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1. 发明申请

US20090221600A1 PYRIDO-PYRIDIMIDINE DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS 审中-公开
标题翻译：用作抗炎药物的吡咯并吡啶衍生物
公开(公告)号：US20090221600A1
公开(公告)日：2009-09-03
申请号：US12088538
申请日：2006-09-28
申请人： Ashwani Kumar Verma , Yogesh Bhaskarrao Waman , Venkata P. Palle , Atul Kondaskar , Abhijit Ray , Malini Bajpai , Geeta Sharma
发明人： Ashwani Kumar Verma , Yogesh Bhaskarrao Waman , Venkata P. Palle , Atul Kondaskar , Abhijit Ray , Malini Bajpai , Geeta Sharma
IPC分类号： A61K31/519 , C07D471/04 , A61P29/00
CPC分类号： C07D471/04
摘要： Provided are novel pyrido-pyrimidine derivatives, having the structure of Formula (I): which can be used as anti-inflammatory agents. Also provided are pharmaceutical compositions comprising one or more pyrido-pyrimidine derivatives, as well as methods of treating autoimmune diseases, inflammation or associated pathologies, including for example, sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis, comprising administering such compounds or pharmaceutical compositions comprising them.
摘要翻译：提供具有式（I）结构的新型吡啶并嘧啶衍生物：其可用作抗炎剂。还提供了包含一种或多种吡啶并嘧啶衍生物的药物组合物，以及治疗自身免疫性疾病，炎症或相关病理学的方法，包括例如败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性肺部疾病，器官移植排斥和牛皮癣，包括施用这样的化合物或包含它们的药物组合物。

2. 发明申请

US20090131430A1 PYRIDO'2,3-DIPYRIMIDINES AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：吡咯烷-2,3-二吡啶作为抗炎剂
公开(公告)号：US20090131430A1
公开(公告)日：2009-05-21
申请号：US11720047
申请日：2005-11-23
申请人： Venkata P. Palle , Rakesh Kumar Singh , Sanjay Malhotra , Yogesh Bhaskarrao Waman , Ashwani Verma , Abhijit Ray , Geeta Sharma
发明人： Venkata P. Palle , Rakesh Kumar Singh , Sanjay Malhotra , Yogesh Bhaskarrao Waman , Ashwani Verma , Abhijit Ray , Geeta Sharma
IPC分类号： A61K31/5377 , C07D471/04 , A61P29/00 , A61K31/519
CPC分类号： C07D471/04
摘要： The present invention relates to novel azabicyclo derivatives as anti-inflammatory agents. The compounds provided herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis. Also provided herein are pharmacological compositions containing compounds provided herein and associated methods of treating sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis, and other inflammatory and/or autoimmune disorders, using the compounds.
摘要翻译：本发明涉及新型的氮杂二环衍生物作为抗炎剂。本文提供的化合物可用于抑制和预防炎症和相关病理，包括炎性和自身免疫性疾病，例如败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性肺病，器官移植排斥反应和牛皮癣。本文还提供含有本文提供的化合物的药物组合物和治疗败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性肺病，器官移植排斥反应和牛皮癣以及其它炎性和/或自身免疫性疾病的相关方法，使用该化合物。

3. 发明申请

US20090036472A1 AZABICYCLO DERIVATIVES AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：作为抗炎剂的雅各布酚衍生物
公开(公告)号：US20090036472A1
公开(公告)日：2009-02-05
申请号：US11815251
申请日：2006-02-01
申请人： Venkata P. Palle , Ashwani Verma , Rakesh Kumar Singh , Yogesh Bhaskarrao Waman , Arti Walia , Abhijit Ray , Geeta Sharma
发明人： Venkata P. Palle , Ashwani Verma , Rakesh Kumar Singh , Yogesh Bhaskarrao Waman , Arti Walia , Abhijit Ray , Geeta Sharma
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00 , A61P19/02 , A61P11/00 , A61P9/00 , A61P3/00 , A61P3/10 , A61P1/00
CPC分类号： C07D471/04
摘要： The present invention relates to novel azabicyclo derivatives of Formula (I) as anti-inflammatory agents which are useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis.
摘要翻译：本发明涉及式（I）的新型氮杂双环衍生物作为抗炎剂，其可用于抑制和预防炎症和相关病理学，包括炎性和自身免疫疾病如败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性肺病，器官移植排斥和牛皮癣。

4. 发明授权

US08420666B2 Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors 有权
标题翻译：吡唑并（3,4-B）吡啶衍生物作为磷酸二酯酶抑制剂
公开(公告)号：US08420666B2
公开(公告)日：2013-04-16
申请号：US12531043
申请日：2008-03-14
申请人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Vinayak Vasantrao Khairnar , Mandadapu Raghu Ramaiah , Venkata P. Palle , Sarala Balachandran , Atul Kondaskar , Manohar Salla , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
发明人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Vinayak Vasantrao Khairnar , Mandadapu Raghu Ramaiah , Venkata P. Palle , Sarala Balachandran , Atul Kondaskar , Manohar Salla , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
IPC分类号： C07D513/02 , C07D515/02 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formula 1: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.
摘要翻译：本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。本文公开的具有式1结构的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE型4 / PDE 7型抑制剂的用途。

5. 发明申请

US20100292196A1 PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS 有权
标题翻译：吡咯烷（3,4-B）吡啶衍生物作为磷酸二酯酶抑制剂
公开(公告)号：US20100292196A1
公开(公告)日：2010-11-18
申请号：US12531043
申请日：2008-03-14
申请人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Vinayak Vasantrao Khairnar , Mandadapu Raghu Ramaiah , Venkata P. Palle , Sarala Balachandran , Atul Kondaskar , Manohar Salla , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
发明人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Vinayak Vasantrao Khairnar , Mandadapu Raghu Ramaiah , Venkata P. Palle , Sarala Balachandran , Atul Kondaskar , Manohar Salla , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
IPC分类号： A61K31/573 , C07D519/00 , A61K31/437 , C07D471/04 , A61P17/00 , A61P19/00 , A61P11/00 , A61P35/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formula 1: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.
摘要翻译：本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。本文公开的具有式1结构的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE型4 / PDE 7型抑制剂的用途。

6. 发明授权

US07674811B2 5-lipoxygenase inhibitors 失效
标题翻译： 5-脂氧合酶抑制剂
公开(公告)号：US07674811B2
公开(公告)日：2010-03-09
申请号：US11685892
申请日：2007-03-14
申请人： Ashwani Kumar Verma , Sanjay Malhotra , Abhijit Ray , Shirumalla Raj Kumar
发明人： Ashwani Kumar Verma , Sanjay Malhotra , Abhijit Ray , Shirumalla Raj Kumar
IPC分类号： C07D249/08 , A61K31/4196
CPC分类号： C07D405/12 , C07D405/14 , C07D413/14
摘要： The present invention relates to 5-lipoxygenase inhibitors. Compounds disclosed herein can be useful in the treatment of bronchial asthma, chronic obstructive pulmonary disorder, arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, urticaria, atopic dermatitis, allergic rhinitis, other inflammatory, and autoimmune diseases. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as 5-lipoxygenase inhibitors are also provided.
摘要翻译：本发明涉及5-脂氧合酶抑制剂。本文公开的化合物可用于治疗支气管哮喘，慢性阻塞性肺病，关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症，荨麻疹，特应性皮炎，过敏性鼻炎，其他炎症和自身免疫性疾病。还提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为5-脂氧合酶抑制剂的用途。

7. 发明申请

US20080300196A1 MONOSACCHARIDE DERIVATIVES 审中-公开
标题翻译：单糖衍生物
公开(公告)号：US20080300196A1
公开(公告)日：2008-12-04
申请号：US11866542
申请日：2007-10-03
申请人： Ashwani Kumar Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Rajkumar Shirumalla , Abhijit Ray
发明人： Ashwani Kumar Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Rajkumar Shirumalla , Abhijit Ray
IPC分类号： A61K31/7052 , C07H17/02 , A61K31/70 , A61P9/00 , A61P37/00 , A61P35/00 , A61P29/00 , C07H15/00
CPC分类号： C07H3/02 , C07H9/04 , C07H15/00
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory, cancer, cardiovascular and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, cancer, cardiovascular diseases, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症，癌症，心血管和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒或过敏性鼻炎。包含本文公开的化合物的药理学组合物和治疗诸如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化症，癌症，心血管疾病，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒症或使用该化合物的过敏性鼻炎和其它炎症和/或自身免疫性疾病。

8. 发明授权

US07790689B2 Monosaccharide derivatives 失效
标题翻译：单糖衍生物
公开(公告)号：US07790689B2
公开(公告)日：2010-09-07
申请号：US11755164
申请日：2007-05-30
申请人： Ashwani Kumar Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Rajkumar Shirumalla
发明人： Ashwani Kumar Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Rajkumar Shirumalla
IPC分类号： A61K31/7008 , A61K31/7012 , A61K31/34 , C07H5/04 , C07H5/06 , C07D323/02 , C07D317/00
CPC分类号： C07H13/12 , C07H9/04
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

9. 发明申请

US20090018174A1 MACROLIDES AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：防腐剂作为抗炎剂
公开(公告)号：US20090018174A1
公开(公告)日：2009-01-15
申请号：US12093041
申请日：2006-11-08
申请人： Pradip Kumar Bhatnagar , Anjan Chakrabarti , Biswajit Das , Malini Bajpai , Abhijit Ray
发明人： Pradip Kumar Bhatnagar , Anjan Chakrabarti , Biswajit Das , Malini Bajpai , Abhijit Ray
IPC分类号： A61K31/365 , A61K31/424
CPC分类号： A61K31/7048
摘要： Provided herein are macrolide derivatives that can be useful in treating or preventing inflammatory diseases. Also provided are pharmaceutical compositions comprising one or more macrolide derivatives optionally together with one or more pharmaceutically acceptable carriers, excipients, diluents or mixtures thereof, as well as methods for treating or preventing inflammatory diseases.
摘要翻译：本文提供可用于治疗或预防炎性疾病的大环内酯衍生物。还提供药物组合物，其包含一种或多种大环内酯衍生物，任选与一种或多种药学上可接受的载体，赋形剂，稀释剂或其混合物，以及治疗或预防炎性疾病的方法。

10. 发明申请

US20100120902A1 STANDARIZED BIOACTIVE HERBAL EXTRACTS 审中-公开
标题翻译：标准生物活性草药提取物
公开(公告)号：US20100120902A1
公开(公告)日：2010-05-13
申请号：US12532815
申请日：2008-03-24
申请人： Chandra Kant Katiyar , Anil Kanaujia , Rajeev Duggar , Satyapal Singh Yadav , Navin Sharma , Abhijit Ray , Rajkumar Shirumalla , Malini Bajpai , Gyanesh Shukla , Baddireddi Subhadra Lakshmi , Kontham Sanathkumar Vinaykumar
发明人： Chandra Kant Katiyar , Anil Kanaujia , Rajeev Duggar , Satyapal Singh Yadav , Navin Sharma , Abhijit Ray , Rajkumar Shirumalla , Malini Bajpai , Gyanesh Shukla , Baddireddi Subhadra Lakshmi , Kontham Sanathkumar Vinaykumar
IPC分类号： A61K31/352 , A61P29/00 , A61P19/02 , A61P19/00
CPC分类号： A61K36/185
摘要： The present invention relates to standardized extracts of Boerhaavia diffusa, wherein the extracts have anti inflammatory and analgesic activities. The present invention also includes bioassay guided fractionation of Boerhaavia diffusa leading to the identification of bioactive markers; processes for the isolation of the bioactive markers; processes for the preparation of the extracts enriched with bioactive markers from Boerhaavia diffusa; pharmaceutical compositions comprising bioactive markers, or standardized extracts of Boerhaavia diffusa and methods of standardization of the extracts.
摘要翻译：本发明涉及双歧杆菌的标准化提取物，其中提取物具有抗炎和止痛活性。本发明还包括生物测定引导分离的Boerhaavia diffusa，导致鉴定生物活性标记; 分离生物活性标记物的方法; 用于制备富含Boerhaavia diffusa的生物活性标记物的提取物的方法; 包含生物活性标记物或Boerhaavia diffusa的标准化提取物的药物组合物和提取物的标准化方法。

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