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    • 5. 发明申请
    • 4-Fluoro-N-indan-2-yl benzamide and its use as a pharmaceutical
    • 4-氟-N-茚满-2-基苯甲酰胺及其作为药物的用途
    • US20040019114A1
    • 2004-01-29
    • US10623775
    • 2003-07-22
    • Aventis Pharma Deutschland GmbH
    • Paulus WohlfartTeri SuzukiRamalinga M. DharanipragadaAlena SafarovaArmin WalserHartmut Strobel
    • A61K031/165
    • C07C233/65A61K31/166C07C2602/08
    • The present invention relates to the method of stimulating the expression of endothelial NO-synthase in a mammal, which method comprises administering a physiologically active amount of 4-fluoro-N-indan-2-yl benzamide according to the formula (I) 1 to the said mammal. The compound (I) can be used for the therapy and prophylaxis of cardiovascular diseases like stable and unstable angina pectoris, Prinzmetal angina (spasm), acute coronary syndrome, heart failure, myocardial infarction, stroke, thrombosis, peripheral artery occlusive disease PAOD, atherosclerosis, restenosis, endothelial damage after PTCA, essential hypertension, pulmonary hypertension, secondary hypertension, renovascular chronic glomerulonephritis, erectile dysfunction, ventricular arrhythmia, and the lowering of cardiovascular risk of postmenopausal women or after intake of contraceptives, the therapy and prophylaxis of diabetes and diabetes complications (nephropathy, retinopathy), angiogenesis, asthma bronchiale, chronic renal failure, cirrhosis of the liver, restricted memory performance or a restricted ability to learn.
    • 本发明涉及刺激哺乳动物内皮细胞NO合成酶表达的方法,该方法包括将生理活性量的式(I)的4-氟-N-茚满-2-基苯甲酰胺给予 哺乳动物说 化合物(I)可用于治疗和预防心血管疾病如稳定和不稳定型心绞痛,Prinzmetal心绞痛(痉挛),急性冠状动脉综合征,心力衰竭,心肌梗死,中风,血栓形成,外周动脉闭塞性疾病PAOD,动脉粥样硬化 ,PTCA后再狭窄,内皮损伤,原发性高血压,肺动脉高压,继发性高血压,肾血管性慢性肾小球肾炎,勃起功能障碍,室性心律失常,绝经后妇女心血管危险降低或避孕药物摄入后,糖尿病和糖尿病的治疗和预防 并发症(肾病,视网膜病变),血管生成,哮喘支气管炎,慢性肾功能衰竭,肝硬化,限制性记忆能力或受限的学习能力。