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    • 7. 发明授权
    • Cyclic amino benzoic acid derivative
    • 环状氨基苯甲酸衍生物
    • US07902367B2
    • 2011-03-08
    • US11659854
    • 2005-08-11
    • Masahiro NomuraYasuo TakanoKazuhiro YumotoTakehiro ShinozakiShigeki IsogaiKoji Murakami
    • Masahiro NomuraYasuo TakanoKazuhiro YumotoTakehiro ShinozakiShigeki IsogaiKoji Murakami
    • C07D401/00A01N43/40
    • C07D417/12C07D211/22C07D211/26C07D211/42C07D211/56C07D211/60
    • The present invention relates to cyclic amino benzoic acid derivatives which are effective in therapy of lipid metabolism abnormality, diabetes and the like as a human peroxisome proliferators-activated receptor (PPAR) agonist, in particular, as an agonist against human PPARα isoform, and addition salts thereof, and pharmaceutical compositions containing these compounds.A cyclic amino benzoic acid derivative represented by the general formula (1) [wherein a ring Ar represents an aryl group which may have substituent, or the like; Y represents a C1-C4 alkylene, C2-C4 alkenylene, C2-C4 alkynylene, or the like; Z represents an oxygen atom, sulfur atom or —(CH2)n— (n represents 0, 1 or 2); X represents a hydrogen atom, halogen atom, lower alkyl group which may be substituted with a halogen atom, or the like; R represents a hydrogen atom or lower alkyl group, and —COOR substitutes for an ortho position or metha position of binding position of ring W] or a pharmaceutically acceptable salt thereof.
    • 本发明涉及有效治疗脂质代谢异常的环状氨基苯甲酸衍生物,作为人类过氧化物酶体增殖物激活受体(PPAR)激动剂的糖尿病等,特别是作为对人PPARα同种型的激动剂的添加 其盐,以及含有这些化合物的药物组合物。 由通式(1)表示的环状氨基苯甲酸衍生物[其中环Ar表示可具有取代基的芳基等; Y表示C1-C4亚烷基,C2-C4亚链烯基,C2-C4亚炔基等; Z表示氧原子,硫原子或 - (CH 2)n - (n表示0,1或2); X表示氢原子,卤素原子,可被卤素原子取代的低级烷基等; R代表氢原子或低级烷基,-COOR代替环W的结合位置的邻位或甲基位置]或其药学上可接受的盐。