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1. 发明授权

US07618634B2 Neurotoxic oligomers 有权
标题翻译：神经毒性低聚物
公开(公告)号：US07618634B2
公开(公告)日：2009-11-17
申请号：US10312437
申请日：2001-06-28
申请人： Ashley Bush , Robert Cherny , Rudolph Emile Tanzi
发明人： Ashley Bush , Robert Cherny , Rudolph Emile Tanzi
IPC分类号： A61K39/00 , A61K38/00 , A61K38/04
CPC分类号： A61K38/1709 , A61K39/0007 , A61K47/64 , A61K2039/6081 , C07K16/18 , G01N33/6896
摘要： This invention relates to methods and compositions for the treatment or alleviation of Alzheimer's disease and of other conditions related to abnormal protein aggregation. In particular, the invention relates to methods and compositions for the immunotherapy of Alzheimer's disease, Parkinson's disease, and cataract. In one aspect the invention provides a method of prophylaxis, treatment or alleviation of a condition characterized by pathological aggregation and accumulation of a specific protein associated with an immunizing-effective dose of one or more tyrosine cross-linked compounds, and optionally also comprising copper ions complexed to the compound. Alternatively passive immunization against a tyrosine cross-linked compound may be used. Prophylactic or therapeutic compositions and diagnostic methods are also disclosed and claimed.
摘要翻译：本发明涉及用于治疗或缓解阿尔茨海默病和与异常蛋白质聚集相关的其它病症的方法和组合物。特别地，本发明涉及用于阿尔茨海默氏病，帕金森病和白内障的免疫治疗的方法和组合物。一方面，本发明提供了一种预防，治疗或缓解特征在于与免疫有效剂量的一种或多种酪氨酸交联化合物相关的特异性蛋白质的病理性聚集和积累的病症的方法，以及任选还包含铜离子复合化合物。或者可以使用针对酪氨酸交联化合物的被动免疫。还公开并要求保护的预防或治疗组合物和诊断方法。

2. 发明申请

US20060074104A1 Use of clioquinol for the therapy of alzheimer's disease 审中-公开
标题翻译：氯喹啉用于治疗阿尔茨海默病
公开(公告)号：US20060074104A1
公开(公告)日：2006-04-06
申请号：US11099693
申请日：2005-04-06
申请人： Ashley Bush , Rudolph Tanzi , Mikhal Xilinas , Robert Cherny
发明人： Ashley Bush , Rudolph Tanzi , Mikhal Xilinas , Robert Cherny
IPC分类号： A61K31/47
CPC分类号： A61K31/714 , A61K31/47 , A61K31/715 , A61K45/06 , A61K2300/00
摘要： The invention relates to the identification of clioquinol as a pharmaceutically therapeutic agent for treatment of Alzheimer's disease and related pathological conditions.
摘要翻译：本发明涉及作为治疗阿尔茨海默病和相关病理状况的药学治疗剂的氯碘喹啉的鉴定。

3. 发明授权

US08318171B2 Neurotoxic oligomers 有权
标题翻译：神经毒性低聚物
公开(公告)号：US08318171B2
公开(公告)日：2012-11-27
申请号：US12466094
申请日：2009-05-14
申请人： Ashley Bush , Robert Cherny
发明人： Ashley Bush , Robert Cherny
IPC分类号： A61K39/395
CPC分类号： A61K38/1709 , A61K39/0007 , A61K47/64 , A61K2039/6081 , C07K16/18 , G01N33/6896
摘要： This invention relates to methods and compositions for the treatment or alleviation of Alzheimer's disease and of other conditions related to abnormal protein aggregation. In particular, the invention relates to methods and compositions for the immunotherapy of Alzheimer's disease, Parkinson's disease, and cataract. In one aspect the invention provides a method of prophylaxis, treatment or alleviation of a condition characterized by pathological aggregation and accumulation of a specific protein associated with an immunizing-effective dose of one or more tyrosine cross-linked compounds, and optionally also comprising copper ions complexed to the compound. Alternatively passive immunization against a tyrosine cross-linked compound may be used. Prophylactic or therapeutic compositions and diagnostic methods are also disclosed and claimed.
摘要翻译：本发明涉及用于治疗或缓解阿尔茨海默病和与异常蛋白质聚集相关的其它病症的方法和组合物。特别地，本发明涉及用于阿尔茨海默氏病，帕金森病和白内障的免疫治疗的方法和组合物。一方面，本发明提供了一种预防，治疗或缓解特征在于与免疫有效剂量的一种或多种酪氨酸交联化合物相关的特异性蛋白质的病理性聚集和积累的病症的方法，以及任选还包含铜离子复合化合物。或者可以使用针对酪氨酸交联化合物的被动免疫。还公开并要求保护的预防或治疗组合物和诊断方法。

4. 发明申请

US20090297538A1 NEUROTOXIC OLIGOMERS 有权
标题翻译：神经毒素寡聚体
公开(公告)号：US20090297538A1
公开(公告)日：2009-12-03
申请号：US12466094
申请日：2009-05-14
申请人： Ashley Bush , Robert Cherny
发明人： Ashley Bush , Robert Cherny
IPC分类号： A61K39/395 , A61P25/28
CPC分类号： A61K38/1709 , A61K39/0007 , A61K47/64 , A61K2039/6081 , C07K16/18 , G01N33/6896
摘要： This invention relates to methods and compositions for the treatment or alleviation of Alzheimer's disease and of other conditions related to abnormal protein aggregation. In particular, the invention relates to methods and compositions for the immunotherapy of Alzheimer's disease, Parkinson's disease, and cataract. In one aspect the invention provides a method of prophylaxis, treatment or alleviation of a condition characterized by pathological aggregation and accumulation of a specific protein associated with an immunizing-effective dose of one or more tyrosine cross-linked compounds, and optionally also comprising copper ions complexed to the compound. Alternatively passive immunization against a tyrosine cross-linked compound may be used. Prophylactic or therapeutic compositions and diagnostic methods are also disclosed and claimed.
摘要翻译：本发明涉及用于治疗或缓解阿尔茨海默病和与异常蛋白质聚集相关的其它病症的方法和组合物。特别地，本发明涉及用于阿尔茨海默氏病，帕金森病和白内障的免疫治疗的方法和组合物。一方面，本发明提供了一种预防，治疗或缓解特征在于与免疫有效剂量的一种或多种酪氨酸交联化合物相关的特异性蛋白质的病理性聚集和积累的病症的方法，以及任选还包含铜离子复合化合物。或者可以使用针对酪氨酸交联化合物的被动免疫。还公开并要求保护的预防或治疗组合物和诊断方法。

5. 发明申请

US20070037848A1 Treatment of neurological conditions 审中-公开
标题翻译：治疗神经病症
公开(公告)号：US20070037848A1
公开(公告)日：2007-02-15
申请号：US10552258
申请日：2004-04-02
申请人： Colin Masters , Robert Cherny
发明人： Colin Masters , Robert Cherny
IPC分类号： A61K31/4709
CPC分类号： A61K45/06 , A61K31/47 , A61K31/4709 , A61K31/473 , Y02A50/411 , A61K2300/00
摘要： The present invention relates generally to the treatment of conditions and/or disorders associated with or exacerbated by oxidative stress and which have symptoms including cognitive impairment such as pre- or mild cognitive impairment or memory loss. The agents and methods useful for the practice of the present invention are proposed to modulate and in particular reduce levels of reactive oxygen species thereby minimizing oxidative stress. The present invention further provides methods and agents for the treatment of and/or prophylaxis of neurological diseases and in particular those associated with or facilitated by oxidative stress. Neurological disorders contemplated herein include any condition leading to cognitive impairment such as pre- or mild cognitive impairment or memory loss. The present invention provides therefore methods and agents for treating, ameliorating the symptoms of and/or otherwise arresting cognitive impairment such as pre- or mild cognitive impairment or memory loss.
摘要翻译：本发明一般涉及与氧化应激相关或加剧的病症和/或病症的治疗，其具有包括认知障碍（例如轻度或轻度认知障碍或记忆丧失）的症状。提出了用于实施本发明的试剂和方法，以调节并且特别地降低活性氧的含量，从而使氧化应激最小化。本发明还提供了用于治疗和/或预防神经系统疾病，特别是与氧化应激相关或由氧化应激促进的方法和药剂。本文考虑的神经障碍包括导致认知障碍的任何状况，例如轻度或轻度认知障碍或记忆丧失。因此，本发明提供了用于治疗，改善诸如前期或轻度认知障碍或记忆丧失的认知障碍和/或其他阻滞的症状的方法和试剂。

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