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1. 发明授权

US11578367B2 Diagnosis of sepsis 有权
公开(公告)号：US11578367B2
公开(公告)日：2023-02-14
申请号：US16596481
申请日：2019-10-08
申请人： Becton, Dickinson and Company
发明人： James A. Garrett , Sha-Sha Wang , Keith Thornton , Richard L. Moore , William Keating , William A. Nussbaumer , Craig C. Whiteford
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6883 , G01N33/68 , G01N33/569 , C12Q1/6888
摘要： Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

2. 发明申请

US20220372554A1 METHODS AND COMPOSITIONS FOR DIRECT CHEMICAL LYSIS 有权
公开(公告)号：US20220372554A1
公开(公告)日：2022-11-24
申请号：US17883403
申请日：2022-08-08
申请人： Becton, Dickinson and Company
发明人： Feng Yang , Sha-Sha Wang , Laurence Michael Vaughan , Michael Porter , Elaine Rose
IPC分类号： C12Q1/6806 , C12N1/06 , C12Q1/70 , G01N33/569
摘要： A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.

3. 发明申请

US20210087632A1 DIAGNOSIS OF SEPSIS 有权
公开(公告)号：US20210087632A1
公开(公告)日：2021-03-25
申请号：US16596481
申请日：2019-10-08
申请人： Becton, Dickinson and Company
发明人： James A. Garrett , Sha-Sha Wang , Keith Thornton , Richard L. Moore , William Keating , William A. Nussbaumer , Craig C. Whiteford
IPC分类号： C12Q1/6883 , G01N33/68 , G01N33/569 , C12Q1/6888
摘要： Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

4. 发明授权

US10443099B2 Diagnosis of sepsis 有权
公开(公告)号：US10443099B2
公开(公告)日：2019-10-15
申请号：US14850933
申请日：2015-09-10
申请人： Becton, Dickinson and Company
发明人： James A. Garrett , Sha-Sha Wang , Keith Thornton , Richard L. Moore , William Keating , William A. Nussbaumer , Craig C. Whiteford
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6883 , G01N33/569 , G01N33/68 , C12Q1/6888
摘要： Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

5. 发明申请

US20160168638A1 DIAGNOSIS OF SEPSIS 审中-公开
标题翻译： SEPSIS诊断
公开(公告)号：US20160168638A1
公开(公告)日：2016-06-16
申请号：US14850933
申请日：2015-09-10
申请人： Becton, Dickinson and Company
发明人： James A. Garrett , Sha-Sha Wang , Keith Thornton , Richard L. Moore , William Keating , William A. Nussbaumer , Craig C. Whiteford
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： C12Q1/6883 , C12Q1/6888 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N33/56911 , G01N33/6893 , G01N2333/5412 , G01N2333/5421 , G01N2800/26 , G01N2800/50
摘要： Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.
摘要翻译：提供了预防脓毒症风险发生的患者脓毒症发展的方法。在一种方法中，评估受试者的生物标志物特征中的特征。如果这些特征满足特定的值集合，主体可能会发展为败血症。提供了预防脓毒症发展阶段脓毒症发展阶段发展的方法。在一种方法中，评估受试者的生物标志物轮廓中的多个特征。如果这些特征值满足特定的值集合，受试者可能具有脓毒症的阶段。提供诊断受试者败血症的方法。在一种这样的方法中，评估对象的生物标志物轮廓中的多个特征。当多个特征满足特定值集合时，受试者可能发展为败血症。

6. 发明授权

US09499858B2 Immuno-amplification 有权
公开(公告)号：US09499858B2
公开(公告)日：2016-11-22
申请号：US13739378
申请日：2013-01-11
申请人： Becton, Dickinson and Company
发明人： James G. Nadeau , Tobin Hellyer , Dolores M. Berger , William Nussbaumer , Robert Rosenstein , Andrew Kuhn , Sha-Sha Wang , Keith Edward Thornton
IPC分类号： C07H21/02 , C07H21/04 , C07H21/00 , C12Q1/68 , G01N33/53 , C12P19/34 , A61K39/00 , A61K39/38 , A61K38/00 , C07K1/00
CPC分类号： C12Q1/6804 , C12Q1/6851
摘要： A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.

7. 发明申请

US20150152473A1 IMMUNO-AMPLIFICATION 有权
标题翻译：免疫放大
公开(公告)号：US20150152473A1
公开(公告)日：2015-06-04
申请号：US13739378
申请日：2013-01-11
申请人： Becton, Dickinson and Company
发明人： James G. Nadeau , Tobin Hellyer , Dolores M. Berger , William Nussbaumer , Robert Rosenstein , Andrew Kuhn , Sha-Sha Wang , Keith Edward Thornton
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , C12Q1/6851
摘要： A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.
摘要翻译：提供了高灵敏度，低背景的免疫扩增测定法，其提供流线型工作流程，适用于临床相关样品如血液和其他体液的高通量测定。该测定包括使用两个邻近成员，每个邻近成员包含与寡核苷酸缀合的分析物特异性结合成分。结合分析物使邻近成员的寡核苷酸部分充分紧密接触，使寡核苷酸形成扩增子。然后通过扩增扩增子和扩增核酸的检测来检测分析物的存在。通过防止与分析物不复合的邻近成员形成假的或非特异性的扩增子来提高本发明的测定的灵敏度。

8. 发明公开

US20240060132A1 DIAGNOSIS OF SEPSIS 审中-公开
公开(公告)号：US20240060132A1
公开(公告)日：2024-02-22
申请号：US18168517
申请日：2023-02-13
申请人： Becton, Dickinson and Company
发明人： James A. Garrett , Sha-Sha Wang , Keith Thornton , Richard L. Moore , William Keating , William A. Nussbaumer , Craig C. Whiteford
IPC分类号： C12Q1/6883 , G01N33/68 , G01N33/569 , C12Q1/6888
CPC分类号： C12Q1/6883 , G01N33/6893 , G01N33/56911 , C12Q1/6888 , G01N2800/26 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N2333/5412 , G01N2333/5421 , G01N2800/50
摘要： Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

9. 发明授权

US11434519B2 Methods and compositions for direct chemical lysis 有权
公开(公告)号：US11434519B2
公开(公告)日：2022-09-06
申请号：US16399305
申请日：2019-04-30
申请人： BECTON DICKINSON AND COMPANY
发明人： Feng Yang , Sha-Sha Wang , Laurence Michael Vaughan , Michael Porter , Elaine Rose
IPC分类号： C12Q1/68 , C12N1/06 , C12Q1/70 , C12Q1/6806 , G01N33/569
摘要： A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.

10. 发明申请

US20190256893A1 METHODS AND COMPOSITIONS FOR DIRECT CHEMICAL LYSIS 审中-公开
公开(公告)号：US20190256893A1
公开(公告)日：2019-08-22
申请号：US16399305
申请日：2019-04-30
申请人： BECTON DICKINSON AND COMPANY
发明人： Feng Yang , Sha-Sha Wang , Laurence Michael Vaughan , Michael Porter , Elaine Rose
IPC分类号： C12Q1/6806 , G01N33/569 , C12N1/06 , C12Q1/70
摘要： A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.

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