专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090062226A1 Method and Compositions for Inhibiting MAGE Protein Interaction With KAP-1 有权
标题翻译：用KAP-1抑制MAGE蛋白相互作用的方法和组合物
公开(公告)号：US20090062226A1
公开(公告)日：2009-03-05
申请号：US11956177
申请日：2007-12-13
申请人： B. Jack Longley , Bing Yang , Jianqiang Wu , Yongsheng Ma
发明人： B. Jack Longley , Bing Yang , Jianqiang Wu , Yongsheng Ma
IPC分类号： A61K31/7105 , C12N5/06 , G01N33/53 , C12Q1/68 , A61P35/00 , A61P15/00
CPC分类号： C12N15/113 , C07K16/30 , C12N2310/11 , C12N2310/14 , C12N2310/3515
摘要： Method for inhibiting tumor cell formation or tumor cell growth, and method for inducing apoptosis in sperms, the method comprising administering to a patient in need thereof an antagonist that inhibits the binding of MAGE protein to KAP-1, thereby inhibiting MAGE gene function. Also disclosed are pharmaceutical compositions comprising the same, and method for screening a substance that inhibits MAGE protein binding to KAP-1.
摘要翻译：用于抑制肿瘤细胞形成或肿瘤细胞生长的方法，以及诱导精子凋亡的方法，所述方法包括向有需要的患者施用抑制MAGE蛋白与KAP-1结合从而抑制MAGE基因功能的拮抗剂。还公开了包含其的药物组合物和用于筛选抑制MAGE蛋白与KAP-1结合的物质的方法。

2. 发明授权

US07846909B2 Method and compositions for inhibiting MAGE protein interaction with KAP-1 有权
标题翻译：抑制MAGE蛋白与KAP-1相互作用的方法和组合物
公开(公告)号：US07846909B2
公开(公告)日：2010-12-07
申请号：US11956177
申请日：2007-12-13
申请人： B. Jack Longley , Bing Yang , Jianqiang Wu , Yongsheng Ma
发明人： B. Jack Longley , Bing Yang , Jianqiang Wu , Yongsheng Ma
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/113 , C07K16/30 , C12N2310/11 , C12N2310/14 , C12N2310/3515
摘要： Method for inhibiting tumor cell formation or tumor cell growth, and method for inducing apoptosis in sperms, the method comprising administering to a patient in need thereof an antagonist that inhibits the binding of MAGE protein to KAP-1, thereby inhibiting MAGE gene function. Also disclosed are pharmaceutical compositions comprising the same, and method for screening a substance that inhibits MAGE protein binding to KAP-1.
摘要翻译：用于抑制肿瘤细胞形成或肿瘤细胞生长的方法，以及诱导精子凋亡的方法，所述方法包括向有需要的患者施用抑制MAGE蛋白与KAP-1结合从而抑制MAGE基因功能的拮抗剂。还公开了包含其的药物组合物和用于筛选抑制MAGE蛋白与KAP-1结合的物质的方法。

3. 发明申请

US20050265997A1 Cancer treatment method by inhibiting MAGE gene expression or function 审中-公开
标题翻译：通过抑制MAGE基因表达或功能的癌症治疗方法
公开(公告)号：US20050265997A1
公开(公告)日：2005-12-01
申请号：US11137415
申请日：2005-05-26
申请人： B. Jack Longley , Bing Yang
发明人： B. Jack Longley , Bing Yang
IPC分类号： A61K39/395 , A61K48/00 , C07K16/30 , C12N15/113
CPC分类号： C12N15/113 , C07K16/30 , C12N2310/14
摘要： Method for inhibiting tumor cell formation or tumor cell growth, and method for inducing apoptosis in sperms, the method comprising administering to a patient in need thereof an antagonist that inhibits MAGE gene expression or MAGE protein function. Preferably, the antagonist is an anti-MAGE antibody, an antisense molecule, an siRNA molecule, a molecule for forming a triplex nucleic acid molecule with a MAGE encoding polynucleotide, or a small molecule inhibitor of MAGE function. Also disclosed are pharmaceutical compositions comprising the same, and method for screening a substance that inhibits MAGE gene expression of MAGE protein function.
摘要翻译：用于抑制肿瘤细胞形成或肿瘤细胞生长的方法，以及诱导精子凋亡的方法，所述方法包括向有需要的患者施用抑制MAGE基因表达或MAGE蛋白功能的拮抗剂。优选地，拮抗剂是抗MAGE抗体，反义分子，siRNA分子，用MAGE编码多核苷酸形成三重核酸分子的分子或MAGE功能的小分子抑制剂。还公开了包含其的药物组合物和用于筛选抑制MAGE蛋白功能的MAGE基因表达的物质的方法。

4. 发明申请

US20120114575A1 METHODS FOR INHIBITING CUTANEOUS INFLAMMATION AND HYPERPIGMENTATION 失效
标题翻译：抑制胰腺炎症和高血压的方法
公开(公告)号：US20120114575A1
公开(公告)日：2012-05-10
申请号：US13048622
申请日：2011-03-15
申请人： B. Jack Longley
发明人： B. Jack Longley
IPC分类号： A61K8/64 , A61K8/60 , A61Q19/02
CPC分类号： C07K16/2803
摘要： This invention provides a method of preventing or treating in a subject contact dermatitis which comprises administering to the subject an amount of a compound capable of inhibiting the stem cell factor signaling pathway effective to prevent or treating contact dermatitis so as to thereby prevent or treat contact dermatitis in the subject. This invention also provides a method of preventing or treating in a subject hyperpigmentation, asthma, cutaneous inflammation, anaphylaxis and bronchospasm, mastocytosis, tumors which express activated kit, and conception.
摘要翻译：本发明提供一种预防或治疗受试者接触性皮炎的方法，其包括向受试者施用一定量的能够有效预防或治疗接触性皮炎的干细胞因子信号传导途径的化合物，从而预防或治疗接触性皮炎在主题。本发明还提供了预防或治疗受试者色素沉着过度，哮喘，皮肤炎症，过敏反应和支气管痉挛，肥大细胞增多症，表达活化试剂盒的肿瘤和受孕的方法。

5. 发明授权

US06989248B2 Methods of use of compounds which inhibit the stem cell signaling pathway 失效
标题翻译：抑制干细胞信号传导途径的化合物的使用方法
公开(公告)号：US06989248B2
公开(公告)日：2006-01-24
申请号：US09474478
申请日：1999-12-29
申请人： B. Jack Longley
发明人： B. Jack Longley
IPC分类号： C12N15/09
CPC分类号： C07K16/2803
摘要： This invention provides a method of preventing or treating in a subject contact dermatitis which comprises administering to the subject an amount of a compound capable of inhibiting the stem cell factor signaling pathway effective to prevent or treat contact dermatitis so as to thereby prevent or treat contact dermatitis in the subject. This invention also provides a methods of preventing or treating in a subject hyperpigmentation, asthma, cutaneous inflammation, anaphylaxis and bronchospasm, mastocytosis, tumors which express activated kit, and conception.
摘要翻译：本发明提供一种预防或治疗受试者接触性皮炎的方法，其包括向受试者施用一定量的能够抑制干细胞因子信号通路有效预防或治疗接触性皮炎的化合物，从而预防或治疗接触性皮炎在主题。本发明还提供了预防或治疗受试者色素沉着过度，哮喘，皮肤炎症，过敏反应和支气管痉挛，肥大细胞增多症，表达活化试剂盒的肿瘤和受孕的方法。

6. 发明授权

US06339100B1 Methods for inhibiting mastocytosis 失效
标题翻译：抑制肥大细胞增多症的方法
公开(公告)号：US06339100B1
公开(公告)日：2002-01-15
申请号：US09474474
申请日：1999-12-29
申请人： B. Jack Longley
发明人： B. Jack Longley
IPC分类号： A61K3140
CPC分类号： A61K31/496 , A61K31/404
摘要： A method of preventing or treating in a subject mastocytosis which comprises administering to the subject a therapeutically effective amount of a compound having the structure: or a pharmaceutically acceptable salt thereof so as to thereby prevent or treat mastocytosis in the subject.
摘要翻译：一种预防或治疗受试者肥大细胞增多症的方法，其包括向受试者施用治疗有效量的具有以下结构的化合物：或其药学上可接受的盐，从而预防或治疗受试者的肥大细胞增多症。

7. 发明授权

US08278067B2 Method for inhibiting hyperpigmentation 失效
标题翻译：抑制色素沉着的方法
公开(公告)号：US08278067B2
公开(公告)日：2012-10-02
申请号：US13048622
申请日：2011-03-15
申请人： B. Jack Longley
发明人： B. Jack Longley
IPC分类号： C12N15/09
CPC分类号： C07K16/2803
摘要： This invention provides a method of preventing or treating in a subject contact dermatitis which comprises administering to the subject an amount of a compound capable of inhibiting the stem cell factor signaling pathway effective to prevent or treating contact dermatitis so as to thereby prevent or treat contact dermatitis in the subject. This invention also provides a method of preventing or treating in a subject hyperpigmentation, asthma, cutaneous inflammation, anaphylaxis and bronchospasm, mastocytosis, tumors which express activated kit, and conception.
摘要翻译：本发明提供一种预防或治疗受试者接触性皮炎的方法，其包括向受试者施用一定量的能够有效预防或治疗接触性皮炎的干细胞因子信号传导途径的化合物，从而预防或治疗接触性皮炎在主题。本发明还提供了预防或治疗受试者色素沉着过度，哮喘，皮肤炎症，过敏反应和支气管痉挛，肥大细胞增多症，表达活化试剂盒的肿瘤和受孕的方法。

8. 发明申请

US20090136497A1 Methods for inhibiting cutaneous inflammation and hyperpigmentation 失效
标题翻译：抑制皮肤炎症和色素沉着的方法
公开(公告)号：US20090136497A1
公开(公告)日：2009-05-28
申请号：US12291462
申请日：2008-11-10
申请人： B. Jack Longley
发明人： B. Jack Longley
IPC分类号： A61K39/395 , A61K38/02 , A61K31/7052 , G01N33/00 , A61P29/00
CPC分类号： C07K16/2803
摘要： This invention provides a method of preventing or treating in a subject contact dermatitis which comprises administering to the subject an amount of a compound capable of inhibiting the stem cell factor signaling pathway effective to prevent or treat contact dermatitis so as to thereby prevent or treat contact dermatitis in the subject. This invention also provides a method of preventing or treating in a subject hyperpigmentation, asthma, cutaneous inflammation, anaphylaxis and bronchospasm, mastocytosis, tumors which express activated kit, and conception.
摘要翻译：本发明提供一种预防或治疗受试者接触性皮炎的方法，其包括向受试者施用一定量的能够抑制干细胞因子信号通路有效预防或治疗接触性皮炎的化合物，从而预防或治疗接触性皮炎在主题。本发明还提供了预防或治疗受试者色素沉着过度，哮喘，皮肤炎症，过敏反应和支气管痉挛，肥大细胞增多症，表达活化试剂盒的肿瘤和受孕的方法。

9. 发明授权

US07449309B2 Methods for desensitizing a subject to an agent 失效
标题翻译：使受试者脱敏的方法
公开(公告)号：US07449309B2
公开(公告)日：2008-11-11
申请号：US11314421
申请日：2005-12-20
申请人： B. Jack Longley
发明人： B. Jack Longley
IPC分类号： C12N15/09
CPC分类号： C07K16/2803
摘要： This invention provides a method of preventing or treating in a subject contact dermatitis which comprises administering to the subject an amount of a compound capable of inhibiting the stem cell factor signaling pathway effective to prevent or treat contact dermatitis so as to thereby prevent or treat contact dermatitis in the subject. This invention also provides a method of preventing or treating in a subject hyperpigmentation, asthma, cutaneous inflammation, anaphylaxis and bronchospasm, mastocytosis, tumors which express activated kit, and conception.
摘要翻译：本发明提供一种预防或治疗受试者接触性皮炎的方法，其包括向受试者施用一定量的能够抑制干细胞因子信号通路有效预防或治疗接触性皮炎的化合物，从而预防或治疗接触性皮炎在主题。本发明还提供了预防或治疗受试者色素沉着过度，哮喘，皮肤炎症，过敏反应和支气管痉挛，肥大细胞增多症，表达活化试剂盒的肿瘤和受孕的方法。

10. 发明授权

US07906302B2 Methods of preventing or treating contact dermatitis 失效
标题翻译：预防或治疗接触性皮炎的方法
公开(公告)号：US07906302B2
公开(公告)日：2011-03-15
申请号：US12291462
申请日：2008-11-10
申请人： B. Jack Longley
发明人： B. Jack Longley
IPC分类号： C12N15/09
CPC分类号： C07K16/2803
摘要： This invention provides a method of preventing or treating in a subject contact dermatitis which comprises administering to the subject an amount of a compound capable of inhibiting the stem cell factor signaling pathway effective to prevent or treat contact dermatitis so as to thereby prevent or treat contact dermatitis in the subject.
摘要翻译：本发明提供一种预防或治疗受试者接触性皮炎的方法，其包括向受试者施用一定量的能够抑制干细胞因子信号通路有效预防或治疗接触性皮炎的化合物，从而预防或治疗接触性皮炎在主题。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式