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1. 发明授权

US06323235B1 Benzene-condensed heterocyclic derivatives and their uses 失效
标题翻译：苯稠合杂环衍生物及其用途
公开(公告)号：US06323235B1
公开(公告)日：2001-11-27
申请号：US09482279
申请日：2000-01-13
申请人： Atsushi Ohtake , Kazuhiro Hoshi , Shunji Tsukamoto , Takahiro Takeda , Naohiro Yamada , Kazuhisa Matsumoto , Michihiro Ohno , Kiyotaka Ohno
发明人： Atsushi Ohtake , Kazuhiro Hoshi , Shunji Tsukamoto , Takahiro Takeda , Naohiro Yamada , Kazuhisa Matsumoto , Michihiro Ohno , Kiyotaka Ohno
IPC分类号： C07D20918
CPC分类号： C07D307/79 , C07D209/08 , C07D307/86 , C07D407/12 , C07D409/12 , C07D413/06
摘要： Novel compounds having strong TXA2 receptor antagonist activities and PGI2 receptor agonist activities, which are effective for therapy and prevention of diseases related to TXA2, are disclosed. The compound of the present invention is represented by the following formula (I). (wherein the meanings of the symbols in the formula are as described in the specification).
摘要翻译：公开了具有强的TXA2受体拮抗剂活性和PGI2受体激动剂活性的新型化合物，其有效治疗和预防与TXA2相关的疾病。本发明的化合物由下式（I）表示（式中的符号的含义如说明书所述）。

2. 发明授权

US6043264A Benzene-condensed heterocyclic derivatives and their uses 失效
标题翻译：苯稠合杂环衍生物及其用途
公开(公告)号：US6043264A
公开(公告)日：2000-03-28
申请号：US700477
申请日：1997-06-26
申请人： Atsushi Ohtake , Kazuhiro Hoshi , Shunji Tsukamoto , Takahiro Takeda , Naohiro Yamada , Kazuhisa Matsumoto , Michihiro Ohno , Kiyotaka Ohno, deceased
发明人： Atsushi Ohtake , Kazuhiro Hoshi , Shunji Tsukamoto , Takahiro Takeda , Naohiro Yamada , Kazuhisa Matsumoto , Michihiro Ohno , Kiyotaka Ohno, deceased
IPC分类号： C07D209/08 , C07D307/79 , C07D307/86 , C07D407/12 , C07D409/12 , C07D413/06 , A61K31/34 , C07D307/80 , C07D307/81
CPC分类号： C07D307/79 , C07D209/08 , C07D307/86 , C07D407/12 , C07D409/12 , C07D413/06
摘要： Novel compounds having strong TXA.sub.2 receptor antagonist activities and PGI.sub.2 receptor agonist activities, which are effective for therapy and prevention of diseases related to TXA.sub.2, are disclosed. The compound of the present invention is represented by the following formula (I). ##STR1## (wherein the meanings of the symbols in the formula are as described in the specification).
摘要翻译： PCT No.PCT / JP96 / 00011 Sec。 371日期：1997年6月26日 102（e）日期1996年6月26日PCT提交1996年1月8日PCT公布。出版物WO96 / 20925 日期1996年7月11日公开了具有强的TXA2受体拮抗剂活性和PGI2受体激动剂活性的新型化合物，其有效治疗和预防与TXA2相关的疾病。本发明的化合物由下式（I）表示。（其中式中符号的含义如说明书中所述）。

3. 发明授权

US06407096B1 Benzene fused heterocyclic derivatives having thromboxane A2 receptor antagonistic activity and prostaglandin I2 Agonistic activity and application thereof 失效
标题翻译：具有血栓烷A2受体拮抗活性的苯稠合杂环衍生物和前列腺素I2激动剂活性及其应用
公开(公告)号：US06407096B1
公开(公告)日：2002-06-18
申请号：US09509909
申请日：2000-05-04
申请人： Atsushi Ohtake , Michihiro Ohno , Kazuhiro Hoshi , Takahiro Takeda , Naohiro Yamada
发明人： Atsushi Ohtake , Michihiro Ohno , Kazuhiro Hoshi , Takahiro Takeda , Naohiro Yamada
IPC分类号： A61K315415
CPC分类号： C07D215/20
摘要： Benzene fused derivatives represented by the following formula: having strong TXA2 receptor antagonistic action and PGI2 receptor agonistic action, and effective for treating or preventing diseases concerning TXA2.
摘要翻译：由下式表示的苯融合衍生物：具有强的TXA2受体拮抗作用和PGI2受体激动作用，并且有效治疗或预防与TXA2相关的疾病。

4. 发明授权

US5496849A Sulfonic acid derivative and its pharmaceutical application 失效
标题翻译：磺酸衍生物及其制药应用
公开(公告)号：US5496849A
公开(公告)日：1996-03-05
申请号：US244141
申请日：1994-05-17
申请人： Kiyotaka Ohno , Atsushi Ohtake , Shintaro Nishio , Kazuhiro Hoshi , Shunji Tsukamoto
发明人： Kiyotaka Ohno , Atsushi Ohtake , Shintaro Nishio , Kazuhiro Hoshi , Shunji Tsukamoto
IPC分类号： C07D307/93 , A61K31/34 , C07D307/78 , C07D307/80
CPC分类号： C07D307/93
摘要： The present invention discloses sulfonamide derivative represented by the following general formula: ##STR1## [wherein, R.sub.1 is(i) --COOR.sub.2 (where, R.sub.2 is (1) hydrogen, (2) a pharmacologically acceptable cation, or (3) an alkyl having 1 to 14 carbon atoms) or,(ii) --C(.dbd.O)--R.sub.3 (wherein, R.sub.3 represents an alkyl having 1 to 4 carbon atoms); A is(i) --(CH.sub.2)n-- (wherein, n represents an integer of 0 to 3),(ii) --CH.dbd.CH--, or the group:(iii) --O--C(R.sub.4) (R.sub.5)-- (wherein, R.sub.4 and R.sub.5 represent (1) hydrogen or (2) an alkyl having 1 to 4 carbon atoms, and R.sub.4 and R.sub.5 may be identical or different); and,w is NH or --O--], as well as a thromboxane A2 receptor antagonistic drug having said derivative for its active ingredient.Since the compound of the present invention has excellent thromboxane A2 receptor antagonistic action, it can be used as a thromboxane A2 receptor antagonist of high activity and long duration.
摘要翻译： PCT No.PCT / JP93 / 01339 Sec。 371日期：1994年5月17日 102（e）日期1994年5月17日PCT提交1993年9月17日PCT公布。出版物WO94 / 06785 日本3月3日公开本发明公开了由以下通式表示的磺酰胺衍生物：其中，R 1为（ⅰ）-COOR 2（其中，R 2为（1）氢），（2）药理学上可接受的阳离子，或（3）具有1至14个碳原子的烷基）或（ii）-C（= O）-R 3（其中，R 3表示具有1至4个碳原子的烷基）; A是（i） - （CH 2）n - （其中，n表示0至3的整数），（ii）-CH = CH-或基团：（iii）-OC（R4）（R5） - （其中，R4和R5表示（1）氢或（2）具有1至4个碳原子的烷基，R4和R5可以相同或不同）; 和w是NH或-O-]，以及具有所述衍生物作为其活性成分的血栓素A2受体拮抗药。由于本发明化合物具有优异的血栓素A2受体拮抗作用，因此可用作活性高且持续时间长的血栓烷A2受体拮抗剂。

5. 发明授权

US5086071A 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 derivatives 失效
标题翻译： 2,5,6,7-四取代-4,8-间 - 间 - 苯基PGI 2衍生物
公开(公告)号：US5086071A
公开(公告)日：1992-02-04
申请号：US493109
申请日：1990-03-13
申请人： Kiyotaka Ohno , Atsushi Ohtake , Takashi Endoh , Shigeki Itou , Kazuhiro Hoshi
发明人： Kiyotaka Ohno , Atsushi Ohtake , Takashi Endoh , Shigeki Itou , Kazuhiro Hoshi
IPC分类号： C07D307/93 , A61K31/557 , A61P33/10 , A61P43/00 , C07C405/00
CPC分类号： C07D307/93
摘要： Pharmaceutically useful compounds are 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 derivatives which are excellently stable and potent in vivo.

6. 发明授权

US5401768A 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2, derivative, manufacturing process thereof and its use 失效
标题翻译： 2,5,6,7-四去甲-4,8-间间亚苯基PGI 2，其衍生物及其制备方法及其用途
公开(公告)号：US5401768A
公开(公告)日：1995-03-28
申请号：US90995
申请日：1993-07-13
申请人： Kiyotaka Ohno , Toshiya Takahashi , Atsushi Ohtake , Hisanori Wakita , Shintaro Nishio
发明人： Kiyotaka Ohno , Toshiya Takahashi , Atsushi Ohtake , Hisanori Wakita , Shintaro Nishio
IPC分类号： C07D307/93 , C07D407/14 , C07D493/04 , A61K31/34
CPC分类号： C07D407/14 , C07D307/93 , C07D493/04
摘要： Disclosed are 2,5,6,7-tetranor-4,8-inter-m-phemylene PGI.sub.2 derivatives such as 16-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 and methyl ester thereof, 17-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 and methyl ester thereof, 15-phenyl-2,5,6,7,16,17,18,19,20-nonanor-4,8-inter-m-phenylene PGI.sub.2, 16-methyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI.sub.2, 16,16-dimethyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI.sub.2, 16-methyl-16-phenoxy-2,5,6,7,17,18,19,20-octanor-4,8-inter-m-phenylene PGI.sub.2, 16-methyl-16-phenoxy-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI.sub.2 and methyl ester thereof, and 3-decarboxy-3-hydroxymethyl-16-methyl-16-phenoxy-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI.sub.2, which are useful as pharmaceuticals.These compounds are useful as an antiulcer drug, antihypertensive drug, antithrombus drug or the like.
摘要翻译： PCT No.PCT / JP88 / 01048 Sec。 371日期1989年8月14日 102（e）日期1989年8月14日PCT提交1988年10月14日PCT公布。出版物WO89 / 03387 日期：1989年4月20日。公开的是2,5,6,7-四去甲-4,8-间m-亚氨基PGI 2衍生物，如16-甲基-2,5,6,7-四去甲-4,8- 间 - 亚苯基PGI 2及其甲酯，17-甲基-2,5,6,7-四酮-4,8-间 - 间 - 亚苯基PGI 2及其甲酯，15-苯基-2,5,6， 7,16,17,18,19,20-壬腈-4,8-间间 - 亚苯基PGI2,16-甲基-17-苯基-2,5,6,7,18,19,20-庚酮-4 ，8-间 - 间 - 亚苯基PGI2,16,16-二甲基-17-苯基-2,5,6,7,18,19,20-庚烷-4,8-间间苯撑PGI2,16-甲基 -16-苯氧基-2,5,6,7,17,18,19,20-辛腈-4,8-间间苯撑PGI2,16-甲基-16-苯氧基-2,5,6,7， 18,19,20-庚酮-4,8-间 - 间 - 亚苯基PGI 2及其甲酯和3-脱羧基-3-羟甲基-16-甲基-16-苯氧基-2,5,6,7,18， 19,20-庚酮-4,8-间间 - 亚苯基PGI2，其可用作药物。这些化合物可用作抗溃疡药，抗高血压药，抗血栓药物等。

7. 发明授权

US4775692A 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 derivatives 失效
标题翻译： 2,5,6,7-四去甲-4,8-间 - 间 - 亚苯基PGI 2衍生物
公开(公告)号：US4775692A
公开(公告)日：1988-10-04
申请号：US7291
申请日：1987-01-23
申请人： Kiyotaka Ohno , Atsushi Ohtake , Hiroshi Nagase , Shintaro Nishio , Toshiya Takahashi , Hisanori Wakita
发明人： Kiyotaka Ohno , Atsushi Ohtake , Hiroshi Nagase , Shintaro Nishio , Toshiya Takahashi , Hisanori Wakita
IPC分类号： C07D307/93 , A61K31/335
CPC分类号： C07D307/93
摘要： Disclosed herein are novel prostaglandin I.sub.2 (PGI.sub.2) derivatives exhibiting excellent in vivo duration and activities, said derivatives being represented by the general formula: ##STR1## wherein R.sub.1, X, R.sub.2 and R.sub.3 are as defined herein.
摘要翻译：本文公开了表现出优异的体内持续时间和活性的新型前列腺素I2（PGI2）衍生物，所述衍生物由以下通式表示：其中R1，X，R2和R3如本文所定义。

8. 发明授权

US06201015B1 Therapeutic method for thrombocytopathy treatment 失效
标题翻译：血小板病变治疗方法
公开(公告)号：US06201015B1
公开(公告)日：2001-03-13
申请号：US09068807
申请日：1998-05-27
申请人： Mitsuko Miyamoto , Naohiro Yamada , Atsushi Ohtake , Hisanori Wakita
发明人： Mitsuko Miyamoto , Naohiro Yamada , Atsushi Ohtake , Hisanori Wakita
IPC分类号： A61K3134
CPC分类号： A61K31/5585 , A61K31/34
摘要： A platelet function increment agent including a prostaglandin I2 derivative as an active ingredient, and a therapeutic method for thrombocytopathy using the same. The platelet function increment agent of the present invention does not induce platelet aggregation, has superior activating action on platelets and is greatly useful as a platelet function increment agent.
摘要翻译：包含前列腺素I2衍生物作为活性成分的血小板功能增量剂和使用其的血小板病变的治疗方法。本发明的血小板功能增量剂不诱导血小板聚集，对血小板具有优异的活化作用，非常有用作为血小板功能增量剂。

9. 发明申请

US20050172034A1 Method and system for managing programs for web service system 审中-公开
标题翻译：用于管理Web服务系统的方法和系统
公开(公告)号：US20050172034A1
公开(公告)日：2005-08-04
申请号：US10969101
申请日：2004-10-19
申请人： Nobuyoshi Sakai , Atsushi Ohtake , Jun Sugihara
发明人： Nobuyoshi Sakai , Atsushi Ohtake , Jun Sugihara
IPC分类号： G06F11/00 , G06F9/445 , G06F15/16 , G06F17/30
CPC分类号： G06F16/95
摘要： When a message is transmitted to an information processing device from a communication unit, the method of this invention receives a response from the destination information processing device by the communication unit and checks whether an error has occurred which was caused by a change made to the interface definition information representing an interface with the information processing device. In the event of an error caused by a change made to the interface definition information, the method of this invention test-transmits to the information processing device from the communication unit a message to identify an input type at a location of that change. According to the location of change and a result of test transmission, the method of this invention changes a content of a program on a memory unit which transmits the messages to the information processing device.
摘要翻译：当从通信单元向信息处理设备发送消息时，本发明的方法从通信单元接收来自目的地信息处理设备的响应，并检查是否发生由接口发生的改变引起的错误表示与信息处理装置的接口的定义信息。在由于对接口定义信息的改变引起的错误的情况下，本发明的方法从通信单元向信息处理设备发送消息以在该变化的位置识别输入类型。根据变更的位置和测试传输的结果，本发明的方法将发送消息的存储单元中的节目内容改变到信息处理设备。

10. 发明申请

US20140377539A1 Electrical Insulation Resin Composition, Cured Product Thereof, Methods of Preparing the Composition and the Product, and High Voltage Apparatuses and Power Transmission and Distribution Apparatuses Using the Composition and the Product 审中-公开
标题翻译：电绝缘树脂组合物，其固化产品，组合物和产品的制备方法以及使用组合物和产品的高压设备和输配电设备
公开(公告)号：US20140377539A1
公开(公告)日：2014-12-25
申请号：US14376349
申请日：2012-02-17
申请人： Hironori Matsumoto , Atsushi Ohtake , Akihiro Sano
发明人： Hironori Matsumoto , Atsushi Ohtake , Akihiro Sano
IPC分类号： H01B3/40 , H01B3/28 , H01B3/02 , C08L63/00
CPC分类号： H01B3/40 , C08K3/36 , C08L9/06 , C08L63/00 , C08L2203/206 , H01B3/02 , H01B3/28 , Y10T428/25 , Y10T428/254 , Y10T428/259
摘要： The present invention is aimed at enhancing dispersibility of filler, maintaining uniform low-thermal-expansion properties and mechanical strength, enhancing insulation characteristics, especially treeing resistivity, of a resin composition or a cured resin product, and enhancing the reliability of a high voltage apparatus, a power transmission and distribution apparatus or the like to which the resin composition or the cured resin product is applied.An insulating resin composition contains an insulating resin 1 as a matrix, a large particle diameter filler 2, and a small particle diameter filler 3 smaller in particle diameter than the large particle diameter filler 2, the large particle diameter filler 2 and the small particle diameter filler 3 being dispersed in the insulating resin 1, wherein the insulating resin 1 and the large particle diameter filler 2 has an affinity for each other, whereas the insulating resin 1 and the small particle diameter filler 3 have no affinity for each other.
摘要翻译：本发明的目的在于提高填料的分散性，保持树脂组合物或固化树脂制品的均匀的低热膨胀性能和机械强度，提高树脂电阻率的绝缘特性，特别是树枝电阻率，提高高压装置的可靠性，施加了树脂组合物或固化树脂制品的动力传动配送装置等。绝缘树脂组合物含有作为基质的绝缘树脂1，大粒径填料2和小粒径填料3，其粒径小于大粒径填料2，大粒径填料2和小粒径填料3分散在绝缘树脂1中，其中绝缘树脂1和大粒径填料2彼此具有亲和性，而绝缘树脂1和小粒径填料3彼此不具有亲和力。

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