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1. 发明授权

US09649388B2 Magnetic nanoparticle-samirna complex and method for preparing same 有权
公开(公告)号：US09649388B2
公开(公告)日：2017-05-16
申请号：US14372211
申请日：2013-01-17
申请人： BIONEER CORPORATION
发明人： Jeiwook Chae , Hyunjin Chung , Boreum Lee , Han Oh Park
IPC分类号： A61K47/48 , C12N15/11 , A61K49/18 , A61K9/14 , A61K31/7105 , A61K9/51 , A61K31/713 , A61K33/24 , A61K9/50
CPC分类号： A61K47/48015 , A61K9/14 , A61K9/5094 , A61K9/5115 , A61K31/7105 , A61K31/713 , A61K33/24 , A61K47/6923 , A61K49/1857 , C12N15/11 , A61K2300/00
摘要： Provided are a SAMiRNA-magnetic nanoparticle complex capable of effectively delivering a double-stranded oligo RNA and magnetic nanoparticles into a cell and a composition capable of simultaneously performing diagnosis and therapy of diseases such as cancer, and the like, containing the same. More specifically, provided is the SAMiRNA-magnetic nanoparticle complex consisting of double-stranded oligo RNA-polymer structures in which a hydrophilic material and a second hydrophobic material are bound to the double-stranded oligo RNA by a simple covalent bond or a linker-mediated covalent bond, and the magnetic nanoparticles in which a first hydrophobic material is bound onto a surface of the magnetic material, as a core.The SAMiRNA-magnetic nanoparticle complex may have a homogeneous size by a hydrophobic interaction between the first hydrophobic material of the present invention and the second hydrophobic material of the double-stranded oligo RNA structure.In addition, the hydrophilic material and the second hydrophobic material bound to the double-stranded oligo RNA structure may improve in vivo stability of the double-stranded oligo RNA, an additionally bound ligand may deliver the SAMiRNA-magnetic nanoparticle complex into a target cell even at a relative low concentration of dosage, and the magnetic materials of the magnetic nanoparticles may be used as an imaging agent for diagnosis.

2. 发明申请

US20150056145A1 MAGNETIC NANOPARTICLE-SAMIRNA COMPLEX AND METHOD FOR PREPARING SAME 有权
标题翻译：磁性纳米材料 - SAMIRNA复合物及其制备方法
公开(公告)号：US20150056145A1
公开(公告)日：2015-02-26
申请号：US14372211
申请日：2013-01-17
申请人： BIONEER CORPORATION
发明人： Jeiwook Chae , Hyunjin Chung , Boreum Lee , Han Oh Park
IPC分类号： A61K47/48 , C12N15/11 , A61K49/18 , A61K9/14
CPC分类号： A61K47/48015 , A61K9/14 , A61K9/5094 , A61K9/5115 , A61K31/7105 , A61K31/713 , A61K33/24 , A61K47/6923 , A61K49/1857 , C12N15/11 , A61K2300/00
摘要： Provided are a SAMiRNA-magnetic nanoparticle complex capable of effectively delivering a double-stranded oligo RNA and magnetic nanoparticles into a cell and a composition capable of simultaneously performing diagnosis and therapy of diseases such as cancer, and the like, containing the same. More specifically, provided is the SAMiRNA-magnetic nanoparticle complex consisting of double-stranded oligo RNA-polymer structures in which a hydrophilic material and a second hydrophobic material are bound to the double-stranded oligo RNA by a simple covalent bond or a linker-mediated covalent bond, and the magnetic nanoparticles in which a first hydrophobic material is bound onto a surface of the magnetic material, as a core.The SAMiRNA-magnetic nanoparticle complex may have a homogeneous size by a hydrophobic interaction between the first hydrophobic material of the present invention and the second hydrophobic material of the double-stranded oligo RNA structure.In addition, the hydrophilic material and the second hydrophobic material bound to the double-stranded oligo RNA structure may improve in vivo stability of the double-stranded oligo RNA, an additionally bound ligand may deliver the SAMiRNA-magnetic nanoparticle complex into a target cell even at a relative low concentration of dosage, and the magnetic materials of the magnetic nanoparticles may be used as an imaging agent for diagnosis.
摘要翻译：提供了能够有效地将双链寡RNA和磁性纳米颗粒递送到细胞中的SAMiRNA-磁性纳米颗粒复合物，以及能够同时进行包含其的癌症等疾病的诊断和治疗的组合物。更具体地，提供了由双链寡聚RNA结构组成的SAMiRNA-磁性纳米颗粒复合物，其中亲水性材料和第二疏水性材料通过简单的共价键或连接体介导的结合到双链寡聚RNA上共价键和其中第一疏水性材料结合到磁性材料的表面上的磁性纳米粒子作为核心。 SAMiRNA磁性纳米颗粒复合物可以通过本发明的第一疏水性材料与双链寡聚RNA结构的第二疏水性材料之间的疏水相互作用而具有均匀的尺寸。此外，与双链寡聚RNA结构结合的亲水性材料和第二疏水性材料可以提高双链寡聚RNA的体内稳定性，附加结合的配体可以将SAMiRNA-磁性纳米颗粒复合体均匀地递送到靶细胞中在相对低的剂量浓度下，磁性纳米颗粒的磁性材料可以用作诊断的显像剂。

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