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1. 发明申请

US20060159617A1 Small technetium-99m and rhenium labeled agents and methods for imaging tissues, organs and tumors 审中-公开
标题翻译：小锝-99m和铼标记的试剂和成像组织，器官和肿瘤的方法
公开(公告)号：US20060159617A1
公开(公告)日：2006-07-20
申请号：US10534225
申请日：2003-11-08
申请人： Ashfaq Mahmood , Zhen Cheng , Alun Jones , Alan Davison
发明人： Ashfaq Mahmood , Zhen Cheng , Alun Jones , Alan Davison
IPC分类号： A61K51/00 , C07F13/00 , C07F5/00 , C07D211/26
CPC分类号： C07C323/41 , A61K51/0455 , A61K51/0478 , C07C323/25 , C07D211/14 , C07D211/52 , C07D211/58 , C07F13/005
摘要： The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors. In another embodiment, the invention relates the methods of imaging tissues, organs or tumors using radiolabeled metal complexes, particularly tissues, organs, or tumors which express certain receptors to which the compounds or complexes of the invention have an affinity. The present invention also relates to methods of treating cancer, particularly those cancer lines which express certain receptors to which the compounds or complexes of the invention have an affinity. In yet another embodiment, the present invention provides methods of imaging and/or inhibiting receptors or neuroreceptors using compounds or complexes of the invention which have an affinity for the receptor or neuroreceptor to be imaged and/or inhibited.
摘要翻译：本发明涉及适用于组织，器官或肿瘤的成像或治疗性治疗的化合物及其相关锝和铼络合物。在另一个实施方案中，本发明涉及使用放射性标记的金属络合物，特别是表达本发明的化合物或复合物具有亲和力的某些受体的组织，器官或肿瘤来成像组织，器官或肿瘤的方法。本发明还涉及治疗癌症的方法，特别是那些表达本发明化合物或复合物具有亲和力的某些受体的那些癌症系。在另一个实施方案中，本发明提供使用对受体或神经受体成像和/或抑制的亲和力的本发明化合物或复合物成像和/或抑制受体或神经受体的方法。

2. 发明申请

US20080226550A1 SMALL TECHNETIUM-99M AND RHENIUM LABELED AGENTS AND METHODS FOR IMAGING TUMORS 审中-公开
标题翻译：小技术-99M和氙标签代理和成像肿瘤的方法
公开(公告)号：US20080226550A1
公开(公告)日：2008-09-18
申请号：US12017328
申请日：2008-01-21
申请人： Ashfaq Mahmood , Matthias Friebe , Cristina Bolzati , Alun G. Jones , Alan Davison
发明人： Ashfaq Mahmood , Matthias Friebe , Cristina Bolzati , Alun G. Jones , Alan Davison
IPC分类号： A61K51/04 , C07F5/00 , C07D211/00 , A61P35/00 , C07D295/00
CPC分类号： C07D295/13 , A61K51/0478 , C07C323/41 , C07F13/005 , C07K5/06026
摘要： The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tumors, e.g., carcinomas, melanomas and other tumors. In another embodiment, the invention relates to methods of imaging tumors using radiolabeled metal complexes. Preferred radiolabeled complexes for imaging tumors include technetium and rhenium complexes. The high tumor uptake and significant tumor/nontumor ratios of the technetium complexes of the invention indicate that such small technetium-99m-based molecular probes can be developed as in-vivo diagnostic agents for melanoma and its metastases. In yet another embodiment, the invention relates to methods of treatment of tumors using a radiolabeled metal complex as a radiopharmaceutical agent to treat the tumor.
摘要翻译：本发明涉及适用于肿瘤例如癌，黑素瘤和其他肿瘤的成像或治疗性治疗的化合物及其相关的锝和铼络合物。在另一个实施方案中，本发明涉及使用放射性标记的金属络合物成像肿瘤的方法。用于成像肿瘤的优选放射性标记复合物包括锝和铼络合物。本发明的锝络合物的高肿瘤摄取和显着的肿瘤/非肿瘤比率表明，这种基于锝-99m的小分子探针可以作为黑色素瘤及其转移的体内诊断剂开发。在另一个实施方案中，本发明涉及使用放射性标记的金属络合物作为放射性药物治疗肿瘤的方法治疗肿瘤。

3. 发明授权

US07321027B2 Small technetium-99m and rhenium labeled agents and methods for imaging tumors 失效
标题翻译：小锝-99m和铼标记的药剂和肿瘤成像方法
公开(公告)号：US07321027B2
公开(公告)日：2008-01-22
申请号：US10279214
申请日：2002-10-23
申请人： Ashfaq Mahmood , Matthias Friebe , Cristina Bolzati , Alun G. Jones , Alan Davison
发明人： Ashfaq Mahmood , Matthias Friebe , Cristina Bolzati , Alun G. Jones , Alan Davison
IPC分类号： C07F13/00
CPC分类号： C07D295/13 , A61K51/0478 , C07C323/41 , C07F13/005 , C07K5/06026
摘要： The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tumors, e.g., carcinomas, melanomas and other tumors. In another embodiment, the invention relates to methods of imaging tumors using radiolabeled metal complexes. Preferred radiolabeled complexes for imaging tumors include technetium and rhenium complexes. The high tumor uptake and significant tumor/nontumor ratios of the technetium complexes of the invention indicate that such small technetium-99m-based molecular probes can be developed as in-vivo diagnostic agents for melanoma and its metastases. In yet another embodiment, the invention relates to methods of treatment of tumors using a radiolabeled metal complex as a radiopharmaceutical agent to treat the tumor.
摘要翻译：本发明涉及适用于肿瘤例如癌，黑素瘤和其他肿瘤的成像或治疗性治疗的化合物及其相关的锝和铼络合物。在另一个实施方案中，本发明涉及使用放射性标记的金属络合物成像肿瘤的方法。用于成像肿瘤的优选放射性标记复合物包括锝和铼络合物。本发明的锝络合物的高肿瘤摄取和显着的肿瘤/非肿瘤比率表明，这种基于锝-99m的小分子探针可以作为黑色素瘤及其转移的体内诊断剂开发。在另一个实施方案中，本发明涉及使用放射性标记的金属络合物作为放射性药物治疗肿瘤的方法治疗肿瘤。

4. 发明授权

US06171576B2 Dopamine transporter imaging agent 失效
标题翻译：多巴胺转运蛋白成像剂
公开(公告)号：US06171576B2
公开(公告)日：2001-01-09
申请号：US08552584
申请日：1995-11-03
申请人： Peter C. Meltzer , Bertha K. Madras , Alan Davison , Paul Blundell , Ashfaq Mahmood , Alun G. Jones
发明人： Peter C. Meltzer , Bertha K. Madras , Alan Davison , Paul Blundell , Ashfaq Mahmood , Alun G. Jones
IPC分类号： A61K5100
CPC分类号： A61K51/0448 , A61K2123/00 , C07C69/753 , C07C2602/44 , C07D451/02
摘要： Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.
摘要翻译：公开了放射性药物化合物。托烷化合物通过8位的N原子连接到能够络合锝或铼的螯合配体以产生选择性结合多巴胺转运蛋白的中性标记复合物。这些化合物可以制备成单独的非对映异构体以及非对映异构体的混合物。还公开了用于制备标记的放射性药物化合物的放射性药物试剂盒。

5. 发明授权

US5692382A Modular non-cryogenic cooled auger conveyor arrangement for chilling food products, slurries and the like 失效
标题翻译：用于冷冻食品，浆料等的模块化非低温冷却螺旋输送机装置
公开(公告)号：US5692382A
公开(公告)日：1997-12-02
申请号：US652406
申请日：1996-05-23
申请人： Alan Davison
发明人： Alan Davison
IPC分类号： A23L3/36 , F25D13/06
CPC分类号： F25D13/065 , A23L3/361
摘要： In order to chill foodstuffs and the like type of material a modular chilling unit is provided with a jacketed trough through which a chilled non-cryogenic coolant such as glycol is circulated, and wherein the material to be cooled is moved along the cooled trough using an auger. The chilling unit is arranged so that it can be mounted on another so that the material is transferred from one to another under the influence of gravity and so that the length of chilling path can be suitably elongated. The troughs are each rotatably supported by a structure which allows rotation to a near inverted position wherein jets of cleaning fluid can be ejected into the interior of the trough.
摘要翻译：为了冷却食品和类似类型的材料，模块化冷却单元设置有夹套槽，冷却的非低温冷却剂如乙二醇通过其流通，并且其中待冷却的材料沿着冷却的槽移动，使用螺旋冷却单元被布置成使得其可以安装在另一个上，使得材料在重力的影响下从一个转移到另一个，并且可以适当地延长冷却路径的长度。所述槽各自可旋转地支撑在允许旋转到接近倒置位置的结构上，其中清洗流体的喷射可以喷射到槽的内部。

6. 发明授权

US6054114A Organometallic ligands for the localization and quantification of amyloid in vivo and in vitro 失效
标题翻译：用于体内和体外淀粉样蛋白定位和定量的有机金属配体
公开(公告)号：US6054114A
公开(公告)日：2000-04-25
申请号：US852825
申请日：1997-05-07
申请人： Peter T. Lansbury, Jr. , Hogyu Han , Cheon-Gyu Cho , Weiguo Zhen , James D. Harper , Alan Davison
发明人： Peter T. Lansbury, Jr. , Hogyu Han , Cheon-Gyu Cho , Weiguo Zhen , James D. Harper , Alan Davison
IPC分类号： A61K49/06 , A61K51/04 , C07B59/00 , C07F13/00 , A61K51/00 , A61K49/00
CPC分类号： C07F13/005 , A61K49/06 , A61K51/0478 , A61K51/0482 , C07B59/002 , A61K2123/00
摘要： Novel organometallic compounds for binding amyloid are described. Methods using such compounds for determining by imaging the localization or quantification of amyloid fibrils in a mammal, for diagnosing the degree of progression of Alzheimer's disease in a mammal, for monitoring the response to a therapy in a mammal having Alzheimer's disease, for identifying an agent useful for treating Alzheimer's disease, for treating Alzheimer's disease, and for detecting the presence of the infectious form of the prion protein, are also described.
摘要翻译：描述了用于结合淀粉样蛋白的新型有机金属化合物。使用这些化合物来测定哺乳动物淀粉状蛋白原纤维的定位或定量的方法，用于诊断哺乳动物中阿尔茨海默病的进展程度，用于监测对具有阿尔茨海默病的哺乳动物的治疗的反应，用于鉴定药剂也描述了用于治疗阿尔茨海默病，用于治疗阿尔茨海默病和用于检测朊病毒蛋白的感染形式的存在的方法。

7. 发明授权

US4707544A Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents 失效
标题翻译：用于制备用于标记和成像剂的放射性核素复合物的金属 - 异腈加合物
公开(公告)号：US4707544A
公开(公告)日：1987-11-17
申请号：US675540
申请日：1984-11-28
申请人： Alun G. Jones , Alan Davison , Michael J. Abrams
发明人： Alun G. Jones , Alan Davison , Michael J. Abrams
IPC分类号： G01N33/60 , A61K51/04 , C07F3/06 , C07F9/00 , C07F11/00 , C07F13/00 , C07F15/00 , G01N33/58 , A61K43/00 , A61K49/00 , C07C121/20 , C07F1/08
CPC分类号： C07F13/00 , A61K51/0476 , C07F3/06 , A61K2123/00
摘要： A method for preparing a coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta is disclosed. The method comprises preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal isonitrile salt with a salt comprising said radioactive metal in a suitable solvent to displace said displaceable metal with the radioactive metal thereby forming said coordination. The complex is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.
摘要翻译：公开了制备诸如Tc，Ru，Co，Pt，Fe，Os，Ir，W，Re，Cr，Mo，Mn，Ni，Rh，Pd，Nb和Ta之类的异腈配体和放射性核素的配位络合物的方法。该方法包括通过将所述配体与可选择的金属的盐混合制备所述异腈配体的可溶性金属加合物，所述可置换金属的盐具有选自Zn，Ga，Cd，In，Sn，Hg，Tl， Pb和Bi以形成可溶性金属 - 异腈盐，并将所述金属异腈盐与包含所述放射性金属的盐在合适的溶剂中混合，以用放射性金属置换所述可置换金属，从而形成所述配位。该复合物可用作标记脂质体或囊泡的诊断剂，以及选择的含有脂质膜的活细胞如血凝块，心肌组织，胆囊组织等。

8. 发明授权

US4746505A Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands 失效
标题翻译：来自双酰胺二硫醇配体的锝放射性诊断脂肪酸
公开(公告)号：US4746505A
公开(公告)日：1988-05-24
申请号：US727582
申请日：1985-04-26
申请人： Alun G. Jones , John Lister-James , Alan Davison
发明人： Alun G. Jones , John Lister-James , Alan Davison
IPC分类号： A61K51/00 , A61K51/04 , C07C67/00 , C07C313/00 , C07C323/41 , C07C323/60 , C07C325/00 , C07C327/36 , C07F13/00 , A61K43/00 , A61K49/00 , A61K49/02 , C07C149/23
CPC分类号： C07F13/005 , A61K51/04 , A61K2123/00
摘要： A bisamide-bisthiol ligand containing fatty acid substituted thiol useful for producing Tc-labelled radiodiagnostic imaging agents is described. The ligand forms a complex with the radionuclide .sup.99m Tc suitable for administration as a radiopharmaceutical to obtain images of the heart for diagnosis of myocardial disfunction.
摘要翻译：描述了含有用于制备Tc-标记的放射诊断显像剂的含有脂肪酸取代的硫醇的双酰胺 - 二硫醇配体。配体与放射性核素99mTc形成复合物，适合作为放射性药物的给药，以获得用于心肌功能障碍诊断的心脏图像。

9. 发明授权

US11525535B1 Toolless disassembly rotational vacuum coupling 有权
公开(公告)号：US11525535B1
公开(公告)日：2022-12-13
申请号：US16810397
申请日：2020-03-05
申请人： Clay Owens , Alan Davison , Chris Clouse
发明人： Clay Owens , Alan Davison , Chris Clouse
IPC分类号： F16L37/10 , F16L37/14 , F16L35/00
摘要： A hand disassembly rotational valve coupling for tool less manipulation by a user's hands and fingers using a coupling housing body defining an output seal aperture close to an output handle retention slot and slot lip, where the slot lip has a slot handle gap and an output seal retainer including a coupling handle ring with a first triangulated offset body retention ears and hand graspable handles separated by a ring handle gap for hand assembly and disassembly from the coupling housing body.

10. 发明授权

US4872561A Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes 失效
标题翻译：羧基，烷氧羰基和氨基甲酰取代的异腈核苷配合物
公开(公告)号：US4872561A
公开(公告)日：1989-10-10
申请号：US139289
申请日：1987-12-29
申请人： Alun G. Jones , Alan Davison , James Kronauge , Michael J. Abrams
发明人： Alun G. Jones , Alan Davison , James Kronauge , Michael J. Abrams
IPC分类号： A61K51/00 , A61K51/04 , C07F13/00
CPC分类号： C07F13/005 , C07C251/00 , A61K2123/00
摘要： A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula:(CNX)R,where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms. R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same of different is disclosed. Kits that can be used to form these complexes are also disclosed.
摘要翻译：包含选自Tc，Ru，Co，Pt和Re的放射性同位素的放射性核素的配位络合物和式（CNX）R的异腈配体，其中X是具有1至4个碳原子的低级烷基其中R选自COOR1和CONR2R3，其中R1可以是H，药学上可接受的阳离子或具有1至4个碳原子的取代或未取代的烷基。 R2和R3可以是H，或者取代或未取代的具有1至4个碳原子的烷基，R2和R3可以是不同的。还可以公开可用于形成这些络合物的试剂盒。

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