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1. 发明申请

US20100298204A1 FOOD MATERIAL FOR PROMOTING THE DIFFERENTIATION OF OSTEOBLAST AND INHIBITING THE DIFFERENTIATION OF OSTEOCLAST 审中-公开
标题翻译：用于促进骨质疏松症的抑制和抑制骨质疏松的分化的食物
公开(公告)号：US20100298204A1
公开(公告)日：2010-11-25
申请号：US12740752
申请日：2008-10-28
申请人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
发明人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
IPC分类号： A23J1/20 , C12N5/02
CPC分类号： A23K50/40 , A21D2/263 , A23C19/082 , A23J1/20 , A23J3/08 , A23K20/147 , A23L2/66 , A23L33/19 , A23V2002/00 , A61K35/20 , A61K38/018 , C07K14/47 , A23V2200/306 , A23V2250/5424
摘要： Disclosed is an osteoblast differentiation promoting and osteoclast differentiation inhibiting agent which comprises a milk protein fraction having the following characteristics (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 75,000 to 85,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 13 to 15 wt % in the constitutional amino acid composition, and has a basic amino acid/acidic amino acid of 0.5 to 0.7; and (4) the milk protein fraction has an osteoblast differentiation promoting effect and an osteoclast differentiation inhibiting.
摘要翻译：公开了一种成骨细胞分化促进和破骨细胞分化抑制剂，其包含具有以下特征（1）至（4）的乳蛋白质级分：（1）乳蛋白质级分来自牛奶; （2）乳蛋白质级分是含有分子量为75,000至85,000道尔顿的蛋白质组分的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为13〜15重量％，碱性氨基酸/酸性氨基酸为0.5〜0.7，和（4）乳蛋白级分具有成骨细胞分化促进作用和破骨细胞分化抑制作用。

2. 发明申请

US20100234296A1 FOOD MATERIAL FOR INHIBITING OSTEOCLASTOGENESIS 审中-公开
标题翻译：用于抑制OSTEOCLASTOGENESIS的食品
公开(公告)号：US20100234296A1
公开(公告)日：2010-09-16
申请号：US12740743
申请日：2008-10-28
申请人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
发明人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
IPC分类号： A61K38/16 , A61P19/00
CPC分类号： C07K14/4703 , A21D2/263 , A21D13/80 , A23C19/082 , A23K20/147 , A23K50/40 , A23L2/02 , A23L2/52 , A23L33/19 , A23V2002/00 , A61K35/00 , A61K38/00 , A23V2250/032 , A23V2250/5424 , A23V2250/1578 , A23V2200/306 , A23V2250/5488 , A23V2250/5118 , A23V2250/70 , A23V2250/156 , A23V2250/5108 , A23V2250/54246 , A23V2250/0632 , A23V2250/628
摘要： Disclosed is an osteoclastogenesis inhibitory agent which comprises a milk protein fraction having the following properties (1) to (4) and the agent is excellent in an osteoclastogenesis inhibitory effect and useful for preventing or treating bone diseases: (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein having a molecular weight of 80,000 to 85,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 16 to 18 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.65 to 0.85; and (4) the milk protein fraction has an osteoclastogenesis inhibitory effect .
摘要翻译：公开了一种破骨细胞发生抑制剂，其包含具有以下性质（1）至（4）的乳蛋白质级分，该成分具有优异的破骨细胞发生抑制作用，可用于预防或治疗骨病：（1）乳蛋白质分数为来自牛奶; （2）乳蛋白质级分是含有分子量为80,000至85,000道尔顿的蛋白质的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为16〜18重量％，碱性氨基酸的量与酸性氨基酸的量（s ）为0.65〜0.85; 和（4）乳蛋白级分具有破骨细胞发生抑制作用。

3. 发明授权

US08580740B2 Bone resorption inhibitory food material for inhibiting bone resorption 有权
标题翻译：用于抑制骨吸收的骨吸收抑制性食物
公开(公告)号：US08580740B2
公开(公告)日：2013-11-12
申请号：US12740711
申请日：2008-10-28
申请人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
发明人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： A23K50/40 , A21D2/263 , A23C19/082 , A23J1/20 , A23J3/343 , A23K20/147 , A23L2/395 , A23L2/66 , A23L33/19 , A23V2002/00 , A61K35/20 , C07K14/4703 , A23V2250/5424 , A23V2200/306
摘要： A milk protein fraction having following properties (1) to (4) is excellent in bone resorption inhibitory effect, and is useful for preventing or treating bone diseases: (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein having a molecular weight of 12,000 to 16,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 18 to 20 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.7 to 0.9; and (4) the milk protein fraction has a bone resorption inhibitory effect.
摘要翻译：具有以下特性（1）〜（4）的乳蛋白质级分骨吸收抑制效果优异，可用于预防或治疗骨病：（1）乳蛋白质分数来自牛奶; （2）乳蛋白质级分是含有分子量为12,000至16,000道尔顿的蛋白质的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为18〜20重量％，碱性氨基酸的量与酸性氨基酸的量（s ）为0.7〜0.9; 和（4）乳蛋白质分数具有骨吸收抑制作用。

4. 发明申请

US20100298228A1 BONE-REINFORCING FOOD MATERIAL 有权
标题翻译：骨质增强食品
公开(公告)号：US20100298228A1
公开(公告)日：2010-11-25
申请号：US12740709
申请日：2008-10-28
申请人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
发明人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
IPC分类号： A61K38/00 , A61P19/00
CPC分类号： A61K35/20 , A21D2/263 , A23C19/082 , A23C19/0917 , A23J1/20 , A23L2/66 , A23L33/19 , A23V2002/00 , A23V2300/30 , A23V2200/306 , A23V2250/5424
摘要： Disclosed is a bone-reinforcing agent which comprises a milk protein fraction having the following properties (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 6,000 to 150,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 12 to 14 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.5 to 0.7; and (4) the milk protein fraction has an activity of accelerating the calcification in an osteoblast.
摘要翻译：公开了一种骨增强剂，其包含具有以下性质（1）至（4）的乳蛋白质级分：（1）乳蛋白质级分来自牛奶; （2）乳蛋白质级分是含有分子量为6,000至150,000道尔顿的蛋白质组分的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为12〜14重量％，碱性氨基酸的量与酸性氨基酸的量（s ）为0.5〜0.7; 和（4）乳蛋白质级分具有促进成骨细胞钙化的活性。

5. 发明申请

US20100261883A1 BONE RESORPTION INHIBITORY FOOD MATERIAL FOR INHIBITING BONE RESORPTION 有权
标题翻译：用于抑制骨骼再吸收的骨吸收抑制食物材料
公开(公告)号：US20100261883A1
公开(公告)日：2010-10-14
申请号：US12740711
申请日：2008-10-28
申请人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
发明人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
IPC分类号： C07K14/47
CPC分类号： A23K50/40 , A21D2/263 , A23C19/082 , A23J1/20 , A23J3/343 , A23K20/147 , A23L2/395 , A23L2/66 , A23L33/19 , A23V2002/00 , A61K35/20 , C07K14/4703 , A23V2250/5424 , A23V2200/306
摘要： A milk protein fraction having following properties (1) to (4) is excellent in bone resorption inhibitory effect, and is useful for preventing or treating bone diseases: (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein having a molecular weight of 12,000 to 16,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 18 to 20 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.7 to 0.9; and (4) the milk protein fraction has a bone resorption inhibitory effect.
摘要翻译：具有以下特性（1）〜（4）的乳蛋白质级分骨吸收抑制效果优异，可用于预防或治疗骨病：（1）乳蛋白质分数来自牛奶; （2）乳蛋白质级分是含有分子量为12,000至16,000道尔顿的蛋白质的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为18〜20重量％，碱性氨基酸的量与酸性氨基酸的量（s ）为0.7〜0.9; 和（4）乳蛋白质分数具有骨吸收抑制作用。

6. 发明授权

US08420599B2 Bone-reinforcing food material 有权
标题翻译：骨质补强食品
公开(公告)号：US08420599B2
公开(公告)日：2013-04-16
申请号：US12740709
申请日：2008-10-28
申请人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
发明人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
IPC分类号： A61K38/00 , A61P19/08
CPC分类号： A61K35/20 , A21D2/263 , A23C19/082 , A23C19/0917 , A23J1/20 , A23L2/66 , A23L33/19 , A23V2002/00 , A23V2300/30 , A23V2200/306 , A23V2250/5424
摘要： Disclosed is a bone-reinforcing agent which comprises a milk protein fraction having the following properties (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 6,000 to 150,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 12 to 14 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.5 to 0.7; and (4) the milk protein fraction has an activity of accelerating the calcification in an osteoblast.
摘要翻译：公开了一种骨增强剂，其包含具有以下性质（1）至（4）的乳蛋白质级分：（1）乳蛋白质级分来自牛奶; （2）乳蛋白质级分是含有分子量为6,000至150,000道尔顿的蛋白质组分的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为12〜14重量％，碱性氨基酸的量与酸性氨基酸的量（s ）为0.5〜0.7; 和（4）乳蛋白质级分具有促进成骨细胞钙化的活性。

7. 发明申请

US20100087372A1 GROWTH HORMONE SECRETION STIMULATOR 审中-公开
标题翻译：生长激素分泌刺激物
公开(公告)号：US20100087372A1
公开(公告)日：2010-04-08
申请号：US12531227
申请日：2008-03-11
申请人： Aiko Ono , Hiroaki Matsuyama , Yoshikazu Morita , Atsushi Serizawa , Satoshi Higurashi
发明人： Aiko Ono , Hiroaki Matsuyama , Yoshikazu Morita , Atsushi Serizawa , Satoshi Higurashi
IPC分类号： A61K38/17 , C07K14/46 , A61P5/00
CPC分类号： A61K38/018 , A23L2/52 , A23L2/66 , A23L33/19
摘要： Provided are: an agent for promoting growth hormone-secretion, containing a milk-derived basic protein fraction as an active ingredient, with the promotion of growth hormone-secretion being mediated by the promotion of secretion of ghrelin having an effect for promoting growth hormone-secretion; and a method of promoting the secretion of ghrelin by using a milk-derived basic protein fraction. The agent for promoting growth hormone-secretion may be ingested on a daily basis and is highly safe even with its ingestion for a long period.
摘要翻译：提供：促进生长激素分泌的药剂，其含有来自乳的碱性蛋白质级分作为活性成分，促进生长激素分泌是通过促进生长激素分泌促进生长激素释放的生长素释放肽介导的，分泌; 以及通过使用乳源性碱性蛋白质级分促进生长素释放肽的分泌的方法。促进生长激素分泌的药物可以每天摄入，即使长时间摄取，也是高度安全的。

8. 发明授权

US08207131B2 Peptide 有权
标题翻译：肽
公开(公告)号：US08207131B2
公开(公告)日：2012-06-26
申请号：US12298190
申请日：2007-04-25
申请人： Yukiko Kunieda , Satoshi Higurashi , Mutsumi Motouri , Hiroaki Matsuyama , Atsushi Serizawa , Hiroshi Kawakami
发明人： Yukiko Kunieda , Satoshi Higurashi , Mutsumi Motouri , Hiroaki Matsuyama , Atsushi Serizawa , Hiroshi Kawakami
IPC分类号： A61K38/08 , A61K38/06 , A61K38/07 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K5/1024 , A21D2/26 , A21D2/268 , A23C9/1544 , A23C19/082 , A23C19/086 , A23K20/147 , A23K50/40 , A23L2/02 , A23L2/52 , A23L33/18 , A61K38/00 , C07K7/06
摘要： The present invention relates to a peptide that is derived from a milk protein and has an antioxidative effect, an antioxidant that includes the peptide as an active ingredient, and an antioxidative food, drink, or feed that includes the peptide. The present invention also relates to a peptide that is derived from a milk protein and has an adiponectin production promotion effect, an adiponectin production promoter that includes the peptide as an active ingredient, and an adiponectin production promotion food, drink, or feed that includes the peptide. The present invention further relates to a blood adiponectin level increase promotion and/or decrease inhibition agent that includes a component contained in cheese as an active ingredient, and a blood adiponectin level increase promotion and/or decrease inhibition food or drink that includes a component contained in cheese. The present invention to the peptide that consists of an amino acid sequence shown by His-Pro-Ile-Lys-His-Gln-Gly-Leu-Pro-Gln (1), His-Pro-Ile-Lys (2) or His-Gln-Gly-Leu-Pro-Gln (3), and has an antioxidative effect.
摘要翻译：本发明涉及一种衍生自乳蛋白并具有抗氧化作用的肽，包含该肽作为活性成分的抗氧化剂和包含该肽的抗氧化食品，饮料或饲料。本发明还涉及一种衍生自乳蛋白质并具有脂联素生产促进作用的肽，包含该肽作为活性成分的脂联素生产促进剂，以及含有所述脂联素生产促进食品，饮料或饲料肽。本发明还涉及包含酪乳中含有的成分作为活性成分的血液脂联素含量增加促进和/或减少抑制剂，并且血液脂联素水平升高促进和/或减少抑制食品或饮料，其包含含有在奶酪里本发明涉及由His-Pro-Ile-Lys-His-Gln-Gly-Leu-Pro-Gln（1），His-Pro-Ile-Lys（2）或His -Gln-Gly-Leu-Pro-Gln（3），具有抗氧化作用。

9. 发明申请

US20150258184A1 NOVEL PROTEIN MATERIAL 审中-公开
标题翻译：新蛋白质材料
公开(公告)号：US20150258184A1
公开(公告)日：2015-09-17
申请号：US14418276
申请日：2012-07-31
申请人： Aiko Ohmachi , Hiroaki Matsuyama , Yoshikazu Morita , Yuko Ishida , Takayuki Nara , Ken Kato , Atsushi Serizawa
发明人： Aiko Ohmachi , Hiroaki Matsuyama , Yoshikazu Morita , Yuko Ishida , Takayuki Nara , Ken Kato , Atsushi Serizawa
IPC分类号： A61K38/57 , C12P21/06 , A23L1/305 , A61K38/46
CPC分类号： A61K38/57 , A23L33/17 , A23L33/18 , A23V2002/00 , A23V2200/00 , A61K38/01 , A61K38/22 , A61K38/465 , C12P21/06 , C12Y301/27 , A23V2200/306
摘要： The invention relates to a protein material includes angiogenin and/or angiogenin hydrolysate in an amount of 2 to 15 mg/100 mg, and cystatin and/or cystatin hydrolysate in the mass ratio to angiogenin and/or angiogenin hydrolysate of 0.003 to 0.6.
摘要翻译：本发明涉及一种蛋白质材料，其包含2至15mg / 100mg量的血管生成素和/或血管生成素水解产物，以及与血管生成素和/或血管生成素水解产物的质量比为0.003至0.6的半胱氨酸蛋白酶抑制剂和/或半胱氨酸蛋白酶抑制剂水解产物。

10. 发明申请

US20080206226A1 AGENT FOR PROMOTING OSTEOGENESIS AND/OR INHIBITING BONE RESORPTION 审中-公开
标题翻译：促进骨质疏松和/或抑制骨质疏松症的药剂
公开(公告)号：US20080206226A1
公开(公告)日：2008-08-28
申请号：US12102552
申请日：2008-04-14
申请人： Yoshikazu Morita , Atsushi Serizawa , Hiroaki Matsuyama , Mutsumi Motouri , Hiroshi Kawakami
发明人： Yoshikazu Morita , Atsushi Serizawa , Hiroaki Matsuyama , Mutsumi Motouri , Hiroshi Kawakami
IPC分类号： A61K38/48 , A61P19/08
CPC分类号： A61K38/1729 , A23K20/147 , A23K20/189 , A23L33/17 , A61K38/1725
摘要： Provided is a novel agent for promoting osteogenesis and/or inhibiting bone resorption, which: can be directly taken from daily meals by mouth for long periods without any trouble in taste; directly impart a promoting effect on osteogenesis and an inhibiting effect on bone resorption to the bone; and can be expected to have therapeutic effects for preventing or ameliorating/treating various bone diseases. The above agent includes, as an active ingredient, any one or more of β2-microglobulin, histone, complement component 3, monocyte chemotactic protein 1, lysozyme, ribonuclease, prothrombin, cytochrome P-450, plasminogen, transferrin, thrombin, plasmin, complement component 4, and β defensin, and enzymatic digestion products thereof. Those substances have a remarkable inhibiting effect on bone resorption by osteoclasts and/or a promoting effect on osteogenesis via promotion of the proliferation and differentiation of osteoblasts.
摘要翻译：本发明提供一种用于促进成骨和/或抑制骨吸收的新型药剂，其可以直接从日常饮食中口服长时间，没有任何麻烦的味道; 直接对骨骼发生促进作用，对骨吸收骨骼具有抑制作用; 并且可以预期具有预防或改善/治疗各种骨疾病的治疗效果。作为活性成分，上述试剂包含β2 - 亚微球蛋白，组蛋白，补体成分3，单核细胞趋化蛋白1，溶菌酶，核糖核酸酶，凝血酶原，细胞色素P-450，纤溶酶原中的任何一种或多种，转铁蛋白，凝血酶，纤溶酶，补体成分4和β防御素及其酶消化产物。这些物质通过促进成骨细胞的增殖和分化对破骨细胞的骨吸收和/或对成骨的促进作用具有显着的抑制作用。

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