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1. 发明申请

US20210163975A1 OILS, LIPIDS AND FATTY ACIDS PRODUCED IN TRANSGENIC BRASSICA PLANT 有权
公开(公告)号：US20210163975A1
公开(公告)日：2021-06-03
申请号：US17085135
申请日：2020-10-30
申请人： BASF PLANT SCIENCE GMBH
发明人： Petra Cirpus , Joerg Bauer , Xiao Qiu , Guohai Wu , Bifang Cheng , Martin Truksa , Tom Wetjen
IPC分类号： C12N15/82 , C12N9/02 , C12N9/10 , C12N15/52 , C12P7/64
摘要： The invention relates to a method for producing eicosapentanoic acid, docosapentanoic acid and/or docohexanoic acid in transgenic plants. According to said method, the plant is provided with at least one nucleic acid sequence coding for a polypetide with a Δ6 desaturase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ6 elongase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ5 desaturase activity, and at least one nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity, the nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity being modified in relation to the nucleic acid sequence in the organism from which the sequence originates, such that it is adapted to the codon use in at least one type of plant. For the production of docosahexanoic acid, at least one nucleic acid sequence coding for a polypeptide with a Δ4 desaturase activity is also introduced into the plant.

2. 发明申请

US20160369290A1 METHOD FOR PRODUCING POLYUNSATURATED FATTY ACIDS 审中-公开
标题翻译：生产聚氨酯脂肪酸的方法
公开(公告)号：US20160369290A1
公开(公告)日：2016-12-22
申请号：US15256914
申请日：2016-09-06
申请人： BASF Plant Science GmbH
发明人： Petra Cirpus , Jörg Bauer , Xiao Qiu , Guohai Wu , Bifang Cheng , Martin Truksa , Tom Wetjen
IPC分类号： C12N15/82 , C12P7/64 , C12N15/52 , C12N9/02
CPC分类号： C12N15/8247 , C12N9/0071 , C12N9/0083 , C12N9/1029 , C12N15/52 , C12P7/6427 , C12Y114/19
摘要： The invention relates to a method for producing eicosapentanoic acid, docosapentanoic acid and/or docohexanoic acid in transgenic plants. According to said method, the plant is provided with at least one nucleic acid sequence coding for a polypetide with a Δ6 desaturase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ6 elongase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ5 desaturase activity, and at least one nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity, the nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity being modified in relation to the nucleic acid sequence in the organism from which the sequence originates, such that it is adapted to the codon use in at least one type of plant. For the production of docosahexanoic acid, at least one nucleic acid sequence coding for a polypeptide with a Δ4 desaturase activity is also introduced into the plant.
摘要翻译：本发明涉及在转基因植物中生产二十烷酸，二十二烷酸和/或二十二酸的方法。根据所述方法，向植物提供编码具有Δ6去饱和酶活性的多肽的至少一种核酸序列，至少一种编码具有Δ6延伸酶活性的多肽的核酸序列，至少一种编码具有Δ5去饱和酶活性的多肽和编码具有Δ5延伸酶活性的多肽的至少一种核酸序列，编码具有相对于生物体中的核酸序列修饰的Δ5延伸酶活性的多肽的核酸序列序列来自该序列，使得其适于在至少一种类型的植物中的密码子使用。为了生产二十二碳六烯酸，还将至少一种编码具有Δ4去饱和酶活性的多肽的核酸序列引入植物中。

3. 发明授权

US10533182B2 Oils, lipids and fatty acids produced in transgenic brassica plant 有权
公开(公告)号：US10533182B2
公开(公告)日：2020-01-14
申请号：US16371451
申请日：2019-04-01
申请人： BASF Plant Science GmbH
发明人： Petra Cirpus , Jörg Bauer , Xiao Qiu , Guohai Wu , Bifang Cheng , Martin Truksa , Tom Wetjen
IPC分类号： A61K31/20 , C12N15/82 , C12N9/02 , C12N9/10 , C12N15/52 , C12P7/64
摘要： The invention relates to a method for producing eicosapentanoic acid, docosapentanoic acid and/or docohexanoic acid in transgenic plants. According to said method, the plant is provided with at least one nucleic acid sequence coding for a polypeptide with a Δ6 desaturase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ6 elongase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ5 desaturase activity, and at least one nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity, the nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity being modified in relation to the nucleic acid sequence in the organism from which the sequence originates, such that it is adapted to the codon use in at least one type of plant. For the production of docosahexanoic acid, at least one nucleic acid sequence coding for a polypeptide with a Δ4 desaturase activity is also introduced into the plant.

4. 发明授权

US10301638B2 Oils, lipids and fatty acids produced in transgenic Brassica plant 有权
公开(公告)号：US10301638B2
公开(公告)日：2019-05-28
申请号：US15256914
申请日：2016-09-06
申请人： BASF Plant Science GmbH
发明人： Petra Cirpus , Jörg Bauer , Xiao Qiu , Guohai Wu , Bifang Cheng , Martin Truksa , Tom Wetjen
IPC分类号： A61K31/20 , C12N15/82 , C12N9/02 , C12N9/10 , C12N15/52 , C12P7/64
摘要： The invention relates to a method for producing eicosapentaenoic acid, docosapentaenoic acid and/or docohexanoic acid in transgenic plants. According to said method, the plant is provided with at least one nucleic acid sequence coding for a polypeptide with a Δ6 desaturase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ6 elongase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ5 desaturase activity, and at least one nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity, the nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity being modified in relation to the nucleic acid sequence in the organism from which the sequence originates, such that it is adapted to the codon use in at least one type of plant. For the production of docosahexanoic acid, at least one nucleic acid sequence coding for a polypeptide with a Δ4 desaturase activity is also introduced into the plant.

5. 发明授权

US10113189B2 Isolation and characterization of a novel pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains 有权
公开(公告)号：US10113189B2
公开(公告)日：2018-10-30
申请号：US14684682
申请日：2015-04-13
申请人： BASF Plant Science GmbH , Bioriginal Food & Science Corp.
发明人： Jörg Bauer , Guohai Wu , Xiao Qiu
IPC分类号： C12P7/64 , C12N15/82 , C12N9/02 , C12N15/52 , C12N9/04 , A61K8/92 , A61K31/202 , A61K8/64 , A61Q19/00
摘要： The present invention relates to a polynucleotide encoding an omega 3 (ω-3) desaturase from Pythium irregulare with specificity to long chain polyunsaturated omega 6 (ω-6) fatty acids as well as a vector containing the polynucleotide, and a host cell containing the vector or the polynucleotide. Moreover, the present invention pertains to a polypeptide encoded by the polynucleotide, antibodies against the polypeptide as well as a method for the manufacture of the polypeptide. Further, encompassed by the present invention are transgenic non-human organisms. Finally, the present invention relates to methods for the manufacture of compounds and oil-fatty acid-, or lipid-containing compositions.

6. 发明授权

US10035989B2 Method for producing polyunsaturated fatty acids in transgenic plants 有权
公开(公告)号：US10035989B2
公开(公告)日：2018-07-31
申请号：US14823253
申请日：2015-08-11
申请人： BASF Plant Science GmbH
发明人： Petra Cirpus , Jörg Bauer , Xiao Qiu , Guohai Wu , Nagamani Datla
IPC分类号： C12N15/82 , C12N9/02 , A23D9/00 , A61K8/92 , A61Q19/00 , C12N9/10 , A61K8/36 , A61K31/202
CPC分类号： C12N9/0071 , A23D9/00 , A61K8/361 , A61K8/922 , A61K31/202 , A61K2800/86 , A61Q19/00 , C12N9/0083 , C12N9/1029 , C12N15/8247 , C12Y114/19
摘要： The present invention relates to a process for the production of polyunsaturated fatty acids in the seed of transgenic plants by introducing, into the organism, nucleic acids which encode polypeptides with a ω3-desaturase, Δ12-desaturase, Δ6-desaturase, Δ6-elongase, Δ5-desaturase, Δ5-elongase and/or Δ4-desaturase activity. The invention furthermore relates to recombinant nucleic acid molecules comprising the nucleic acid sequences which encode the aforementioned polypeptides, either jointly or individually, and transgenic plants which comprise the aforementioned recombinant nucleic acid molecules. Furthermore, the invention relates to the generation of a transgenic plant and to oils, lipids and/or fatty acids with an elevated content of polyunsaturated fatty acids, in particular arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid, as the result of the expression of the elongases and desaturases used in the process according to the invention.

7. 发明申请

US20220213497A1 Oils, Lipids and Fatty Acids Produced in Transgenic Brassica Plant 有权
公开(公告)号：US20220213497A1
公开(公告)日：2022-07-07
申请号：US17571091
申请日：2022-01-07
申请人： BASF Plant Science GMBH
发明人： Petra Cirpus , Jorg Bauer , Xiao Qiu , Guohai Wu , Bifang Cheng , Martin Truksa , Tom Wetjen
IPC分类号： C12N15/82 , C12N9/02 , C12N9/10 , C12N15/52 , C12P7/6427
摘要： The invention relates to a method for producing eicosapentanoic acid, docosapentanoic acid and/or docohexanoic acid in transgenic plants. According to said method, the plant is provided with at least one nucleic acid sequence coding for a polypetide with a Δ6 desaturase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ6 elongase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ5 desaturase activity, and at least one nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity, the nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity being modified in relation to the nucleic acid sequence in the organism from which the sequence originates, such that it is adapted to the codon use in at least one type of plant. For the production of docosahexanoic acid, at least one nucleic acid sequence coding for a polypeptide with a Δ4 desaturase activity is also introduced into the plant.

8. 发明授权

US10533183B2 Oils, lipids and fatty acids produced in transgenic Brassica plant 有权
公开(公告)号：US10533183B2
公开(公告)日：2020-01-14
申请号：US16371837
申请日：2019-04-01
申请人： BASF Plant Science GmbH
发明人： Petra Cirpus , Jörg Bauer , Xiao Qiu , Guohai Wu , Bifang Cheng , Martin Truksa , Tom Wetjen
IPC分类号： A61K31/20 , C12N15/82 , C12N9/02 , C12N9/10 , C12N15/52 , C12P7/64
摘要： The invention relates to a method for producing eicosapentanoic acid, docosapentanoic acid and/or docohexanoic acid in transgenic plants. According to said method, the plant is provided with at least one nucleic acid sequence coding for a polypeptide with a Δ6 desaturase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ6 elongase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ5 desaturase activity, and at least one nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity, the nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity being modified in relation to the nucleic acid sequence in the organism from which the sequence originates, such that it is adapted to the codon use in at least one type of plant. For the production of docosahexanoic acid, at least one nucleic acid sequence coding for a polypeptide with a Δ4 desaturase activity is also introduced into the plant.

9. 发明申请

US20150361404A1 METHOD FOR PRODUCING POLYUNSATURATED FATTY ACIDS IN TRANSGENIC PLANTS 审中-公开
标题翻译：在转基因植物中生产聚氨酯脂肪酸的方法
公开(公告)号：US20150361404A1
公开(公告)日：2015-12-17
申请号：US14823253
申请日：2015-08-11
申请人： BASF Plant Science GmbH
发明人： Petra Cirpus , Jörg Bauer , Xiao Qiu , Guohai Wu , Nagamani Datla
IPC分类号： C12N9/02 , A23D9/00 , A61K31/202 , C12N15/82 , A61K8/36
CPC分类号： C12N9/0071 , A23D9/00 , A61K8/361 , A61K8/922 , A61K31/202 , A61K2800/86 , A61Q19/00 , C12N9/0083 , C12N9/1029 , C12N15/8247 , C12Y114/19
摘要： The present invention relates to a process for the production of polyunsaturated fatty acids in the seed of transgenic plants by introducing, into the organism, nucleic acids which encode polypeptides with a ω3-desaturase, Δ12-desaturase, Δ6-desaturase, Δ6-elongase, Δ5-desaturase, Δ5-elongase and/or Δ4-desaturase activity. The invention furthermore relates to recombinant nucleic acid molecules comprising the nucleic acid sequences which encode the aforementioned polypeptides, either jointly or individually, and transgenic plants which comprise the aforementioned recombinant nucleic acid molecules. Furthermore, the invention relates to the generation of a transgenic plant and to oils, lipids and/or fatty acids with an elevated content of polyunsaturated fatty acids, in particular arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid, as the result of the expression of the elongases and desaturases used in the process according to the invention.
摘要翻译：本发明涉及一种在转基因植物种子中生产多不饱和脂肪酸的方法，其通过向生物体中引入用ω3-去饱和酶，D-去饱和酶，6-去饱和酶，＆Dgr; 6-延伸酶，＆Dgr; 5-去饱和酶，＆Dgr; 5-延伸酶和/或＆Dgr; 4-去饱和酶活性。本发明还涉及包含共同或单独编码前述多肽的核酸序列的重组核酸分子以及包含上述重组核酸分子的转基因植物。此外，本发明涉及转基因植物的产生以及具有升高的多不饱和脂肪酸含量的油，脂和/或脂肪酸，特别是花生四烯酸，二十碳五烯酸和/或二十二碳六烯酸，作为表达的结果的根据本发明的方法中使用的延伸酶和去饱和酶。

10. 发明申请

US20150211032A1 ISOLATION AND CHARACTERIZATION OF A NOVEL PYTHIUM OMEGA 3 DESATURASE WITH SPECIFICITY TO ALL OMEGA 6 FATTY ACIDS LONGER THAN 18 CARBON CHAINS 审中-公开
标题翻译：一个新的磷酸三钙脱硫剂的分离和表征对所有欧米茄6脂肪酸长18个碳链具有特异性
公开(公告)号：US20150211032A1
公开(公告)日：2015-07-30
申请号：US14684682
申请日：2015-04-13
申请人： BASF Plant Science GmbH , Bioriginal Food & Science Corp.
发明人： Jörg Bauer , Guohai Wu , Xiao Qiu
IPC分类号： C12P7/64 , A61K31/202 , A23K1/16 , A61K8/92
CPC分类号： C12P7/6472 , A61K8/64 , A61K8/922 , A61K31/202 , A61K2800/10 , A61Q19/00 , C12N9/0006 , C12N9/0083 , C12N9/0093 , C12N15/52 , C12P7/6427 , C12P7/6436
摘要： The present invention relates to a polynucleotide encoding an omega 3 (ω-3) desaturase from Pythium irregulare with specificity to long chain polyunsaturated omega 6 (ω-6) fatty acids as well as a vector containing the polynucleotide, and a host cell containing the vector or the polynucleotide. Moreover, the present invention pertains to a polypeptide encoded by the polynucleotide, antibodies against the polypeptide as well as a method for the manufacture of the polypeptide. Further, encompassed by the present invention are transgenic non-human organisms. Finally, the present invention relates to methods for the manufacture of compounds and oil- fatty acid-, or lipid-containing compositions.
摘要翻译：本发明涉及编码具有对长链多不饱和ω-6（ω-6）脂肪酸的特异性的非腐霉菌的ω3（ω-3）去饱和酶的多核苷酸以及含有该多核苷酸的载体，以及含有载体或多核苷酸。此外，本发明涉及由多核苷酸编码的多肽，针对多肽的抗体以及制备多肽的方法。此外，本发明包括转基因非人生物体。最后，本发明涉及制备化合物和油 - 脂肪酸或含脂质组合物的方法。

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