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1. 发明授权

US07812180B2 Electropolymerisable monomers that are soluble in aqueous solution and electroactive probes that can be obtained with such monomers 有权
标题翻译：可溶于水溶液的电聚合单体和可用这些单体获得的电活性探针
公开(公告)号：US07812180B2
公开(公告)日：2010-10-12
申请号：US11988655
申请日：2006-07-07
申请人： Aurelie Bouchet , Carole Chaix , Bernard Mandrand
发明人： Aurelie Bouchet , Carole Chaix , Bernard Mandrand
IPC分类号： C07D207/00
CPC分类号： C08G73/0611 , C07F17/02 , C08F2/10 , C08F2/16 , C08F2/52 , C08G61/124
摘要： The invention relates to an electropolymerizable monomer, intended to be polymerized in aqueous solution, comprising a single electropolymerizable unit and an electron-donating group, characterized in that it also comprises at least one arm ionizable in aqueous solution. The invention also relates to the polymerization process, to the electroactive probe thus obtained and to the method for the detection of a target ligand in a biological sample.
摘要翻译：本发明涉及旨在在水溶液中聚合的电聚合单体，其包含单个可电聚合单元和给电子基团，其特征在于其还包含至少一个可在水溶液中电离的臂。本发明还涉及聚合方法，由此获得的电活性探针和生物样品中靶配体的检测方法。

2. 发明申请

US20090053826A1 Electropolymerisable monomers that are soluble in aqueous solution and electroactive probes that can be obtained with such monomers 有权
标题翻译：可溶于水溶液的电聚合单体和可用这些单体获得的电活性探针
公开(公告)号：US20090053826A1
公开(公告)日：2009-02-26
申请号：US11988655
申请日：2006-07-07
申请人： Aurelie Bouchet , Carole Chaix , Bernard Mandrand
发明人： Aurelie Bouchet , Carole Chaix , Bernard Mandrand
IPC分类号： G01N33/53 , C07H21/00 , C07K2/00 , C07K14/00 , C07K16/00 , C08B37/00 , C07D235/02 , C07D207/30 , C07D333/02 , C07D209/04 , C07C211/43 , C07C11/24 , C07C15/02 , C07C15/38 , C07D307/34 , C07D237/02 , C07D209/82 , C07C69/52 , C08F2/16 , C07F15/02
CPC分类号： C08G73/0611 , C07F17/02 , C08F2/10 , C08F2/16 , C08F2/52 , C08G61/124
摘要： The invention relates to an electropolymerizable monomer, intended to be polymerized in aqueous solution, comprising a single electropolymerizable unit and an electron-donating group, characterized in that it also comprises at least one arm ionizable in aqueous solution. The invention also relates to the polymerization process, to the electroactive probe thus obtained and to the method for the detection of a target ligand in a biological sample.
摘要翻译：本发明涉及旨在在水溶液中聚合的电聚合单体，其包含单个可电聚合单元和给电子基团，其特征在于其还包含至少一个可在水溶液中电离的臂。本发明还涉及聚合方法，由此获得的电活性探针和生物样品中靶配体的检测方法。

3. 发明申请

US20060189555A1 Pyrroles substituted by oligonucleotides 失效
标题翻译：由寡核苷酸取代的吡咯
公开(公告)号：US20060189555A1
公开(公告)日：2006-08-24
申请号：US10536317
申请日：2003-12-16
申请人： Bernard Mandrand , Daniela Zsoldos , Alain Laurent , Carole Chaix , Nicolas Spinelli
发明人： Bernard Mandrand , Daniela Zsoldos , Alain Laurent , Carole Chaix , Nicolas Spinelli
IPC分类号： A61K48/00 , A61K31/7056 , C07H21/02 , C07H19/04
CPC分类号： C07H21/00 , Y02P20/55
摘要： The invention relates to novel pyrrole derivatives of the formula (I) which make it possible to immobilize and address oligonucleotides by electropolymerization. Said invention also relates to thus produced electroactive polymers and to methods for using them for detecting, identifying and dosing analytes in a sampe. (I) wherein R1 is one type of oligonucleotide, Y is S or O, X is a spacer arm selected from —(CH2)—O—, —(CH2) P O—[(CH2)2—O]q—, —(CH2)r; —CO—NR—(CH2)r-0-, —CH2r—NCH3—(CH2)r—O—, —CH2)rCO—NR′—[CH2)2—O]s—, —(CH2)rNCH3[(CH2)2—O] S —, R′ is H or CH3, n is an integer number ranging from 1 to 5, p is an integer number ranging from 1 to 2, q is an integer number ranging from 1 to 4, r is an integer number ranging from 1 to 3, r′ is an integer number ranging from 1 to 3, s is an integer number ranging from 1 to 3, n, p, q, r, r′ and s are identical or different, a pyrrole cycle is substituted in a position 2, 3, 4 or 5.
摘要翻译：本发明涉及式（I）的新型吡咯衍生物，其可以通过电聚合固定和解决寡核苷酸。所述发明还涉及由此产生的电活性聚合物及其用于检测，鉴定和给予分析物的方法。（I）其中R 1是一种类型的寡核苷酸，Y是S或O，X是选自以下的间隔臂 - （CH 2）2 - ， - （ CH 2 O - [（CH 2）2 -O] q > - ， - （CH 2）r < -CO-NR-（CH 2）r -O - ， - CH 2 R n -NCH 3 - （CH 2） -O - ， - CH 2）NR CO - NR' - [CH 2 N 2） 2 - - - - - - - - - - - - - - - - - - - （CH 2） [（CH 2）2 -O] -S SB， - R'是H或CH 3，n是 1〜5的整数，p为1〜2的整数，q为1〜4的整数，r为1〜3的整数，r'为从 1至3，s为1至3的整数，n，p，q，r，r'和s相同或不同，在2,3,4或5位置上取代吡咯环。

4. 发明授权

US07446186B2 Pyrroles substituted by oligonucleotides 失效
标题翻译：由寡核苷酸取代的吡咯
公开(公告)号：US07446186B2
公开(公告)日：2008-11-04
申请号：US10536317
申请日：2003-12-16
申请人： Bernard Mandrand , Daniela Zsoldos , Alain Laurent , Carole Chaix , Nicolas Spinelli
发明人： Bernard Mandrand , Daniela Zsoldos , Alain Laurent , Carole Chaix , Nicolas Spinelli
IPC分类号： C07H21/00 , C12Q1/68
CPC分类号： C07H21/00 , Y02P20/55
摘要： The invention relates to novel pyrrole derivatives of the formula (I) which make it possible to immobilize and address oligonucleotides by electropolymerization. Said invention also relates to thus produced electroactive polymers and to methods for using them for detecting, identifying and dosing analytes in a sample. (I) wherein R1 is one type of oligonucleotide, Y is S or O, X is a spacer arm selected from —(CH2)—O—, —(CH2) P O—[(CH2)2—O]q—, —(CH2)r; —CO—NR′—(CH2)r—O—, —CH2r—NCH3—(CH2)r—O—, —CH2)rCO—NR′—[CH2)2—O]s—, —(CH2)rNCH3[(CH2)2—O] S —, R′ is H or CH3, n is an integer number ranging from 1 to 5, p is an integer number ranging from 1 to 2, q is an integer number ranging from 1 to 4, r is an integer number ranging from 1 to 3, r′ is an integer number ranging from 1 to 3, s is an integer number ranging from 1 to 3, n, p, q, r, r′ and s are identical or different, a pyrrole cycle is substituted in a position 2, 3, 4 or 5.
摘要翻译：本发明涉及式（I）的新型吡咯衍生物，其可以通过电聚合固定和解决寡核苷酸。所述发明还涉及如此制备的电活性聚合物以及使用它们用于检测，鉴定和给药样品中分析物的方法。（I）其中R 1是一种类型的寡核苷酸，Y是S或O，X是选自以下的间隔臂 - （CH 2）2 - ， - （ CH 2 O - [（CH 2）2 -O] q - ， - （CH 2）n - -CO-NR' - （CH 2）2 -O - ， - CH 2 R n -NCH 3 - （CH 2）n -O - ， - CH 2）n CO-NR' - [CH 2 - 2 - > - - - - - - - - - - - - - - - - （CH 2） [（CH 2）2 -O] -SS - ，R'是H或CH 3， 3 ，n为1〜5的整数，p为1〜2的整数，q为1〜4的整数，r为1〜3的整数， r'为1〜3的整数，s为1〜3的整数，n，p，q，r，r'和s相同或不同，吡咯环在2位， 3，4或5。

5. 发明授权

US09359396B2 Material for supported synthesis and method for growing oligonucleotides or peptides 有权
标题翻译：用于支持合成的材料和用于生长寡核苷酸或肽的方法
公开(公告)号：US09359396B2
公开(公告)日：2016-06-07
申请号：US14131490
申请日：2012-07-10
申请人： Carole Chaix , Gabriel De Crozals , Carole Farre
发明人： Carole Chaix , Gabriel De Crozals , Carole Farre
IPC分类号： C07K1/04 , B05D7/00 , C07H21/00 , B05D1/18 , B05D7/22 , B82Y30/00
CPC分类号： C07K1/042 , B01J2219/00632 , B01J2219/00641 , B01J2219/00722 , B05D1/185 , B05D7/00 , B05D7/22 , B82Y30/00 , C07H21/00 , Y10T428/2982
摘要： The invention concerns a material composed of a porous support on which functionalized nanoparticles are grafted by covalent bonding, characterized in that at least part of the nanoparticles grafted by covalent bonding is housed inside surface pores of the support, and in that the support is silica-based and is in the form of porous particles of heterogeneous shape and size, the size of the particles being larger than 1 μm and preferably within the range of 5 to 200 μm.The invention further concerns a growth method for oligonucleotides or peptides characterized in that growth is performed on a material formed of a porous support on which functionalized nanoparticles are grafted by covalent bonding, characterized in that at least a part of the nanoparticles grafted by covalent bonding is housed inside surface pores of the support.
摘要翻译：本发明涉及一种由多孔载体组成的材料，功能化纳米颗粒通过共价键接枝在其上，其特征在于通过共价键接枝的至少部分纳米颗粒被容纳在载体的表面孔内，并且载体是二氧化硅 - 并且呈不均匀形状和尺寸的多孔颗粒的形式，颗粒的尺寸大于1μm，优选在5至200μm的范围内。本发明还涉及一种用于寡核苷酸或肽的生长方法，其特征在于在由多孔载体形成的材料上进行生长，多孔载体上通过共价键接枝官能化纳米颗粒，其特征在于，通过共价键接枝的至少一部分纳米颗粒是容纳在支撑体的内表面孔中。

6. 发明申请

US20140135478A1 MATERIAL FOR SUPPORTED SYNTHESIS AND METHOD FOR GROWING OLIGONUCLEOTIDES OR PEPTIDES 有权
标题翻译：支持合成的材料和生长寡核苷酸或肽的方法
公开(公告)号：US20140135478A1
公开(公告)日：2014-05-15
申请号：US14131490
申请日：2012-07-10
申请人： Carole Chaix , Gabriel De Crozals , Carole Farre
发明人： Carole Chaix , Gabriel De Crozals , Carole Farre
IPC分类号： C07K1/04 , C07H21/00
CPC分类号： C07K1/042 , B01J2219/00632 , B01J2219/00641 , B01J2219/00722 , B05D1/185 , B05D7/00 , B05D7/22 , B82Y30/00 , C07H21/00 , Y10T428/2982
摘要： The invention concerns a material composed of a porous support on which functionalized nanoparticles are grafted by covalent bonding, characterized in that at least part of the nanoparticles grafted by covalent bonding is housed inside surface pores of the support, and in that the support is silica-based and is in the form of porous particles of heterogeneous shape and size, the size of the particles being larger than 1 μm and preferably within the range of 5 to 200 μm.The invention further concerns a growth method for oligonucleotides or peptides characterized in that growth is performed on a material formed of a porous support on which functionalized nanoparticles are grafted by covalent bonding, characterized in that at least a part of the nanoparticles grafted by covalent bonding is housed inside surface pores of the support.
摘要翻译：本发明涉及一种由多孔载体组成的材料，功能化纳米颗粒通过共价键接枝在其上，其特征在于通过共价键接枝的至少部分纳米颗粒被容纳在载体的表面孔内，并且载体是二氧化硅 - 并且呈不均匀形状和尺寸的多孔颗粒的形式，颗粒的尺寸大于1μm，优选在5至200μm的范围内。本发明还涉及一种用于寡核苷酸或肽的生长方法，其特征在于在由多孔载体形成的材料上进行生长，多孔载体上通过共价键接枝官能化纳米颗粒，其特征在于，通过共价键接枝的至少一部分纳米颗粒是容纳在支撑体的内表面孔中。

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