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1. 发明申请

US20050054560A1 Cd44 variants carrying heparan sulfate chains and uses thereof 审中-公开
标题翻译：携带硫酸乙酰肝素链的Cd44变体及其用途
公开(公告)号：US20050054560A1
公开(公告)日：2005-03-10
申请号：US10486226
申请日：2002-08-08
申请人： Avner Yayon , Shlomo Nedvetzki , David Naor , Itshak Golan
发明人： Avner Yayon , Shlomo Nedvetzki , David Naor , Itshak Golan
IPC分类号： A61K38/00 , C07K14/705 , A61K38/17 , A61K31/727
CPC分类号： C07K14/70585 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： Modulation of the activity of a heparin-binding growth factor (HBGF) by enhancing or inhibiting high affinity binding of said HBGF to its receptor, can be achieved with an agent selected from: (i) a soluble CD44 isoform carrying at least one chain of a heparan sulfate; (ii) a recombinant chimeric fusion protein comprising the amino acid sequence of a soluble CD44 isoform fused to a tag suitable for proteoglycan purification, said fusion molecule being post-translationally glycosylated to carry at least one chain of a heparan sulfate; and (iii) a sugar molecule being a heparan sulfate derived from a CD44 isoform, or a fragment thereof. The agents (i) and (ii) when the soluble CD44 isoform is the soluble CD44 variant expressed in synovial cells of rheumatoid arthritis patients (CD44vRA), and the heparan sulfate of (iii), are novel.
摘要翻译：通过增强或抑制所述HBGF与其受体的高亲和力结合来调节肝素结合生长因子（HBGF）的活性可以用选自以下的试剂来实现：（i）携带至少一条链的可溶性CD44亚型硫酸乙酰肝素; （ii）重组嵌合融合蛋白，其包含与适于蛋白多糖纯化的标签融合的可溶性CD44同种型的氨基酸序列，所述融合分子被翻译后糖基化以携带至少一种硫酸乙酰肝素链; 和（iii）衍生自CD44同种型的硫酸乙酰肝素的糖分子或其片段。当可溶性CD44同种型是在类风湿性关节炎患者（CD44vRA）的滑膜细胞中表达的可溶性CD44变体和（iii）的硫酸乙酰肝素时，试剂（i）和（ii）是新颖的。

2. 发明申请

US20110207678A1 CD44 POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME, ANTIBODIES DIRECTED THEREAGAINST AND METHOD OF USING SAME FOR DIAGNOSING AND TREATING INFLAMMATORY DISEASES 失效
标题翻译： CD44多肽，编码它们的多核苷酸，抗体，以及用于诊断和治疗炎症疾病的方法
公开(公告)号：US20110207678A1
公开(公告)日：2011-08-25
申请号：US13021807
申请日：2011-02-07
申请人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
发明人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
IPC分类号： A61K38/17 , C07K7/06 , C07K7/08 , C07K14/705 , A61K38/08 , A61K38/10 , A61P29/00
CPC分类号： C07K14/70585 , A61K38/00 , A61K2039/505 , C07K16/2884 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y10S435/81 , Y10S435/975
摘要： An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ID NO: 4 or 6.
摘要翻译：提供分离的多肽。分离的多肽包含能够特异性结合SEQ ID NO：2所示CD44多肽的抗原识别结构域，并且不能结合选自SEQ ID NO：4或6的CD44多肽。

3. 发明授权

US07534605B2 CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 失效
公开(公告)号：US07534605B2
公开(公告)日：2009-05-19
申请号：US11130206
申请日：2005-05-17
申请人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
发明人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
IPC分类号： C12N5/20 , C07K16/00 , C07K16/28 , A61K39/395
CPC分类号： C07K14/70585 , A61K38/00 , A61K2039/505 , C07K16/2884 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y10S435/81 , Y10S435/975
摘要： An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ID NO: 4 or 6.

4. 发明授权

US08193311B2 CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 失效
标题翻译： CD44多肽，编码它们的多核苷酸，针对其的抗体及其用于诊断和治疗炎性疾病的方法
公开(公告)号：US08193311B2
公开(公告)日：2012-06-05
申请号：US13021807
申请日：2011-02-07
申请人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
发明人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
IPC分类号： A61K38/04
CPC分类号： C07K14/70585 , A61K38/00 , A61K2039/505 , C07K16/2884 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y10S435/81 , Y10S435/975
摘要： An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ID NO: 4 or 6.
摘要翻译：提供分离的多肽。分离的多肽包含能够特异性结合SEQ ID NO：2所示的CD44多肽的抗原识别结构域，并且不能结合选自SEQ ID NO：4或6的CD44多肽。

5. 发明授权

US07883857B2 CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 失效
公开(公告)号：US07883857B2
公开(公告)日：2011-02-08
申请号：US12230899
申请日：2008-09-08
申请人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
发明人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
IPC分类号： G01N33/53 , C07K16/00 , C07K16/24 , A61K39/395
CPC分类号： C07K14/70585 , A61K38/00 , A61K2039/505 , C07K16/2884 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y10S435/81 , Y10S435/975
摘要： An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ID NO: 4 or 6.

6. 发明申请

US20090104202A1 CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 失效
标题翻译： CD44多肽，编码它们的多核苷酸，针对其的抗体及其用于诊断和治疗炎性疾病的方法
公开(公告)号：US20090104202A1
公开(公告)日：2009-04-23
申请号：US12230899
申请日：2008-09-08
申请人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
发明人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
IPC分类号： A61K39/395 , C07K14/00 , C07K16/18 , G01N33/566 , A61K39/00 , C40B30/04
CPC分类号： C07K14/70585 , A61K38/00 , A61K2039/505 , C07K16/2884 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y10S435/81 , Y10S435/975
摘要： An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ID NO: 4 or 6.
摘要翻译：提供分离的多肽。分离的多肽包含能够特异性结合SEQ ID NO：2所示的CD44多肽的抗原识别结构域，并且不能结合选自SEQ ID NO：4或6的CD44多肽。

7. 发明申请

US20090093053A1 CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 失效
公开(公告)号：US20090093053A1
公开(公告)日：2009-04-09
申请号：US12230900
申请日：2008-09-08
申请人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
发明人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
IPC分类号： C12N5/08 , C12N15/11 , C12N15/00
CPC分类号： C07K14/70585 , A61K38/00 , A61K2039/505 , C07K16/2884 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y10S435/81 , Y10S435/975
摘要： An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ID NO: 4 or 6.

8. 发明授权

US07901909B2 CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 失效
标题翻译： CD44多肽，编码它们的多核苷酸，针对其的抗体及其用于诊断和治疗炎性疾病的方法
公开(公告)号：US07901909B2
公开(公告)日：2011-03-08
申请号：US12230900
申请日：2008-09-08
申请人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
发明人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
IPC分类号： C07H21/04 , C12N15/00 , C12N1/20 , C12N5/02 , C12N15/87 , C12P21/06
CPC分类号： C07K14/70585 , A61K38/00 , A61K2039/505 , C07K16/2884 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y10S435/81 , Y10S435/975
摘要： An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ID NO: 4 or 6.
摘要翻译：提供分离的多肽。分离的多肽包含能够特异性结合SEQ ID NO：2所示的CD44多肽的抗原识别结构域，并且不能结合选自SEQ ID NO：4或6的CD44多肽。

9. 发明申请

US20060019340A1 CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 失效
公开(公告)号：US20060019340A1
公开(公告)日：2006-01-26
申请号：US11130206
申请日：2005-05-17
申请人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
发明人： David Naor , Shlomo Nedvetzki , Itshak Golan , Irina Kessel , Lora Melnik
IPC分类号： C12P21/06 , C07H21/02 , C12N5/06 , C07K16/28
CPC分类号： C07K14/70585 , A61K38/00 , A61K2039/505 , C07K16/2884 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y10S435/81 , Y10S435/975
摘要： An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ID NO: 4 or 6.

10. 发明申请

US20080139460A1 Binding agents for CD44 glycoproteins and methods of use 审中-公开
标题翻译： CD44糖蛋白的结合剂及其使用方法
公开(公告)号：US20080139460A1
公开(公告)日：2008-06-12
申请号：US11907893
申请日：2007-10-18
申请人： Lora Melnik , Itshak Golan , David Naor , Yehiel Zick
发明人： Lora Melnik , Itshak Golan , David Naor , Yehiel Zick
IPC分类号： A61K38/16 , A61P43/00
CPC分类号： A61K38/1709
摘要： The present invention is based on the finding that Gal-8 binds to carbohydrates of cell surface CD44std and CD44v and activates a chain of biological events within the cells. A specific effect exhibited was the induction of apoptosis in the CD44std and CD44v expressing cells.Thus, the present invention concerns the use of an active agent for achieving a therapeutic effect on a target cell, the therapeutic effect comprises binding of said active agent to a standard CD44 (CD44std) glycoprotein or to a CD44 variant (CD44v) expressed by said target cell, the active agent being galectin-8 (Gal-8) or a functional derivative thereof. The active ingredient may be used for the preparation of a pharmaceutical composition, for the treatment of a disease or a disorder or for diagnostic purposes.
摘要翻译：本发明基于Gal-8与细胞表面CD44std和CD44v的碳水化合物结合并激活细胞内生物学事件链的发现。具体表现为CD44std和CD44v表达细胞凋亡诱导。因此，本发明涉及活性剂用于实现对靶细胞的治疗作用的用途，治疗效果包括将所述活性剂与标准CD44（CD44std）糖蛋白或由所述的CD44（CD44std）糖蛋白表达的CD44变体（CD44v）的结合靶细胞，活性剂是半乳凝素-8（Gal-8）或其功能性衍生物。活性成分可用于制备药物组合物，用于治疗疾病或病症或用于诊断目的。

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