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1. 发明授权

US09198860B2 Particulate pharmaceutical composition 有权
标题翻译：颗粒状药物组成
公开(公告)号：US09198860B2
公开(公告)日：2015-12-01
申请号：US13122546
申请日：2011-02-14
申请人： Atsushi Ishii , Yasuki Kato
发明人： Atsushi Ishii , Yasuki Kato
IPC分类号： A61K9/14 , A61K31/7088 , A61K38/02 , A61K9/107 , A61K31/7084 , A61K9/16 , A61K9/19 , A61K47/24 , A61K47/34
CPC分类号： A61K9/1075 , A61K9/16 , A61K9/19 , A61K31/7084 , A61K31/713 , A61K47/24 , A61K47/34
摘要： The present invention provides a particulate pharmaceutical composition which has improved drug encapsulation stability and is suitable for a drug delivery system. The particulate pharmaceutical composition 1 contains: a plurality of block copolymer unit 2 arranged radially, each of which has a hydrophobic polymer-chain segment 2b, which is arranged radially inside, and a hydrophilic polymer-chain segment 2a, which is arranged radially outside; a drug 4, which includes a biomacromolecule; and a charged lipid 3, which has an electrical charge opposite to that of the drug 4; wherein the charged lipid 3 is being attracted to the hydrophobic polymer-chain segment 2b, and the drug 3 is positioned radially inside the hydrophobic polymer-chain segment 2b. The pharmaceutical composition 1 can effectively prevent the drug 4 from disengaging from the particle.
摘要翻译：本发明提供了具有改善的药物包封稳定性并且适合于药物递送系统的颗粒药物组合物。颗粒状药物组合物1包含：径向配置的多个嵌段共聚物单元2，其各自具有径向配置的疏水性聚合物链段2b和位于径向外侧的亲水性聚合物链段2a; 包括生物大分子的药物4; 和带电荷的脂质3，其具有与药物4的电荷相反的电荷; 其中带电脂质3被吸引到疏水聚合物链段2b，并且药物3位于疏水性聚合物链段2b的径向内侧。药物组合物1可以有效地防止药物4与粒子分离。

2. 发明授权

US08853167B2 Short-chain cationic polyamino acid and use thereof 有权
标题翻译：短链阳离子聚氨基酸及其用途
公开(公告)号：US08853167B2
公开(公告)日：2014-10-07
申请号：US13258663
申请日：2011-02-23
申请人： Yasuki Kato , Atsushi Ishii , Naoya Shibata , Tatsuyuki Hayashi , Kazunori Kataoka , Kanjiro Miyata , Nobuhiro Nishiyama
发明人： Yasuki Kato , Atsushi Ishii , Naoya Shibata , Tatsuyuki Hayashi , Kazunori Kataoka , Kanjiro Miyata , Nobuhiro Nishiyama
IPC分类号： A61K47/48 , C08G69/10 , C12N15/11
CPC分类号： C08G69/10 , A61K47/60 , A61K47/6455 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： The present invention provides a cationic polyamino acid suitable for a carrier that can form a stable complex with a nucleic acid under a physiological condition and release the nucleic acid in cells suitably. The cationic polyamino acid can associate with a nucleic acid and includes a cationic amino acid residue having a cationic group in a side chain and a hydrophobic amino acid residue having a hydrophobic group in a side chain. The cationic polyamino acid includes 1 to 20 units of the cationic amino acid residue and is represented by the following formula (1). The meaning of each symbol in the formula is as shown in the description.
摘要翻译：本发明提供一种适用于可在生理条件下与核酸形成稳定复合物的载体的阳离子聚氨基酸，并适当地释放细胞中的核酸。阳离子聚氨基酸可以与核酸结合，并且包括在侧链中具有阳离子基团的阳离子氨基酸残基和在侧链中具有疏水基团的疏水性氨基酸残基。阳离子聚氨基酸包含1〜20个单元的阳离子氨基酸残基，由下式（1）表示。公式中每个符号的含义如说明书所示。

3. 发明授权

US08720242B2 Rolling mill for a plate or a sheet and its control technique 有权
标题翻译：轧板机或板材及其控制技术
公开(公告)号：US08720242B2
公开(公告)日：2014-05-13
申请号：US12734439
申请日：2008-10-30
申请人： Shigeru Ogawa , Atsushi Ishii , Yoji Nakamura , Yasuhiro Higashida
发明人： Shigeru Ogawa , Atsushi Ishii , Yoji Nakamura , Yasuhiro Higashida
IPC分类号： B21B37/00
CPC分类号： B21B37/46 , B21B35/00 , B21B35/04 , B21B2275/04 , B21B2275/12
摘要： The present invention provides a rolling mill of a plate or a sheet which eliminates rolling trouble due to warping of the rolled material and wavy shaped flatness defects running through the plate or sheet width direction such as “waviness”, “full waves, and “small waves” by providing a pair of a top and bottom work rolls, a pair of electric motors independently driving the pair of rolls, and control means for controlling one electric motor using the roll rotational speed as a control target value and controlling the other electric motor using the rolling torque applied to the rolled material from the work roll driven by that electric motor becoming substantially constant as a control target and using the drive torque as a control amount and a control technique of such a rolling mill of a plate or a sheet.
摘要翻译：本发明提供了一种板材或片材的轧机，其消除由于轧制材料的翘曲引起的滚动故障，并且穿过板或纸宽度方向的波浪状平坦度缺陷如“波纹”，“全波”和“小波通过设置一对上下工作辊，独立驱动该对辊的一对电动机，以及控制装置，用于使用辊旋转速度控制一个电动机作为控制目标值，并控制另一个电动机使用施加到来自由该电动机驱动的工作辊的轧制材料的轧制转矩作为控制目标而变得基本恒定，并且使用驱动转矩作为控制量，以及这样的板或板的轧机的控制技术。

4. 发明授权

US08683146B2 Storage apparatus and controlling method of storage apparatus 有权
标题翻译：存储装置的存储装置和控制方法
公开(公告)号：US08683146B2
公开(公告)日：2014-03-25
申请号：US13416567
申请日：2012-03-09
申请人： Wataru Iizuka , Atsushi Ishii , Noboru Ishiwata , Masanori Itoh , Yoshihito Konta
发明人： Wataru Iizuka , Atsushi Ishii , Noboru Ishiwata , Masanori Itoh , Yoshihito Konta
IPC分类号： G06F12/00
CPC分类号： G06F11/3034 , G06F11/2005 , G06F11/2015 , G06F11/2089 , G06F11/3058
摘要： A storage apparatus including: a first controller that generates an access to a storage device; the first controller includes: a first relay unit configured to relay the access to the storage device; and an access control unit configured to be activated after activation of the first relay unit and to relay the access to the storage device via a second relay unit; and a second controller that includes the second relay unit and generates the access to the storage device, wherein when the first relay unit receives a connection request for an access path between the first relay unit and the storage device from the second controller, the first relay unit establishes the access path to the storage device irrespective of an activation state of the access control unit.
摘要翻译：一种存储装置，包括：第一控制器，其生成对存储装置的访问; 第一控制器包括：第一中继单元，被配置为将访问中继到存储设备; 以及访问控制单元，被配置为在所述第一中继单元激活之后被激活，并且经由第二中继单元中继对所述存储设备的访问; 以及第二控制器，其包括所述第二中继单元并且生成对所述存储设备的访问，其中当所述第一中继单元从所述第二控制器接收到所述第一中继单元和所述存储设备之间的访问路径的连接请求时，所述第一中继单元建立到存储设备的访问路径，而与访问控制单元的激活状态无关。

5. 发明申请

US20130331092A1 DEVICES FOR DETERMINING WHETHER TO SCAN FOR CELLULAR SERVICE 审中-公开
标题翻译：用于确定无需扫描细胞服务的设备
公开(公告)号：US20130331092A1
公开(公告)日：2013-12-12
申请号：US13491351
申请日：2012-06-07
申请人： Atsushi Ishii
发明人： Atsushi Ishii
IPC分类号： H04W24/00 , H04W88/06
CPC分类号： H04W48/16 , H04W48/04
摘要： A wireless communication device for determining whether to scan for cellular service is described. The wireless communication device includes a processor and memory in electronic communication with the processor. Executable instructions are stored in the memory. The wireless communication device obtains a location of the wireless communication device. The wireless communication device also obtains a distance between the wireless communication device and a cellular service area. The wireless communication device also determines whether the distance is less than a threshold. The wireless communication device additionally avoids scanning for cellular service if the distance is not less than the threshold.
摘要翻译：描述用于确定是否扫描蜂窝服务的无线通信设备。无线通信设备包括处理器和与处理器电子通信的存储器。可执行指令存储在内存中。无线通信设备获得无线通信设备的位置。无线通信设备还获得无线通信设备和蜂窝服务区域之间的距离。无线通信设备还确定距离是否小于阈值。如果距离不小于阈值，则无线通信设备还避免了蜂窝业务的扫描。

6. 发明授权

US08365567B2 Rolling mill and rolling method for flat products of steel 有权
标题翻译：轧钢机轧制方法钢材平板产品
公开(公告)号：US08365567B2
公开(公告)日：2013-02-05
申请号：US12735362
申请日：2009-02-24
申请人： Shigeru Ogawa , Atsushi Ishii , Daisuke Kasai
发明人： Shigeru Ogawa , Atsushi Ishii , Daisuke Kasai
IPC分类号： B21B13/14
CPC分类号： B21B13/145 , B21B38/105 , B21B2013/025 , B21B2013/026 , B21B2013/028 , B21B2031/206
摘要： The object is to eliminate the difference in offset of work rolls at the upper and lower and left and right of the rolling mill occurring in the kiss roll state of the zero point adjustment work before rolling or during rolling and eliminate the problem of warping of the flat products or meander or camber due to the thrust force acting between the work rolls and backup rolls.For this, there are provided a rolling mill for flat products having a pair of upper and lower work rolls driven by electric motors, a pair of upper and lower backup rolls contacting the work rolls and supporting the rolling reaction force applied to the work rolls, and devices for applying substantially horizontal direction external forces to the upper and lower work rolls, the rolling mill for flat products characterized in that a direction of horizontal direction external forces applied to the work rolls is the same direction as the horizontal direction force component of the rolling reaction force applied to the work rolls due to the rolling direction offset and in that the horizontal direction external forces applied to the work rolls are supported by rolling mill housing project blocks or work roll chock support members, and a rolling method for flat products using the same.
摘要翻译：本发明的目的是为了消除在滚轧前或轧制过程中在零点调整工作的接触滚动状态下发生的轧机上下左右工作辊的偏移差异，并消除了轧制过程中的翘曲问题由于在工作辊和支承辊之间作用的推力，平板产品或曲折或弯曲。为此，提供了一种用于平板产品的轧机，其具有由电动机驱动的一对上下工作辊，一对上下支承辊与工作辊接触并支撑施加到工作辊上的轧制反作用力，以及用于将大致水平方向外力施加到上下工作辊的装置，用于平板产品的轧机，其特征在于，施加到工作辊上的水平方向外力的方向与所述工作辊的水平方向力分量相同由于轧制方向偏移而施加到工作辊上的轧制反作用力，并且施加到工作辊上的水平方向外力由轧机壳体工程块或工作辊轴承座支撑构件支撑，并且使用用于平板产品的轧制方法一样。

7. 发明授权

US08232650B2 Semiconductor device and method for manufacturing the same 失效
标题翻译：半导体装置及其制造方法
公开(公告)号：US08232650B2
公开(公告)日：2012-07-31
申请号：US13180202
申请日：2011-07-11
申请人： Hiroyuki Chibahara , Atsushi Ishii , Naoki Izumi , Masahiro Matsumoto
发明人： Hiroyuki Chibahara , Atsushi Ishii , Naoki Izumi , Masahiro Matsumoto
IPC分类号： H01L23/48
CPC分类号： H01L23/02 , H01L23/522 , H01L23/585 , H01L2924/0002 , H01L2924/00
摘要： A semiconductor device wherein destruction of a sealing ring caused by cracking of an interlayer dielectric film is difficult to occur, as well as a method for manufacturing the semiconductor device, are provided. A first laminate comprises first interlayer dielectric films having a first mechanical strength. A second laminate comprises second interlayer dielectric films having a mechanical strength higher than the first mechanical strength. A first region includes first metallic layers and vias provided within the first laminate. A second region includes second metallic layers and vias provided within the second laminate. When seen in plan, the second region overlaps at least a part of the first region, is not coupled with the first region by vias, and sandwiches the second interlayer dielectric film between it and the first region.
摘要翻译：提供了难以发生由层间电介质膜的破裂引起的密封环破坏的半导体装置，以及半导体装置的制造方法。第一层压板包括具有第一机械强度的第一层间绝缘膜。第二层压体包括具有高于第一机械强度的机械强度的第二层间介电膜。第一区域包括设置在第一层压体内的第一金属层和通孔。第二区域包括设置在第二层压体内的第二金属层和通孔。当在平面图中看到时，第二区域与第一区域的至少一部分重叠，不通过通孔与第一区域耦合，并且在其与第一区域之间夹住第二层间电介质膜。

8. 发明授权

US08161474B2 Diagnostic information preservation during installations of over the air update of wireless handset software 有权
标题翻译：在无线手机软件的空中更新安装过程中进行诊断信息的保存
公开(公告)号：US08161474B2
公开(公告)日：2012-04-17
申请号：US12002109
申请日：2007-12-14
申请人： Atsushi Ishii
发明人： Atsushi Ishii
IPC分类号： H04Q7/34
CPC分类号： H04W24/02 , G06F11/0742 , G06F11/0748 , G06F11/0787 , H04W88/02
摘要： A method and system for failsafe preservation of diagnostic information that identifies problems encountered during installation of over the air updates of wireless handset software includes logging code stored in an area of the handset that is not updated during over the air updates and that is executable to generate and store diagnostic information in an area of the handset that is not updated during over the air updates. By disposing a logging code and diagnostic information in areas of the handset that are invulnerable to corruption during installation of over the air updates, diagnostic information is guaranteed to be generated by the handset and transferable to an external diagnostics system for analysis even in the event of a fatal error.
摘要翻译：用于识别安装无线手持机软件的空中更新期间遇到的问题的诊断信息的故障安全保存的方法和系统包括存储在手机区域中的记录代码，所述区域在空中更新期间未更新，并且可执行以生成并且将诊断信息存储在手机的在空中更新过程中未更新的区域中。通过在手机安装过程中不受侵害的区域中放置测井代码和诊断信息，可以保证手机产生诊断信息，并将其转移到外部诊断系统进行分析，即使在一个致命的错误。

9. 发明授权

US08008730B2 Semiconductor device, and manufacturing method thereof 有权
标题翻译：半导体装置及其制造方法
公开(公告)号：US08008730B2
公开(公告)日：2011-08-30
申请号：US12502008
申请日：2009-07-13
申请人： Shoichi Fukui , Noboru Morimoto , Yasutaka Nishioka , Junko Izumitani , Atsushi Ishii
发明人： Shoichi Fukui , Noboru Morimoto , Yasutaka Nishioka , Junko Izumitani , Atsushi Ishii
IPC分类号： H01L21/02
CPC分类号： H01L23/5329 , H01L21/76801 , H01L21/76819 , H01L21/76828 , H01L21/76829 , H01L21/76832 , H01L21/76837 , H01L21/76849 , H01L21/76867 , H01L23/53295 , H01L2924/0002 , H01L2924/00
摘要： To provide a manufacturing method of a semiconductor device which can improve the reliability of the semiconductor device. A first insulating film for covering a semiconductor element formed in a semiconductor substrate is formed by a thermal CVD method or the like which has a good embedding property. A second insulating film is formed to cover the first insulating film by a plasma CVD method which has excellent humidity resistance. A plug is formed to penetrate the first insulating film and the second insulating film. A third insulating film comprised of a low-k film having a relatively low dielectric constant is formed over the second insulating film. A wiring is formed in the third insulating film by a damascene technique to be electrically coupled to the plug.
摘要翻译：提供能提高半导体器件的可靠性的半导体器件的制造方法。用于覆盖半导体衬底中形成的半导体元件的第一绝缘膜通过具有良好嵌入特性的热CVD法等形成。通过等离子体CVD法形成第二绝缘膜以覆盖第一绝缘膜，其具有优异的耐湿性。形成插塞以穿透第一绝缘膜和第二绝缘膜。在第二绝缘膜上形成由具有较低介电常数的低k膜构成的第三绝缘膜。通过镶嵌技术在第三绝缘膜中形成布线以与插头电耦合。

10. 发明申请

US20110183438A1 Method for Sensing a Substance to be Detected in a Sample 审中-公开
公开(公告)号：US20110183438A1
公开(公告)日：2011-07-28
申请号：US13081177
申请日：2011-04-06
申请人： Kazuhiko MATSUMOTO , Koichi Mukasa , Atsushi Ishii , Seiji Takeda , Makoto Sawamura , Agus Subagyo , Hirotaka Hosoi , Kazuhisa Sueoka , Hiroshi Kida , Yoshihiro Sakoda
发明人： Kazuhiko MATSUMOTO , Koichi Mukasa , Atsushi Ishii , Seiji Takeda , Makoto Sawamura , Agus Subagyo , Hirotaka Hosoi , Kazuhisa Sueoka , Hiroshi Kida , Yoshihiro Sakoda
IPC分类号： G01N33/566
CPC分类号： H01L51/0545 , B82Y10/00 , B82Y30/00 , G01N27/4146 , H01L51/0048
摘要： A single-electron transistor comprising at least a substrate, a source electrode and a drain electrode formed on top of the substrate opposing to each other, and a channel arranged between the source electrode is disclosed wherein the channel is composed of ultra fine fibers. By having such a constitution, a sensor can have excellent sensitivity.

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