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1. 发明授权

US08609715B2 Heteroarylcarboxylic acid ester derivative 有权
公开(公告)号：US08609715B2
公开(公告)日：2013-12-17
申请号：US13484822
申请日：2012-05-31
申请人： Atsushi Konishi , Munetaka Tokumasu , Tamotsu Suzuki , Takahiro Koshiba , Koji Ohsumi , Osamu Ikehara , Yuko Kodama
发明人： Atsushi Konishi , Munetaka Tokumasu , Tamotsu Suzuki , Takahiro Koshiba , Koji Ohsumi , Osamu Ikehara , Yuko Kodama
IPC分类号： A61K31/381 , C07D333/20
CPC分类号： A61K31/4535 , A61K31/341 , A61K31/381 , A61K31/4025 , A61K31/426 , A61K31/4525 , C07C53/18 , C07D277/20 , C07D277/56 , C07D307/68 , C07D333/38 , C07D405/06 , C07F9/3808 , C07F9/65515
摘要： Compounds represented by formula (I): wherein each symbol is as defined in the description, and pharmaceutically acceptable salts thereof are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.

2. 发明申请

US20120283222A1 HETEROARYLCARBOXYLIC ACID ESTER DERIVATIVE 有权
标题翻译：偶氮羧酸酯衍生物
公开(公告)号：US20120283222A1
公开(公告)日：2012-11-08
申请号：US13484822
申请日：2012-05-31
申请人： Atsushi KONISHI , Munetaka Tokumasu , Tamotsu Suzuki , Takahiro Koshiba , Koji Ohsumi , Osamu Ikehara , Yuko Kodama
发明人： Atsushi KONISHI , Munetaka Tokumasu , Tamotsu Suzuki , Takahiro Koshiba , Koji Ohsumi , Osamu Ikehara , Yuko Kodama
IPC分类号： A61K31/341 , C07D405/06 , A61K31/4025 , C07D333/38 , A61K31/381 , C07D277/56 , A61K31/426 , A61K31/4525 , C07F9/655 , A61K31/665 , C07D409/06 , A61K31/4535 , C07F9/6553 , A61K31/67 , A61P3/10 , A61P3/08 , A61P3/04 , A61P3/06 , A61P3/00 , C07D307/68
CPC分类号： A61K31/4535 , A61K31/341 , A61K31/381 , A61K31/4025 , A61K31/426 , A61K31/4525 , C07C53/18 , C07D277/20 , C07D277/56 , C07D307/68 , C07D333/38 , C07D405/06 , C07F9/3808 , C07F9/65515
摘要： Compounds represented by formula (I): wherein each symbol is as defined in the description, and pharmaceutically acceptable salts thereof are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.
摘要翻译：由式（I）表示的化合物：其中每个符号如说明书中所定义，及其药学上可接受的盐可用作具有丝氨酸蛋白酶抑制作用的高血糖抑制剂和用作糖尿病的预防或治疗药物。

3. 发明授权

US09024044B2 Heteroarylcarboxylic acid ester derivative 有权
标题翻译：杂芳基羧酸酯衍生物
公开(公告)号：US09024044B2
公开(公告)日：2015-05-05
申请号：US13517805
申请日：2012-06-14
申请人： Takahiro Koshiba , Munetaka Tokumasu , Taisuke Ichimaru , Koji Ohsumi , Tadakiyo Nakagawa , Tatsuhiro Yamada , Kayo Matsumoto , Tamotsu Suzuki
发明人： Takahiro Koshiba , Munetaka Tokumasu , Taisuke Ichimaru , Koji Ohsumi , Tadakiyo Nakagawa , Tatsuhiro Yamada , Kayo Matsumoto , Tamotsu Suzuki
IPC分类号： C07D319/12
CPC分类号： A61K31/381 , A61K31/19 , A61K31/396 , A61K31/397 , A61K31/4025 , A61K31/41 , A61K31/4436 , A61K31/4535 , A61K31/4725 , A61K38/05 , C07D319/12 , C07D333/38 , C07D333/40 , C07D409/06 , C07D409/12
摘要： Compounds represented by the following formula (I), are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.
摘要翻译：由下式（I）表示的化合物可用作具有丝氨酸蛋白酶抑制作用的高血糖抑制剂和用作糖尿病的预防或治疗药物。

4. 发明申请

US20130338132A1 HETEROARYLCARBOXYLIC ACID ESTER DERIVATIVE 有权
标题翻译：偶氮羧酸酯衍生物
公开(公告)号：US20130338132A1
公开(公告)日：2013-12-19
申请号：US13517805
申请日：2012-06-14
申请人： Takahiro Koshiba , Munetaka Tokumasu , Taisuke Ichimaru , Koji Ohsumi , Tadakiyo Nakagawa , Tatsuhiro Yamada , Kayo Matsumoto , Tamotsu Suzuki
发明人： Takahiro Koshiba , Munetaka Tokumasu , Taisuke Ichimaru , Koji Ohsumi , Tadakiyo Nakagawa , Tatsuhiro Yamada , Kayo Matsumoto , Tamotsu Suzuki
IPC分类号： A61K31/381 , C07D409/06 , A61K31/4025 , A61K31/4535 , C07D409/12 , A61P3/00 , A61K31/397 , A61K31/4725 , A61K31/396 , A61K31/41 , A61P3/10 , A61P3/06 , C07D333/38 , A61K31/4436
CPC分类号： A61K31/381 , A61K31/19 , A61K31/396 , A61K31/397 , A61K31/4025 , A61K31/41 , A61K31/4436 , A61K31/4535 , A61K31/4725 , A61K38/05 , C07D319/12 , C07D333/38 , C07D333/40 , C07D409/06 , C07D409/12
摘要： Compounds represented by the following formula (I), are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.
摘要翻译：由下式（I）表示的化合物可用作具有丝氨酸蛋白酶抑制作用的高血糖抑制剂和用作糖尿病的预防或治疗药物。

5. 发明授权

US08309561B2 Phenylalanine derivatives 有权
标题翻译：苯丙氨酸衍生物
公开(公告)号：US08309561B2
公开(公告)日：2012-11-13
申请号：US11963144
申请日：2007-12-21
申请人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
发明人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
IPC分类号： A61K31/517 , A61K31/519 , C07D239/70 , C07D239/95
CPC分类号： C07D239/70 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/04 , C07D471/04 , C07D487/04
摘要： Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：特定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

6. 发明申请

US20050222141A1 Novel phenylalanine derivatives 有权
标题翻译：新型苯丙氨酸衍生物
公开(公告)号：US20050222141A1
公开(公告)日：2005-10-06
申请号：US11018226
申请日：2004-12-22
申请人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
发明人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
IPC分类号： A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , C07D239/70 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/02 , C07D417/02 , C07D471/04 , C07D487/04 , C07D43/02
CPC分类号： C07D239/70 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/04 , C07D471/04 , C07D487/04
摘要： Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：具体的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

7. 发明申请

US20080108634A1 NOVEL PHENYLALANINE DERIVATIVES 有权
标题翻译：新型苯乙烯胺衍生物
公开(公告)号：US20080108634A1
公开(公告)日：2008-05-08
申请号：US11963144
申请日：2007-12-21
申请人： Kazuyuki SAGI , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
发明人： Kazuyuki SAGI , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
IPC分类号： A61K31/517 , A61P29/00
CPC分类号： C07D239/70 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/04 , C07D471/04 , C07D487/04
摘要： Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：具体的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

8. 发明授权

US07345049B2 Phenylalanine derivatives 有权
标题翻译：苯丙氨酸衍生物
公开(公告)号：US07345049B2
公开(公告)日：2008-03-18
申请号：US11018226
申请日：2004-12-22
申请人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
发明人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
IPC分类号： A61K31/517 , A61K31/519 , C07D239/70 , C07D239/95
CPC分类号： C07D239/70 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/04 , C07D471/04 , C07D487/04
摘要： Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：具体的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

9. 发明授权

US08940119B2 Process and apparatus for producing beam member 有权
标题翻译：用于生产梁构件的工艺和设备
公开(公告)号：US08940119B2
公开(公告)日：2015-01-27
申请号：US13500521
申请日：2010-10-13
申请人： Tatsuya Hanawa , Tamotsu Suzuki
发明人： Tatsuya Hanawa , Tamotsu Suzuki
IPC分类号： B32B3/04 , B32B38/08 , B32B37/12 , B29C70/50 , B29C70/86 , B29B11/16 , B29L31/00
CPC分类号： B29C70/50 , B29B11/16 , B29C70/865 , B29D99/0003 , B29D99/0007 , B29L2031/008 , Y10T156/1051 , Y10T428/24264
摘要： A process for producing a beam member formed by a reinforcing fiber base material which has a web portion and at least a pair of flange portions extending to both sides via at least a branching point from the web portion, at a cross-sectional surface orthogonal to a longitudinal direction of the beam member, and by a shaped filler which fills a gap having a wedge shape formed at the branching point, is provided. The shaped filler is produced by: (A) a filler supply process for supplying a filler member configured by reinforcing fibers; (B) a preshaping process for providing a preshaped filler having at least a wedge projection portion, by pressurizing the filler member by a preshaping mold; and (C) a filler deforming process for providing a shaped filler by deforming the preshaped filler.
摘要翻译：一种用于制造由增强纤维基材形成的梁构件的方法，所述加强纤维基材具有腹板部分和至少一对凸缘部分，所述至少一对凸缘部分在与所述腹板部分的至少一个分支点延伸到两侧的横截面处，提供了梁构件的纵向方向，以及填充在分支点处形成有楔形的间隙的成形填料。成形填料是通过以下方法制造的：（A）用于供给由增强纤维构成的填料构件的填料供给工序; （B）预成型方法，用于提供具有至少楔形突出部分的预成型填料，通过预成型模具对填料构件加压; 和（C）通过使预成形填料变形来提供成形填料的填料变形过程。

10. 发明申请

US20110079348A1 PROCESS FOR PRODUCING A REINFORCING WOVEN FABRIC, A PREFORM AND A FIBER REINFORCED PLASTIC MOLDED COMPONENT 有权
标题翻译：生产加强织物，预制品和纤维增强塑料成型组件的方法
公开(公告)号：US20110079348A1
公开(公告)日：2011-04-07
申请号：US12969046
申请日：2010-12-15
申请人： Seiji Tsuji , Masatoshi Tsukamoto , Hidehiro Takemoto , Tamotsu Suzuki
发明人： Seiji Tsuji , Masatoshi Tsukamoto , Hidehiro Takemoto , Tamotsu Suzuki
IPC分类号： B32B38/10
CPC分类号： D03D15/00 , B29B11/16 , B29B15/105 , B29C70/22 , B29C70/465 , B29C70/506 , D03D1/0017 , D03D15/0011 , D03D15/0088 , D10B2101/06 , D10B2101/12 , D10B2321/10 , D10B2505/00 , D10B2505/02 , D10B2505/12 , Y10T156/1043 , Y10T442/20 , Y10T442/30 , Y10T442/3854
摘要： A process for producing a reinforcing woven fabric includes sticking a resin material on at least one surface of a fabric substrate including a plurality of reinforcing fiber bundles and varying the relative position of a plurality of reinforcing fiber bundles to peel the resin material stuck over two or more reinforcing fiber bundles from a part of the two or more reinforcing fiber bundles.
摘要翻译：一种增强机织物的制造方法，其特征在于，在包含多根增强纤维束的织物基材的至少一个表面上粘贴树脂材料，改变多根强化纤维束的相对位置，剥离两层以上的树脂材料来自两个以上的增强纤维束的一部分的增强纤维束。

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