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1. 发明公开

US20230172949A1 THERMO-KINETIC MIXING FOR PHARMACEUTICAL APPLICATIONS 审中-公开
公开(公告)号：US20230172949A1
公开(公告)日：2023-06-08
申请号：US17814567
申请日：2022-07-25
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , AustinPx, LLC
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61K9/14 , A61K9/16 , A61K9/20 , A61J3/00 , A61J3/07 , A61J3/10 , A61K31/343 , A61K31/496 , A61K47/32 , A61K47/38
CPC分类号： A61K31/573 , A61K9/146 , A61K9/1694 , A61K9/2077 , A61J3/00 , A61J3/07 , A61J3/10 , A61K31/343 , A61K31/496 , A61K47/32 , A61K47/38
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

2. 发明申请

US20160250230A1 THERMO-KINETIC MIXING FOR PHARMACEUTICAL APPLICATIONS 审中-公开
标题翻译：用于药物应用的热动力学混合
公开(公告)号：US20160250230A1
公开(公告)日：2016-09-01
申请号：US15154083
申请日：2016-05-13
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , DISPERSOL TECHNOLOGIES, LLC
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61J3/10 , A61K47/32 , A61K31/496 , A61K31/343 , A61J3/07 , A61K47/38
CPC分类号： A61K31/573 , A61J3/00 , A61J3/07 , A61J3/10 , A61K9/146 , A61K9/1694 , A61K9/2077 , A61K31/343 , A61K31/496 , A61K47/32 , A61K47/38
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
摘要翻译：用于制备药物剂型的组合物和方法包括制备药物组合物，其包含一种或多种活性药物成分（API）与一种或多种药学上可接受的赋形剂，通过热动力学复合制成复合材料。将包含一种或多种API的复合材料与一种或多种赋形剂预处理的组合物和方法包括热动力学复合，其包括将所述API与所述赋形剂的热机械加工成复合材料，其中所述复合材料可以通过本领域已知的常规方法进一步加工，热熔挤出，熔融造粒，压缩成型，片剂压缩，胶囊填充，薄膜包衣或注塑成型。

3. 发明申请

US20200261473A1 THERMO-KINETIC MIXING FOR PHARMACEUTICAL APPLICATIONS 审中-公开
公开(公告)号：US20200261473A1
公开(公告)日：2020-08-20
申请号：US16866676
申请日：2020-05-05
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , DISPERSOL TECHNOLOGIES, LLC
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61K47/38 , A61K47/32 , A61K31/496 , A61K31/343 , A61J3/10 , A61J3/07 , A61J3/00 , A61K9/20 , A61K9/16 , A61K9/14
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can he further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

4. 发明申请

US20180360850A1 THERMO-KINETIC MIXING FOR PHARMACEUTICAL APPLICATIONS 审中-公开
公开(公告)号：US20180360850A1
公开(公告)日：2018-12-20
申请号：US16012025
申请日：2018-06-19
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , DISPERSOL TECHNOLOGIES, LLC
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61K9/16 , A61K9/20 , A61K9/14 , A61J3/10 , A61K47/32 , A61K31/496 , A61K31/343 , A61J3/00 , A61K47/38 , A61J3/07
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

5. 发明申请

US20160101057A1 HOT-MELT EXTRUSION OF MODIFIED RELEASE MULTI-PARTICULATES 审中-公开
标题翻译：改性释放多颗粒的热熔胶挤出
公开(公告)号：US20160101057A1
公开(公告)日：2016-04-14
申请号：US14873176
申请日：2015-10-01
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： James W. MCGINITY , Sandra U. SCHILLING
IPC分类号： A61K9/20 , A61K31/522 , A61K9/16
CPC分类号： A61K9/2077 , A61K9/1641 , A61K9/1694 , A61K9/2081 , A61K31/522 , B29C47/00 , B29C47/0014 , B29K2105/0035
摘要： The present invention includes compositions and methods of making a modified release pharmaceutical formulation and a method of preparation for the embedding of modified release multi-particulates into a polymeric or wax-like matrix. The modified release multi-particulates comprise an effective amount of a therapeutic compound having a known or desired drug-release profile. Modified release multi-particulates may include a polymeric coat or may be incorporated into particle or core material. The polymer matrix comprises a thermoplastic polymer or lipophilic carrier or a mixture thereof that softens or melts at elevated temperature and allows the distribution of the modified release multi-particulates in the polymer matrix during thermal processing. Formulation compounds and processing conditions are selected in a manner to preserve the controlled release characteristics and/or drug-protective properties of the original modified release multi-particulates.
摘要翻译：本发明包括制备改性释放药物制剂的组合物和方法以及将改性释放多颗粒包埋在聚合物或蜡状基质中的制备方法。改性释放多颗粒包含有效量的具有已知或期望的药物释放曲线的治疗化合物。改性释放多颗粒可以包括聚合物涂层或可以结合到颗粒或芯材料中。聚合物基质包括在高温下软化或熔化的热塑性聚合物或亲脂性载体或其混合物，并且允许在热加工期间将改性释放多颗粒分布在聚合物基质中。选择配制化合物和加工条件以保持原来的改性释放多颗粒的控制释放特性和/或药物保护性质。

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