专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4540792A Process for the preparation of a free L .alpha.-amino acid 失效
标题翻译：制备游离Lα-氨基酸的方法
公开(公告)号：US4540792A
公开(公告)日：1985-09-10
申请号：US472479
申请日：1983-03-07
申请人： Auguste Commeyras , Aldo Previero , Martine Pugniere
发明人： Auguste Commeyras , Aldo Previero , Martine Pugniere
IPC分类号： C12P13/04 , C07C67/00 , C07C227/00 , C07C227/16 , C07C227/18 , C07C227/36 , C07C229/02 , C07D213/48 , C12P41/00 , C07D233/64 , C07D207/16 , C07D209/20
CPC分类号： C12P41/005 , C07D213/48
摘要： This invention relates to a process for the preparation of free L .alpha.-amino acids by the complete conversion of their D antipodes taken individually or possibly in racemic mixtures.The process according to the present invention is characterized in that the D antipodes of an ester of said .alpha.-amino acid is racemized in the presence of a chemical catalyst formed by at least one aromatic aldehyde corresponding to the general formula: ##STR1## wherein: Ar represents an aromatic ring optionally containing a heteroatom, such as nitrogen, andB represents a basic function,to produce a mixture in dynamic equilibrium of the two forms D and L of said ester, the ester which is present in the L form is hydrolyzed enzymatically and irreversibly to produce the corresponding stereostable L .alpha.-amino acid, said stages of chemical racemization and of enzymatic hydrolysis being carried out under identical reaction conditions, and the free L .alpha.-amino acid is recovered.
摘要翻译：本发明涉及一种通过其单独或可能在外消旋混合物中完全转化其对映体的方法制备游离的L-α-氨基酸的方法。根据本发明的方法的特征在于，所述α-氨基酸的酯的D对映体在由至少一种芳族醛形成的化学催化剂的存在下外消旋化，所述芳族醛对应于以下通式：）其中：Ar表示任选地含有杂原子如氮的芳环，B表示碱性官能团，以产生所述酯的两种形式D和L的动态平衡混合物，所述酯存在于L 形式水解并不可逆地产生相应的立体立构的Lα-氨基酸，在相同的反应条件下进行化学外消旋和酶水解的所述阶段，回收游离的Lα-氨基酸。

2. 发明授权

US06452012B1 3-phenyl-2,6-dioxopiperidin-3-ylpropionamide derivatives and method for preparing same 失效
标题翻译： 3-苯基-2,6-二氧代哌啶-3-基丙酰胺衍生物及其制备方法
公开(公告)号：US06452012B1
公开(公告)日：2002-09-17
申请号：US10008892
申请日：2001-11-13
申请人： Bertrand Castro , Hélène Mattras , Aldo Previero
发明人： Bertrand Castro , Hélène Mattras , Aldo Previero
IPC分类号： C07D21188
CPC分类号： C07D295/185 , C07C235/78 , C07D211/26 , C07D211/88
摘要： This invention relates to 3-(3-phenyl-2,6-dioxopiperidin-3-yl) propionamide derivatives, and to processes for preparing the same.
摘要翻译：本发明涉及3-（3-苯基-2,6-二氧代哌啶-3-基）丙酰胺衍生物及其制备方法。

3. 发明授权

US06342607B1 3-phenyl-2, 6-dioxopiperidin-3-yl propionamide derivatives and method for preparing same 失效
标题翻译： 3-苯基-2,6-二氧代哌啶-3-基丙酰胺衍生物及其制备方法
公开(公告)号：US06342607B1
公开(公告)日：2002-01-29
申请号：US09857885
申请日：2001-06-12
申请人： Bertrand Castro , Hélène Mattras , Aldo Previero
发明人： Bertrand Castro , Hélène Mattras , Aldo Previero
IPC分类号： C07D40106
CPC分类号： C07D295/185 , C07C235/78 , C07D211/26 , C07D211/88
摘要： This invention relates to 3-(3-phenyl-2,6-dioxopiperidin-3-yl)propionamide derivatives, and to processes for preparing the same.
摘要翻译：本发明涉及3-（3-苯基-2,6-二氧代哌啶-3-基）丙酰胺衍生物及其制备方法。

4. 发明授权

US6080875A Method for preparing 2-thienylethylamine derivatives 有权
标题翻译： 2-噻吩乙胺衍生物的制备方法
公开(公告)号：US6080875A
公开(公告)日：2000-06-27
申请号：US380450
申请日：1999-09-02
申请人： Bertrand Castro , Jean-Robert Dormoy , Aldo Previero
发明人： Bertrand Castro , Jean-Robert Dormoy , Aldo Previero
IPC分类号： B01J31/14 , A61K31/45 , C07D20060101 , C07D333/20 , C07D333/22 , C07D333/24
CPC分类号： C07D333/20
摘要： The present invention relates to a process for the preparation of 2-thienylethylamine derivatives of general formula: ##STR1## as well as their acid addition salts, in which R represents a halogen atom and R.sub.1 represents a C.sub.1 -C.sub.4 alkyl group, characterized in that a thienylglycidic derivative of general formula: ##STR2## in which M represents an alkali metal atom or a fraction of an alkaline-earth metal atom, is reacted with a phenylglycine ester, optionally in the form of a strong acid salt, of general formula: ##STR3## in which R and R.sub.1 have the same meaning as above, in the presence of an alkali metal borchydride of general formula:X--Y IVin which X represents an alkali metal atom and Y represents a group of formula:--BH.sub.3 CN or --BH.sub.(4-w) Z.sub.win which Z represents a carboxylic acid residue and optionally in the presence of a C.sub.1 -C.sub.4 carboxylic acid, which gives the desired compound in the form of a free base which can be treated, if necessary, with an acid in order to obtain an addition salt of this compound.
摘要翻译： PCT No.PCT / FR98 / 00441 Sec。 371 1999年9月2日第 102（e）1999年9月2日PCT 1998年3月5日PCT PCT。第WO98 / 39322号公报日本公开日1998年9月11日本发明涉及制备通式的2-噻吩乙胺衍生物及其酸加成盐的方法，其中R表示卤素原子，R1表示C1-C4烷基，其特征在于其中通式为：其中M表示碱金属原子或碱土金属原子的部分的噻吩基缩水甘油衍生物与任选呈强酸盐形式的苯基甘氨酸酯反应，通式为：在其中R和R 1具有与上述相同的含义，在通式为X-YIV的碱金属硼氢化物的存在下，其中X代表碱金属原子，Y代表下列基团：-BH 3 CN或-BH（4- w）Zw，其中Z表示羧酸残基并且任选地在C1-C4羧酸存在下，其得到游离碱形式的所需化合物，如果需要，可以用酸处理，以便获得此加成盐复合。

5. 发明授权

US4851576A Process for catalytic hydrolysis of an .alpha.-amino- nitrile in heterogeneous phase, and polymeric resins having catalytic activity for affecting the process 失效
标题翻译：在非均相中催化水解α-氨基腈的方法以及具有催化活性以影响该方法的聚合物树脂
公开(公告)号：US4851576A
公开(公告)日：1989-07-25
申请号：US454003
申请日：1982-12-28
申请人： Auguste A. Commeyras , Jacques R. Taillades , Jean Brugidou , Regine Sola , Aldo Previero , Louis Mion , Robert J. Pascal , Monique Lasperas , Alain Rousset
发明人： Auguste A. Commeyras , Jacques R. Taillades , Jean Brugidou , Regine Sola , Aldo Previero , Louis Mion , Robert J. Pascal , Monique Lasperas , Alain Rousset
IPC分类号： C07B61/00 , B01J31/00 , B01J31/06 , C07C67/00 , C07C227/00 , C07C227/26 , C07C229/02 , C07C229/08 , C07C231/00 , C07C231/06 , C07C233/05 , C07C237/06 , C07C253/30 , C08F8/12 , C08F8/30
CPC分类号： C08F8/12
摘要： This invention relates to a process for the catalytic hydrolysis of an .alpha.-aminonitrile in the heterogeneous phase, and to polymeric resins having a catalytic activity for carrying out the present process.The process according to this invention is characterized in that said .alpha.-aminonitrile or one of the salts thereof is reacted in an aqueous medium, in the heterogeneous phase and in the presence of hydroxide ions on a polymeric resin which contains side chains carrying a carbonyl group, and which is insoluble in the aqueous basic medium.
摘要翻译：本发明涉及在非均相阶段催化水解α-氨基腈的方法以及具有用于实施本方法的催化活性的聚合物树脂。根据本发明的方法的特征在于，所述α-氨基腈或其盐之一在非水相介质中，在氢氧根离子存在下在含有携带羰基的侧链的聚合物树脂上反应，其不溶于碱性水溶液。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式