12N1/21 , C12N15/31 , C07H21/04
CPC分类号： C07K14/295 , A01K2217/05 , A61K39/00
摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia pneumoniae genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia pneumoniae infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia pneumoniae, infections.
摘要翻译：本发明的主题是编码肺炎衣原体多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程中或在毒力中参与代谢，由此编码的多肽序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。本发明还涉及可用于控制微生物生长的肺炎衣原体基因组的转录基因产物，例如反义和核酶分子。本发明还涉及检测这些核酸或多肽的方法以及用于诊断肺炎衣原体感染的试剂盒。本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。本发明最终包括用于预防和/或治疗细菌，特别是肺炎衣原体感染的药物，特别是疫苗组合物。

4. 发明授权

US08143024B2 Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection 有权
标题翻译：沙眼衣原体基因组序列和多肽，其片段及其用途，特别是用于诊断，预防和治疗感染
公开(公告)号：US08143024B2
公开(公告)日：2012-03-27
申请号：US13036310
申请日：2011-02-28
申请人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
发明人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
IPC分类号： C12P21/06 , C12N15/09 , C07H21/04 , A61K39/118
CPC分类号： C07K14/295
摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.
摘要翻译：本发明的主题是编码沙眼衣原体的多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程或毒力中涉及代谢，或由其编码的多肽序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。本发明还涉及沙眼衣原体基因组的转录基因产物，例如反义和核酶分子，其可用于控制微生物的生长。本发明还涉及检测这些核酸或多肽的方法以及用于诊断沙眼衣原体感染的试剂盒。本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。本发明最终包括用于预防和/或治疗细菌特别是沙眼衣原体感染的药物，特别是疫苗组合物。

5. 发明授权

US07910329B2 Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection 有权
标题翻译：沙眼衣原体基因组序列和多肽，其片段及其用途，特别是用于诊断，预防和治疗感染
公开(公告)号：US07910329B2
公开(公告)日：2011-03-22
申请号：US12491474
申请日：2009-06-25
申请人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
发明人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
IPC分类号： C12N15/09 , C12N1/20 , C12P21/04 , C07H21/04 , A61K39/118
CPC分类号： C07K14/295
摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.
摘要翻译：本发明的主题是编码沙眼衣原体的多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程或毒力中涉及代谢，或由其编码的多肽序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。本发明还涉及沙眼衣原体基因组的转录基因产物，例如反义和核酶分子，其可用于控制微生物的生长。本发明还涉及检测这些核酸或多肽的方法以及用于诊断沙眼衣原体感染的试剂盒。本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。本发明最终包括用于预防和/或治疗细菌特别是沙眼衣原体感染的药物，特别是疫苗组合物。

6. 发明授权

US07575913B2 Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection 有权
标题翻译：沙眼衣原体基因组序列和多肽，其片段及其用途，特别是用于诊断，预防和治疗感染
公开(公告)号：US07575913B2
公开(公告)日：2009-08-18
申请号：US11366965
申请日：2006-03-02
申请人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
发明人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
IPC分类号： C12N1/21 , C12N15/31 , C07H21/04
CPC分类号： C07K14/295
摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.
摘要翻译：本发明的主题是编码沙眼衣原体的多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程或毒力中涉及代谢，或由其编码的多肽序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。本发明还涉及沙眼衣原体基因组的转录基因产物，例如反义和核酶分子，其可用于控制微生物的生长。本发明还涉及检测这些核酸或多肽的方法以及用于诊断沙眼衣原体感染的试剂盒。本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。本发明最终包括用于预防和/或治疗细菌特别是沙眼衣原体感染的药物，特别是疫苗组合物。

7. 发明申请

US20070053927A1 Chlamydia pneumoniae polynucleotides and uses thereof 失效
标题翻译：肺炎衣原体多核苷酸及其用途
公开(公告)号：US20070053927A1
公开(公告)日：2007-03-08
申请号：US11366942
申请日：2006-03-02
申请人： Remy Griffais , Susan Hoiseth , Robert Zagursky , Benjamin Metcalf , Joel Peek , Banumathi Sankaran , Leah Fletcher
发明人： Remy Griffais , Susan Hoiseth , Robert Zagursky , Benjamin Metcalf , Joel Peek , Banumathi Sankaran , Leah Fletcher
IPC分类号： A61K39/02 , C07H21/04 , C12P21/06 , C12N1/21 , C12N15/74 , C07K14/295 , C07K16/12
CPC分类号： C07K14/295 , A01K2217/05 , A61K39/00
摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia pneumoniae genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia pneumoniae infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia pneumoniae, infections.
摘要翻译：本发明的主题是编码肺炎衣原体多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程中或在毒力中参与代谢，由此编码的多肽序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。本发明还涉及可用于控制微生物生长的肺炎衣原体基因组的转录基因产物，例如反义和核酶分子。本发明还涉及检测这些核酸或多肽的方法以及用于诊断肺炎衣原体感染的试剂盒。本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。本发明最终包括用于预防和/或治疗细菌，特别是肺炎衣原体感染的药物，特别是疫苗组合物。

8. 发明授权

US07101963B2 Chlamydia pneumoniae polypeptides and uses thereof 失效
标题翻译：肺炎衣原体多肽及其用途
公开(公告)号：US07101963B2
公开(公告)日：2006-09-05
申请号：US10289762
申请日：2002-11-07
申请人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
发明人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
IPC分类号： A61K38/00 , A61K39/00 , C07K1/00 , C12Q1/68 , C12N15/00
CPC分类号： C07K14/295 , A01K2217/05 , A61K39/00
摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia pneumoniae genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia pneumoniae infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia pneumoniae, infections.
摘要翻译：本发明的主题是编码肺炎衣原体多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程中或在毒力中参与代谢，由此编码的多肽序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。本发明还涉及可用于控制微生物生长的肺炎衣原体基因组的转录基因产物，例如反义和核酶分子。本发明还涉及检测这些核酸或多肽的方法以及用于诊断肺炎衣原体感染的试剂盒。本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。本发明最终包括用于预防和/或治疗细菌，特别是肺炎衣原体感染的药物，特别是疫苗组合物。

9. 发明授权

US07041490B1 Chlamydia trachomatis polynucleotides and vectors, recombinant host cells, DNA chips or kits containing the same 失效
标题翻译：衣原体沙眼衣原体多核苷酸和载体，重组宿主细胞，DNA芯片或含有其的试剂盒
公开(公告)号：US07041490B1
公开(公告)日：2006-05-09
申请号：US09201228
申请日：1998-11-30
申请人： Remy Griffais , Susan K. Hoiseth , Robert John Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah Diane Fletcher
发明人： Remy Griffais , Susan K. Hoiseth , Robert John Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah Diane Fletcher
IPC分类号： C12N1/21 , C12N15/31
CPC分类号： C07K14/295
摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.
摘要翻译：本发明的主题是编码沙眼衣原体的多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程或毒力中涉及代谢，或由其编码的多肽序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。本发明还涉及沙眼衣原体基因组的转录基因产物，例如反义和核酶分子，其可用于控制微生物的生长。本发明还涉及检测这些核酸或多肽的方法以及用于诊断沙眼衣原体感染的试剂盒。本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。本发明最终包括用于预防和/或治疗细菌特别是沙眼衣原体感染的药物，特别是疫苗组合物。

10. 发明授权

US08835183B2 Determination of sFlt-1:angiogenic factor complex 有权
标题翻译： sFlt-1：血管生成因子复合物的测定
公开(公告)号：US08835183B2
公开(公告)日：2014-09-16
申请号：US12350090
申请日：2009-01-07
申请人： George Bashirians , Deborah Byrne , Sarah Groulx , Sharon Jackson , Heather Lane-Brown , Banumathi Sankaran , Edward Scalice , Karen Yang , Jian Zheng
发明人： George Bashirians , Deborah Byrne , Sarah Groulx , Sharon Jackson , Heather Lane-Brown , Banumathi Sankaran , Edward Scalice , Karen Yang , Jian Zheng
IPC分类号： G01N33/543 , G01N33/68 , G01N33/566
CPC分类号： G01N33/689 , G01N33/543 , G01N33/566 , G01N33/6872 , G01N2333/475 , G01N2333/515 , G01N2333/71 , G01N2333/91205 , G01N2800/368 , G01N2800/50 , G01N2800/56
摘要： Methods for determining the presence or amount of a complex comprising a first and second molecular entity are provided, preferably an sFlt-1:PlGF complex. A determination of the presence or amount of the complex can be used in methods for predicting, detecting, monitoring a disease, or guiding therapy in respect to a disease such as vascular, vascular-related disease, cardiac, cardiac-related disease, cancer, cancer-related disease, preeclampsia, and preeclampsia-related disease. Determining sFlt-1:angiogenic factor complex is particularly useful for predicting and detecting preeclampsia in early stages of gestation and in stages of the disease where clinical evaluation may be uninformative.
摘要翻译：提供了确定包含第一和第二分子实体的复合物的存在或量的方法，优选为sFlt-1：PlGF复合物。复合物的存在或量的确定可用于预测，检测，监测疾病或指导治疗相关疾病如血管，血管相关疾病，心脏，心脏相关疾病，癌症，癌症相关疾病，先兆子痫和先兆子痫相关疾病。测定sFlt-1：血管生成因子复合物特别可用于预测和检测妊娠早期阶段和疾病阶段的先兆子痫，其临床评估可能是不知情的。

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