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1. 发明授权

US06206528B1 Surface figure control for coated optics 有权
标题翻译：涂层光学元件的表面图形控制
公开(公告)号：US06206528B1
公开(公告)日：2001-03-27
申请号：US09164413
申请日：1998-09-30
申请人： Avijit K. Ray-Chaudhuri , Paul A. Spence , Michael P. Kanouff
发明人： Avijit K. Ray-Chaudhuri , Paul A. Spence , Michael P. Kanouff
IPC分类号： G02B7182
CPC分类号： G03F7/70216 , G02B7/182 , G03F7/70825
摘要： A pedestal optical substrate that simultaneously provides high substrate dynamic stiffness, provides low surface figure sensitivity to mechanical mounting hardware inputs, and constrains surface figure changes caused by optical coatings to be primarily spherical in nature. The pedestal optical substrate includes a disk-like optic or substrate section having a top surface that is coated, a disk-like base section that provides location at which the substrate can be mounted, and a connecting cylindrical section between the base and optics or substrate sections. The optic section has an optical section thickness2/optical section diameter ratio of between about 5 to 10 mm, and a thickness variation between front and back surfaces of less than about 10%. The connecting cylindrical section may be attached via three spaced legs or members. However, the pedestal optical substrate can be manufactured from a solid piece of material to form a monolith, thus avoiding joints between the sections, or the disk-like base can be formed separately and connected to the connecting section. By way of example, the pedestal optical substrate may be utilized in the fabrication of optics for an extreme ultraviolet (EUV) lithography imaging system, or in any optical system requiring coated optics and substrates with reduced sensitivity to mechanical mounts.
摘要翻译：同时提供高基板动态刚度的基座光学基板，为机械安装硬件输入提供低的表面图灵敏度，并且将由光学涂层引起的表面图形变化限制为主要是球形的。基座光学基板包括具有被涂覆的顶表面的盘状光学元件或基板部分，提供可安装基板的位置的盘状基部部分和基部与光学元件或基板之间的连接圆柱形部分部分。光学部分的光学部分厚度2 /光学截面直径比在约5至10mm之间，前表面和背面之间的厚度变化小于约10％。连接圆柱形部分可以通过三个间隔开的腿或构件附接。然而，基座光学基板可以由固体材料制成以形成整料，从而避免了两部分之间的接合，或者可以单独地形成盘状基底并连接到连接部分。作为示例，基座光学基板可以用于制造用于极紫外（EUV）光刻成像系统的光学器件，或者可用于需要涂覆的光学器件和对机械安装件的灵敏度降低的基板的任何光学系统中。

2. 发明申请

US20180193139A1 COILED ANCHOR FOR SUPPORTING PROSTHETIC HEART VALVE, PROSTHETIC HEART VALVE, AND DEPLOYMENT DEVICE 审中-公开
公开(公告)号：US20180193139A1
公开(公告)日：2018-07-12
申请号：US15912971
申请日：2018-03-06
申请人： Mark Chau , Alexander J. Siegel , Paul A. Spence , Landon H. Tompkins
发明人： Mark Chau , Alexander J. Siegel , Paul A. Spence , Landon H. Tompkins
IPC分类号： A61F2/24
摘要： A system including an anchor for docking a prosthetic valve at a native valve of a heart can have a first end, a second end, and a central axis extending between the first and second ends, and defines an inner space coaxial with the central axis. The valve prosthesis can include a protective layer or annular ring that surrounds a bottom edge of the second frame end. The protective layer or annular ring can include two layers, and the two layers can be different materials.

3. 发明申请

US20150306289A1 METHODS AND SYSTEMS FOR COUNTERPULSATION OF BLOOD FLOW TO AND FROM THE CIRCULATORY SYSTEM 审中-公开
标题翻译：用于计算循环系统血液流量的方法和系统
公开(公告)号：US20150306289A1
公开(公告)日：2015-10-29
申请号：US14792651
申请日：2015-07-07
申请人： Paul A. Spence
发明人： Paul A. Spence
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/1005 , A61M1/1008 , A61M1/1037 , A61M1/1044 , A61M1/1055 , A61M1/106 , A61M1/107 , A61M1/1086 , A61M1/122 , A61M1/127 , A61M2205/8243
摘要： Counterpulsation methods and systems for assisting the heart of a patient involve, for example, coordinating the operation of a pulsatile pump to suction blood from an artery through a blood flow conduit while the heart is in systole and expel the blood into the blood flow conduit and the artery while the heart is in diastole.
摘要翻译：用于辅助患者心脏的反搏方法和系统涉及例如通过血液导管将脉动泵的动作与动脉抽吸血液进行协调，同时心脏收缩并将血液排出到血流导管中，心脏舒张期的动脉。

4. 发明授权

US08864822B2 Devices and methods for introducing elements into tissue 有权
标题翻译：将元素引入组织的装置和方法
公开(公告)号：US08864822B2
公开(公告)日：2014-10-21
申请号：US11685242
申请日：2007-03-13
申请人： Paul A. Spence , Donald S. Baim , Edward I. McNamara , Hiroatsu Sugimoto , Aaron M. Call , Steven D. Cahalane , Mark Maguire , Richard J. Morrill
发明人： Paul A. Spence , Donald S. Baim , Edward I. McNamara , Hiroatsu Sugimoto , Aaron M. Call , Steven D. Cahalane , Mark Maguire , Richard J. Morrill
IPC分类号： A61F2/24 , A61B17/04 , A61B19/00 , A61B17/00
CPC分类号： A61B17/0469 , A61B17/0401 , A61B17/0467 , A61B17/0487 , A61B90/39 , A61B2017/00243 , A61B2017/0406 , A61B2017/0417 , A61B2017/0419 , A61B2017/048 , A61B2017/0488 , A61B2017/0496 , A61B2090/0801 , A61B2090/0811 , A61F2/2466
摘要： Systems, devices and methods for securing tissue including the annulus of a mitral valve. The systems, devices and methods may employ catheter based techniques and devices to plicate tissue and perform an annuloplasty.
摘要翻译：用于固定包括二尖瓣环的组织的系统，装置和方法。系统，装置和方法可以使用基于导管的技术和装置来铺展组织并执行瓣膜成形术。

5. 发明申请

US20130172660A1 METHODS, DEVICES AND SYSTEMS FOR COUNTERPULSATION OF BLOOD FLOW TO AND FROM THE CIRCULATORY SYSTEM 失效
标题翻译：血液流向循环系统的方法，装置和系统
公开(公告)号：US20130172660A1
公开(公告)日：2013-07-04
申请号：US13778835
申请日：2013-02-27
申请人： Paul A. Spence
发明人： Paul A. Spence
IPC分类号： A61M1/12 , A61M1/10
CPC分类号： A61M1/1005 , A61M1/1008 , A61M1/1037 , A61M1/1044 , A61M1/1055 , A61M1/106 , A61M1/107 , A61M1/1086 , A61M1/122 , A61M1/127 , A61M2205/8243
摘要： Counterpulsation methods and systems for assisting the heart of a patient involve, for example, coordinating the operation of a pulsatile pump to suction blood from an artery through a blood flow conduit while the heart is in systole and expel the blood into the blood flow conduit and the artery while the heart is in diastole.
摘要翻译：用于辅助患者心脏的反搏方法和系统涉及例如通过血液导管将脉动泵的动作与动脉抽吸血液进行协调，同时心脏收缩并将血液排出到血流导管中，心脏舒张期的动脉。

6. 发明授权

US08460371B2 Method and apparatus for performing catheter-based annuloplasty using local plications 有权
标题翻译：使用局部麻醉进行基于导管的瓣膜成形术的方法和装置
公开(公告)号：US08460371B2
公开(公告)日：2013-06-11
申请号：US10689872
申请日：2003-10-21
申请人： Edwin J. Hlavka , Paul A. Spence
发明人： Edwin J. Hlavka , Paul A. Spence
IPC分类号： A61F2/24
CPC分类号： A61B17/00234 , A61B17/0469 , A61B17/0487 , A61B17/0643 , A61B17/0644 , A61B2017/00243 , A61B2017/00349 , A61B2017/00867 , A61B2017/0417 , A61B2017/0462 , A61B2017/0464 , A61B2017/0472 , A61B2017/0496 , A61B2017/0649
摘要： The present invention relates to minimally invasive methods and apparatus for performing annuloplasty. According to one aspect of the present invention, a method for performing annuloplasty includes creating a first plication in the tissue near a mitral valve of a heart, using at least a first plication element, and creating a second plication in the tissue near the mitral valve such that the second plication is substantially coupled to the first plication. In another aspect, an apparatus for performing annuloplasty includes a distal catheter portion having a sidewall defining a lumen, anchor delivery structure disposed in the lumen, and al least one anchor supported on the anchor delivery structure. The anchor delivery structure is movable from a first position wherein the anchor is disposed within the lumen, to a second position wherein the anchor is moved through an opening.
摘要翻译：本发明涉及用于进行瓣环成形术的微创方法和装置。根据本发明的一个方面，一种用于进行瓣环成形术的方法包括：使用至少第一塌陷元件在心脏的二尖瓣附近的组织中产生第一塌陷，并在二尖瓣附近的组织中产生第二valve肿使得第二塌陷基本上与第一塌陷相耦合。在另一方面，一种用于执行瓣膜成形术的装置包括远侧导管部分，其具有限定内腔的侧壁，设置在内腔中的锚定器输送结构以及支撑在锚定器输送结构上的至少一个锚固件。锚定器传送结构可从第一位置移动，其中锚固件设置在内腔内，到第二位置，其中锚固件移动通过开口。

7. 发明授权

US08317695B2 Device to permit offpump beating heart coronary bypass surgery 有权
标题翻译：允许偏心跳动心脏冠状动脉旁路手术的装置
公开(公告)号：US08317695B2
公开(公告)日：2012-11-27
申请号：US12336290
申请日：2008-12-16
申请人： Paul A. Spence , Warren P. Williamson, IV , Mark Ortiz
发明人： Paul A. Spence , Warren P. Williamson, IV , Mark Ortiz
IPC分类号： A61B1/32
CPC分类号： A61B17/0218 , A61B17/00491 , A61B17/02 , A61B17/0206 , A61B17/0293 , A61B17/04 , A61B17/064 , A61B17/068 , A61B17/29 , A61B2017/00305 , A61B2017/00309 , A61B2017/0243 , A61B2017/308
摘要： A system for manipulating a heart during cardiac surgery permits coronary surgery on a beating heart while maintaining cardiac output unabated and uninterrupted. Circumflex coronary artery surgery can be performed using the system. A component of the system engages the heart with a heart positioning device, repositions the heart into a displaced position and maintains it in the displaced position while the heart continues to beat with substantially unabated and uninterrupted cardiac output. One form of the system can be used in minimally invasive surgery.
摘要翻译：在心脏手术期间操作心脏的系统允许在跳动心脏上进行冠状动脉手术，同时保持心输出量不变且不间断。 Circumflex冠状动脉手术可以使用系统进行。该系统的一个组件与心脏定位装置的心脏接合，将心脏重新定位到位移位置，并将其保持在位移位置，同时心脏继续以基本上不间断的和不间断的心输出量搏动。该系统的一种形式可用于微创手术。

8. 发明授权

US08202315B2 Catheter-based annuloplasty using ventricularly positioned catheter 有权
标题翻译：基于导管的瓣膜成形术使用心室定位导管
公开(公告)号：US08202315B2
公开(公告)日：2012-06-19
申请号：US12848995
申请日：2010-08-02
申请人： Edwin Hlavka , Jonathan Podmore , Paul A. Spence
发明人： Edwin Hlavka , Jonathan Podmore , Paul A. Spence
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/08 , A61B17/083 , A61B2017/00004 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0406 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0464 , A61B2017/0472 , A61B2017/048 , A61B2017/0488 , A61B2017/0496 , A61B2017/081 , A61F2/2442 , A61F2/2448 , A61F2/246 , A61F2/2466
摘要： The present invention relates to a minimally invasive method of performing annuloplasty. According to one aspect of the present invention, a method for performing annuloplasty includes accessing a left ventricle of a heart to provide a discrete plication element to the left ventricle, and engaging the plication element to tissue near a mitral valve of the heart. Engaging the plication element includes causing the plication element to gather a portion of the tissue to create a plication. In one embodiment, accessing the left ventricle of the heart to provide the plication element includes accessing the left ventricle of the heart using a catheter arrangement.
摘要翻译：本发明涉及执行瓣环成形术的微创方法。根据本发明的一个方面，一种用于进行瓣膜成形术的方法包括进入心脏的左心室以向左心室提供离散的折叠元件，并且将折叠元件接合到心脏二尖瓣附近的组织。使折叠元件接合包括使折叠元件收集组织的一部分以产生折痕。在一个实施例中，进入心脏的左心室以提供脓肿元件包括使用导管装置进入心脏的左心室。

9. 发明授权

US08100964B2 Heart valve repair apparatus and methods 失效
标题翻译：心脏瓣膜修复装置及方法
公开(公告)号：US08100964B2
公开(公告)日：2012-01-24
申请号：US12403745
申请日：2009-03-13
申请人： Paul A. Spence
发明人： Paul A. Spence
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2412 , A61F2/2418 , A61F2/2445 , A61F2/2454 , A61F2/2457 , A61F2/2466 , A61F2220/0091
摘要： Valve repair apparatus and methods for ensuring proper coaptation and operation of the leaflets of a heart valve. Main aspects of the disclosure relate to devices including a support member configured for attachment to the heart valve annulus, a post extending from the support member away from the plane of the annulus and a connector coupled with the post and configured for attachment to at least one of the leaflets. The various embodiments may include a replacement heart valve connected with the support member for facilitating full replacement as opposed to near repair of an existing native heart valve. Various other devices include support structure and one or more posts connected to opposite sides of the support structure and extending from one side of the valve annulus to another to modify the shape of the annulus.
摘要翻译：瓣膜修复装置和方法，用于确保心脏瓣膜单张的适当接合和操作。本公开的主要方面涉及包括构造成用于附接到心脏瓣膜环的支撑构件的装置，从支撑构件远离环的平面延伸的柱以及与柱连接的连接件，并且构造成用于附接至至少一个的传单。各种实施例可以包括与支撑构件连接的替换心脏瓣膜，以便于完全替换，而不是现有天然心脏瓣膜的近修复。各种其他装置包括支撑结构和连接到支撑结构的相对侧并且从阀环的一侧延伸到另一侧的一个或多个柱，以改变环的形状。

10. 发明申请

US20100280306A1 METHODS, DEVICES AND SYSTEMS FOR COUNTERPULSATION OF BLOOD FLOW TO AND FROM THE CIRCULATORY SYSTEM 有权
标题翻译：血液流向循环系统的方法，装置和系统
公开(公告)号：US20100280306A1
公开(公告)日：2010-11-04
申请号：US12827227
申请日：2010-06-30
申请人： Paul A. Spence
发明人： Paul A. Spence
IPC分类号： A61M1/12
CPC分类号： A61M1/1005 , A61M1/1008 , A61M1/1037 , A61M1/1044 , A61M1/1055 , A61M1/106 , A61M1/107 , A61M1/1086 , A61M1/122 , A61M1/127 , A61M2205/8243
摘要： Counterpulsation methods and systems for assisting the heart of a patient involve, for example, coordinating the operation of a pulsatile pump to suction blood from an artery through a first conduit while the heart is in systole and expel the blood into the first conduit and the artery while the heart is in diastole.
摘要翻译：用于辅助患者心脏的反脉冲方法和系统涉及例如协调脉搏泵的操作，以在心脏收缩期间从动脉抽吸血液，并将血液排出到第一导管和动脉而心脏处于舒缓期。

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